+データを開く
-基本情報
登録情報 | データベース: SASBDB / ID: SASDED2 |
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試料 | Polyglutamine tract-binding protein 1 (PQBP-1)
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機能・相同性 | 機能・相同性情報 neuronal ribonucleoprotein granule / alternative mRNA splicing, via spliceosome / cellular response to exogenous dsRNA / regulation of dendrite morphogenesis / regulation of RNA splicing / positive regulation of type I interferon production / positive regulation of defense response to virus by host / ribonucleoprotein complex binding / activation of innate immune response / mRNA Splicing - Major Pathway ...neuronal ribonucleoprotein granule / alternative mRNA splicing, via spliceosome / cellular response to exogenous dsRNA / regulation of dendrite morphogenesis / regulation of RNA splicing / positive regulation of type I interferon production / positive regulation of defense response to virus by host / ribonucleoprotein complex binding / activation of innate immune response / mRNA Splicing - Major Pathway / cytoplasmic stress granule / neuron projection development / double-stranded DNA binding / defense response to virus / transcription coactivator activity / nuclear body / nuclear speck / innate immune response / regulation of DNA-templated transcription / DNA binding / nucleoplasm / nucleus / cytoplasm 類似検索 - 分子機能 |
生物種 | Homo sapiens (ヒト) |
引用 | ジャーナル: Biophys J / 年: 2012 タイトル: Solution model of the intrinsically disordered polyglutamine tract-binding protein-1. 著者: Martin Rees / Christian Gorba / Cesira de Chiara / Tam T T Bui / Mitla Garcia-Maya / Alex F Drake / Hitoshi Okazawa / Annalisa Pastore / Dmitri Svergun / Yu Wai Chen / 要旨: Polyglutamine tract-binding protein-1 (PQBP-1) is a 265-residue nuclear protein that is involved in transcriptional regulation. In addition to its role in the molecular pathology of the polyglutamine ...Polyglutamine tract-binding protein-1 (PQBP-1) is a 265-residue nuclear protein that is involved in transcriptional regulation. In addition to its role in the molecular pathology of the polyglutamine expansion diseases, mutations of the protein are associated with X-linked mental retardation. PQBP-1 binds specifically to glutamine repeat sequences and proline-rich regions, and interacts with RNA polymerase II and the spliceosomal protein U5-15kD. In this work, we obtained a biophysical characterization of this protein by employing complementary structural methods. PQBP-1 is shown to be a moderately compact but largely disordered molecule with an elongated shape, having a Stokes radius of 3.7 nm and a maximum molecular dimension of 13 nm. The protein is monomeric in solution, has residual β-structure, and is in a premolten globule state that is unaffected by natural osmolytes. Using small-angle x-ray scattering data, we were able to generate a low-resolution, three-dimensional model of PQBP-1. |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-モデル
モデル #2194 | タイプ: dummy / ソフトウェア: (1.1.0 r980) / ダミー原子の半径: 2.70 A / カイ2乗値: 1.018081 / P-value: 0.058031 Omokage検索でこの集合体の類似形状データを探す (詳細) |
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-試料
試料 | 名称: Polyglutamine tract-binding protein 1 (PQBP-1) / 試料濃度: 7.00-13.00 |
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バッファ | 名称: 20 mM Tris, 150 mM NaCl, 1mM DTT, / pH: 7 |
要素 #1201 | 名称: PQBP-1 / タイプ: protein / 記述: Polyglutamine-binding protein 1 / 分子量: 30.626 / 分子数: 1 / 由来: Homo sapiens / 参照: UniProt: O60828 配列: GPMPLPVALQ TRLAKRGILK HLEPEPEEEI IAEDYDDDPV DYEATRLEGL PPSWYKVFDP SCGLPYYWNA DTDLVSWLSP HDPNSVVTKS AKKLRSSNAD AEEKLDRSHD KSDRGHDKSD RSHEKLDRGH DKSDRGHDKS DRDRERGYDK VDRERERDRE RDRDRGYDKA ...配列: GPMPLPVALQ TRLAKRGILK HLEPEPEEEI IAEDYDDDPV DYEATRLEGL PPSWYKVFDP SCGLPYYWNA DTDLVSWLSP HDPNSVVTKS AKKLRSSNAD AEEKLDRSHD KSDRGHDKSD RSHEKLDRGH DKSDRGHDKS DRDRERGYDK VDRERERDRE RDRDRGYDKA DREEGKERRH HRREELAPYP KSKKAVSRKD EELDPMDPSS YSDAPRGTWS TGLPKRNEAK TGADTTAAGP LFQQRPYPSP GAVLRANAEA SRTKQQD |
-実験情報
ビーム | 設備名称: DORIS III EMBL X33 / 地域: Hamburg / 国: Germany / 形状: 0.6 / 線源: X-ray synchrotron / 波長: 0.15 Å / スペクトロメータ・検出器間距離: 2.7 mm | ||||||||||||||||||||||||||||||||||||
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検出器 | 名称: Pilatus 1M-W / Pixsize x: 0.172 mm | ||||||||||||||||||||||||||||||||||||
スキャン | タイトル: Polyglutamine tract-binding protein 1 (PQBP-1) 測定日: 2009年11月18日 / 保管温度: 20 °C / セル温度: 20 °C / 照射時間: 15 sec. / フレーム数: 8 / 単位: 1/nm /
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距離分布関数 P(R) | ソフトウェア P(R): GNOM 4.5a / ポイント数: 500 /
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結果 | カーブのタイプ: merged
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