+Open data
-Basic information
Entry | Database: PDB / ID: 1zec | ||||||
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Title | NMR Solution structure of NEF1-25, 20 structures | ||||||
Components | NEF1-25 | ||||||
Keywords | VIRAL PEPTIDE / CYTOLYSIN / POLYPEPTIDE | ||||||
Function / homology | Function and homology information perturbation by virus of host immune response / negative regulation of CD4 production / symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I / symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II / symbiont-mediated suppression of host apoptosis / suppression by virus of host autophagy / CD4 receptor binding / thioesterase binding / MHC class I protein binding / host cell Golgi membrane ...perturbation by virus of host immune response / negative regulation of CD4 production / symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I / symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II / symbiont-mediated suppression of host apoptosis / suppression by virus of host autophagy / CD4 receptor binding / thioesterase binding / MHC class I protein binding / host cell Golgi membrane / regulation of calcium-mediated signaling / viral life cycle / SH3 domain binding / virion component / ATPase binding / signaling receptor binding / GTP binding / protein kinase binding / apoptotic process / host cell plasma membrane / extracellular region / membrane Similarity search - Function | ||||||
Biological species | Human immunodeficiency virus 1 | ||||||
Method | SOLUTION NMR | ||||||
Authors | Barnham, K.J. / Monks, S.A. / Hinds, M.G. / Azad, A.A. / Norton, R.S. | ||||||
Citation | Journal: Biochemistry / Year: 1997 Title: Solution structure of a polypeptide from the N terminus of the HIV protein Nef. Authors: Barnham, K.J. / Monks, S.A. / Hinds, M.G. / Azad, A.A. / Norton, R.S. #1: Journal: Aids Res.Hum.Retroviruses / Year: 1994 Title: Fusogenic Activity of Amino-Terminal Region of HIV Type 1 Nef Protein Authors: Curtain, C.C. / Separovic, F. / Rivett, D. / Kirkpatrick, A. / Waring, A.J. / Gordon, L.M. / Azad, A.A. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1zec.cif.gz | 164.5 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1zec.ent.gz | 136.2 KB | Display | PDB format |
PDBx/mmJSON format | 1zec.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 1zec_validation.pdf.gz | 350.1 KB | Display | wwPDB validaton report |
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Full document | 1zec_full_validation.pdf.gz | 451.3 KB | Display | |
Data in XML | 1zec_validation.xml.gz | 10.4 KB | Display | |
Data in CIF | 1zec_validation.cif.gz | 17.5 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/ze/1zec ftp://data.pdbj.org/pub/pdb/validation_reports/ze/1zec | HTTPS FTP |
-Related structure data
Similar structure data |
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-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein/peptide | Mass: 2842.309 Da / Num. of mol.: 1 / Fragment: N-TERMINAL FRAGMENT OF NEF Source method: isolated from a genetically manipulated source Source: (gene. exp.) Human immunodeficiency virus 1 / Genus: Lentivirus / Gene: N-TERMINAL FRAGMENT OF / Production host: Escherichia coli (E. coli) / References: UniProt: P04324, UniProt: P03404*PLUS |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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NMR details | Text: SOLVENT METHANOL |
-Sample preparation
Sample conditions | pH: 5 / Temperature: 281 K |
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Crystal grow | *PLUS Method: other / Details: NMR |
-Processing
Software |
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NMR software | Name: X-PLOR / Developer: BRUNGER / Classification: refinement | ||||||||
NMR ensemble | Conformers submitted total number: 20 |