Entry Database : PDB / ID : 3w5k Structure visualization Downloads & linksTitle Crystal structure of Snail1 and importin beta complex ComponentsImportin subunit beta-1 Zinc finger protein SNAI1 DetailsKeywords NUCLEAR PROTEIN/METAL BINDING PROTEIN / Importin Beta / nuclear transport factor Snail1 / transcription repressor / NUCLEAR PROTEIN-METAL BINDING PROTEIN complexFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of cell differentiation involved in embryonic placenta development / cartilage morphogenesis / left/right pattern formation / negative regulation of vitamin D biosynthetic process / Regulation of CDH11 gene transcription / RNA import into nucleus / Inhibition of nitric oxide production / mitotic chromosome movement towards spindle pole / epithelial cell migration / endoplasmic reticulum tubular network ... negative regulation of cell differentiation involved in embryonic placenta development / cartilage morphogenesis / left/right pattern formation / negative regulation of vitamin D biosynthetic process / Regulation of CDH11 gene transcription / RNA import into nucleus / Inhibition of nitric oxide production / mitotic chromosome movement towards spindle pole / epithelial cell migration / endoplasmic reticulum tubular network / epithelial to mesenchymal transition involved in endocardial cushion formation / trophoblast giant cell differentiation / heterochromatin organization / establishment of mitotic spindle localization / astral microtubule organization / Epithelial-Mesenchymal Transition (EMT) during gastrulation / Transport of Ribonucleoproteins into the Host Nucleus / Regulation of cholesterol biosynthesis by SREBP (SREBF) / importin-alpha family protein binding / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage / ribosomal protein import into nucleus / Initiation of Nuclear Envelope (NE) Reformation / NS1 Mediated Effects on Host Pathways / E-box binding / NLS-dependent protein nuclear import complex / Apoptosis induced DNA fragmentation / Nuclear import of Rev protein / aortic valve morphogenesis / regulation of bicellular tight junction assembly / Postmitotic nuclear pore complex (NPC) reformation / nuclear import signal receptor activity / nuclear localization sequence binding / mitotic metaphase chromosome alignment / hair follicle morphogenesis / NLS-bearing protein import into nucleus / roof of mouth development / negative regulation of DNA damage response, signal transduction by p53 class mediator / mesoderm formation / mitotic spindle assembly / canonical Wnt signaling pathway / epithelial to mesenchymal transition / pericentric heterochromatin / nuclear pore / positive regulation of epithelial to mesenchymal transition / Notch signaling pathway / Regulation of PTEN gene transcription / Assembly of the ORC complex at the origin of replication / RNA polymerase II transcription regulatory region sequence-specific DNA binding / kinase binding / DNA-binding transcription repressor activity, RNA polymerase II-specific / Hsp90 protein binding / ISG15 antiviral mechanism / fibrillar center / small GTPase binding / cytoplasmic stress granule / osteoblast differentiation / specific granule lumen / protein import into nucleus / nuclear envelope / SARS-CoV-1 activates/modulates innate immune responses / Interferon alpha/beta signaling / sequence-specific double-stranded DNA binding / nuclear membrane / ficolin-1-rich granule lumen / positive regulation of cell migration / RNA polymerase II cis-regulatory region sequence-specific DNA binding / protein domain specific binding / intracellular membrane-bounded organelle / Neutrophil degranulation / positive regulation of DNA-templated transcription / regulation of DNA-templated transcription / enzyme binding / negative regulation of transcription by RNA polymerase II / RNA binding / zinc ion binding / extracellular exosome / extracellular region / nucleoplasm / membrane / nucleus / metal ion binding / cytoplasm / cytosol Similarity search - Function C2H2-type zinc finger / Importin beta family / HEAT-like repeat / Importin-beta N-terminal domain profile. / Importin-beta N-terminal domain / Importin-beta N-terminal domain / Importin-beta, N-terminal domain / HEAT repeat profile. / HEAT, type 2 / Armadillo/beta-catenin-like repeat ... C2H2-type zinc finger / Importin beta family / HEAT-like repeat / Importin-beta N-terminal domain profile. / Importin-beta N-terminal domain / Importin-beta N-terminal domain / Importin-beta, N-terminal domain / HEAT repeat profile. / HEAT, type 2 / Armadillo/beta-catenin-like repeat / Armadillo/beta-catenin-like repeats / Armadillo / Leucine-rich Repeat Variant / Leucine-rich Repeat Variant / Zinc finger, C2H2 type / zinc finger / Zinc finger C2H2 type domain profile. / Zinc finger C2H2 superfamily / Zinc finger C2H2 type domain signature. / Zinc finger C2H2-type / Armadillo-like helical / Alpha Horseshoe / Armadillo-type fold / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MAD / Resolution : 2.6 Å DetailsAuthors Choi, S. / Yamashita, E. / Yasuhara, N. / Song, J. / Son, S.Y. / Won, Y.H. / Shin, Y.S. / Sekimoto, T. / Park, I.Y. / Yoneda, Y. / Lee, S.J. CitationJournal : Acta Crystallogr.,Sect.D / Year : 2014Title : Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin beta.Authors : Choi, S. / Yamashita, E. / Yasuhara, N. / Song, J. / Son, S.Y. / Won, Y.H. / Hong, H.R. / Shin, Y.S. / Sekimoto, T. / Park, I.Y. / Yoneda, Y. / Lee, S.J. History Deposition Jan 30, 2013 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Mar 5, 2014 Provider : repository / Type : Initial releaseRevision 1.1 May 7, 2014 Group : Database referencesRevision 1.2 Mar 20, 2024 Group : Data collection / Database references / Derived calculationsCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_conn_angle / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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