- PDB-2fwu: Second Ca2+ binding domain of the Na,Ca-exchanger (NCX1) -
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基本情報
登録情報
データベース: PDB / ID: 2fwu
タイトル
Second Ca2+ binding domain of the Na,Ca-exchanger (NCX1)
要素
Sodium/calcium exchanger 1
キーワード
METAL TRANSPORT REGULATOR / beta-sandwich / greek key / beta-bulge / Ca2+ binding
機能・相同性
機能・相同性情報
Reduction of cytosolic Ca++ levels / Sodium/Calcium exchangers / calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration / Ion homeostasis / calcium:sodium antiporter activity / cell communication / intracellular sodium ion homeostasis / sodium ion import across plasma membrane / ankyrin binding / positive regulation of the force of heart contraction ...Reduction of cytosolic Ca++ levels / Sodium/Calcium exchangers / calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration / Ion homeostasis / calcium:sodium antiporter activity / cell communication / intracellular sodium ion homeostasis / sodium ion import across plasma membrane / ankyrin binding / positive regulation of the force of heart contraction / calcium ion import across plasma membrane / sodium ion transmembrane transport / positive regulation of bone mineralization / response to muscle stretch / calcium ion transmembrane transport / 筋鞘 / postsynapse / calmodulin binding / 神経繊維 / calcium ion binding / 核質 / 細胞膜 類似検索 - 分子機能
Sodium/calcium exchanger, isoform 1 / CalX-beta domain / Sodium/calcium exchanger protein / Sodium/calcium exchanger domain, C-terminal extension / C-terminal extension of sodium/calcium exchanger domain / Na-Ca exchanger/integrin-beta4 / Calx-beta domain / Domains in Na-Ca exchangers and integrin-beta4 / NCX, central ion-binding domain superfamily / Sodium/calcium exchanger membrane region ...Sodium/calcium exchanger, isoform 1 / CalX-beta domain / Sodium/calcium exchanger protein / Sodium/calcium exchanger domain, C-terminal extension / C-terminal extension of sodium/calcium exchanger domain / Na-Ca exchanger/integrin-beta4 / Calx-beta domain / Domains in Na-Ca exchangers and integrin-beta4 / NCX, central ion-binding domain superfamily / Sodium/calcium exchanger membrane region / Sodium/calcium exchanger protein / CalX-like domain superfamily / DnaJ domain / Immunoglobulin-like / サンドイッチ / Mainly Beta 類似検索 - ドメイン・相同性
手法: torsion angle dynamics / ソフトェア番号: 1 詳細: The structures are based on 2394 NOE-derived distance constraints, 185 dihedral angle restraints (talos), 8 distance constraints to the 2 Ca2+ ions
代表構造
選択基準: closest to the average
NMRアンサンブル
コンフォーマー選択の基準: structures with the lowest energy 計算したコンフォーマーの数: 100 / 登録したコンフォーマーの数: 20