+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 7l83 | |||||||||
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タイトル | NMR solution structure of Nav1.5 DIV S3b-S4a paddle motif in DPC micelle | |||||||||
要素 | Sodium channel protein type 5 subunit alphaナトリウムチャネル | |||||||||
キーワード | MEMBRANE PROTEIN (膜タンパク質) / Sodium channel (ナトリウムチャネル) / voltage sensing | |||||||||
機能・相同性 | 機能・相同性情報 voltage-gated sodium channel activity involved in AV node cell action potential / voltage-gated sodium channel activity involved in bundle of His cell action potential / voltage-gated sodium channel activity involved in SA node cell action potential / bundle of His cell action potential / AV node cell action potential / SA node cell action potential / AV node cell to bundle of His cell communication / membrane depolarization during SA node cell action potential / cardiac ventricle development / response to denervation involved in regulation of muscle adaptation ...voltage-gated sodium channel activity involved in AV node cell action potential / voltage-gated sodium channel activity involved in bundle of His cell action potential / voltage-gated sodium channel activity involved in SA node cell action potential / bundle of His cell action potential / AV node cell action potential / SA node cell action potential / AV node cell to bundle of His cell communication / membrane depolarization during SA node cell action potential / cardiac ventricle development / response to denervation involved in regulation of muscle adaptation / regulation of ventricular cardiac muscle cell membrane depolarization / regulation of atrial cardiac muscle cell membrane repolarization / membrane depolarization during atrial cardiac muscle cell action potential / membrane depolarization during action potential / voltage-gated sodium channel activity involved in Purkinje myocyte action potential / regulation of sodium ion transmembrane transport / brainstem development / membrane depolarization during AV node cell action potential / voltage-gated sodium channel activity involved in cardiac muscle cell action potential / membrane depolarization during bundle of His cell action potential / positive regulation of action potential / atrial cardiac muscle cell action potential / membrane depolarization during Purkinje myocyte cell action potential / telencephalon development / cardiac conduction system development / regulation of atrial cardiac muscle cell membrane depolarization / voltage-gated sodium channel complex / membrane depolarization during cardiac muscle cell action potential / positive regulation of sodium ion transport / cardiac muscle cell action potential involved in contraction / ventricular cardiac muscle cell action potential / high voltage-gated calcium channel activity / regulation of cardiac muscle cell contraction / voltage-gated sodium channel activity / regulation of ventricular cardiac muscle cell membrane repolarization / Interaction between L1 and Ankyrins / ankyrin binding / sodium ion transport / fibroblast growth factor binding / voltage-gated calcium channel complex / nitric-oxide synthase binding / Phase 0 - rapid depolarisation / odontogenesis of dentin-containing tooth / regulation of heart rate by cardiac conduction / 脱分極 / calcium ion import across plasma membrane / sodium ion transmembrane transport / 介在板 / lateral plasma membrane / cardiac muscle contraction / 横行小管 / cellular response to calcium ion / regulation of heart rate / cerebellum development / positive regulation of epithelial cell proliferation / カベオラ / 筋鞘 / Z disc / scaffold protein binding / transmembrane transporter binding / calmodulin binding / protein domain specific binding / ubiquitin protein ligase binding / 核小体 / protein kinase binding / perinuclear region of cytoplasm / enzyme binding / 細胞膜 / 小胞体 / 核質 / 生体膜 / 細胞膜 類似検索 - 分子機能 | |||||||||
生物種 | Homo sapiens (ヒト) | |||||||||
手法 | 溶液NMR / simulated annealing | |||||||||
データ登録者 | Hussein, A.K. / Bhuiyan, M.H. / Arshava, B. / Zhuang, J. / Poget, S.F. | |||||||||
資金援助 | 米国, 2件
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引用 | ジャーナル: Biorxiv / 年: 2021 タイトル: NMR solution structure and analysis of isolated S3b-S4a motif of repeat IV of the human cardiac sodium channel 著者: Hussein, A.K. / Bhuiyan, M.H. / Arshava, B. / Zhuang, J. / Poget, S.F. | |||||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 7l83.cif.gz | 141.4 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb7l83.ent.gz | 117.8 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 7l83.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/l8/7l83 ftp://data.pdbj.org/pub/pdb/validation_reports/l8/7l83 | HTTPS FTP |
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-関連構造データ
類似構造データ | |
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その他のデータベース |
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-リンク
-集合体
登録構造単位 |
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NMR アンサンブル |
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-要素
#1: タンパク質・ペプチド | 分子量: 4209.139 Da / 分子数: 1 / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 遺伝子: SCN5A / 発現宿主: Escherichia coli (大腸菌) / 参照: UniProt: Q14524 |
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-実験情報
-実験
実験 | 手法: 溶液NMR | ||||||||||||||||||||||||||||||||||||
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NMR実験 |
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-試料調製
詳細 |
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試料 |
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試料状態 | イオン強度: 10 Nacl, 10 potassium phosphate mM / pH: 7 / PH err: 0.05 / 圧: 1 atm / 温度: 310 K
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-NMR測定
NMRスペクトロメーター |
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-解析
NMR software |
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精密化 | 手法: simulated annealing / ソフトェア番号: 1 | ||||||||||||||||||
代表構造 | 選択基準: medoid | ||||||||||||||||||
NMRアンサンブル | コンフォーマー選択の基準: structures with the lowest energy 計算したコンフォーマーの数: 100 / 登録したコンフォーマーの数: 10 |