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Yorodumi- PDB-3jwq: Crystal structure of chimeric PDE5/PDE6 catalytic domain complexe... -
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-Basic information
Entry | Database: PDB / ID: 3jwq | ||||||
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Title | Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with sildenafil | ||||||
Components | cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera | ||||||
Keywords | HYDROLASE / mostly alpha / Allosteric enzyme / cGMP / cGMP-binding / Magnesium / Metal-binding / Nucleotide-binding / Phosphoprotein / Cell membrane / Lipoprotein / Membrane / Methylation / Prenylation / Sensory transduction / Vision | ||||||
Function / homology | Function and homology information positive regulation of oocyte development / retinal cone cell development / 3',5'-cyclic-GMP phosphodiesterase / regulation of nitric oxide mediated signal transduction / negative regulation of cardiac muscle contraction / phototransduction, visible light / oocyte development / relaxation of cardiac muscle / RHOBTB1 GTPase cycle / positive regulation of cardiac muscle hypertrophy ...positive regulation of oocyte development / retinal cone cell development / 3',5'-cyclic-GMP phosphodiesterase / regulation of nitric oxide mediated signal transduction / negative regulation of cardiac muscle contraction / phototransduction, visible light / oocyte development / relaxation of cardiac muscle / RHOBTB1 GTPase cycle / positive regulation of cardiac muscle hypertrophy / cGMP catabolic process / cGMP effects / 3',5'-cyclic-nucleotide phosphodiesterase activity / cGMP binding / Smooth Muscle Contraction / 3',5'-cyclic-GMP phosphodiesterase activity / 3',5'-cyclic-AMP phosphodiesterase activity / negative regulation of T cell proliferation / T cell proliferation / visual perception / cAMP-mediated signaling / metal ion binding / plasma membrane / cytosol Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.87 Å | ||||||
Authors | Barren, B. / Gakhar, L. / Muradov, H. / Boyd, K.K. / Ramaswamy, S. / Artemyev, N.O. | ||||||
Citation | Journal: Embo J. / Year: 2009 Title: Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit Authors: Barren, B. / Gakhar, L. / Muradov, H. / Boyd, K.K. / Ramaswamy, S. / Artemyev, N.O. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 3jwq.cif.gz | 268 KB | Display | PDBx/mmCIF format |
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PDB format | pdb3jwq.ent.gz | 218.8 KB | Display | PDB format |
PDBx/mmJSON format | 3jwq.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 3jwq_validation.pdf.gz | 1.8 MB | Display | wwPDB validaton report |
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Full document | 3jwq_full_validation.pdf.gz | 1.9 MB | Display | |
Data in XML | 3jwq_validation.xml.gz | 47.6 KB | Display | |
Data in CIF | 3jwq_validation.cif.gz | 63.2 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/jw/3jwq ftp://data.pdbj.org/pub/pdb/validation_reports/jw/3jwq | HTTPS FTP |
-Related structure data
Related structure data | 3jwrC 2h42S C: citing same article (ref.) S: Starting model for refinement |
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Similar structure data |
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-Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Component-ID: 1
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