登録情報 | データベース: PDB / ID: 3rsr |
---|
タイトル | Crystal Structure of 5-NITP Inhibition of Yeast Ribonucleotide Reductase |
---|
要素 | Ribonucleoside-diphosphate reductase large chain 1 |
---|
キーワード | OXIDOREDUCTASE (酸化還元酵素) / 10-stranded alpha/beta barrel / nucleotide reduction / oxidized |
---|
機能・相同性 | 機能・相同性情報
ribonucleoside-diphosphate reductase complex / リボヌクレオシド二リン酸レダクターゼ / ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor / deoxyribonucleotide biosynthetic process / DNA複製 / nucleotide binding / ATP binding / identical protein binding / 細胞核 / 細胞質類似検索 - 分子機能 Ribonucleotide reductase, class I , alpha subunit / Ribonucleotide reductase large subunit signature. / Ribonucleoside-diphosphate reductase large subunit / ATP-cone domain / ATP cone domain / ATP-cone domain profile. / Ribonucleotide reductase R1 subunit, N-terminal / Ribonucleotide reductase large subunit, N-terminal / Ribonucleotide reductase, all-alpha domain / Ribonucleotide reductase large subunit, C-terminal ...Ribonucleotide reductase, class I , alpha subunit / Ribonucleotide reductase large subunit signature. / Ribonucleoside-diphosphate reductase large subunit / ATP-cone domain / ATP cone domain / ATP-cone domain profile. / Ribonucleotide reductase R1 subunit, N-terminal / Ribonucleotide reductase large subunit, N-terminal / Ribonucleotide reductase, all-alpha domain / Ribonucleotide reductase large subunit, C-terminal / Ribonucleotide reductase, barrel domain / Anaerobic Ribonucleotide-triphosphate Reductase Large Chain / Anaerobic Ribonucleotide-triphosphate Reductase Large Chain - #20 / Alpha-Beta Barrel / Alpha Beta類似検索 - ドメイン・相同性 Chem-N5P / Ribonucleoside-diphosphate reductase large chain 1類似検索 - 構成要素 |
---|
生物種 | Saccharomyces cerevisiae (パン酵母) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.3 Å |
---|
データ登録者 | Wan, Q. / Mohammed, F. / Jha, S. / Motea, E. / Berdis, A. / Dealwis, C.G. |
---|
引用 | ジャーナル: Mol.Cancer Ther. / 年: 2012 タイトル: Evaluating the therapeutic potential of a non-natural nucleotide that inhibits human ribonucleotide reductase. 著者: Ahmad, M.F. / Wan, Q. / Jha, S. / Motea, E. / Berdis, A. / Dealwis, C. |
---|
履歴 | 登録 | 2011年5月2日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2012年11月14日 | Provider: repository / タイプ: Initial release |
---|
|
---|