+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 6igc | |||||||||||||||||||||
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タイトル | Crystal structure of HPV58/33/52 chimeric L1 pentamer | |||||||||||||||||||||
要素 | Major capsid protein L1 | |||||||||||||||||||||
キーワード | STRUCTURAL PROTEIN / capsid protein | |||||||||||||||||||||
機能・相同性 | 機能・相同性情報 T=7 icosahedral viral capsid / endocytosis involved in viral entry into host cell / host cell nucleus / virion attachment to host cell / structural molecule activity 類似検索 - 分子機能 | |||||||||||||||||||||
生物種 | Human papillomavirus type 58 (パピローマウイルス) | |||||||||||||||||||||
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.5 Å | |||||||||||||||||||||
データ登録者 | Li, Z.H. / Song, S. / He, M.Z. / Gu, Y. / Li, S.W. | |||||||||||||||||||||
資金援助 | 中国, 6件
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引用 | ジャーナル: Nat Commun / 年: 2018 タイトル: Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity. 著者: Zhihai Li / Shuo Song / Maozhou He / Daning Wang / Jingjie Shi / Xinlin Liu / Yunbing Li / Xin Chi / Shuangping Wei / Yurou Yang / Zhiping Wang / Jinjin Li / Huilian Qian / Hai Yu / Qingbing ...著者: Zhihai Li / Shuo Song / Maozhou He / Daning Wang / Jingjie Shi / Xinlin Liu / Yunbing Li / Xin Chi / Shuangping Wei / Yurou Yang / Zhiping Wang / Jinjin Li / Huilian Qian / Hai Yu / Qingbing Zheng / Xiaodong Yan / Qinjian Zhao / Jun Zhang / Ying Gu / Shaowei Li / Ningshao Xia / 要旨: Sequence variability in surface-antigenic sites of pathogenic proteins is an important obstacle in vaccine development. Over 200 distinct genomic sequences have been identified for human ...Sequence variability in surface-antigenic sites of pathogenic proteins is an important obstacle in vaccine development. Over 200 distinct genomic sequences have been identified for human papillomavirus (HPV), of which more than 18 are associated with cervical cancer. Here, based on the high structural similarity of L1 surface loops within a group of phylogenetically close HPV types, we design a triple-type chimera of HPV33/58/52 using loop swapping. The chimeric VLPs elicit neutralization titers comparable with a mix of the three wild-type VLPs both in mice and non-human primates. This engineered region of the chimeric protein recapitulates the conformational contours of the antigenic surfaces of the parental-type proteins, offering a basis for this high immunity. Our stratagem is equally successful in developing other triplet-type chimeras (HPV16/35/31, HPV56/66/53, HPV39/68/70, HPV18/45/59), paving the way for the development of an improved HPV prophylactic vaccine against all carcinogenic HPV strains. This technique may also be extrapolated to other microbes. | |||||||||||||||||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 6igc.cif.gz | 6.4 MB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb6igc.ent.gz | 表示 | PDB形式 | |
PDBx/mmJSON形式 | 6igc.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
文書・要旨 | 6igc_validation.pdf.gz | 775.8 KB | 表示 | wwPDB検証レポート |
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文書・詳細版 | 6igc_full_validation.pdf.gz | 890.7 KB | 表示 | |
XML形式データ | 6igc_validation.xml.gz | 501.3 KB | 表示 | |
CIF形式データ | 6igc_validation.cif.gz | 684.6 KB | 表示 | |
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/ig/6igc ftp://data.pdbj.org/pub/pdb/validation_reports/ig/6igc | HTTPS FTP |
-関連構造データ
-リンク
-集合体
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非結晶学的対称性 (NCS) | NCSドメイン:
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