+Open data
-Basic information
Entry | Database: PDB chemical components / ID: HMT | ||||
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Name | Name: ( Synonyms: Homoharringtonine; Cephalotaxine; [3(R)]-4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate Wikipedia | Wikipedia - Omacetaxine mepesuccinate: Omacetaxine mepesuccinate (INN, trade names Synribo ), formerly named as homoharringtonine or HHT, is a pharmaceutical drug substance that is indicated for treatment of chronic myeloid leukemia (CML).
| HHT is a natural plant alkaloid derived from Cephalotaxus fortunei. HHT and related compound esters of cephalotaxine were described first in 1970, and were the subject of intensive research efforts by Chinese investigators to clarify their role as anticancer and antileukemic agents from the 1970s until the present... Comment | anticancer, alkaloid*YM | |
-Chemical information
Composition | Formula: C29H39NO9 / Number of atoms: 78 / Formula weight: 545.621 / Formal charge: 0 | ||||||
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Others | Type: NON-POLYMER / PDB classification: HETAIN / Three letter code: HMT / Ideal coordinates details: Corina / Model coordinates PDB-ID: 3G6E | ||||||
History |
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External links | UniChem / BindingDB / ChEBI / ChEMBL / DailyMed / DrugBank / GtoPharmacology / Metabolights / NMRShiftDB / Nikkaji / PubChem / PubChem_TPharma / SureChEMBL / ZINC / ChemSpider / Wikipedia search / Google search |
-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Details
-SMILES
ACDLabs 10.04 | CACTVS 3.341 | OpenEye OEToolkits 1.5.0 | |
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-SMILES CANONICAL
CACTVS 3.341 | OpenEye OEToolkits 1.5.0 | |
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-InChI
InChI 1.03 |
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-InChIKey
InChI 1.03 |
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-PDB entries
Showing all 6 items
PDB-3g6e:
Co-crystal structure of Homoharringtonine bound to the large ribosomal subunit
PDB-4u4q:
Crystal structure of Homoharringtonine bound to the yeast 80S ribosome
PDB-6qzp:
High-resolution cryo-EM structure of the human 80S ribosome
PDB-7ewh:
Crystal structure of human PHGDH in complex with Homoharringtonine
PDB-8a3d:
Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound
PDB-8g6j:
mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state 2)