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- SASDF63: Bruton's Tyrosine Kinase - SH2-kinase domain (Bruton's tyrosine k... -

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Basic information

Entry
Database: SASBDB / ID: SASDF63
SampleBruton's Tyrosine Kinase - SH2-kinase domain
  • Bruton's tyrosine kinase - Src homolgy domain 2 - kinase domain (protein), hBtk - SH2-KD, Homo sapiens
Biological speciesHomo sapiens (human)
Contact author
  • Daniel Duarte (EPFL)

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Models

Model #2817
Type: dummy / Radius of dummy atoms: 2.50 A / Chi-square value: 1.119 / P-value: 0.237315
Search similar-shape structures of this assembly by Omokage search (details)

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Sample

SampleName: Bruton's Tyrosine Kinase - SH2-kinase domain / Specimen concentration: 20.4 mg/ml
BufferName: 20mM Tris, 150mM NaCl, 1mM TCEP, 5% glycerol / pH: 7.5
Entity #1453Name: hBtk - SH2-KD / Type: protein
Description: Bruton's tyrosine kinase - Src homolgy domain 2 - kinase domain
Formula weight: 45.519 / Num. of mol.: 1 / Source: Homo sapiens
Sequence: GAMGSMTEAE DSIEMYEWYS KHMTRSQAEQ LLKQEGKEGG FIVRDSSKAG KYTVSVFAKS TGDPQGVIRH YVVCSTPQSQ YYLAEKHLFS TIPELINYHQ HNSAGLISRL KYPVSQQNKN APSTAGLGYG SWEIDPKDLT FLKELGTGQF GVVKYGKWRG QYDVAIKMIK ...Sequence:
GAMGSMTEAE DSIEMYEWYS KHMTRSQAEQ LLKQEGKEGG FIVRDSSKAG KYTVSVFAKS TGDPQGVIRH YVVCSTPQSQ YYLAEKHLFS TIPELINYHQ HNSAGLISRL KYPVSQQNKN APSTAGLGYG SWEIDPKDLT FLKELGTGQF GVVKYGKWRG QYDVAIKMIK EGSMSEDEFI EEAKVMMNLS HEKLVQLYGV CTKQRPIFII TEYMANGCLL NYLREMRHRF QTQQLLEMCK DVCEAMEYLE SKQFLHRDLA ARNCLVNDQG VVKVSDFGLS RYVLDDEYTS SVGSKFPVRW SPPEVLMYSK FSSKSDIWAF GVLMWEIYSL GKMPYERFTN SETAEHIAQG LRLYRPHLAS EKVYTIMYSC WHEKADERPT FKILLSNILD VMDEES

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Experimental information

BeamInstrument name: ESRF BM29 / City: Grenoble / 国: France / Type of source: X-ray synchrotron / Wavelength: 0.09919 Å / Dist. spec. to detc.: 2.869 mm
DetectorName: Pilatus 1M / Type: Dectris / Pixsize x: 172 mm
Scan
Title: Bruton's Tyrosine Kinase - SH2-kinase domain / Measurement date: Nov 3, 2018 / Storage temperature: 10 °C / Cell temperature: 10 °C / Exposure time: 2100 sec. / Number of frames: 2100 / Unit: 1/nm /
MinMax
Q0.0589 4.9462
Distance distribution function P(R)
Sofotware P(R): GNOM 5.0 / Number of points: 561 /
MinMax
Q0.186178 2.82542
P(R) point1 561
R0 9.4
Result
Type of curve: sec /
ExperimentalPorod
MW46.65 kDa40 kDa
Volume-64.47 nm3

P(R)GuinierGuinier error
Forward scattering, I085.59 85.1 0.13
Radius of gyration, Rg2.872 nm2.8 nm0.01

MinMax
D-9.4
Guinier point33 86

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