登録情報 データベース : PDB / ID : 2cjx 構造の表示 ダウンロードとリンクタイトル Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis 要素(CASPASE-3 カスパーゼ-3 ) x 2 PHQ-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE 詳細キーワード HYDROLASE/HYDROLASE INHIBITOR / PROTEASE (プロテアーゼ) / APOPTOSIS (アポトーシス) / CYSTEINE PROTEASE (システインプロテアーゼ) / THIOL PROTEASE (システインプロテアーゼ) / ICE / CLAN CD / HYDROLASE-HYDROLASE INHIBITOR COMPLEX機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
カスパーゼ-3 / Stimulation of the cell death response by PAK-2p34 / phospholipase A2 activator activity / anterior neural tube closure / intrinsic apoptotic signaling pathway in response to osmotic stress / leukocyte apoptotic process / positive regulation of pyroptotic inflammatory response / glial cell apoptotic process / NADE modulates death signalling / luteolysis ... カスパーゼ-3 / Stimulation of the cell death response by PAK-2p34 / phospholipase A2 activator activity / anterior neural tube closure / intrinsic apoptotic signaling pathway in response to osmotic stress / leukocyte apoptotic process / positive regulation of pyroptotic inflammatory response / glial cell apoptotic process / NADE modulates death signalling / luteolysis / response to cobalt ion / cysteine-type endopeptidase activity involved in apoptotic signaling pathway / death-inducing signaling complex / cyclin-dependent protein serine/threonine kinase inhibitor activity / cellular response to staurosporine / Apoptosis induced DNA fragmentation / cysteine-type endopeptidase activity involved in execution phase of apoptosis / Caspase activation via Dependence Receptors in the absence of ligand / Apoptotic cleavage of cell adhesion proteins / death receptor binding / SMAC, XIAP-regulated apoptotic response / axonal fasciculation / Activation of caspases through apoptosome-mediated cleavage / Signaling by Hippo / SMAC (DIABLO) binds to IAPs / SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes / cysteine-type endopeptidase activity involved in apoptotic process / fibroblast apoptotic process / execution phase of apoptosis / negative regulation of cytokine production / epithelial cell apoptotic process / platelet formation / Other interleukin signaling / positive regulation of amyloid-beta formation / Apoptotic cleavage of cellular proteins / negative regulation of B cell proliferation / pyroptotic inflammatory response / T cell homeostasis / negative regulation of activated T cell proliferation / neurotrophin TRK receptor signaling pathway / B cell homeostasis / protein maturation / negative regulation of cell cycle / response to X-ray / regulation of macroautophagy / Caspase-mediated cleavage of cytoskeletal proteins / 細胞分化 / response to amino acid / Pyroptosis / response to tumor necrosis factor / enzyme activator activity / response to glucose / response to UV / response to glucocorticoid / keratinocyte differentiation / striated muscle cell differentiation / Degradation of the extracellular matrix / intrinsic apoptotic signaling pathway / 赤血球形成 / hippocampus development / apoptotic signaling pathway / sensory perception of sound / response to nicotine / protein catabolic process / regulation of protein stability / neuron differentiation / response to hydrogen peroxide / protein processing / response to wounding / positive regulation of neuron apoptotic process / response to estradiol / heart development / peptidase activity / neuron apoptotic process / protease binding / response to lipopolysaccharide / aspartic-type endopeptidase activity / learning or memory / response to hypoxia / response to xenobiotic stimulus / cysteine-type endopeptidase activity / neuronal cell body / apoptotic process / DNA damage response / protein-containing complex binding / タンパク質分解 / 核質 / 細胞核 / 細胞質基質 / 細胞質 類似検索 - 分子機能 Caspase-like / Rossmann fold - #1460 / Peptidase family C14A, His active site / Caspase family histidine active site. / Peptidase C14, caspase non-catalytic subunit p10 / Peptidase family C14A, cysteine active site / Caspase family cysteine active site. / Caspase family p10 domain profile. / Peptidase C14A, caspase catalytic domain / Caspase, interleukin-1 beta converting enzyme (ICE) homologues ... Caspase-like / Rossmann fold - #1460 / Peptidase family C14A, His active site / Caspase family histidine active site. / Peptidase C14, caspase non-catalytic subunit p10 / Peptidase family C14A, cysteine active site / Caspase family cysteine active site. / Caspase family p10 domain profile. / Peptidase C14A, caspase catalytic domain / Caspase, interleukin-1 beta converting enzyme (ICE) homologues / Peptidase C14, p20 domain / Caspase family p20 domain profile. / : / Caspase domain / Caspase-like domain superfamily / Alpha-Beta Plaits / ロスマンフォールド / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 N-[(benzyloxy)carbonyl]-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-L-valinamide / カスパーゼ-3 類似検索 - 構成要素生物種 HOMO SAPIENS (ヒト)SYNTHETIC CONSTRUCT (人工物) 手法 X線回折 / フーリエ合成 / 解像度 : 1.7 Å 詳細データ登録者 Ganesan, R. / Mittl, P.R.E. / Jelakovic, S. / Grutter, M.G. 引用ジャーナル : J.Mol.Biol. / 年 : 2006タイトル : Extended Substrate Recognition in Caspase-3 Revealed by High Resolution X-Ray Structure Analysis著者 : Ganesan, R. / Mittl, P.R.E. / Jelakovic, S. / Grutter, M.G. 履歴 登録 2006年4月9日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2006年6月27日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Atomic model / Database references ... Atomic model / Database references / Derived calculations / Non-polymer description / Structure summary / Version format compliance 改定 1.2 2012年11月30日 Group : Other改定 1.3 2016年12月21日 Group : Data collection / Source and taxonomy改定 1.4 2017年6月28日 Group : Data collection / カテゴリ : diffrn_source / Item : _diffrn_source.type
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