+Open data
-Basic information
Entry | Database: PDB chemical components / ID: 4KL | ||||
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Name | Name: Synonyms: Xanthurenate; 8-Hydroxykynurenic acid; 4,8-Dihydroxyquinaldic acid Wikipedia | Wikipedia - Xanthurenic acid: Xanthurenic acid, or xanthurenate, is a metabolic intermediate that accumulates and is excreted by pyridoxine (vitamin B6) deficient animals after the ingestion of tryptophan.
| Xanthurenic acid is suspected to be an endogenous agonist for Group II metabotropic glutamate receptors in humans. It is also known to be a potent VGLUT inhibitor, thereby preventing the movement of glutamate from the cytoplasm into synaptic vesicles, an action that it mediates via competitive blockade of vesicular glutamate transporters (Ki = 0.19 mM). In 2015 researchers reported a marked reduction of xanthurenic acid levels in the serum of patients with schizophrenia... Comment | inhibitor, agonist*YM | |
-Chemical information
Composition | Formula: C10H7NO4 / Number of atoms: 22 / Formula weight: 205.167 / Formal charge: 0 | ||||||
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Others | Type: NON-POLYMER / PDB classification: HETAIN / Three letter code: 4KL / Ideal coordinates details: Corina / Model coordinates PDB-ID: 4Z3K | ||||||
History |
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External links | UniChem / BindingDB / Brenda / ChEBI / ChEMBL / ChemicalBook / CompTox / HMDB / KEGG_Ligand / Metabolights / NMRShiftDB / Nikkaji / PubChem / PubChem_TPharma / SureChEMBL / ZINC / ChemSpider / Wikipedia search / Google search |
-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Details
-SMILES
ACDLabs 12.01 | CACTVS 3.385 | OpenEye OEToolkits 1.9.2 | |
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-SMILES CANONICAL
CACTVS 3.385 | OpenEye OEToolkits 1.9.2 | |
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-InChI
InChI 1.03 |
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-InChIKey
InChI 1.03 |
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-SYSTEMATIC NAME
ACDLabs 12.01 | OpenEye OEToolkits 1.9.2 | |
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-PDB entries
Showing all 1 items
PDB-4z3k:
Human sepiapterin reductase in complex with the cofactor NADP+ and the trypthophan metabolite xanthurenic acid