Entry Database : PDB / ID : 4wuy Structure visualization Downloads & linksTitle Crystal Structure of Protein Lysine Methyltransferase SMYD2 in complex with LLY-507, a Cell-Active, Potent and Selective Inhibitor ComponentsN-lysine methyltransferase SMYD2 Details Keywords Transferase/transferase inhibitor / SMYD2 - LLY-507 / Transferase-transferase inhibitor complexFunction / homology Function and homology informationFunction Domain/homology Component
lysine N-methyltransferase activity / [histone H3]-lysine4 N-trimethyltransferase / peptidyl-lysine monomethylation / peptidyl-lysine dimethylation / histone H3K4 trimethyltransferase activity / histone H3K36 methyltransferase activity / protein-lysine N-methyltransferase activity / histone H3 methyltransferase activity / regulation of DNA damage response, signal transduction by p53 class mediator / RNA polymerase II complex binding ... lysine N-methyltransferase activity / [histone H3]-lysine4 N-trimethyltransferase / peptidyl-lysine monomethylation / peptidyl-lysine dimethylation / histone H3K4 trimethyltransferase activity / histone H3K36 methyltransferase activity / protein-lysine N-methyltransferase activity / histone H3 methyltransferase activity / regulation of DNA damage response, signal transduction by p53 class mediator / RNA polymerase II complex binding / Transferases; Transferring one-carbon groups; Methyltransferases / regulation of signal transduction by p53 class mediator / PKMTs methylate histone lysines / Regulation of TP53 Activity through Methylation / p53 binding / heart development / negative regulation of cell population proliferation / negative regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / metal ion binding / cytoplasm / cytosol Similarity search - Function SMYD2, SET domain / : / MYND finger / Zinc finger, MYND-type / Zinc finger MYND-type signature. / Zinc finger MYND-type profile. / Beta-clip-like / SET domain / Tetratricopeptide repeat domain / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain ... SMYD2, SET domain / : / MYND finger / Zinc finger, MYND-type / Zinc finger MYND-type signature. / Zinc finger MYND-type profile. / Beta-clip-like / SET domain / Tetratricopeptide repeat domain / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain superfamily / SET domain / SET domain profile. / SET domain / Beta Complex / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Alpha Horseshoe / Tetratricopeptide-like helical domain superfamily / Mainly Beta / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / Resolution : 1.63 Å DetailsAuthors Nguyen, H. / Allali-Hassani, A. / Antonysamy, S. / Chang, S. / Chen, L.H. / Curtis, C. / Emtage, S. / Fan, L. / Gheyi, T. / Li, F. ...Nguyen, H. / Allali-Hassani, A. / Antonysamy, S. / Chang, S. / Chen, L.H. / Curtis, C. / Emtage, S. / Fan, L. / Gheyi, T. / Li, F. / Liu, S. / Martin, J.R. / Mendel, D. / Olsen, J.B. / Pelletier, L. / Shatseva, T. / Wu, S. / Zhang, F.F. / Arrowsmith, C.H. / Brown, P.J. / Campbell, R.M. / Garcia, B.A. / Barsyte-Lovejoy, D. / Mader, M. / Vedadi, M. CitationJournal : J.Biol.Chem. / Year : 2015Title : LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2.Authors: Nguyen, H. / Allali-Hassani, A. / Antonysamy, S. / Chang, S. / Chen, L.H. / Curtis, C. / Emtage, S. / Fan, L. / Gheyi, T. / Li, F. / Liu, S. / Martin, J.R. / Mendel, D. / Olsen, J.B. / ... Authors : Nguyen, H. / Allali-Hassani, A. / Antonysamy, S. / Chang, S. / Chen, L.H. / Curtis, C. / Emtage, S. / Fan, L. / Gheyi, T. / Li, F. / Liu, S. / Martin, J.R. / Mendel, D. / Olsen, J.B. / Pelletier, L. / Shatseva, T. / Wu, S. / Zhang, F.F. / Arrowsmith, C.H. / Brown, P.J. / Campbell, R.M. / Garcia, B.A. / Barsyte-Lovejoy, D. / Mader, M. / Vedadi, M. History Deposition Nov 4, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 8, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Apr 15, 2015 Group : Database referencesRevision 1.2 Jun 10, 2015 Group : Database referencesRevision 1.3 Dec 27, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Source and taxonomy Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / database_2 / entity_src_gen / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_assembly_prop / pdbx_struct_oper_list Item : _citation.journal_id_CSD / _database_2.pdbx_DOI ... _citation.journal_id_CSD / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity_src_gen.pdbx_alt_source_flag / _pdbx_database_status.pdb_format_compatible / _pdbx_struct_assembly.oligomeric_details / _pdbx_struct_assembly_prop.type / _pdbx_struct_assembly_prop.value / _pdbx_struct_oper_list.symmetry_operation
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