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Structure paper

TitleThe structure of the yeast mitochondrial ribosome.
Journal, issue, pagesScience, Vol. 355, Issue 6324, Page 528-531, Year 2017
Publish dateFeb 3, 2017
AuthorsNirupa Desai / Alan Brown / Alexey Amunts / V Ramakrishnan /
PubMed AbstractMitochondria have specialized ribosomes (mitoribosomes) dedicated to the expression of the genetic information encoded by their genomes. Here, using electron cryomicroscopy, we have determined the ...Mitochondria have specialized ribosomes (mitoribosomes) dedicated to the expression of the genetic information encoded by their genomes. Here, using electron cryomicroscopy, we have determined the structure of the 75-component yeast mitoribosome to an overall resolution of 3.3 angstroms. The mitoribosomal small subunit has been built de novo and includes 15S ribosomal RNA (rRNA) and 34 proteins, including 14 without homologs in the evolutionarily related bacterial ribosome. Yeast-specific rRNA and protein elements, including the acquisition of a putatively active enzyme, give the mitoribosome a distinct architecture compared to the mammalian mitoribosome. At an expanded messenger RNA channel exit, there is a binding platform for translational activators that regulate translation in yeast but not mammalian mitochondria. The structure provides insights into the evolution and species-specific specialization of mitochondrial translation.
External linksScience / PubMed:28154081 / PubMed Central
MethodsEM (single particle)
Resolution3.2 - 4.97 Å
Structure data

3551

5mrc

EMDB-3551, PDB-5mrc:
Structure of the yeast mitochondrial ribosome - Class A
Method: EM (single particle) / Resolution: 3.25 Å

3552

5mre

EMDB-3552, PDB-5mre:
Structure of the yeast mitochondrial ribosome - Class B
Method: EM (single particle) / Resolution: 3.75 Å

3553

5mrf

EMDB-3553, PDB-5mrf:
Structure of the yeast mitochondrial ribosome - Class C
Method: EM (single particle) / Resolution: 4.97 Å

EMDB-3554:
Yeast mitochondrial ribosome - small subunit head (fitted to EMD 3551)
Method: EM (single particle) / Resolution: 3.5 Å

EMDB-3555:
Yeast mitochondrial ribosome - small subunit body (fitted to EMD 3551)
Method: EM (single particle) / Resolution: 3.3 Å

EMDB-3556:
Yeast mitochondrial ribosome - large subunit (fitted to EMD 3551)
Method: EM (single particle) / Resolution: 3.2 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM / Guanosine diphosphate

Source
  • saccharomyces cerevisiae (brewer's yeast)
  • Baker's yeast (brewer's yeast)
KeywordsRIBOSOME / yeast / mitochondrial / saccharomyces cerevisiae

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