登録情報 データベース : PDB / ID : 3v6o 構造の表示 ダウンロードとリンクタイトル Leptin Receptor-antibody complex 要素(Monoclonal antibody 9F8 fab fragment ...) x 2 Leptin receptor 詳細キーワード IMMUNE SYSTEM (免疫系) / Receptor-antibody complex / Cytokine receptor / Antibody Fab fragment / Immunoglobulin fold / Leptin Receptor-antibody complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
leptin receptor activity / regulation of transport / 骨化 / leptin-mediated signaling pathway / regulation of bone remodeling / response to leptin / regulation of feeding behavior / 有性生殖 / multicellular organism development / energy reserve metabolic process ... leptin receptor activity / regulation of transport / 骨化 / leptin-mediated signaling pathway / regulation of bone remodeling / response to leptin / regulation of feeding behavior / 有性生殖 / multicellular organism development / energy reserve metabolic process / Signaling by Leptin / cytokine receptor activity / glycogen metabolic process / cytokine binding / transport across blood-brain barrier / T cell differentiation / glial cell proliferation / negative regulation of gluconeogenesis / 食作用 / energy homeostasis / cholesterol metabolic process / negative regulation of autophagy / 糖新生 / cytokine-mediated signaling pathway / transmembrane signaling receptor activity / glucose homeostasis / positive regulation of cold-induced thermogenesis / basolateral plasma membrane / 血管新生 / cell surface receptor signaling pathway / receptor complex / positive regulation of protein phosphorylation / external side of plasma membrane / extracellular region / identical protein binding 類似検索 - 分子機能 Leptin receptor, immunoglobulin-like domain / Obesity receptor immunoglobulin like domain / Immunoglobulin C2-set-like, ligand-binding / 免疫グロブリンスーパーファミリー / Short hematopoietin receptor, family 1, conserved site / Long hematopoietin receptor, Gp130 family 2, conserved site / Long hematopoietin receptor, gp130 family signature. / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III ... Leptin receptor, immunoglobulin-like domain / Obesity receptor immunoglobulin like domain / Immunoglobulin C2-set-like, ligand-binding / 免疫グロブリンスーパーファミリー / Short hematopoietin receptor, family 1, conserved site / Long hematopoietin receptor, Gp130 family 2, conserved site / Long hematopoietin receptor, gp130 family signature. / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Ig-like domain profile. / Immunoglobulin-like domain / 抗体 / Immunoglobulin-like fold / Immunoglobulin-like / サンドイッチ / Mainly Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)Mus musculus (ハツカネズミ)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.95 Å 詳細データ登録者 Carpenter, B. / Hemsworth, G.R. / Ross, R.J. / Artymiuk, P.J. 引用ジャーナル : Structure / 年 : 2012タイトル : Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody.著者 : Carpenter, B. / Hemsworth, G.R. / Wu, Z. / Maamra, M. / Strasburger, C.J. / Ross, R.J. / Artymiuk, P.J. 履歴 登録 2011年12月20日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2012年3月14日 Provider : repository / タイプ : Initial release改定 1.1 2012年4月25日 Group : Database references改定 1.2 2020年7月29日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Structure summary カテゴリ : chem_comp / entity ... chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / pdbx_struct_conn_angle / struct_conn / struct_ref_seq / struct_site / struct_site_gen Item : _chem_comp.name / _chem_comp.type ... _chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ref_seq.db_align_beg / _struct_ref_seq.db_align_end 解説 : Carbohydrate remediation / Provider : repository / タイプ : Remediation改定 1.3 2023年12月27日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Structure summary カテゴリ : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / struct_conn Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ... _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_seq_id
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