PDB-9z9c: Crystal structure of a glyceraldehyde-3-phosphate dehydrogenase f...

Basic information

• Entry: Database: PDB / ID: 9z9c
• Title: Crystal structure of a glyceraldehyde-3-phosphate dehydrogenase from Neisseria gonorrhoeae in complex with NAD (P1 form)
• Components: Glyceraldehyde-3-phosphate dehydrogenase
• Keywords: OXIDOREDUCTASE / SSGCID / STRUCTURAL GENOMICS / SEATTLE STRUCTURAL GENOMICS CENTER FOR INFECTIOUS DISEASE

Function / homology

Function:

Oxidoreductases; Acting on the aldehyde or oxo group of donors; With NAD+ or NADP+ as acceptor / oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor / glucose metabolic process / NAD binding / NADP binding

Domain/homology:

Glyceraldehyde 3-phosphate dehydrogenase, active site / Glyceraldehyde 3-phosphate dehydrogenase active site. / Glyceraldehyde-3-phosphate dehydrogenase, type I / Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain / Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain / Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain / Glyceraldehyde/Erythrose phosphate dehydrogenase family / Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain / Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain / NAD(P)-binding domain superfamily

Component:

NICOTINAMIDE-ADENINE-DINUCLEOTIDE / TRIETHYLENE GLYCOL / Glyceraldehyde-3-phosphate dehydrogenase

• Biological species: Neisseria gonorrhoeae NCCP11945 (bacteria)
• Method: X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.3 Å
• Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Funding support

United States, 2items

Organization	Grant number	Country
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)	75N93022C00036	United States
National Institutes of Health/Office of the Director	S10OD030394	United States

• Citation: Journal: To be published; Title: Crystal structure of a glyceraldehyde-3-phosphate dehydrogenase from Neisseria gonorrhoeae in complex with NAD (P1 form); Authors: Liu, L. / Lovell, S. / Seibold, S. / Battaile, K.P.

History

Deposition	Nov 18, 2025	Deposition site: RCSB / Processing site: RCSB
Revision 1.0	Nov 26, 2025	Provider: repository / Type: Initial release

Assembly

Deposited unit

A: Glyceraldehyde-3-phosphate dehydrogenase

B: Glyceraldehyde-3-phosphate dehydrogenase

C: Glyceraldehyde-3-phosphate dehydrogenase

D: Glyceraldehyde-3-phosphate dehydrogenase

E: Glyceraldehyde-3-phosphate dehydrogenase

F: Glyceraldehyde-3-phosphate dehydrogenase

G: Glyceraldehyde-3-phosphate dehydrogenase

H: Glyceraldehyde-3-phosphate dehydrogenase

I: Glyceraldehyde-3-phosphate dehydrogenase

J: Glyceraldehyde-3-phosphate dehydrogenase

K: Glyceraldehyde-3-phosphate dehydrogenase

L: Glyceraldehyde-3-phosphate dehydrogenase

M: Glyceraldehyde-3-phosphate dehydrogenase

N: Glyceraldehyde-3-phosphate dehydrogenase

O: Glyceraldehyde-3-phosphate dehydrogenase

P: Glyceraldehyde-3-phosphate dehydrogenase

Q: Glyceraldehyde-3-phosphate dehydrogenase

R: Glyceraldehyde-3-phosphate dehydrogenase

S: Glyceraldehyde-3-phosphate dehydrogenase

T: Glyceraldehyde-3-phosphate dehydrogenase

U: Glyceraldehyde-3-phosphate dehydrogenase

V: Glyceraldehyde-3-phosphate dehydrogenase

W: Glyceraldehyde-3-phosphate dehydrogenase

X: Glyceraldehyde-3-phosphate dehydrogenase

hetero molecules

Summary:

• 900 kDa, 24 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	899,987	49
Polymers	883,915	24
Non-polymers	16,072	25
Water	13,619	756

1

A: Glyceraldehyde-3-phosphate dehydrogenase

B: Glyceraldehyde-3-phosphate dehydrogenase

C: Glyceraldehyde-3-phosphate dehydrogenase

D: Glyceraldehyde-3-phosphate dehydrogenase

hetero molecules

Summary:

• defined by author&software
• Evidence: gel filtration
• 150 kDa, 4 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	149,973	8
Polymers	147,319	4
Non-polymers	2,654	4
Water	72	4

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	19670 Å2
ΔGint	-121 kcal/mol
Surface area	42710 Å2
Method	PISA

2

E: Glyceraldehyde-3-phosphate dehydrogenase

F: Glyceraldehyde-3-phosphate dehydrogenase

G: Glyceraldehyde-3-phosphate dehydrogenase

H: Glyceraldehyde-3-phosphate dehydrogenase

hetero molecules

Summary:

• defined by author&software
• 150 kDa, 4 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	150,123	9
Polymers	147,319	4
Non-polymers	2,804	5
Water	72	4

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	19390 Å2
ΔGint	-119 kcal/mol
Surface area	43160 Å2
Method	PISA

3

I: Glyceraldehyde-3-phosphate dehydrogenase

J: Glyceraldehyde-3-phosphate dehydrogenase

K: Glyceraldehyde-3-phosphate dehydrogenase

L: Glyceraldehyde-3-phosphate dehydrogenase

hetero molecules

Summary:

• defined by author&software
• 150 kDa, 4 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	149,973	8
Polymers	147,319	4
Non-polymers	2,654	4
Water	72	4

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	19660 Å2
ΔGint	-124 kcal/mol
Surface area	43020 Å2
Method	PISA

4

M: Glyceraldehyde-3-phosphate dehydrogenase

N: Glyceraldehyde-3-phosphate dehydrogenase

O: Glyceraldehyde-3-phosphate dehydrogenase

P: Glyceraldehyde-3-phosphate dehydrogenase

hetero molecules

Summary:

• defined by author&software
• 150 kDa, 4 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	149,973	8
Polymers	147,319	4
Non-polymers	2,654	4
Water	72	4

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	19620 Å2
ΔGint	-113 kcal/mol
Surface area	43100 Å2
Method	PISA

5

Q: Glyceraldehyde-3-phosphate dehydrogenase

R: Glyceraldehyde-3-phosphate dehydrogenase

S: Glyceraldehyde-3-phosphate dehydrogenase

T: Glyceraldehyde-3-phosphate dehydrogenase

hetero molecules

Summary:

• defined by author&software
• 150 kDa, 4 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	149,973	8
Polymers	147,319	4
Non-polymers	2,654	4
Water	72	4

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	19560 Å2
ΔGint	-118 kcal/mol
Surface area	43140 Å2
Method	PISA

6

U: Glyceraldehyde-3-phosphate dehydrogenase

V: Glyceraldehyde-3-phosphate dehydrogenase

W: Glyceraldehyde-3-phosphate dehydrogenase

X: Glyceraldehyde-3-phosphate dehydrogenase

hetero molecules

Summary:

• defined by author&software
• 150 kDa, 4 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	149,973	8
Polymers	147,319	4
Non-polymers	2,654	4
Water	72	4

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	19550 Å2
ΔGint	-122 kcal/mol
Surface area	41890 Å2
Method	PISA

Unit cell

Length a, b, c (Å)	105.534, 137.842, 157.786
Angle α, β, γ (deg.)	85.95, 77.63, 86.88
Int Tables number	1
Space group name H-M	P1

Components

#1: Protein

A B C D E F G H I J K L M N O P Q R S ...
Glyceraldehyde-3-phosphate dehydrogenase

Details:

Mass: 36829.789 Da / Num. of mol.: 24 / Fragment: residues 24-357
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Neisseria gonorrhoeae NCCP11945 (bacteria)
Gene: NGK_2321 / Plasmid: NegoA.00617.a.B1 / Production host: Escherichia coli BL21(DE3) (bacteria)
References: UniProt: B4RPP8, Oxidoreductases; Acting on the aldehyde or oxo group of donors; With NAD+ or NADP+ as acceptor

#2: Chemical

A-401 B-401 C-401 D-401 E-401 F-401 G-401 H-401 I-401 J-401 K-401 L-401 M-401 N-401 O-401 P-401 Q-401 R-401 S-401 T-401 ...
ChemComp-NAD / NICOTINAMIDE-ADENINE-DINUCLEOTIDE

Details:

Mass: 663.425 Da / Num. of mol.: 24 / Source method: obtained synthetically / Formula: C₂₁H₂₇N₇O₁₄P₂ / Feature type: SUBJECT OF INVESTIGATION / Comment: NAD*YM

#3: Chemical

H-402 ChemComp-PGE / TRIETHYLENE GLYCOL

Details:

Mass: 150.173 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C₆H₁₄O₄

#4: Water

ChemComp-HOH / water

Details:

Mass: 18.015 Da / Num. of mol.: 756 / Source method: isolated from a natural source / Formula: H₂O

• Has ligand of interest: Y
• Has protein modification: N

Experimental details

Experiment

• Experiment: Method: X-RAY DIFFRACTION / Number of used crystals: 1

Sample preparation

• Crystal: Density Matthews: 2.53 ų/Da / Density % sol: 51.35 %
• Crystal grow: Temperature: 291 K / Method: vapor diffusion, sitting drop / pH: 5.5 ; Details: Berkeley D8 : 25% PEG 3350, 0.10M MES pH 5.5, 5% iso-Propanol, 0.10M ammonium citrate dibasic. NegoA.00617.a.B1.PS38018 at 8 mg/mL. plate 20061 D8 drop 1, Puck: PSL-2202, Cryo: 80% crystallant + 20% PEG 200

Data collection

• Diffraction: Mean temperature: 100 K / Serial crystal experiment: N
• Diffraction source: Source: SYNCHROTRON / Site: NSLS-II / Beamline: 19-ID / Wavelength: 0.9786 Å
• Detector: Type: DECTRIS EIGER2 XE 9M / Detector: PIXEL / Date: Jun 28, 2025
• Radiation: Monochromator: Double Crystal Si 111 / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
• Radiation wavelength: Wavelength: 0.9786 Å / Relative weight: 1
• Reflection: Resolution: 2.3→49.02 Å / Num. obs: 374646 / % possible obs: 97.4 % / Redundancy: 3.5 % / CC_1/2: 0.977 / R_merge(I) obs: 0.208 / R_pim(I) all: 0.13 / R_rim(I) all: 0.246 / Χ²: 0.89 / Net I/σ(I): 7.3 / Num. measured all: 1327731
• Reflection shell: Resolution: 2.3→2.36 Å / % possible obs: 97.2 % / Redundancy: 3.5 % / R_merge(I) obs: 1.008 / Num. measured all: 96270 / Num. unique obs: 27683 / CC_1/2: 0.519 / R_pim(I) all: 0.64 / R_rim(I) all: 1.199 / Χ²: 0.96 / Net I/σ(I) obs: 1.6

Processing

Software

Name	Version	Classification
PHENIX	(dev_5438: ???)	refinement
Aimless		data scaling
XDS		data reduction
PHASER		phasing
PDB_EXTRACT		data extraction

Refinement

Method to determine structure: MOLECULAR REPLACEMENT / Resolution: 2.3→48.53 Å / SU ML: 0.3 / Cross valid method: FREE R-VALUE / σ(F): 1.96 / Phase error: 25.04 / Stereochemistry target values: ML

	Rfactor	Num. reflection	% reflection
Rfree	0.2316	18761	5.01 %
Rwork	0.1939	-	-
obs	0.1958	374549	97.38 %

• Solvent computation: Shrinkage radii: 0.9 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL

Refinement step

Cycle: LAST / Resolution: 2.3→48.53 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	58784	0	1066	756	60606

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.005	60801
X-RAY DIFFRACTION	f_angle_d	0.735	82736
X-RAY DIFFRACTION	f_dihedral_angle_d	13.025	22792
X-RAY DIFFRACTION	f_chiral_restr	0.049	9804
X-RAY DIFFRACTION	f_plane_restr	0.007	10632

LS refinement shell

Resolution (Å)	Rfactor Rfree	Num. reflection Rfree	Rfactor Rwork	Num. reflection Rwork	Refine-ID	% reflection obs (%)
2.3-2.33	0.3251	603	0.2784	11879	X-RAY DIFFRACTION	97
2.33-2.35	0.3339	586	0.2673	11902	X-RAY DIFFRACTION	97
2.35-2.38	0.324	622	0.2659	11747	X-RAY DIFFRACTION	97
2.38-2.41	0.3063	637	0.264	11808	X-RAY DIFFRACTION	97
2.41-2.44	0.3164	636	0.2613	11836	X-RAY DIFFRACTION	97
2.44-2.48	0.3041	612	0.2506	11863	X-RAY DIFFRACTION	97
2.48-2.51	0.3098	672	0.2432	11826	X-RAY DIFFRACTION	97
2.51-2.55	0.3018	620	0.2463	11850	X-RAY DIFFRACTION	97
2.55-2.59	0.293	578	0.2432	11848	X-RAY DIFFRACTION	97
2.59-2.63	0.2955	606	0.2516	11678	X-RAY DIFFRACTION	96
2.63-2.68	0.3031	613	0.243	11705	X-RAY DIFFRACTION	96
2.68-2.73	0.2683	595	0.2173	11970	X-RAY DIFFRACTION	98
2.73-2.78	0.279	599	0.2189	11920	X-RAY DIFFRACTION	98
2.78-2.84	0.2671	624	0.2075	11844	X-RAY DIFFRACTION	98
2.84-2.9	0.2753	659	0.219	11845	X-RAY DIFFRACTION	98
2.9-2.97	0.261	630	0.2123	11973	X-RAY DIFFRACTION	98
2.97-3.04	0.262	632	0.2167	11842	X-RAY DIFFRACTION	98
3.04-3.12	0.2566	613	0.2245	11925	X-RAY DIFFRACTION	98
3.12-3.21	0.2563	654	0.2179	11898	X-RAY DIFFRACTION	98
3.21-3.32	0.2453	633	0.2015	11887	X-RAY DIFFRACTION	98
3.32-3.44	0.2393	614	0.1975	11883	X-RAY DIFFRACTION	98
3.44-3.57	0.227	667	0.1977	11903	X-RAY DIFFRACTION	98
3.57-3.74	0.2262	627	0.1844	11869	X-RAY DIFFRACTION	97
3.74-3.93	0.2101	647	0.1747	11879	X-RAY DIFFRACTION	97
3.93-4.18	0.1855	684	0.1491	11796	X-RAY DIFFRACTION	98
4.18-4.5	0.1588	622	0.1378	11801	X-RAY DIFFRACTION	97
4.5-4.95	0.1745	587	0.141	11891	X-RAY DIFFRACTION	97
4.95-5.67	0.1816	642	0.1526	11705	X-RAY DIFFRACTION	96
5.67-7.14	0.2101	581	0.1746	12102	X-RAY DIFFRACTION	99
7.14-48.53	0.1725	666	0.1667	11913	X-RAY DIFFRACTION	98

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°2)	L12 (°2)	L13 (°2)	L22 (°2)	L23 (°2)	L33 (°2)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å2)	T12 (Å2)	T13 (Å2)	T22 (Å2)	T23 (Å2)	T33 (Å2)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	0.0436	0.0981	0.0017	0.1642	-0.0152	0.1615	-0.0515	-0.0792	-0.0095	0.061	0.0009	-0.1435	0.1194	0.0649	-0	0.2081	0.0404	-0.0204	0.3357	0.0219	0.3002	54.0478	100.5969	66.4135
2	0.1022	-0.1031	-0.0289	0.1328	-0.0452	0.0373	-0.054	0.0343	-0.0692	-0.09	0.0633	-0.1296	-0.0004	0.0044	-0	0.2147	0.0011	0.034	0.3566	-0.0235	0.2534	50.4843	108.8213	42.2155
3	0.0749	-0.0473	-0.0368	0.0532	0.0098	0.0647	-0.1004	-0.041	0.184	0.0322	-0.0291	0.0784	-0.2821	-0.1083	-0.0325	0.2603	-0.0144	-0.0749	0.3724	0.0344	0.3053	16.4022	141.4422	44.2749
4	0.0299	-0.0072	0.0402	0.0019	-0.0184	0.1378	-0.1556	0.1392	0.1823	-0.1368	0.1263	0.1095	-0.1626	-0.1244	0.0002	0.3268	-0.0647	-0.1019	0.4082	0.0855	0.2209	20.6633	137.6988	26.564
5	0.1409	-0.0021	0.0091	0.2354	-0.0396	0.1334	-0.1276	0.0802	0.0229	-0.1179	0.0987	-0.0359	0.0187	0.0015	-0.0123	0.221	-0.0677	-0.0253	0.3616	0.0397	0.1898	40.4134	129.3977	35.0196
6	0.039	-0.0194	-0.0018	0.0578	-0.0622	0.0575	-0.0958	0.1593	0.193	-0.0344	0.0087	0.0229	-0.1375	0.1707	-0	0.2227	-0.0126	-0.065	0.331	-0.0016	0.3193	48.353	142.7375	63.3053
7	0.2077	-0.0022	0.0583	0.2305	0.0926	0.1681	-0.0853	-0.0653	0.0737	0.1195	0.0436	0.0482	0.0069	0.0128	-0.0188	0.2061	0.0408	-0.0419	0.3187	-0.0341	0.2401	33.2773	134.2791	76.8698
8	0.0088	-0.0198	-0.0082	0.0234	0.01	0.029	-0.1055	0.2634	-0.0265	0.0168	0.0618	0.0384	0.0418	0.2175	-0	0.2568	-0.0118	-0.0023	0.3367	0.0039	0.241	16.7757	99.1223	47.872
9	0.0218	0.0076	0.021	0.0224	-0.0164	0.0529	-0.1296	0.0524	-0.0127	0.0172	-0.1471	-0.0453	-0.0429	0.0714	-0.0029	0.2089	0.0358	0.0353	0.3503	-0.0657	0.2761	24.5366	97.6061	44.2409
10	0.2867	0.1159	-0.1182	0.1914	-0.0573	0.1968	-0.0543	0.0069	-0.0422	0.0876	0.0379	0.1139	0.018	-0.0028	0.0003	0.1772	0.0138	0.011	0.2661	0.0028	0.2492	13.8263	108.7744	65.7416
11	0.025	-0.0097	0.0084	0.005	0.0041	0.0128	-0.0584	-0.0386	-0.1188	-0.1426	0.1494	0.0198	-0.0431	-0.0252	0.0004	0.5522	-0.1359	0.0934	0.2749	-0.0333	0.2533	91.6984	119.0442	-20.0371
12	0.0131	0.0083	0.0107	0.0181	-0.0071	0.0146	0.0197	-0.0164	-0.1211	-0.2225	0.1483	0.0013	-0.0185	-0.0919	0.0022	0.4556	-0.0694	0.0677	0.2734	-0.0548	0.2844	91.4068	106.7855	-18.412
13	0.0031	0.0009	-0.0027	0.0029	0.005	0.0003	0.0523	0.0185	0.0071	-0.1632	-0.0338	-0.0889	-0.0143	-0.0436	-0	0.7847	-0.1285	0.1533	0.3931	-0.0838	0.3804	101.5538	115.3376	-25.0606
14	0.0065	0.0125	-0.0003	0.0194	-0.012	0.0049	-0.1167	0.0131	0.1323	-0.2448	0.1726	-0.0998	-0.0337	0.0489	0	0.577	-0.1302	0.165	0.3474	-0.078	0.4525	104.668	124.5302	-19.1546
15	0.0137	-0.0031	0.0121	0.0046	0.003	0.0253	-0.1125	0.0192	-0.0353	-0.0464	-0.0795	-0.1609	0.0014	0.0461	-0.0214	0.4513	-0.1642	0.0946	0.2827	-0.0153	0.3071	101.748	130.8368	-14.1522
16	0.0499	0.0131	0.0319	0.0246	0.0035	0.0148	-0.0563	-0.0286	-0.0276	-0.057	0.1121	-0.0967	-0.1335	0.1178	-0	0.3913	-0.0475	0.0479	0.2827	-0.0121	0.3055	91.5885	134.1623	-1.7371
17	0.0018	0.0001	0.0025	0.0022	0.0021	-0.002	0.0506	-0.0147	0.0248	-0.0865	0.0939	0.0146	-0.0267	-0.1639	0	0.2823	-0.0502	0.1064	0.2475	-0.083	0.3865	104.7646	111.3449	3.9428
18	0.0647	0.0563	0.0288	0.046	-0.0038	0.0561	0.0417	-0.0179	-0.0278	-0.1176	-0.0069	-0.0106	-0.0639	0.0217	0	0.3327	-0.0294	0.0235	0.2833	-0.0319	0.2689	94.2758	127.7003	7.4525
19	0.0056	-0.0033	0.0053	0.0028	-0.0013	0.004	0.0752	0.1141	0.0589	-0.1335	0.0594	0.0078	-0.0875	-0.0624	0	0.3428	0.0038	0.0207	0.2999	0.0291	0.3562	76.6571	130.7582	4.1982
20	-0.0057	-0.0056	0.0042	0.0198	-0.0159	0.0099	-0.0157	-0.092	-0.0346	0.0288	0.1687	0.0773	-0.007	-0.1261	-0	0.3369	-0.0266	0.0241	0.2796	-0.0161	0.3048	81.229	126.4865	7.615
21	0.0361	0.0438	0.0093	0.0334	0.0083	0.0091	-0.108	-0.0212	0.1397	-0.0498	0.0862	0.0322	0.04	0.0722	-0	0.407	-0.0337	0.0037	0.279	-0.0012	0.2438	88.0659	127.9846	-4.1766
22	0.156	-0.0207	0.0649	0.079	0.0134	0.1435	-0.0495	-0.0907	-0.1379	0.0307	-0.0342	-0.0208	-0.0846	-0.0888	-0.0019	0.2158	0.015	-0.0225	0.348	-0.0192	0.2636	83.6247	98.0272	36.5357
23	0.0474	0.063	0.0243	0.1609	-0.2199	0.2201	-0.0008	-0.0152	-0.0249	0.0451	0.0095	-0.0642	-0.0621	-0.0098	-0	0.2651	-0.0214	-0.0413	0.2413	-0.0439	0.2334	92.6714	119.1723	26.1829
24	0.122	-0.1323	0.1505	0.195	-0.2028	0.2345	-0.1254	0.0706	-0.1254	-0.1155	0.1617	-0.705	-0.0825	0.1412	-0.0294	0.2913	-0.0731	0.1222	0.3588	-0.1177	0.8241	119.2044	98.7299	9.8112
25	0.0289	-0.0068	-0.0268	0.0089	-0.007	0.0366	0.0235	0.0212	0.0407	-0.0713	0.0024	-0.1678	-0.0257	0.0299	0.0177	0.1776	0.0309	0.3603	0.3158	-0.2945	0.8233	118.2978	80.8705	1.8486
26	0.0171	0.0286	0.0599	0.0249	0.0336	0.0427	-0.0207	-0.0035	-0.0341	-0.2095	0.018	-0.2307	0.0025	0.1163	-0	0.3483	-0.0239	0.0872	0.2981	-0.0581	0.3359	98.1941	85.3519	-1.359
27	0.0557	-0.088	0.0251	0.1144	-0.0337	-0.0088	-0.1248	-0.0663	-0.0543	-0.094	0.1302	-0.2498	0.1044	0.0291	-0.0001	0.2744	-0.0214	0.0562	0.2634	-0.0613	0.363	98.3553	78.4296	11.1824
28	0.0349	-0.0834	-0.0253	0.1063	0.0304	0.1157	0.0839	-0.0039	0.0928	-0.0695	0.0159	0.2205	-0.1029	-0.0405	0.0002	0.2697	-0.011	-0.0654	0.2829	0.0354	0.2355	60.0124	104.3845	4.3011
29	0.0752	0.0365	-0.0445	0.0892	-0.0572	0.0447	-0.0528	-0.0494	0.0281	-0.1936	0.1155	0.0738	0.1899	-0.0702	0.0216	0.3602	-0.0634	-0.0979	0.3228	0.0046	0.2442	67.4312	83.8536	-3.6215
30	-0.001	-0.0014	-0.0014	0.0034	0.0055	0.0073	-0.0245	0.018	0.0237	-0.1152	0.0563	0.1345	-0.0245	-0.146	-0	0.2254	-0.0064	-0.0006	0.2871	-0.0265	0.2918	79.8075	93.9244	16.3131
31	0.0628	-0.0563	0.0778	0.1095	-0.0634	0.0588	-0.0303	-0.0834	0.0079	-0.2485	0.0306	-0.0445	0.0831	0.0445	-0	0.4014	-0.048	-0.0276	0.2679	-0.0312	0.2185	80.7188	82.6955	-3.3508
32	0.3164	-0.1455	0.0597	0.4524	0.1311	0.1156	-0.1563	0.0511	0.1144	-0.4249	0.1685	-0.177	0.062	0.0282	0.0045	0.4581	-0.0428	-0.0011	0.2862	-0.0133	0.1979	77.9293	89.9167	-9.7447
33	0.0141	-0.0105	-0.0006	0.0037	0.0045	0.0089	-0.0107	0.1132	0.0059	-0.0048	0.0572	-0.0949	0.0388	-0.0313	-0	0.2369	0.0273	-0.0588	0.2986	-0.0209	0.4738	126.3399	33.0328	82.989
34	0.0141	0.0065	0.0056	0.0086	0.0156	0.0117	-0.0222	0.0292	0.1269	0.1412	0.011	-0.1766	-0.0757	-0.0382	0	0.2975	0.0065	-0.0513	0.342	0.0044	0.4342	125.2407	45.3463	82.7805
35	0.0182	-0.0043	-0.0035	0.0066	-0.003	0.0027	-0.1073	-0.0823	-0.0981	-0.0788	0.0058	-0.1149	0.0246	0.0462	0	0.31	0.0033	0.0037	0.4634	-0.0057	0.5416	133.0762	35.9589	73.9816
36	0.0059	0.0004	0.0157	0.0081	0.0187	0.0318	-0.0987	0.0171	-0.0675	-0.1575	0.1287	-0.2905	0.1338	0.02	0.0002	0.2788	0.0638	0.006	0.3051	-0.0437	0.488	125.0221	25.0525	71.1832
37	0.0276	-0.0006	0.0333	0.0116	0.0722	0.2202	-0.0265	0.0041	-0.1195	0.2162	0.0578	0.1428	-0.0065	0.1352	-0.0031	0.2559	0.0616	0.0478	0.251	0.0066	0.4777	107.2378	18.9302	80.6923
38	-0.0003	0.0029	-0.0026	0.0035	-0.0116	0.0117	-0.0148	-0.0529	-0.027	0.0104	0.0466	-0.081	0.1341	-0.0192	-0	0.2618	0.0017	-0.0205	0.2595	-0.0235	0.3124	105.5887	41.2205	65.9202
39	0.1247	0.0426	0.13	0.0375	0.0824	0.1622	-0.1987	0.0855	-0.1615	0.09	0.1474	0.1452	0.0637	0.0937	-0.0109	0.2992	0.0212	0.06	0.2709	-0.0303	0.4622	99.0514	25.7304	76.3258
40	0.0026	0.0013	-0.0088	0.0145	-0.0304	0.0829	-0.0138	-0.0146	-0.0636	0.1087	-0.0168	0.0608	-0.0575	-0.0082	-0.0119	0.4288	0.1192	0.1605	0.2084	0.1001	0.5201	99.1898	23.3285	94.3617
41	0.0042	-0.0246	-0.0115	0.0248	0.0566	0.0949	-0.1575	-0.0787	0.0123	0.3708	0.0952	0.1879	0.185	0.1153	-0.0091	0.3234	0.0552	0.0572	0.2969	0.0242	0.4906	104.5298	26.1494	86.3618
42	0.0312	-0.0034	0.0286	0.0372	-0.007	0.0343	0.1058	0.0168	-0.073	-0.0881	-0.0057	0.1363	-0.1785	-0.0699	0	0.3074	0.0402	0.0378	0.338	0.0392	0.3598	72.3497	61.1429	78.9978
43	0.1173	-0.1478	-0.0349	0.0901	-0.0833	0.1626	-0.0601	0.0245	-0.2167	0.0747	0.0419	0.1997	0.0477	-0.0552	-0.0004	0.2524	-0.0117	0.0406	0.3056	-0.0032	0.5241	78.7752	36.882	76.2867
44	0.0644	0.0458	0.0662	0.0262	0.0489	0.0427	-0.098	-0.0046	-0.1509	-0.5472	0.1186	-0.1158	-0.1315	0.0896	-0.0002	0.4758	-0.0192	-0.0168	0.3139	-0.0674	0.3339	100.4502	51.6493	50.7713
45	0.0442	0.223	-0.0141	0.5333	-0.053	0.1253	-0.056	0.0317	0.0005	-0.1716	0.0491	-0.1915	0.0198	0.0142	-0.0022	0.2424	0.0025	0.0317	0.2512	-0.0097	0.2829	107.364	69.5057	65.5563
46	0.1144	0.0041	0.0324	0.0575	-0.0032	0.0551	0.0598	0.0081	-0.0455	0.2481	-0.1484	0.0214	-0.0561	0.0472	-0	0.4694	0.0208	0.0264	0.3496	0.0209	0.36	98.2931	52.6923	109.855
47	0.0414	-0.0291	-0.0352	0.2329	-0.0907	0.0765	-0.0176	0.0319	-0.0055	0.1648	-0.0107	-0.0431	-0.0284	0.0421	-0	0.3221	-0.0204	-0.0586	0.2941	0.0048	0.2843	110.6606	67.0477	93.4971
48	0.1623	0.0307	-0.0631	0.0837	0.1418	0.3503	-0.1143	-0.0299	-0.0602	0.5374	0.1713	-0.0029	0.1631	-0.1345	0.2046	1.0128	0.2067	0.2014	0.257	-0.0254	0.1079	77.9041	122.0269	132.0177
49	0.6229	0.0959	0.062	0.1053	0.063	0.0664	-0.1821	0.0541	0.1402	0.3565	0.1678	0.1383	-0.0575	-0.1068	-0.2348	0.5301	0.1391	0.0845	0.2223	-0.0159	0.2697	74.428	137.8689	118.7422
50	-0	0.0037	-0.004	-0.0006	-0.0019	0.0099	-0.1098	-0.0205	0.028	0.1931	-0.0628	0.0181	0.113	-0.0059	-0	0.334	0.0477	0.1376	0.2683	0.0118	0.3696	66.8254	117.3891	108.1671
51	0.0943	-0.197	-0.137	0.2349	0.2068	0.1924	-0.0214	0.0477	0.0336	0.1025	0.0994	-0.1501	-0.0032	-0.0287	-0.0045	0.3371	0.0618	-0.0025	0.2292	-0.0102	0.2559	84.8461	133.8058	106.3953
52	0.1016	0.0244	-0.002	0.1537	0.1207	0.251	-0.0315	0.0477	-0.0997	-0.0259	-0.0333	-0.0077	-0.0876	-0.0487	-0.0033	0.2405	0.0182	-0.0366	0.2605	-0.0065	0.2061	87.8102	102.2514	76.1633
53	0.081	-0.0794	-0.0253	0.2382	0.1955	0.1541	0.0532	0.0186	-0.0427	-0.1464	-0.0629	0.0459	-0.0371	-0.0324	0	0.2672	0.067	-0.0506	0.2452	-0.0092	0.2259	79.0411	122.7869	86.7971
54	0.0016	-0.0122	0.0165	0.0468	-0.0561	0.0666	-0.0759	-0.0272	-0.059	0.0609	0.1134	0.0616	-0.0246	-0.1255	-0.0137	0.3794	0.0036	0.2917	0.3931	-0.0146	0.907	53.2796	101.9886	102.6052
55	0.0082	0.005	0.0026	0.0054	-0.0067	0.0088	-0.0342	0.0588	-0.0257	0.0142	-0.0578	0.1326	-0.0732	-0.0009	-0	0.2996	0.0061	0.051	0.3497	-0.0733	0.5763	61.0365	109.4134	97.0156
56	0.0178	-0.0028	-0.0006	0.0034	-0.004	0.0014	0.0245	-0.0892	-0.0348	0.1299	0.1898	0.1042	-0.0467	-0.1332	0	0.4595	0.0847	0.0597	0.5139	-0.0363	0.9212	46.3051	107.0292	101.8448
57	0.002	-0.0015	-0.0032	0.0034	0.0053	0.0135	0.0068	-0.0277	-0.0416	0.0445	0.0501	0.0449	-0.0346	-0.1645	0.0522	0.616	0.1599	0.6192	0.664	0.1576	0.9827	49.6022	96.6089	115.5547
58	0.0226	0.0394	-0.0209	0.0694	-0.0331	0.0156	0.049	0.024	-0.0284	-0.0126	0.1133	-0.0296	0.02	-0.1452	0.1222	0.5983	-0.2213	0.6477	0.4345	0.1612	1.0113	54.1698	84.3226	113.2045
59	0.0651	-0.0313	0.0643	0.1324	-0.0751	0.1398	-0.2356	-0.0305	-0.2435	0.4138	0.0344	0.3305	0.124	-0.0536	-0.4962	0.7764	0.0238	0.358	0.1653	0.0601	0.4761	73.5385	90.8274	116.435
60	0.1138	0.0969	0.0853	0.092	0.0863	0.3845	-0.0274	0.0533	-0.0484	0.4538	-0.0397	0.5805	0.1876	0.0094	-0.0159	0.4495	-0.0338	0.1515	0.239	0	0.502	72.7416	84.6395	104.3702
61	0.5562	0.124	-0.4267	0.0208	-0.0928	0.3752	0.0619	0.2608	-0.1353	0.3367	0.0014	-0.5231	-0.1461	-0.1179	0.1691	0.4211	0.1253	-0.3393	0.27	-0.1354	0.4149	106.9747	113.0652	111.6456
62	0.0407	0.0001	-0.0608	0.0149	-0.0264	0.1441	-0.1284	-0.0127	-0.1443	0.1278	-0.2399	-0.1549	-0.1636	0.0214	-0.0392	0.4964	0.0196	-0.2247	0.3441	-0.1609	0.9132	116.6071	114.3026	107.7118
63	0.0581	0.0238	-0.0747	0.0291	0.0123	0.2157	-0.0583	0.0247	0.0535	0.0566	-0.1019	-0.229	0.1144	0.0929	-0.0898	0.5507	0.2443	-0.2705	0.3347	-0.0667	0.76	113.8491	95.9817	109.7781
64	0.1194	-0.0596	-0.0127	0.0237	-0.0139	0.0207	-0.0253	0.014	-0.0176	0.5722	0.1087	-0.3718	0.2064	0.0223	0.129	1.082	0.3723	-0.411	0.1424	0.0156	0.3515	100.4986	89.8137	122.2936
65	0.362	0.0627	-0.1372	0.0639	-0.0155	0.1741	-0.091	0.0902	-0.0335	0.7276	0.15	-0.2138	0.2919	-0.0725	0.1331	0.7567	0.1533	-0.07	0.1248	0.0254	0.2076	90.8949	92.3344	113.5094
66	0.0013	-0.0054	-0.0146	0.0731	-0.0149	0.0711	0.0306	-0.0097	0.0008	0.202	0.0108	0.001	0.1265	-0.1	0.0655	1.1163	0.2287	-0.0651	0.0792	-0.1691	0.0999	90.3952	101.8509	126.8094
67	0.3814	-0.1223	0.2161	0.3019	-0.2654	0.2532	-0.1845	0.0169	0.0017	0.2032	-0.0532	0.0999	0.0904	-0.0392	-0.0791	0.8683	0.0582	0.1113	0.2928	-0.0381	0.2454	84.6947	89.4287	124.6277
68	0.055	-0.0137	0.0212	0.0075	-0.0206	0.0639	-0.0093	0.0191	0.0108	0.04	-0.0234	-0.0373	-0.0348	0.0089	-0.0662	0.819	0.2898	-0.685	0.3686	-0.1451	0.3682	108.8998	100.9809	121.3204
69	0.0104	-0.0032	-0.0062	0.0012	-0.0051	0.0097	0.0499	0.1035	0.1412	0.058	0.0597	-0.0705	-0.0014	-0.0942	-0	0.2871	0.0353	0.0472	0.3403	0.0625	0.4015	39.8071	62.2487	108.885
70	0.0137	-0.0136	-0.0034	0.0175	0.0024	0.0114	0.1555	0.0611	0.2079	-0.0042	-0.0136	0.0974	0.0953	-0.0422	0	0.2631	0.0157	0.0147	0.3112	0.0288	0.3817	31.0677	57.7049	116.4179
71	0.1296	0.0499	-0.1332	0.0449	0.0211	0.1317	0.0161	0.2187	0.0183	-0.1285	0.0239	-0.0846	0.0313	0.0438	-0	0.3064	0.0041	0.0617	0.3666	0.0157	0.3095	49.5406	54.3418	102.5299
72	0.0209	-0.0059	-0.0385	0.005	0.0063	0.0363	-0.0627	0.1394	0.008	-0.1613	0.0566	-0.0015	0.1552	-0.027	-0	0.3236	0.0203	0.0447	0.3543	-0.0028	0.2831	50.7194	38.0279	111.5707
73	0.0404	0.0032	-0.0103	0.0082	-0.0158	0.0942	0.0266	-0.0696	0.1202	0.0674	-0.0039	-0.0343	-0.0264	0.1191	-0	0.2541	0.0177	0.0266	0.3521	-0.012	0.3345	64.4694	49.9439	121.2214
74	0.0106	-0.0004	-0.0173	0.0046	0.0162	0.0246	0.0757	0.0137	0.0637	-0.1092	0.0686	-0.0097	-0.0057	0.0633	0	0.2732	0.0112	0.0525	0.3305	0.0128	0.3433	56.4572	54.8667	112.9502
75	0.2971	-0.2197	0.0258	0.3327	-0.0175	0.0418	-0.1414	-0.4164	-0.2704	0.1203	0.0968	0.122	0.3294	0.1104	-0.0376	0.4788	0.1148	-0.0209	0.4583	0.0328	0.2251	53.8705	19.25	149.89
76	0.0268	0.0034	0.0022	0.0046	-0.0069	0.0047	0.0739	-0.207	-0.0319	0.035	0.0698	-0.1587	0.0529	-0.0456	0.0074	0.4006	0.1639	-0.0933	0.3853	-0.0546	0.3345	71.4468	19.4933	142.0692
77	0.0612	0.0459	-0.0281	0.0944	-0.075	0.0475	0.0041	-0.0199	0.0893	0.0014	0.0253	-0.1107	0.1703	0.0775	0	0.3568	0.0837	0.0083	0.3426	-0.0251	0.2951	63.5676	28.5781	126.1092
78	0.0785	0.0715	0.0174	0.1136	0.0274	0.0542	-0.1389	0.3239	-0.2641	-0.0822	0.0732	-0.0899	0.3282	-0.0374	-0.0104	0.4666	-0.0891	0.0197	0.3632	-0.0608	0.2037	32.9369	16.3349	112.4032
79	0.1956	0.0144	-0.0303	0.1296	0.038	0.1587	0.0536	0.0443	0.0888	0.1022	0.0336	0.0997	0.1823	-0.1164	0.001	0.3382	-0.102	-0.003	0.3607	0.0121	0.2694	20.2601	27.8126	130.5044
80	0.0494	-0.0517	0.0578	0.461	-0.2794	0.2259	0.0451	-0.0433	0.2046	-0.1958	0.0795	-0.0493	0.1118	0.2763	0.0274	0.1885	-0.0071	0.0406	0.3505	-0.0895	0.3885	52.1866	60.9127	146.2477
81	0.1624	-0.0888	-0.1871	0.0934	0.2116	0.4339	0.02	0.0064	0.1036	0.0821	0.058	0.0849	0.0275	-0.048	0.0006	0.2577	-0.0003	0.0498	0.2871	-0.0333	0.3131	29.3926	52.0672	146.5144
82	0.2266	0.0692	0.1166	0.0512	0.0438	0.6479	-0.0956	0.0244	-0.5044	-0.0124	0.0167	0.0061	-0.0757	0.0446	-0.0293	0.2237	0.0024	0.0456	0.2529	-0.0299	0.4814	87.947	52.7247	22.8324
83	0.5257	0.2717	-0.1172	0.3556	-0.1135	0.0742	-0.5492	0.0854	-0.8254	-0.3522	0.0703	-1.1119	0.2836	-0.013	-0.8737	0.3087	0.0475	0.159	-0.0094	0.1431	1.0536	74.6048	32.689	30.981
84	0.0782	-0.0565	-0.0797	0.2735	0.2524	0.2463	0.0132	-0.0286	-0.0032	-0.043	0.2451	0.1014	-0.0477	0.0528	0.0864	0.3333	-0.1054	-0.0693	0.367	0.18	0.3549	33.3267	31.0065	23.5812
85	0.0049	-0.0251	-0.0206	0.1062	0.0642	0.0508	-0.1799	-0.046	0.1062	-0.2106	0.3295	0.449	-0.0811	-0.0514	0.0028	0.2918	-0.0782	-0.0995	0.4375	0.1821	0.5114	29.0397	37.7398	24.9797
86	0.0044	0.0066	0.0018	0.1532	0.1475	0.1646	-0.1231	-0.0238	-0.1356	0.1348	0.3241	0.137	0.1572	-0.1382	0.0243	0.2615	-0.0463	0.0242	0.3367	0.119	0.4038	32.7322	23.0845	36.051
87	0.1365	-0.0234	0.1203	0.0136	-0.0625	0.532	-0.0942	0.0364	-0.2556	-0.4436	0.1322	-0.4801	0.14	-0.1456	-0.0062	0.4115	-0.1008	0.1876	0.2673	-0.0211	0.6517	50.1862	16.3286	26.8234
88	0.0047	-0.0039	0.0037	0.0036	0.0037	0.005	-0.0641	0.0735	-0.0273	0.0546	-0.1423	-0.0377	0.0765	-0.153	-0	0.2809	0.0075	0.0219	0.3148	0.0516	0.3467	52.2579	40.0554	39.0504
89	0.0337	-0.0119	0.1013	0.0088	-0.0487	0.2916	-0.1032	-0.0559	-0.3173	0.0094	-0.1288	-0.0688	-0.0443	-0.083	-0.0335	0.2985	-0.0085	0.1049	0.2573	0.0249	0.4915	55.7304	24.1622	33.7637
90	0.1385	0.0308	0.2454	0.026	0.078	0.5969	-0.2183	0.0921	-0.2799	-0.1961	0.0089	-0.29	0.0304	-0.019	-0.3115	0.2676	-0.025	0.2312	0.2173	-0.0113	0.5685	61.1686	22.939	26.6785
91	0.0039	-0.001	-0.0119	-0.0017	0.0001	0.0378	-0.1002	0.0165	-0.0821	-0.0831	0.0192	-0.1245	0.1398	-0.0466	-0.0602	0.7396	-0.3411	0.7151	0.4058	-0.2009	0.5545	58.1091	19.4167	12.5079
92	0.2022	-0.0021	0.2529	0.0233	-0.076	0.2881	-0.186	-0.1101	-0.22	-0.673	0.1488	-0.5713	0.0419	-0.0076	-0.1382	0.4513	-0.1759	0.2403	0.2822	-0.0251	0.6041	52.1017	22.8233	20.3373
93	0.0018	-0.0101	0.0078	0.0555	-0.0219	0.0156	0.0559	-0.022	0.0331	-0.2544	-0.0043	-0.0398	-0.0243	0.1148	0.048	1.136	-0.4952	0.2389	0.5716	-0.0306	0.2648	55.8652	44.0877	-3.8843
94	0.0189	-0.0094	0.0177	0.066	0.0254	0.0306	-0.0389	0.0126	-0.0309	-0.0894	0.0349	0.0081	-0.0356	0.0431	-0.0057	0.8108	-0.5699	0.0925	0.3583	-0.1842	0.2613	55.8989	36.6922	4.4305
95	0.1083	-0.0377	0.0247	0.0936	-0.0942	0.1075	-0.0563	0.0553	0.055	-0.0964	-0.0327	-0.0503	0.0162	0.0153	-0.066	0.9915	-0.3874	0.1727	0.3591	-0.2487	0.5773	60.8271	37.6057	-8.4435
96	0.0338	-0.0085	0.0163	0.0114	-0.011	0.0106	-0.0169	-0.0169	0.0608	-0.056	-0.0169	-0.0295	0.0533	0.003	-0.0134	1.0882	-0.5655	0.235	0.6551	-0.0556	0.6371	58.1509	57.6502	-4.5734
97	0.3121	0.1332	-0.0596	0.6208	-0.2406	0.5636	-0.3742	0.2592	0.0282	-0.8694	0.6165	0.0692	0.2772	-0.1714	1.4628	0.4541	-0.2342	-0.2926	0.424	0.3141	0.1227	45.9079	62.4245	10.0608
98	0.0076	-0.0058	0.0062	0.0004	0.0044	0.0094	-0.1069	0.0495	0.0164	0.269	-0.032	-0.0682	-0.0968	0.007	0	0.6547	0.0372	-0.0401	0.357	0.0437	0.233	58.2324	58.7074	52.9929
99	0.013	-0.0095	-0.0063	0.0018	0.0024	0.0195	0.0295	0.0372	-0.1283	0.3215	-0.0942	-0.0627	0.0405	-0.076	-0.0028	0.5163	0.002	-0.1126	0.3559	0.0688	0.3109	61.1819	48.4712	50.7538
100	0.0147	0.0045	0.0103	0.0024	-0.0033	0.0112	-0.0895	-0.0853	0.0093	0.2072	-0.0137	0.1546	-0.0041	-0.055	-0.0001	0.9622	0.2366	0.3353	0.5903	0.1255	0.5261	43.6161	57.9947	56.3886
101	0.0017	0.004	-0.0026	0.0249	-0.0139	0.0107	0.0426	-0.0558	0.0686	0.0928	-0.0632	0.0665	0.0246	-0.0501	-0.0159	0.792	0.2009	0.361	0.479	0.0429	0.4085	43.7018	67.1952	51.435
102	0.3781	0.0963	-0.0147	0.0398	-0.0132	0.004	-0.0957	0.0318	0.2648	0.2596	0.1603	0.2668	-0.0636	-0.1278	0.0045	0.449	0.0948	0.1087	0.2285	0.0132	0.2888	49.1947	74.5676	37.7201
103	0.0691	0.0336	-0.012	0.0397	-0.0452	0.0249	-0.0509	-0.0019	0.0777	0.3439	0.2256	0.3984	-0.0065	-0.1518	-0	0.2862	0.025	0.0603	0.3315	0.0693	0.3593	45.3807	63.0281	29.1637
104	0.0195	0.0078	-0.0124	0.0076	0.0026	0.0054	-0.0686	0.0739	0.0095	0.1676	0.0019	0.0044	-0.0668	-0.0034	0	0.3545	0.0311	-0.0535	0.3017	-0.0223	0.3007	62.9526	76.3194	28.619
105	0.1028	0.1089	0.0845	0.0952	0.0536	0.1103	-0.035	0.1085	0.1023	0.2869	0.0984	0.1852	-0.0565	0.1245	0.0158	0.3641	0.0373	0.0092	0.2699	0.0284	0.2985	56.6432	70.2723	33.0098

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details
1	X-RAY DIFFRACTION	1	chain 'A' and (resid 2 through 119 )
2	X-RAY DIFFRACTION	2	chain 'A' and (resid 120 through 334 )
3	X-RAY DIFFRACTION	3	chain 'B' and (resid 2 through 84 )
4	X-RAY DIFFRACTION	4	chain 'B' and (resid 85 through 150 )
5	X-RAY DIFFRACTION	5	chain 'B' and (resid 151 through 334 )
6	X-RAY DIFFRACTION	6	chain 'C' and (resid 2 through 69 )
7	X-RAY DIFFRACTION	7	chain 'C' and (resid 70 through 333 )
8	X-RAY DIFFRACTION	8	chain 'D' and (resid 2 through 46 )
9	X-RAY DIFFRACTION	9	chain 'D' and (resid 47 through 69 )
10	X-RAY DIFFRACTION	10	chain 'D' and (resid 70 through 333 )
11	X-RAY DIFFRACTION	11	chain 'E' and (resid 1 through 33 )
12	X-RAY DIFFRACTION	12	chain 'E' and (resid 34 through 67 )
13	X-RAY DIFFRACTION	13	chain 'E' and (resid 68 through 84 )
14	X-RAY DIFFRACTION	14	chain 'E' and (resid 85 through 111 )
15	X-RAY DIFFRACTION	15	chain 'E' and (resid 112 through 129 )
16	X-RAY DIFFRACTION	16	chain 'E' and (resid 130 through 179 )
17	X-RAY DIFFRACTION	17	chain 'E' and (resid 180 through 199 )
18	X-RAY DIFFRACTION	18	chain 'E' and (resid 200 through 254 )
19	X-RAY DIFFRACTION	19	chain 'E' and (resid 255 through 278 )
20	X-RAY DIFFRACTION	20	chain 'E' and (resid 279 through 303 )
21	X-RAY DIFFRACTION	21	chain 'E' and (resid 304 through 333 )
22	X-RAY DIFFRACTION	22	chain 'F' and (resid 2 through 129 )
23	X-RAY DIFFRACTION	23	chain 'F' and (resid 130 through 334 )
24	X-RAY DIFFRACTION	24	chain 'G' and (resid 4 through 111 )
25	X-RAY DIFFRACTION	25	chain 'G' and (resid 112 through 150 )
26	X-RAY DIFFRACTION	26	chain 'G' and (resid 151 through 249 )
27	X-RAY DIFFRACTION	27	chain 'G' and (resid 250 through 333 )
28	X-RAY DIFFRACTION	28	chain 'H' and (resid 2 through 111 )
29	X-RAY DIFFRACTION	29	chain 'H' and (resid 112 through 179 )
30	X-RAY DIFFRACTION	30	chain 'H' and (resid 180 through 199 )
31	X-RAY DIFFRACTION	31	chain 'H' and (resid 200 through 265 )
32	X-RAY DIFFRACTION	32	chain 'H' and (resid 266 through 333 )
33	X-RAY DIFFRACTION	33	chain 'I' and (resid 1 through 33 )
34	X-RAY DIFFRACTION	34	chain 'I' and (resid 34 through 67 )
35	X-RAY DIFFRACTION	35	chain 'I' and (resid 68 through 84 )
36	X-RAY DIFFRACTION	36	chain 'I' and (resid 85 through 129 )
37	X-RAY DIFFRACTION	37	chain 'I' and (resid 130 through 179 )
38	X-RAY DIFFRACTION	38	chain 'I' and (resid 180 through 199 )
39	X-RAY DIFFRACTION	39	chain 'I' and (resid 200 through 254 )
40	X-RAY DIFFRACTION	40	chain 'I' and (resid 255 through 278 )
41	X-RAY DIFFRACTION	41	chain 'I' and (resid 279 through 333 )
42	X-RAY DIFFRACTION	42	chain 'J' and (resid 2 through 95 )
43	X-RAY DIFFRACTION	43	chain 'J' and (resid 96 through 334 )
44	X-RAY DIFFRACTION	44	chain 'K' and (resid 2 through 84 )
45	X-RAY DIFFRACTION	45	chain 'K' and (resid 85 through 333 )
46	X-RAY DIFFRACTION	46	chain 'L' and (resid 2 through 129 )
47	X-RAY DIFFRACTION	47	chain 'L' and (resid 130 through 333 )
48	X-RAY DIFFRACTION	48	chain 'M' and (resid 1 through 84 )
49	X-RAY DIFFRACTION	49	chain 'M' and (resid 85 through 179 )
50	X-RAY DIFFRACTION	50	chain 'M' and (resid 180 through 199 )
51	X-RAY DIFFRACTION	51	chain 'M' and (resid 200 through 334 )
52	X-RAY DIFFRACTION	52	chain 'N' and (resid 1 through 150 )
53	X-RAY DIFFRACTION	53	chain 'N' and (resid 151 through 334 )
54	X-RAY DIFFRACTION	54	chain 'O' and (resid 3 through 37 )
55	X-RAY DIFFRACTION	55	chain 'O' and (resid 38 through 57 )
56	X-RAY DIFFRACTION	56	chain 'O' and (resid 58 through 91 )
57	X-RAY DIFFRACTION	57	chain 'O' and (resid 92 through 124 )
58	X-RAY DIFFRACTION	58	chain 'O' and (resid 125 through 150 )
59	X-RAY DIFFRACTION	59	chain 'O' and (resid 151 through 254 )
60	X-RAY DIFFRACTION	60	chain 'O' and (resid 255 through 333 )
61	X-RAY DIFFRACTION	61	chain 'P' and (resid 3 through 56 )
62	X-RAY DIFFRACTION	62	chain 'P' and (resid 57 through 88 )
63	X-RAY DIFFRACTION	63	chain 'P' and (resid 89 through 129 )
64	X-RAY DIFFRACTION	64	chain 'P' and (resid 130 through 179 )
65	X-RAY DIFFRACTION	65	chain 'P' and (resid 180 through 265 )
66	X-RAY DIFFRACTION	66	chain 'P' and (resid 266 through 295 )
67	X-RAY DIFFRACTION	67	chain 'P' and (resid 296 through 316 )
68	X-RAY DIFFRACTION	68	chain 'P' and (resid 317 through 333 )
69	X-RAY DIFFRACTION	69	chain 'Q' and (resid 1 through 33 )
70	X-RAY DIFFRACTION	70	chain 'Q' and (resid 34 through 67 )
71	X-RAY DIFFRACTION	71	chain 'Q' and (resid 68 through 179 )
72	X-RAY DIFFRACTION	72	chain 'Q' and (resid 180 through 227 )
73	X-RAY DIFFRACTION	73	chain 'Q' and (resid 228 through 303 )
74	X-RAY DIFFRACTION	74	chain 'Q' and (resid 304 through 333 )
75	X-RAY DIFFRACTION	75	chain 'R' and (resid 2 through 111 )
76	X-RAY DIFFRACTION	76	chain 'R' and (resid 112 through 150 )
77	X-RAY DIFFRACTION	77	chain 'R' and (resid 151 through 334 )
78	X-RAY DIFFRACTION	78	chain 'S' and (resid 2 through 95 )
79	X-RAY DIFFRACTION	79	chain 'S' and (resid 96 through 333 )
80	X-RAY DIFFRACTION	80	chain 'T' and (resid 2 through 84 )
81	X-RAY DIFFRACTION	81	chain 'T' and (resid 85 through 333 )
82	X-RAY DIFFRACTION	82	chain 'U' and (resid 1 through 150 )
83	X-RAY DIFFRACTION	83	chain 'U' and (resid 151 through 333 )
84	X-RAY DIFFRACTION	84	chain 'V' and (resid 2 through 23 )
85	X-RAY DIFFRACTION	85	chain 'V' and (resid 24 through 84 )
86	X-RAY DIFFRACTION	86	chain 'V' and (resid 85 through 129 )
87	X-RAY DIFFRACTION	87	chain 'V' and (resid 130 through 179 )
88	X-RAY DIFFRACTION	88	chain 'V' and (resid 180 through 199 )
89	X-RAY DIFFRACTION	89	chain 'V' and (resid 200 through 227 )
90	X-RAY DIFFRACTION	90	chain 'V' and (resid 228 through 254 )
91	X-RAY DIFFRACTION	91	chain 'V' and (resid 255 through 278 )
92	X-RAY DIFFRACTION	92	chain 'V' and (resid 279 through 334 )
93	X-RAY DIFFRACTION	93	chain 'W' and (resid 5 through 37 )
94	X-RAY DIFFRACTION	94	chain 'W' and (resid 38 through 57 )
95	X-RAY DIFFRACTION	95	chain 'W' and (resid 58 through 92 )
96	X-RAY DIFFRACTION	96	chain 'W' and (resid 93 through 130 )
97	X-RAY DIFFRACTION	97	chain 'W' and (resid 131 through 331 )
98	X-RAY DIFFRACTION	98	chain 'X' and (resid 1 through 33 )
99	X-RAY DIFFRACTION	99	chain 'X' and (resid 34 through 75 )
100	X-RAY DIFFRACTION	100	chain 'X' and (resid 76 through 111 )
101	X-RAY DIFFRACTION	101	chain 'X' and (resid 112 through 129 )
102	X-RAY DIFFRACTION	102	chain 'X' and (resid 130 through 179 )
103	X-RAY DIFFRACTION	103	chain 'X' and (resid 180 through 254 )
104	X-RAY DIFFRACTION	104	chain 'X' and (resid 255 through 278 )
105	X-RAY DIFFRACTION	105	chain 'X' and (resid 279 through 333 )