Entry | Database: PDB / ID: 4ma4 |
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Title | S-glutathionylated PFKFB3 |
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Components | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 |
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Keywords | HYDROLASE / Transferase / S-glutathionylated protein / Rossmann Fold / phosphoryl transferase / S-glutathionylation / cytosol |
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Function / homology | Function and homology information
6-phosphofructo-2-kinase / 6-phosphofructo-2-kinase activity / fructose 2,6-bisphosphate metabolic process / fructose-2,6-bisphosphate 2-phosphatase / fructose-2,6-bisphosphate 2-phosphatase activity / Regulation of glycolysis by fructose 2,6-bisphosphate metabolism / fructose metabolic process / nucleoplasm / ATP binding / cytosolSimilarity search - Function Fructose-2,6-bisphosphatase / 6-phosphofructo-2-kinase / 6-phosphofructo-2-kinase / Phosphoglycerate/bisphosphoglycerate mutase, active site / Phosphoglycerate mutase family phosphohistidine signature. / Phosphoglycerate mutase family / Phosphoglycerate mutase-like / Histidine phosphatase superfamily, clade-1 / Histidine phosphatase superfamily (branch 1) / Histidine phosphatase superfamily ...Fructose-2,6-bisphosphatase / 6-phosphofructo-2-kinase / 6-phosphofructo-2-kinase / Phosphoglycerate/bisphosphoglycerate mutase, active site / Phosphoglycerate mutase family phosphohistidine signature. / Phosphoglycerate mutase family / Phosphoglycerate mutase-like / Histidine phosphatase superfamily, clade-1 / Histidine phosphatase superfamily (branch 1) / Histidine phosphatase superfamily / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase / Rossmann fold / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology ACETIC ACID / ADENOSINE-5'-DIPHOSPHATE / 6-O-phosphono-beta-D-fructofuranose / GLUTATHIONE / MALONIC ACID / 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3Similarity search - Component |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.23 Å |
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Authors | Lee, Y.-H. / Seo, M.-S. |
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Citation | Journal: J.Mol.Biol. / Year: 2014 Title: PFKFB3 Regulates Oxidative Stress Homeostasis via Its S-Glutathionylation in Cancer. Authors: Seo, M. / Lee, Y.H. |
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History | Deposition | Aug 15, 2013 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Dec 11, 2013 | Provider: repository / Type: Initial release |
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Revision 1.1 | Dec 25, 2013 | Group: Database references |
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Revision 1.2 | Feb 12, 2014 | Group: Database references |
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Revision 1.3 | Apr 29, 2015 | Group: Non-polymer description |
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Revision 1.4 | Jul 29, 2020 | Group: Data collection / Derived calculations / Structure summary Category: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item: _chem_comp.mon_nstd_flag / _chem_comp.name ..._chem_comp.mon_nstd_flag / _chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_leaving_atom_flag Description: Carbohydrate remediation / Provider: repository / Type: Remediation |
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