登録情報 | データベース: PDB / ID: 2m0o |
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タイトル | The solution structure of human PHF1 in complex with H3K36me3 |
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要素 | - H3K36me3 peptide
- PHD finger protein 1
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キーワード | PEPTIDE BINDING PROTEIN / Tudor Domain / H3K36me3 binding |
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機能・相同性 | 機能・相同性情報
histone methyltransferase binding / DNA repair-dependent chromatin remodeling / Chromatin modifying enzymes / epigenetic regulation of gene expression / methylated histone binding / telomere organization / RNA Polymerase I Promoter Opening / Interleukin-7 signaling / Assembly of the ORC complex at the origin of replication / DNAメチル化 ...histone methyltransferase binding / DNA repair-dependent chromatin remodeling / Chromatin modifying enzymes / epigenetic regulation of gene expression / methylated histone binding / telomere organization / RNA Polymerase I Promoter Opening / Interleukin-7 signaling / Assembly of the ORC complex at the origin of replication / DNAメチル化 / Condensation of Prophase Chromosomes / transcription corepressor binding / ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression / Chromatin modifications during the maternal to zygotic transition (MZT) / SIRT1 negatively regulates rRNA expression / HCMV Late Events / PRC2 methylates histones and DNA / Defective pyroptosis / HDACs deacetylate histones / RNA Polymerase I Promoter Escape / Transcriptional regulation by small RNAs / Formation of the beta-catenin:TCF transactivating complex / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / NoRC negatively regulates rRNA expression / B-WICH complex positively regulates rRNA expression / HDMs demethylate histones / PKMTs methylate histone lysines / RMTs methylate histone arginines / 遺伝的組換え / Pre-NOTCH Transcription and Translation / nucleosome assembly / Activation of anterior HOX genes in hindbrain development during early embryogenesis / HCMV Early Events / Transcriptional regulation of granulopoiesis / structural constituent of chromatin / ヌクレオソーム / site of double-strand break / RUNX1 regulates transcription of genes involved in differentiation of HSCs / 遺伝子発現 / chromatin organization / Factors involved in megakaryocyte development and platelet production / HATs acetylate histones / Senescence-Associated Secretory Phenotype (SASP) / Oxidative Stress Induced Senescence / Estrogen-dependent gene expression / cadherin binding / protein heterodimerization activity / Amyloid fiber formation / 中心体 / chromatin binding / regulation of DNA-templated transcription / protein-containing complex / DNA binding / extracellular exosome / extracellular region / 核質 / 生体膜 / identical protein binding / metal ion binding / 細胞核 / 細胞質基質類似検索 - 分子機能 : / : / PHD finger protein 1 / Polycomb-like MTF2 factor 2, C-terminal domain / Polycomb-like MTF2 factor 2 / Lysine-specific demethylase 4, Tudor domain / Jumonji domain-containing protein 2A Tudor domain / Tudor domain / Tudor domain / SH3 type barrels. - #140 ...: / : / PHD finger protein 1 / Polycomb-like MTF2 factor 2, C-terminal domain / Polycomb-like MTF2 factor 2 / Lysine-specific demethylase 4, Tudor domain / Jumonji domain-containing protein 2A Tudor domain / Tudor domain / Tudor domain / SH3 type barrels. - #140 / Zinc finger, PHD-type, conserved site / PHD-finger / Zinc finger PHD-type signature. / Zinc finger PHD-type profile. / Zinc finger, PHD-finger / Histone H3 signature 1. / Zinc finger, PHD-type / PHD zinc finger / Histone H3 signature 2. / ヒストンH3 / Histone H3/CENP-A / Histone H2A/H2B/H3 / Core histone H2A/H2B/H3/H4 / Zinc finger, FYVE/PHD-type / SH3 type barrels. / Histone-fold / Zinc finger, RING/FYVE/PHD-type / Roll / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / simulated annealing, molecular dynamics |
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データ登録者 | Song, J. / Patel, D.J. |
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引用 | ジャーナル: Mol.Cell / 年: 2013 タイトル: An H3K36 Methylation-Engaging Tudor Motif of Polycomb-like Proteins Mediates PRC2 Complex Targeting. 著者: Cai, L. / Rothbart, S.B. / Lu, R. / Xu, B. / Chen, W.Y. / Tripathy, A. / Rockowitz, S. / Zheng, D. / Patel, D.J. / Allis, C.D. / Strahl, B.D. / Song, J. / Wang, G.G. |
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履歴 | 登録 | 2012年10月30日 | 登録サイト: BMRB / 処理サイト: RCSB |
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改定 1.0 | 2013年1月16日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2013年2月27日 | Group: Database references |
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