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-Structure paper
Title | Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody. |
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Journal, issue, pages | Structure, Vol. 20, Page 487-497, Year 2012 |
Publish date | Dec 20, 2011 (structure data deposition date) |
Authors | Carpenter, B. / Hemsworth, G.R. / Wu, Z. / Maamra, M. / Strasburger, C.J. / Ross, R.J. / Artymiuk, P.J. |
External links | Structure / PubMed:22405007 |
Methods | X-ray diffraction |
Resolution | 1.95 - 2.27 Å |
Structure data | PDB-3v6o: PDB-3vg0: |
Chemicals | ChemComp-CYS: ChemComp-EDO: ChemComp-ACT: ChemComp-NA: ChemComp-NAG: ChemComp-HOH: ChemComp-SO4: |
Source |
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Keywords | IMMUNE SYSTEM / Receptor-antibody complex / Cytokine receptor / Antibody Fab fragment / Immunoglobulin fold / Leptin Receptor-antibody complex / N-linked Glycosylation site / Fab fragment / LBD domain of ObR receptor |