登録情報 データベース : PDB / ID : 3dda 構造の表示 ダウンロードとリンクタイトル Crystal structure of the catalytic domain of Botulinum neurotoxin serotype a with a snap-25 peptide 要素Botulinum neurotoxin A light chain Synaptosomal-associated protein 25 SNAP25 詳細キーワード HYDROLASE (加水分解酵素) / BOTULINUM NEUROTOXIN TYPE A / BOTOX (ボツリヌストキシン) / CATALYTIC DOMAIN / ENDOPEPTIDASE (エンドペプチダーゼ) / SYNTAXIN / BIO-WARFARE AGENT / METAL-BINDING / METALLOPROTEASE (金属プロテアーゼ) / PROTEASE (プロテアーゼ) / SECRETED (分泌) / TRANSMEMBRANE (膜貫通型タンパク質) / ZINC (亜鉛) / ENZYME-SUBSTRATE COMPLEX (酵素) / Pharmaceutical (医薬品) / Alternative splicing (選択的スプライシング) / Cell junction (細胞結合) / Coiled coil (コイルドコイル) / Lipoprotein (リポタンパク質) / Palmitate (パルミチン酸) / Phosphoprotein / Synapse (シナプス) / Synaptosome (シナプトソーム)機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Toxicity of botulinum toxin type C (botC) / neurotransmitter uptake / host cell junction / Toxicity of botulinum toxin type E (botE) / exocytic insertion of neurotransmitter receptor to postsynaptic membrane / Acetylcholine Neurotransmitter Release Cycle / extrinsic component of presynaptic membrane / synaptic vesicle fusion to presynaptic active zone membrane / synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex / synaptobrevin 2-SNAP-25-syntaxin-1a complex ... Toxicity of botulinum toxin type C (botC) / neurotransmitter uptake / host cell junction / Toxicity of botulinum toxin type E (botE) / exocytic insertion of neurotransmitter receptor to postsynaptic membrane / Acetylcholine Neurotransmitter Release Cycle / extrinsic component of presynaptic membrane / synaptic vesicle fusion to presynaptic active zone membrane / synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex / synaptobrevin 2-SNAP-25-syntaxin-1a complex / Toxicity of botulinum toxin type A (botA) / synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex / Serotonin Neurotransmitter Release Cycle / GABA synthesis, release, reuptake and degradation / presynaptic dense core vesicle exocytosis / ribbon synapse / synaptic vesicle docking / Dopamine Neurotransmitter Release Cycle / Norepinephrine Neurotransmitter Release Cycle / SNARE complex / negative regulation of neurotransmitter secretion / SNAP receptor activity / Glutamate Neurotransmitter Release Cycle / ボツリヌストキシン / host cell presynaptic membrane / neurotransmitter receptor internalization / host cell cytoplasmic vesicle / Sensory processing of sound by inner hair cells of the cochlea / syntaxin-1 binding / SNARE complex assembly / host cell cytosol / synaptic vesicle priming / regulation of neuron projection development / regulation of synapse assembly / endosomal transport / Other interleukin signaling / myosin binding / エキソサイトーシス / voltage-gated potassium channel activity / synaptic vesicle exocytosis / regulation of insulin secretion / 学習 / tertiary granule membrane / protein transmembrane transporter activity / long-term memory / specific granule membrane / axonal growth cone / presynaptic active zone membrane / voltage-gated potassium channel complex / photoreceptor inner segment / 軸索誘導 / locomotory behavior / filopodium / Regulation of insulin secretion / long-term synaptic potentiation / ゴルジ体 / positive regulation of insulin secretion / metalloendopeptidase activity / calcium-dependent protein binding / マイクロフィラメント / シナプス小胞 / lamellipodium / presynaptic membrane / 細胞皮質 / toxin activity / 成長円錐 / postsynapse / chemical synaptic transmission / transmembrane transporter binding / membrane => GO:0016020 / 細胞骨格 / エンドソーム / neuron projection / protein domain specific binding / neuronal cell body / glutamatergic synapse / lipid binding / Neutrophil degranulation / host cell plasma membrane / perinuclear region of cytoplasm / タンパク質分解 / zinc ion binding / extracellular region / 生体膜 / 細胞膜 / 細胞質基質 / 細胞質 類似検索 - 分子機能 SNAP25 / SNAP-25 domain / SNAP-25 family / Zincin-like / Metalloproteases ("zincins"), catalytic domain like / Helical region found in SNAREs / t-SNARE coiled-coil homology domain profile. / Target SNARE coiled-coil homology domain / Clostridium neurotoxin, translocation / Clostridium neurotoxin, Translocation domain ... SNAP25 / SNAP-25 domain / SNAP-25 family / Zincin-like / Metalloproteases ("zincins"), catalytic domain like / Helical region found in SNAREs / t-SNARE coiled-coil homology domain profile. / Target SNARE coiled-coil homology domain / Clostridium neurotoxin, translocation / Clostridium neurotoxin, Translocation domain / Clostridium neurotoxin, translocation domain / Clostridial neurotoxin zinc protease / Botulinum/Tetanus toxin, catalytic chain / Clostridium neurotoxin, receptor binding N-terminal / Clostridium neurotoxin, receptor-binding C-terminal / Clostridium neurotoxin, C-terminal receptor binding / Clostridium neurotoxin, N-terminal receptor binding / Kunitz inhibitor STI-like superfamily / Neutral zinc metallopeptidases, zinc-binding region signature. / Concanavalin A-like lectin/glucanase domain superfamily / Alpha-Beta Complex / Alpha Beta 類似検索 - ドメイン・相同性 Botulinum neurotoxin type A / Botulinum neurotoxin type A / SNAP25 類似検索 - 構成要素生物種 Clostridium botulinum (ボツリヌス菌)手法 X線回折 / シンクロトロン / フーリエ合成 / 解像度 : 1.5 Å 詳細データ登録者 Kumaran, D. / Swaminathan, S. 引用ジャーナル : Plos Pathog. / 年 : 2008タイトル : Substrate binding mode and its implication on drug design for botulinum neurotoxin A著者 : Kumaran, D. / Rawat, R. / Ahmed, S.A. / Swaminathan, S. 履歴 登録 2008年6月5日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2008年9月16日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2023年8月30日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_conn_type / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn_type.id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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