登録情報 データベース : PDB / ID : 2c2o 構造の表示 ダウンロードとリンクタイトル Crystal structures of caspase-3 in complex with aza-peptide Michael acceptor inhibitors. 要素AZA-PEPTIDE INHIBITOR (5S, 8R, 11S)-14-{4-[BENZYL(METHYL) AMINO]-4-OXOBUTANOYL}-8-(2-CARBOXYETHYL)-5-(CARBOXYMETHYL)-11-(1-METHYLETHYL)-3,6,9,12-TETRAOXO-1-PHENYL-2-OXA-4,7,10,13,14-PENTAAZAHEXADECAN-16-OIC ACID CASPASE-3 SUBUNIT P12 カスパーゼ-3 CASPASE-3 SUBUNIT P17 カスパーゼ-3 詳細キーワード HYDROLASE/HYDROLASE INHIBITOR / APOPTOSIS (アポトーシス) / HYDROLASE-HYDROLASE INHIBITOR COMPLEX / CYSTEINE-PROTEASE / ICE / TETRAMER (四量体) / THIOL PROTEASE (システインプロテアーゼ) / ZYMOGEN (酵素前駆体) / CPP32 / YAMA (ヤマ (インド神話)) / AZA-PEPTIDE / MICHAEL ACCEPTOR / AZA-ASP / CLAN CD機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
カスパーゼ-3 / Stimulation of the cell death response by PAK-2p34 / phospholipase A2 activator activity / anterior neural tube closure / intrinsic apoptotic signaling pathway in response to osmotic stress / leukocyte apoptotic process / positive regulation of pyroptotic inflammatory response / glial cell apoptotic process / NADE modulates death signalling / luteolysis ... カスパーゼ-3 / Stimulation of the cell death response by PAK-2p34 / phospholipase A2 activator activity / anterior neural tube closure / intrinsic apoptotic signaling pathway in response to osmotic stress / leukocyte apoptotic process / positive regulation of pyroptotic inflammatory response / glial cell apoptotic process / NADE modulates death signalling / luteolysis / response to cobalt ion / cysteine-type endopeptidase activity involved in apoptotic signaling pathway / death-inducing signaling complex / cyclin-dependent protein serine/threonine kinase inhibitor activity / cellular response to staurosporine / Apoptosis induced DNA fragmentation / cysteine-type endopeptidase activity involved in execution phase of apoptosis / Caspase activation via Dependence Receptors in the absence of ligand / Apoptotic cleavage of cell adhesion proteins / death receptor binding / SMAC, XIAP-regulated apoptotic response / axonal fasciculation / Activation of caspases through apoptosome-mediated cleavage / Signaling by Hippo / SMAC (DIABLO) binds to IAPs / SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes / cysteine-type endopeptidase activity involved in apoptotic process / fibroblast apoptotic process / execution phase of apoptosis / negative regulation of cytokine production / epithelial cell apoptotic process / platelet formation / Other interleukin signaling / positive regulation of amyloid-beta formation / Apoptotic cleavage of cellular proteins / negative regulation of B cell proliferation / pyroptotic inflammatory response / T cell homeostasis / negative regulation of activated T cell proliferation / neurotrophin TRK receptor signaling pathway / B cell homeostasis / protein maturation / negative regulation of cell cycle / response to X-ray / regulation of macroautophagy / Caspase-mediated cleavage of cytoskeletal proteins / 細胞分化 / response to amino acid / Pyroptosis / response to tumor necrosis factor / enzyme activator activity / response to glucose / response to UV / response to glucocorticoid / keratinocyte differentiation / striated muscle cell differentiation / Degradation of the extracellular matrix / intrinsic apoptotic signaling pathway / 赤血球形成 / hippocampus development / apoptotic signaling pathway / sensory perception of sound / response to nicotine / protein catabolic process / regulation of protein stability / neuron differentiation / response to hydrogen peroxide / protein processing / response to wounding / positive regulation of neuron apoptotic process / response to estradiol / heart development / peptidase activity / neuron apoptotic process / protease binding / response to lipopolysaccharide / aspartic-type endopeptidase activity / learning or memory / response to hypoxia / response to xenobiotic stimulus / cysteine-type endopeptidase activity / neuronal cell body / apoptotic process / DNA damage response / protein-containing complex binding / タンパク質分解 / 核質 / 細胞核 / 細胞質基質 / 細胞質 類似検索 - 分子機能 Caspase-like / Rossmann fold - #1460 / Peptidase family C14A, His active site / Caspase family histidine active site. / Peptidase C14, caspase non-catalytic subunit p10 / Peptidase family C14A, cysteine active site / Caspase family cysteine active site. / Caspase family p10 domain profile. / Peptidase C14A, caspase catalytic domain / Caspase, interleukin-1 beta converting enzyme (ICE) homologues ... Caspase-like / Rossmann fold - #1460 / Peptidase family C14A, His active site / Caspase family histidine active site. / Peptidase C14, caspase non-catalytic subunit p10 / Peptidase family C14A, cysteine active site / Caspase family cysteine active site. / Caspase family p10 domain profile. / Peptidase C14A, caspase catalytic domain / Caspase, interleukin-1 beta converting enzyme (ICE) homologues / Peptidase C14, p20 domain / Caspase family p20 domain profile. / : / Caspase domain / Caspase-like domain superfamily / Alpha-Beta Plaits / ロスマンフォールド / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 Cbz-Asp-Glu-Val-AAsp-CHCH-CON(CH3)CH2Ph / カスパーゼ-3 類似検索 - 構成要素生物種 HOMO SAPIENS (ヒト)SYNTHETIC CONSTRUCT (人工物) 手法 X線回折 / その他 / 解像度 : 2.45 Å 詳細データ登録者 Ganesan, R. / Jelakovic, S. / Ekici, O.D. / Li, Z.Z. / James, K.E. / Asgian, J.L. / Campbell, A. / Mikolajczyk, J. / Salvesen, G.S. / Gruetter, M.G. / Powers, J.C. 引用ジャーナル : J.Med.Chem. / 年 : 2006タイトル : Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Selective and Potent Inhibitors of Caspases-2, -3, -6, -7, -8, -9, and - 10.著者 : Ekici, O.D. / Li, Z.Z. / Campbell, A.J. / James, K.E. / Asgian, J.L. / Mikolajczyk, J. / Salvesen, G.S. / Ganesan, R. / Jelakovic, S. / Grutter, M.G. / Powers, J.C. 履歴 登録 2005年9月29日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2006年9月20日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Atomic model / Database references ... Atomic model / Database references / Derived calculations / Non-polymer description / Structure summary / Version format compliance 改定 1.2 2012年11月30日 Group : Other改定 1.3 2017年2月8日 Group : Source and taxonomy改定 1.4 2017年6月28日 Group : Data collection / カテゴリ : diffrn_source / Item : _diffrn_source.type改定 2.0 2023年11月15日 Group : Atomic model / Data collection ... Atomic model / Data collection / Database references / Derived calculations / Other カテゴリ : atom_site / chem_comp_atom ... atom_site / chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_validate_main_chain_plane / pdbx_validate_rmsd_angle / struct_conn Item : _atom_site.auth_atom_id / _atom_site.label_atom_id ... _atom_site.auth_atom_id / _atom_site.label_atom_id / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id
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