- PDB-6bs1: Crystal Structure of Human DNA polymerase kappa in complex with D... -
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基本情報
登録情報
データベース: PDB / ID: 6bs1
タイトル
Crystal Structure of Human DNA polymerase kappa in complex with DNA containing the major cisplatin lesion
要素
DNA (5'-D(*TP*AP*CP*TP*GP*GP*TP*AP*TP*GP*TP*AP*T)-3')
DNA (5'-D(P*AP*TP*AP*CP*AP*TP*AP*CP*C)-3')
DNA polymerase kappaPOLK
キーワード
REPLICATION (DNA複製) / Cisplatin (シスプラチン) / DNA adduct / translesion DNA synthesis (DNA修復) / polymerase kappa / chemoresistance
機能・相同性
機能・相同性情報
nucleotide-excision repair, DNA gap filling / error-prone translesion synthesis / Translesion synthesis by POLK / Gap-filling DNA repair synthesis and ligation in GG-NER / Termination of translesion DNA synthesis / HDR through Homologous Recombination (HRR) / Dual Incision in GG-NER / Dual incision in TC-NER / Gap-filling DNA repair synthesis and ligation in TC-NER / cellular response to UV ...nucleotide-excision repair, DNA gap filling / error-prone translesion synthesis / Translesion synthesis by POLK / Gap-filling DNA repair synthesis and ligation in GG-NER / Termination of translesion DNA synthesis / HDR through Homologous Recombination (HRR) / Dual Incision in GG-NER / Dual incision in TC-NER / Gap-filling DNA repair synthesis and ligation in TC-NER / cellular response to UV / DNA複製 / damaged DNA binding / DNAポリメラーゼ / DNA-directed DNA polymerase activity / nuclear body / DNA修復 / DNA damage response / 核質 / metal ion binding / 細胞核 類似検索 - 分子機能
DNA polymerase; domain 1 - #810 / Rad18-like CCHC zinc finger / DNA polymerase type-Y, HhH motif / IMS family HHH motif / DNA polymerase IV / DNA polymerase, Y-family, little finger domain / MutS, DNA mismatch repair protein, domain I - #60 / Rad18, zinc finger UBZ4-type / Zinc finger UBZ4-type profile. / MutS, DNA mismatch repair protein, domain I ...DNA polymerase; domain 1 - #810 / Rad18-like CCHC zinc finger / DNA polymerase type-Y, HhH motif / IMS family HHH motif / DNA polymerase IV / DNA polymerase, Y-family, little finger domain / MutS, DNA mismatch repair protein, domain I - #60 / Rad18, zinc finger UBZ4-type / Zinc finger UBZ4-type profile. / MutS, DNA mismatch repair protein, domain I / DNA polymerase, Y-family, little finger domain / impB/mucB/samB family C-terminal domain / UmuC domain / DNA polymerase, Y-family, little finger domain superfamily / impB/mucB/samB family / UmuC domain profile. / Reverse transcriptase/Diguanylate cyclase domain / Dna Ligase; domain 1 / DNA polymerase; domain 1 / Reverse transcriptase/Diguanylate cyclase domain / Alpha-Beta Plaits / DNA/RNA polymerase superfamily / 2-Layer Sandwich / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性
シスプラチン / Chem-DZ4 / IODIDE ION / デオキシリボ核酸 / DNA (> 10) / DNA polymerase kappa 類似検索 - 構成要素
ジャーナル: J. Mol. Biol. / 年: 2018 タイトル: Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate Extender. 著者: Jha, V. / Ling, H.
A: DNA polymerase kappa B: DNA polymerase kappa C: DNA (5'-D(P*AP*TP*AP*CP*AP*TP*AP*CP*C)-3') D: DNA (5'-D(*TP*AP*CP*TP*GP*GP*TP*AP*TP*GP*TP*AP*T)-3') P: DNA (5'-D(P*AP*TP*AP*CP*AP*TP*AP*CP*C)-3') T: DNA (5'-D(*TP*AP*CP*TP*GP*GP*TP*AP*TP*GP*TP*AP*T)-3') ヘテロ分子
解像度: 3.15→41.27 Å / Cor.coef. Fo:Fc: 0.926 / Cor.coef. Fo:Fc free: 0.873 / SU B: 39.793 / SU ML: 0.599 / 交差検証法: THROUGHOUT / ESU R Free: 0.582 / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS