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Yorodumi- PDB-2qy0: Active dimeric structure of the catalytic domain of C1r reveals e... -
+Open data
-Basic information
Entry | Database: PDB / ID: 2qy0 | ||||||
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Title | Active dimeric structure of the catalytic domain of C1r reveals enzyme-product like contacts | ||||||
Components | (Complement C1r subcomponent) x 2 | ||||||
Keywords | HYDROLASE / complement / serine protease / beta barrel / Complement pathway / EGF-like domain / Glycoprotein / Hydroxylation / Immune response / Innate immunity / Phosphorylation / Sushi | ||||||
Function / homology | Function and homology information complement subcomponent C_overbar_1r_ / molecular sequestering activity / zymogen activation / Classical antibody-mediated complement activation / Initial triggering of complement / complement activation, classical pathway / serine-type peptidase activity / Regulation of Complement cascade / blood microparticle / immune response ...complement subcomponent C_overbar_1r_ / molecular sequestering activity / zymogen activation / Classical antibody-mediated complement activation / Initial triggering of complement / complement activation, classical pathway / serine-type peptidase activity / Regulation of Complement cascade / blood microparticle / immune response / serine-type endopeptidase activity / innate immune response / calcium ion binding / extracellular space / extracellular exosome / extracellular region / identical protein binding Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.6 Å | ||||||
Authors | Kardos, J. / Harmat, V. / Pallo, A. / Barabas, O. / Szilagyi, K. / Graf, L. / Naray-Szabo, G. / Goto, Y. / Zavodszky, P. / Gal, P. | ||||||
Citation | Journal: Mol.Immunol. / Year: 2008 Title: Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: Structure of the active catalytic region of C1r. Authors: Kardos, J. / Harmat, V. / Pallo, A. / Barabas, O. / Szilagyi, K. / Graf, L. / Naray-Szabo, G. / Goto, Y. / Zavodszky, P. / Gal, P. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 2qy0.cif.gz | 168.6 KB | Display | PDBx/mmCIF format |
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PDB format | pdb2qy0.ent.gz | 132.4 KB | Display | PDB format |
PDBx/mmJSON format | 2qy0.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/qy/2qy0 ftp://data.pdbj.org/pub/pdb/validation_reports/qy/2qy0 | HTTPS FTP |
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-Related structure data
Related structure data | 1gpzS S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Refine code: 4
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