Entry Database : PDB / ID : 4c9w Structure visualization Downloads & linksTitle Crystal structure of NUDT1 (MTH1) with R-crizotinib Components7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE Details Keywords HYDROLASE / CRIZOTINIBFunction / homology Function and homology informationFunction Domain/homology Component
2-hydroxy-ATP hydrolase activity / 2-hydroxy-dATP hydrolase activity / N6-methyl-(d)ATP hydrolase activity / O6-methyl-dGTP hydrolase activity / 2-hydroxy-dATP diphosphatase / dATP diphosphatase activity / ATP diphosphatase activity / 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity / hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides / 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity ... 2-hydroxy-ATP hydrolase activity / 2-hydroxy-dATP hydrolase activity / N6-methyl-(d)ATP hydrolase activity / O6-methyl-dGTP hydrolase activity / 2-hydroxy-dATP diphosphatase / dATP diphosphatase activity / ATP diphosphatase activity / 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity / hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides / 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity / DNA protection / Phosphate bond hydrolysis by NUDT proteins / purine nucleoside catabolic process / snoRNA binding / Hydrolases; Acting on acid anhydrides; In phosphorus-containing anhydrides / response to cadmium ion / acrosomal vesicle / male gonad development / nuclear membrane / response to oxidative stress / mitochondrial matrix / DNA repair / mitochondrion / extracellular space / metal ion binding / nucleus / cytosol / cytoplasm Similarity search - Function Oxidized purine nucleoside triphosphate / NUDIX hydrolase / NUDIX hydrolase, conserved site / Nudix box signature. / Nucleoside Triphosphate Pyrophosphohydrolase / Nucleoside Triphosphate Pyrophosphohydrolase / NUDIX domain / Nudix hydrolase domain profile. / NUDIX hydrolase domain / NUDIX hydrolase-like domain superfamily ... Oxidized purine nucleoside triphosphate / NUDIX hydrolase / NUDIX hydrolase, conserved site / Nudix box signature. / Nucleoside Triphosphate Pyrophosphohydrolase / Nucleoside Triphosphate Pyrophosphohydrolase / NUDIX domain / Nudix hydrolase domain profile. / NUDIX hydrolase domain / NUDIX hydrolase-like domain superfamily / Alpha-Beta Complex / Alpha Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.65 Å DetailsAuthors Elkins, J.M. / Salah, E. / Huber, K. / Superti-Furga, G. / Abdul Azeez, K.R. / Raynor, J. / Krojer, T. / von Delft, F. / Bountra, C. / Edwards, A. / Knapp, S. CitationJournal : Nature / Year : 2014Title : Stereospecific Targeting of Mth1 by (S)-Crizotinib as an Anticancer Strategy.Authors: Huber, K.V.M. / Salah, E. / Radic, B. / Gridling, M. / Elkins, J.M. / Stukalov, A. / Jemth, A. / Gokturk, C. / Sanjiv, K. / Stromberg, K. / Pham, T. / Berglund, U.W. / Colinge, J. / Bennett, ... Authors : Huber, K.V.M. / Salah, E. / Radic, B. / Gridling, M. / Elkins, J.M. / Stukalov, A. / Jemth, A. / Gokturk, C. / Sanjiv, K. / Stromberg, K. / Pham, T. / Berglund, U.W. / Colinge, J. / Bennett, K.L. / Loizou, J.I. / Helleday, T. / Knapp, S. / Superti-Furga, G. History Deposition Oct 3, 2013 Deposition site : PDBE / Processing site : PDBERevision 1.0 Apr 2, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Apr 16, 2014 Group : Database referencesRevision 1.2 Jan 24, 2018 Group : Structure summary / Category : audit_author / Item : _audit_author.nameRevision 1.3 Dec 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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