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TitleThe native structure of the assembled matrix protein 1 of influenza A virus.
Journal, issue, pagesNature, Vol. 587, Issue 7834, Page 495-498, Year 2020
Publish dateSep 9, 2020
AuthorsJulia Peukes / Xiaoli Xiong / Simon Erlendsson / Kun Qu / William Wan / Leslie J Calder / Oliver Schraidt / Susann Kummer / Stefan M V Freund / Hans-Georg Kräusslich / John A G Briggs /
PubMed AbstractInfluenza A virus causes millions of severe cases of disease during annual epidemics. The most abundant protein in influenza virions is matrix protein 1 (M1), which mediates virus assembly by ...Influenza A virus causes millions of severe cases of disease during annual epidemics. The most abundant protein in influenza virions is matrix protein 1 (M1), which mediates virus assembly by forming an endoskeleton beneath the virus membrane. The structure of full-length M1, and how it oligomerizes to mediate the assembly of virions, is unknown. Here we determine the complete structure of assembled M1 within intact virus particles, as well as the structure of M1 oligomers reconstituted in vitro. We find that the C-terminal domain of M1 is disordered in solution but can fold and bind in trans to the N-terminal domain of another M1 monomer, thus polymerizing M1 into linear strands that coat the interior surface of the membrane of the assembling virion. In the M1 polymer, five histidine residues-contributed by three different monomers of M1-form a cluster that can serve as the pH-sensitive disassembly switch after entry into a target cell. These structures therefore reveal mechanisms of influenza virus assembly and disassembly.
External linksNature / PubMed:32908308 / PubMed Central
MethodsEM (tomography) / EM (subtomogram averaging) / EM (helical sym.)
Resolution3.8 - 8.0 Å
Structure data

EMDB-11075:
Tomogram of a influenza A/Hong Kong/1/1968 virions
Method: EM (tomography)

EMDB-11076:
Tomogram of influenza A/Hong Kong/1/1968 virus like particles (HA,NA,M1,M2)
Method: EM (tomography)

EMDB-11077:
Structure of the influenza A matrix protein M1 from influenza A/Hong Kong/1/1968 virions
Method: EM (subtomogram averaging) / Resolution: 8.0 Å

11078

6z5j

EMDB-11078: The structure of the matrix protein M1 from influenza A/Hong Kong/1/1968 VLPs (HA,NA,M1,M2)
PDB-6z5j: Arrangement of the matrix protein M1 in influenza A/Hong Kong/1/1968 VLPs (HA,NA,M1,M2)
Method: EM (subtomogram averaging) / Resolution: 8.0 Å

11079

6z5l

EMDB-11079, PDB-6z5l:
Helical reconstruction of influenza A virus M1 in complex with nucleic acid.
Method: EM (helical sym.) / Resolution: 3.8 Å

Chemicals

ChemComp-HOH:
WATER / Water

Source
  • Influenza A virus
  • influenza a virus (a/puerto rico/8-9nmc3/1934(h1n1))
  • influenza a virus (strain a/puerto rico/8/1934 h1n1)
KeywordsVIRAL PROTEIN / Viral matrix protein / Membrane binding / pH Sensor / Polymer / M1 / Matrix protein / Influenza virus / Assembly / ribonucleoprotein complex

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