登録情報 | データベース: SASBDB / ID: SASDBQ9 |
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試料 | Human Hsp90 co-chaperone Cdc37 (CD37) in complex with fibroblast growth factor receptor 3- Hsp90 co-chaperone Cdc37 (protein), CDC37
, Homo sapiens - Fibroblast growth factor receptor 3
(protein), FGFR3 Fibroblast growth factor receptor 3, Homo sapiens |
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機能・相同性 | 機能・相同性情報
fibroblast growth factor receptor apoptotic signaling pathway / t(4;14) translocations of FGFR3 / negative regulation of developmental growth / Signaling by FGFR3 fusions in cancer / bone maturation / regulation of type II interferon-mediated signaling pathway / HSP90-CDC37 chaperone complex / chondrocyte proliferation / positive regulation of mitophagy in response to mitochondrial depolarization / endochondral bone growth ...fibroblast growth factor receptor apoptotic signaling pathway / t(4;14) translocations of FGFR3 / negative regulation of developmental growth / Signaling by FGFR3 fusions in cancer / bone maturation / regulation of type II interferon-mediated signaling pathway / HSP90-CDC37 chaperone complex / chondrocyte proliferation / positive regulation of mitophagy in response to mitochondrial depolarization / endochondral bone growth / FGFR3b ligand binding and activation / Signaling by activated point mutants of FGFR3 / FGFR3c ligand binding and activation / Phospholipase C-mediated cascade; FGFR3 / fibroblast growth factor receptor activity / endochondral ossification / positive regulation of phospholipase activity / protein kinase regulator activity / protein folding chaperone complex / bone morphogenesis / post-transcriptional regulation of gene expression / PI-3K cascade:FGFR3 / Drug-mediated inhibition of ERBB2 signaling / Resistance of ERBB2 KD mutants to trastuzumab / Resistance of ERBB2 KD mutants to sapitinib / Resistance of ERBB2 KD mutants to tesevatinib / Resistance of ERBB2 KD mutants to neratinib / Resistance of ERBB2 KD mutants to osimertinib / Resistance of ERBB2 KD mutants to afatinib / Resistance of ERBB2 KD mutants to AEE788 / Resistance of ERBB2 KD mutants to lapatinib / Drug resistance in ERBB2 TMD/JMD mutants / fibroblast growth factor binding / bone mineralization / regulation of cyclin-dependent protein serine/threonine kinase activity / cell surface receptor signaling pathway via JAK-STAT / regulation of type I interferon-mediated signaling pathway / PI3K Cascade / fibroblast growth factor receptor signaling pathway / protein targeting / chondrocyte differentiation / RHOBTB2 GTPase cycle / SHC-mediated cascade:FGFR3 / FRS-mediated FGFR3 signaling / positive regulation of tyrosine phosphorylation of STAT protein / 小胞 / Signaling by FGFR3 in disease / Signaling by ERBB2 / heat shock protein binding / Constitutive Signaling by Overexpressed ERBB2 / skeletal system development / Negative regulation of FGFR3 signaling / cell surface receptor protein tyrosine kinase signaling pathway / Signaling by ERBB2 TMD/JMD mutants / Hsp90 protein binding / Constitutive Signaling by EGFRvIII / Signaling by ERBB2 ECD mutants / Signaling by ERBB2 KD Mutants / Regulation of necroptotic cell death / 受容体型チロシンキナーゼ / Downregulation of ERBB2 signaling / kinase binding / Constitutive Signaling by Aberrant PI3K in Cancer / 分裂促進因子活性化タンパク質キナーゼ / unfolded protein binding / フォールディング / PIP3 activates AKT signaling / Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants / cell-cell signaling / protein-folding chaperone binding / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / scaffold protein binding / protein tyrosine kinase activity / positive regulation of MAPK cascade / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of ERK1 and ERK2 cascade / receptor complex / protein stabilization / リン酸化 / positive regulation of cell population proliferation / protein kinase binding / ゴルジ体 / 細胞膜 / 小胞体 / extracellular exosome / extracellular region / ATP binding / identical protein binding / 細胞膜 / 細胞質基質 / 細胞質類似検索 - 分子機能 Fibroblast growth factor receptor 3 transmembrane domain / Cdc37, C-terminal / Cdc37, Hsp90 binding / Cdc37, Hsp90-binding domain superfamily / Cdc37 C terminal domain / Cdc37 Hsp90 binding domain / Cdc37 C terminal domain / Cdc37 Hsp90 binding domain / Cdc37 N terminal kinase binding / Cdc37 ...Fibroblast growth factor receptor 3 transmembrane domain / Cdc37, C-terminal / Cdc37, Hsp90 binding / Cdc37, Hsp90-binding domain superfamily / Cdc37 C terminal domain / Cdc37 Hsp90 binding domain / Cdc37 C terminal domain / Cdc37 Hsp90 binding domain / Cdc37 N terminal kinase binding / Cdc37 / Cdc37, N-terminal domain / Cdc37 N terminal kinase binding / Fibroblast growth factor receptor family / 免疫グロブリンフォールド / Immunoglobulin I-set / Immunoglobulin I-set domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Immunoglobulin subtype / 抗体 / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily類似検索 - ドメイン・相同性 Fibroblast growth factor receptor 3 / Hsp90 co-chaperone Cdc37類似検索 - 構成要素 |
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生物種 | ![](img/tx_human.gif) Homo sapiens (ヒト) |
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引用 | 日付: 2018 Mar タイトル: Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System 著者: Bunney T / Inglis A / Sanfelice D / Farrell B / Kerr C / Thompson G / Masson G / Thiyagarajan N / Svergun D / Williams R / Breeze A |
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登録者 | - Chris Kerr (EMBL-Hamburg, European Molecular Biology Laboratory (EMBL) - Hamburg outstation, Notkestraße 85, Geb. 25A, 22607 Hamburg, Deutschland, Germany)
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