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- PDB-9ru6: Human mitoribosome bound to TACO1 (Translational activator of COX... -

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Basic information

Entry
Database: PDB / ID: 9ru6
TitleHuman mitoribosome bound to TACO1 (Translational activator of COX1), mRNA, A/A-, P/P- and (partial) E/E-tRNAs
Components
  • (28S ribosomal protein ...) x 24
  • (39S ribosomal protein ...) x 46
  • (Large ribosomal subunit protein ...) x 3
  • (Small ribosomal subunit protein ...) x 3
  • 12S mitochondrial rRNA
  • 16S mitochondrial rRNA
  • A-site tRNA (68-MER)
  • Aurora kinase A-interacting protein
  • E-site tRNA (70-MER)
  • Growth arrest and DNA damage-inducible proteins-interacting protein 1
  • MRPS21 isoform 1
  • P-site RNA (70-MER)
  • Pentatricopeptide repeat domain-containing protein 3, mitochondrial
  • Peptidyl-tRNA hydrolase ICT1, mitochondrial
  • Ribosomal protein 63, mitochondrial
  • Translational activator of cytochrome c oxidase 1
  • mRNA (34-MER)
  • tRNA-Val (73-MER)
KeywordsRIBOSOME / mitochondria / mitoribosome / translation activator of COX1
Function / homology
Function and homology information


Complex IV assembly / mitochondrial ribosome binding / positive regulation of mitochondrial translation / rRNA import into mitochondrion / mitochondrial transcription / rescue of stalled mitochondrial ribosome / mitochondrial translational termination / mitochondrial translational elongation / translation release factor activity, codon nonspecific / mitochondrial ribosome assembly ...Complex IV assembly / mitochondrial ribosome binding / positive regulation of mitochondrial translation / rRNA import into mitochondrion / mitochondrial transcription / rescue of stalled mitochondrial ribosome / mitochondrial translational termination / mitochondrial translational elongation / translation release factor activity, codon nonspecific / mitochondrial ribosome assembly / Mitochondrial translation elongation / Mitochondrial translation initiation / Mitochondrial ribosome-associated quality control / Mitochondrial translation termination / peptidyl-tRNA hydrolase / mitochondrial large ribosomal subunit / mitochondrial ribosome / mitochondrial small ribosomal subunit / peptidyl-tRNA hydrolase activity / sperm head-tail coupling apparatus / mitochondrial translation / apoptotic mitochondrial changes / positive regulation of proteolysis / ribosomal small subunit binding / anatomical structure morphogenesis / RNA processing / Mitochondrial protein degradation / apoptotic signaling pathway / fibrillar center / cell junction / regulation of translation / double-stranded RNA binding / 5S rRNA binding / small ribosomal subunit / nuclear membrane / small ribosomal subunit rRNA binding / large ribosomal subunit rRNA binding / Hydrolases; Acting on acid anhydrides; Acting on GTP to facilitate cellular and subcellular movement / cell population proliferation / tRNA binding / mitochondrial inner membrane / negative regulation of translation / nuclear body / rRNA binding / structural constituent of ribosome / ribosome / translation / mitochondrial matrix / ribonucleoprotein complex / protein domain specific binding / nucleotide binding / mRNA binding / GTPase activity / apoptotic process / nucleolus / positive regulation of DNA-templated transcription / GTP binding / mitochondrion / : / RNA binding / nucleoplasm / nucleus / plasma membrane / cytosol / cytoplasm
Similarity search - Function
Transcriptional regulator TACO1-like / Transcriptional regulator TACO1-like, domain 3 / : / : / TACO1/YebC second and third domain / TACO1/YebC protein N-terminal domain / YebC-like / Ribosomal protein L1, mitochondrial / Coiled-coil-helix-coiled-coil-helix domain-containing protein 1 / Cysteine alpha-hairpin motif superfamily ...Transcriptional regulator TACO1-like / Transcriptional regulator TACO1-like, domain 3 / : / : / TACO1/YebC second and third domain / TACO1/YebC protein N-terminal domain / YebC-like / Ribosomal protein L1, mitochondrial / Coiled-coil-helix-coiled-coil-helix domain-containing protein 1 / Cysteine alpha-hairpin motif superfamily / 28S ribosomal protein S26 / Mitochondrial ribosome subunit S26 / 28S ribosomal protein S27, mitochondrial / Ribosomal protein S23, mitochondrial / Ribosomal protein S23/S25, mitochondrial / Mitochondrial 28S ribosomal protein S31 / MRPS27/PTCD2 / Mitochondrial 28S ribosomal protein S27 / Mitochondrial ribosomal protein S23 / Mitochondrial 28S ribosomal protein S31 / Ribosomal protein S22, mitochondrial / 28S ribosomal protein S10, mitochondrial / : / Mitochondrial 28S ribosomal protein S22 / Ribosomal protein S29, mitochondrial / Ribosomal protein S28, mitochondrial / 28S ribosomal protein S18b, mitochondrial / Mitochondrial ribosomal protein MRP-S35 / 28S ribosomal protein S24, mitochondrial / Mitochondrial 28S ribosomal protein S34 / Pentatricopeptide repeat domain-containing protein 3 / 28S ribosomal protein S17, mitochondrial / : / : / Mitochondrial ribosome subunit S24 / Mitochondrial 28S ribosomal protein S34 / Small ribosomal subunit protein uS5m, N-terminal / Small ribosomal subunit protein mS39, PPR / : / 28S ribosomal protein S25, mitochondrial / Ribosomal protein L55, mitochondrial / Mitochondrial ribosomal protein L55 superfamily / : / Mitochondrial ribosomal protein L55 / Mitochondrial ribosomal protein L48 / 39S ribosomal protein L40, mitochondrial / Ribosomal protein S30, mitochondrial / Ribosomal protein L53, mitochondrial / 39S ribosomal protein L53/MRP-L53 / 39S ribosomal protein L42, mitochondrial / Mitochondrial 28S ribosomal protein S32 / Ribosomal protein L37, mitochondrial / Mitochondrial ribosomal protein L37 / Ribosomal protein 63, mitochondrial / Growth arrest/ DNA-damage-inducible protein-interacting protein 1 / Ribosomal protein L35, mitochondrial / Ribosomal protein L51, mitochondrial / Growth arrest and DNA-damage-inducible proteins-interacting protein 1 / Mitochondrial ribosomal subunit / Mitochondrial ribosome protein 63 / Ribosomal protein L37/S30 / Growth arrest and DNA damage-inducible proteins-interacting protein 1 domain superfamily / : / : / Mitochondrial 28S ribosomal protein S30 (PDCD9) / 39S ribosomal protein L52, mitochondrial / Mitoribosomal protein mL52 / : / : / Large ribosomal subunit protein mL44, endonuclease domain / Ribosomal protein L28/L40, mitochondrial / Mitochondrial ribosomal protein L28 / Pentatricopeptide repeat domain / : / : / Large ribosomal subunit protein bL9m C-terminal domain / Large ribosomal subunit protein bL9m N-terminal domain / Tim44-like domain / Tim44-like domain / Tim44 / Ribosomal protein S27/S33, mitochondrial / : / Mitochondrial ribosomal subunit S27 / Ribosomal protein S24/S35, mitochondrial / : / Ribosomal protein L7/L12, oligomerisation / Ribosomal protein L7/L12, oligomerisation domain superfamily / Ribosomal protein L7/L12 dimerisation domain / : / Ribosomal protein L7/L12 / Ribosomal protein L7/L12, C-terminal / Ribosomal protein S24/S35, mitochondrial, conserved domain / Ribosomal protein L7/L12 C-terminal domain / Mitochondrial ribosomal subunit protein / Mitochondrial ribosomal protein L46 NUDIX / Ribosomal protein L50, mitochondria / MRPL44, double-stranded RNA binding domain / Ribosomal subunit 39S / MRPL44 dsRNA-binding domain / Ribosomal protein L46, N-terminal
Similarity search - Domain/homology
Chem-5F0 / ADENOSINE-5'-TRIPHOSPHATE / FE2/S2 (INORGANIC) CLUSTER / GUANOSINE-5'-DIPHOSPHATE / : / NICOTINAMIDE-ADENINE-DINUCLEOTIDE / SPERMIDINE / L-VALINOL / : / : ...Chem-5F0 / ADENOSINE-5'-TRIPHOSPHATE / FE2/S2 (INORGANIC) CLUSTER / GUANOSINE-5'-DIPHOSPHATE / : / NICOTINAMIDE-ADENINE-DINUCLEOTIDE / SPERMIDINE / L-VALINOL / : / : / RNA / RNA (> 10) / RNA (> 100) / RNA (> 1000) / MRPS21 isoform 1 / Small ribosomal subunit protein uS12m / Small ribosomal subunit protein uS14m / Large ribosomal subunit protein bL33m / Large ribosomal subunit protein uL3m / Large ribosomal subunit protein bL19m / Small ribosomal subunit protein mS29 / Large ribosomal subunit protein bL12m / Small ribosomal subunit protein mS22 / Small ribosomal subunit protein mS25 / Small ribosomal subunit protein uS10m / Small ribosomal subunit protein mS35 / Small ribosomal subunit protein uS5m / Small ribosomal subunit protein uS11m / Small ribosomal subunit protein uS15m / Small ribosomal subunit protein mS34 / Small ribosomal subunit protein bS6m / Small ribosomal subunit protein uS9m / Large ribosomal subunit protein bL28m / Large ribosomal subunit protein mL49 / Large ribosomal subunit protein mL62 / Large ribosomal subunit protein uL23m / Large ribosomal subunit protein mL51 / Large ribosomal subunit protein uL2m / Large ribosomal subunit protein mL54 / Large ribosomal subunit protein uL14m / Large ribosomal subunit protein bL21m / Large ribosomal subunit protein mL55 / Large ribosomal subunit protein uL10m / Large ribosomal subunit protein mL52 / Large ribosomal subunit protein mL41 / Large ribosomal subunit protein mL50 / Large ribosomal subunit protein mL43 / Large ribosomal subunit protein mL64 / Large ribosomal subunit protein uL30m / Small ribosomal subunit protein mS27 / Small ribosomal subunit protein mS31 / Large ribosomal subunit protein uL24m / Small ribosomal subunit protein mS37 / Large ribosomal subunit protein mL38 / Small ribosomal subunit protein uS3m / Large ribosomal subunit protein mL53 / Small ribosomal subunit protein mS39 / Large ribosomal subunit protein mL48 / Large ribosomal subunit protein bL34m / Large ribosomal subunit protein mL63 / Large ribosomal subunit protein mL45 / Translational activator of cytochrome c oxidase 1 / Large ribosomal subunit protein bL32m / Large ribosomal subunit protein bL20m / Large ribosomal subunit protein uL13m / Large ribosomal subunit protein bL9m / Large ribosomal subunit protein uL4m / Large ribosomal subunit protein uL1m / Small ribosomal subunit protein mS26 / Large ribosomal subunit protein mL37 / Large ribosomal subunit protein uL18m / Large ribosomal subunit protein mL46 / Large ribosomal subunit protein mL44 / Large ribosomal subunit protein uL29m / Large ribosomal subunit protein mL65 / Large ribosomal subunit protein mL40 / Large ribosomal subunit protein bL17m / Large ribosomal subunit protein mL66 / Small ribosomal subunit protein bS22, mitochondrial / Large ribosomal subunit protein uL22m / Large ribosomal subunit protein uL16m / Large ribosomal subunit protein mL39 / Large ribosomal subunit protein bL35m / Large ribosomal subunit protein uL15m / Large ribosomal subunit protein bL36m / Large ribosomal subunit protein bL27m / Small ribosomal subunit protein mS33 / Small ribosomal subunit protein bS1m / Small ribosomal subunit protein uS17m / Small ribosomal subunit protein uS7m / Small ribosomal subunit protein uS2m / Large ribosomal subunit protein uL11m / Small ribosomal subunit protein bS16m / Small ribosomal subunit protein bS18m / Small ribosomal subunit protein mS23 / Small ribosomal subunit protein mS40 / Large ribosomal subunit protein mL42
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodELECTRON MICROSCOPY / single particle reconstruction / cryo EM / Resolution: 2.64 Å
AuthorsSingh, V. / Khawaja, A. / Rorbach, J.
Funding support Sweden, 2items
OrganizationGrant numberCountry
Knut and Alice Wallenberg FoundationKAW2019.0109 Sweden
Swedish Research CouncilVR2016-02179 Sweden
CitationJournal: To Be Published
Title: Structural basis of TACO1 function in human mitochondrial translation
Authors: Singh, V. / Whitford, P.C. / Khawaja, A. / Rorbach, J.
History
DepositionJul 3, 2025Deposition site: PDBE / Processing site: PDBE
Revision 1.0Jul 15, 2026Provider: repository / Type: Initial release
Revision 1.0Jul 15, 2026Data content type: EM metadata / Data content type: EM metadata / Provider: repository / Type: Initial release
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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A5: Translational activator of cytochrome c oxidase 1
AA: 12S mitochondrial rRNA
AB: 28S ribosomal protein S2, mitochondrial
AC: 28S ribosomal protein S24, mitochondrial
AD: 28S ribosomal protein S5, mitochondrial
AE: 28S ribosomal protein S6, mitochondrial
AF: 28S ribosomal protein S7, mitochondrial
AG: 28S ribosomal protein S9, mitochondrial
AH: 28S ribosomal protein S10, mitochondrial
AI: Small ribosomal subunit protein uS11m
AJ: 28S ribosomal protein S12, mitochondrial
AK: 28S ribosomal protein S14, mitochondrial
AL: 28S ribosomal protein S15, mitochondrial
AM: 28S ribosomal protein S16, mitochondrial
AN: 28S ribosomal protein S17, mitochondrial
AO: 28S ribosomal protein S18b, mitochondrial
AP: 28S ribosomal protein S18c, mitochondrial
AQ: MRPS21 isoform 1
AR: 28S ribosomal protein S22, mitochondrial
AS: 28S ribosomal protein S23, mitochondrial
AT: 28S ribosomal protein S25, mitochondrial
AU: 28S ribosomal protein S26, mitochondrial
AV: 28S ribosomal protein S27, mitochondrial
AW: 28S ribosomal protein S28, mitochondrial
AX: 28S ribosomal protein S29, mitochondrial
AY: 28S ribosomal protein S31, mitochondrial
AZ: 28S ribosomal protein S33, mitochondrial
A0: 28S ribosomal protein S34, mitochondrial
A1: Small ribosomal subunit protein mS35
A2: Small ribosomal subunit protein mS37
A3: Aurora kinase A-interacting protein
A4: Pentatricopeptide repeat domain-containing protein 3, mitochondrial
Aw: A-site tRNA (68-MER)
Ax: P-site RNA (70-MER)
Ay: E-site tRNA (70-MER)
Az: mRNA (34-MER)
A: 16S mitochondrial rRNA
B: tRNA-Val (73-MER)
D: 39S ribosomal protein L2, mitochondrial
E: 39S ribosomal protein L3, mitochondrial
F: 39S ribosomal protein L4, mitochondrial
I: 39S ribosomal protein L10, mitochondrial
J: 39S ribosomal protein L11, mitochondrial
K: Large ribosomal subunit protein uL13m
L: 39S ribosomal protein L14, mitochondrial
M: 39S ribosomal protein L15, mitochondrial
N: 39S ribosomal protein L16, mitochondrial
O: 39S ribosomal protein L17, mitochondrial
P: 39S ribosomal protein L18, mitochondrial
Q: 39S ribosomal protein L19, mitochondrial
R: 39S ribosomal protein L20, mitochondrial
S: 39S ribosomal protein L21, mitochondrial
T: 39S ribosomal protein L22, mitochondrial
U: Large ribosomal subunit protein uL23m
V: 39S ribosomal protein L24, mitochondrial
W: 39S ribosomal protein L27, mitochondrial
X: 39S ribosomal protein L28, mitochondrial
Y: 39S ribosomal protein L47, mitochondrial
Z: 39S ribosomal protein L30, mitochondrial
0: 39S ribosomal protein L32, mitochondrial
1: 39S ribosomal protein L33, mitochondrial
2: 39S ribosomal protein L34, mitochondrial
3: 39S ribosomal protein L35, mitochondrial
4: 39S ribosomal protein L36, mitochondrial
5: 39S ribosomal protein L37, mitochondrial
6: 39S ribosomal protein L38, mitochondrial
7: 39S ribosomal protein L39, mitochondrial
8: 39S ribosomal protein L40, mitochondrial
9: 39S ribosomal protein L41, mitochondrial
a: 39S ribosomal protein L42, mitochondrial
b: 39S ribosomal protein L43, mitochondrial
c: 39S ribosomal protein L44, mitochondrial
d: 39S ribosomal protein L45, mitochondrial
e: 39S ribosomal protein L46, mitochondrial
f: 39S ribosomal protein L48, mitochondrial
g: 39S ribosomal protein L49, mitochondrial
h: 39S ribosomal protein L50, mitochondrial
i: 39S ribosomal protein L51, mitochondrial
j: 39S ribosomal protein L52, mitochondrial
k: Large ribosomal subunit protein mL53
l: 39S ribosomal protein L54, mitochondrial
m: 39S ribosomal protein L55, mitochondrial
o: Ribosomal protein 63, mitochondrial
p: Peptidyl-tRNA hydrolase ICT1, mitochondrial
q: Growth arrest and DNA damage-inducible proteins-interacting protein 1
r: 39S ribosomal protein S18a, mitochondrial
s: 39S ribosomal protein S30, mitochondrial
t: 39S ribosomal protein L12, mitochondrial
u: 39S ribosomal protein L12, mitochondrial
v: 39S ribosomal protein L12, mitochondrial
w: 39S ribosomal protein L12, mitochondrial
x: 39S ribosomal protein L12, mitochondrial
y: 39S ribosomal protein L12, mitochondrial
H: 39S ribosomal protein L9, mitochondrial
z: 39S ribosomal protein L1, mitochondrial
t1: 39S ribosomal protein L12, mitochondrial
hetero molecules


Theoretical massNumber of molelcules
Total (without water)3,187,162342
Polymers3,178,16596
Non-polymers8,997246
Water00
1


  • Idetical with deposited unit
  • defined by author&software
  • Evidence: electron microscopy, not applicable
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1

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Components

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Protein , 7 types, 7 molecules A5AQA3A4opq

#1: Protein Translational activator of cytochrome c oxidase 1 / Coiled-coil domain-containing protein 44 / Translational activator of mitochondrially-encoded ...Coiled-coil domain-containing protein 44 / Translational activator of mitochondrially-encoded cytochrome c oxidase I


Mass: 32532.180 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: TACO1, CCDC44, PRO0477 / Production host: Homo sapiens (human) / References: UniProt: Q9BSH4
#18: Protein MRPS21 isoform 1 / MRPS21 isoform 2 / Mitochondrial ribosomal protein S21


Mass: 10659.494 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS21, CR201_G0018851 / Production host: Homo sapiens (human) / References: UniProt: A0A2J8VEN6
#31: Protein Aurora kinase A-interacting protein / AURKA-interacting protein / 28S ribosomal protein S38 / mitochondrial / MRP-S38 / Mitochondrial ...AURKA-interacting protein / 28S ribosomal protein S38 / mitochondrial / MRP-S38 / Mitochondrial small ribosomal subunit protein mS38


Mass: 22395.326 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: AURKAIP1, AIP, AKIP, MRPS38 / Production host: Homo sapiens (human) / References: UniProt: Q9NWT8
#32: Protein Pentatricopeptide repeat domain-containing protein 3, mitochondrial / 28S ribosomal protein S39 / mitochondrial / MRP-S39 / Mitochondrial small ribosomal subunit protein ...28S ribosomal protein S39 / mitochondrial / MRP-S39 / Mitochondrial small ribosomal subunit protein mS39 / Transformation-related gene 15 protein / TRG-15


Mass: 78648.547 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: PTCD3, MRPS39, TRG15 / Production host: Homo sapiens (human) / References: UniProt: Q96EY7
#83: Protein Ribosomal protein 63, mitochondrial / hMRP63 / Mitochondrial large ribosomal subunit protein mL63 / Mitochondrial ribosomal protein 63 / ...hMRP63 / Mitochondrial large ribosomal subunit protein mL63 / Mitochondrial ribosomal protein 63 / Mitochondrial ribosomal protein L57


Mass: 12292.333 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL57, MRP63 / Production host: Homo sapiens (human) / References: UniProt: Q9BQC6
#84: Protein Peptidyl-tRNA hydrolase ICT1, mitochondrial / 39S ribosomal protein L58 / mitochondrial / MRP-L58 / Digestion substraction 1 / DS-1 / Immature ...39S ribosomal protein L58 / mitochondrial / MRP-L58 / Digestion substraction 1 / DS-1 / Immature colon carcinoma transcript 1 protein / Mitochondrial large ribosomal subunit protein mL62


Mass: 23674.203 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL58, DS1, ICT1 / Production host: Homo sapiens (human) / References: UniProt: Q14197, peptidyl-tRNA hydrolase
#85: Protein Growth arrest and DNA damage-inducible proteins-interacting protein 1 / 39S ribosomal protein L59 / mitochondrial / MRP-L59 / CKII beta-associating protein / CR6- ...39S ribosomal protein L59 / mitochondrial / MRP-L59 / CKII beta-associating protein / CR6-interacting factor 1 / CRIF1 / Mitochondrial large ribosomal subunit protein mL64 / Papillomavirus L2-interacting nuclear protein 1 / PLINP / PLINP-1 / p53-responsive gene 6 protein


Mass: 25426.895 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: GADD45GIP1, MRPL59, PLINP1, PRG6 / Production host: Homo sapiens (human) / References: UniProt: Q8TAE8

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RNA chain , 7 types, 7 molecules AAAwAxAyAzAB

#2: RNA chain 12S mitochondrial rRNA


Mass: 306218.312 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Homo sapiens (human) / References: GenBank: 1858624182
#33: RNA chain A-site tRNA (68-MER)


Mass: 21544.684 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Homo sapiens (human)
#34: RNA chain P-site RNA (70-MER)


Mass: 22355.273 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Homo sapiens (human)
#35: RNA chain E-site tRNA (70-MER)


Mass: 22369.307 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Homo sapiens (human)
#36: RNA chain mRNA (34-MER)


Mass: 10809.431 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Homo sapiens (human)
#37: RNA chain 16S mitochondrial rRNA


Mass: 499786.438 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Homo sapiens (human)
#38: RNA chain tRNA-Val (73-MER)


Mass: 22989.752 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Homo sapiens (human) / References: GenBank: NC_012920.1

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28S ribosomal protein ... , 24 types, 24 molecules ABACADAEAFAGAHAJAKALAMANAOAPARASATAUAVAWAXAYAZA0

#3: Protein 28S ribosomal protein S2, mitochondrial / MRP-S2 / S2mt / Mitochondrial small ribosomal subunit protein uS2m


Mass: 33298.238 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS2, CGI-91 / Production host: Homo sapiens (human) / References: UniProt: Q9Y399
#4: Protein 28S ribosomal protein S24, mitochondrial / MRP-S24 / S24mt / Mitochondrial small ribosomal subunit protein uS3m / bMRP-47 / bMRP47


Mass: 19046.164 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS24, HSPC335 / Production host: Homo sapiens (human) / References: UniProt: Q96EL2
#5: Protein 28S ribosomal protein S5, mitochondrial / MRP-S5 / S5mt / Mitochondrial small ribosomal subunit protein uS5m


Mass: 48094.594 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS5 / Production host: Homo sapiens (human) / References: UniProt: P82675
#6: Protein 28S ribosomal protein S6, mitochondrial / MRP-S6 / S6mt / Mitochondrial small ribosomal subunit protein bS6m


Mass: 14250.588 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS6, C21orf101, RPMS6 / Production host: Homo sapiens (human) / References: UniProt: P82932
#7: Protein 28S ribosomal protein S7, mitochondrial / MRP-S7 / S7mt / Mitochondrial small ribosomal subunit protein uS7m / bMRP-27a / bMRP27a


Mass: 28186.154 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS7 / Production host: Homo sapiens (human) / References: UniProt: Q9Y2R9
#8: Protein 28S ribosomal protein S9, mitochondrial / MRP-S9 / S9mt / Mitochondrial small ribosomal subunit protein uS9m


Mass: 45909.859 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS9, RPMS9 / Production host: Homo sapiens (human) / References: UniProt: P82933
#9: Protein 28S ribosomal protein S10, mitochondrial / MRP-S10 / S10mt / Mitochondrial small ribosomal subunit protein uS10m


Mass: 23033.500 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS10, MSTP040 / Production host: Homo sapiens (human) / References: UniProt: P82664
#11: Protein 28S ribosomal protein S12, mitochondrial / MRP-S12 / S12mt / MT-RPS12 / Mitochondrial small ribosomal subunit protein uS12m


Mass: 15200.947 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS12, RPMS12, RPSM12 / Production host: Homo sapiens (human) / References: UniProt: O15235
#12: Protein 28S ribosomal protein S14, mitochondrial / MRP-S14 / S14mt / Mitochondrial small ribosomal subunit protein uS14m


Mass: 15168.788 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS14 / Production host: Homo sapiens (human) / References: UniProt: O60783
#13: Protein 28S ribosomal protein S15, mitochondrial / MRP-S15 / S15mt / Mitochondrial small ribosomal subunit protein uS15m


Mass: 29903.293 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS15, RPMS15, DC37 / Production host: Homo sapiens (human) / References: UniProt: P82914
#14: Protein 28S ribosomal protein S16, mitochondrial / MRP-S16 / S16mt / Mitochondrial small ribosomal subunit protein bS16m


Mass: 15371.899 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS16, RPMS16, CGI-132 / Production host: Homo sapiens (human) / References: UniProt: Q9Y3D3
#15: Protein 28S ribosomal protein S17, mitochondrial / MRP-S17 / S17mt / Mitochondrial small ribosomal subunit protein uS17m


Mass: 14526.078 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS17, RPMS17, HSPC011 / Production host: Homo sapiens (human) / References: UniProt: Q9Y2R5
#16: Protein 28S ribosomal protein S18b, mitochondrial / MRP-S18-b / Mrps18-b / S18mt-b / 28S ribosomal protein S18-2 / mitochondrial / MRP-S18-2 / ...MRP-S18-b / Mrps18-b / S18mt-b / 28S ribosomal protein S18-2 / mitochondrial / MRP-S18-2 / Mitochondrial small ribosomal subunit protein bS18b / Mitochondrial small ribosomal subunit protein mS40


Mass: 29440.629 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS18B, C6orf14, HSPC183, PTD017 / Production host: Homo sapiens (human) / References: UniProt: Q9Y676
#17: Protein 28S ribosomal protein S18c, mitochondrial / MRP-S18-c / Mrps18-c / S18mt-c / 28S ribosomal protein S18-1 / mitochondrial / MRP-S18-1 / ...MRP-S18-c / Mrps18-c / S18mt-c / 28S ribosomal protein S18-1 / mitochondrial / MRP-S18-1 / Mitochondrial small ribosomal subunit protein bS18c / Mitochondrial small ribosomal subunit protein bS18m


Mass: 15876.786 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS18C, CGI-134 / Production host: Homo sapiens (human) / References: UniProt: Q9Y3D5
#19: Protein 28S ribosomal protein S22, mitochondrial / MRP-S22 / S22mt / Mitochondrial small ribosomal subunit protein mS22


Mass: 41337.316 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS22, C3orf5, RPMS22, GK002 / Production host: Homo sapiens (human) / References: UniProt: P82650
#20: Protein 28S ribosomal protein S23, mitochondrial / MRP-S23 / S23mt / Mitochondrial small ribosomal subunit protein mS23


Mass: 21805.664 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS23, CGI-138, HSPC329 / Production host: Homo sapiens (human) / References: UniProt: Q9Y3D9
#21: Protein 28S ribosomal protein S25, mitochondrial / MRP-S25 / S25mt / Mitochondrial small ribosomal subunit protein mS25


Mass: 20146.428 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS25, RPMS25 / Production host: Homo sapiens (human) / References: UniProt: P82663
#22: Protein 28S ribosomal protein S26, mitochondrial / MRP-S26 / S26mt / 28S ribosomal protein S13 / mitochondrial / MRP-S13 / S13mt / Mitochondrial small ...MRP-S26 / S26mt / 28S ribosomal protein S13 / mitochondrial / MRP-S13 / S13mt / Mitochondrial small ribosomal subunit protein mS26


Mass: 24259.820 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS26, C20orf193, RPMS13 / Production host: Homo sapiens (human) / References: UniProt: Q9BYN8
#23: Protein 28S ribosomal protein S27, mitochondrial / MRP-S27 / S27mt / Mitochondrial ribosomal protein S27 / Mitochondrial small ribosomal subunit protein mS27


Mass: 47669.262 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS27, KIAA0264 / Production host: Homo sapiens (human) / References: UniProt: Q92552
#24: Protein 28S ribosomal protein S28, mitochondrial / MRP-S28 / S28mt / 28S ribosomal protein S35 / mitochondrial / MRP-S35 / S35mt / Mitochondrial small ...MRP-S28 / S28mt / 28S ribosomal protein S35 / mitochondrial / MRP-S35 / S35mt / Mitochondrial small ribosomal subunit protein bS1m


Mass: 20878.846 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS28, MRPS35, HSPC007 / Production host: Homo sapiens (human) / References: UniProt: Q9Y2Q9
#25: Protein 28S ribosomal protein S29, mitochondrial / MRP-S29 / S29mt / Death-associated protein 3 / DAP-3 / Ionizing radiation resistance conferring ...MRP-S29 / S29mt / Death-associated protein 3 / DAP-3 / Ionizing radiation resistance conferring protein / Mitochondrial small ribosomal subunit protein mS29


Mass: 45634.406 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: DAP3, MRPS29 / Production host: Homo sapiens (human) / References: UniProt: P51398
#26: Protein 28S ribosomal protein S31, mitochondrial / MRP-S31 / S31mt / Imogen 38 / Mitochondrial small ribosomal subunit protein mS31


Mass: 45391.473 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS31, IMOGN38 / Production host: Homo sapiens (human) / References: UniProt: Q92665
#27: Protein 28S ribosomal protein S33, mitochondrial / MRP-S33 / S33mt / Mitochondrial small ribosomal subunit protein mS33


Mass: 12657.776 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS33, CGI-139, PTD003 / Production host: Homo sapiens (human) / References: UniProt: Q9Y291
#28: Protein 28S ribosomal protein S34, mitochondrial / MRP-S34 / S34mt / Mitochondrial small ribosomal subunit protein mS34


Mass: 25564.354 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS34 / Production host: Homo sapiens (human) / References: UniProt: P82930

-
Small ribosomal subunit protein ... , 3 types, 3 molecules AIA1A2

#10: Protein Small ribosomal subunit protein uS11m / 28S ribosomal protein S11 / mitochondrial / MRP-S11 / S11mt / Cervical cancer proto-oncogene 2 protein / HCC-2


Mass: 20534.691 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS11, RPMS11, HCC2 / Production host: Homo sapiens (human) / References: UniProt: P82912
#29: Protein Small ribosomal subunit protein mS35 / 28S ribosomal protein S28 / mitochondrial / MRP-S28 / S28mt / 28S ribosomal protein S35 / MRP-S35 / S35mt


Mass: 36884.301 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS35, MRPS28, HDCMD11P, MDS023, PSEC0213 / Production host: Homo sapiens (human) / References: UniProt: P82673
#30: Protein Small ribosomal subunit protein mS37 / 28S ribosomal protein S37 / mitochondrial / MRP-S37 / Coiled-coil-helix-coiled-coil-helix domain- ...28S ribosomal protein S37 / mitochondrial / MRP-S37 / Coiled-coil-helix-coiled-coil-helix domain-containing protein 1 / Nuclear protein C2360


Mass: 13393.661 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: CHCHD1, C10orf34, MRPS37 / Production host: Homo sapiens (human) / References: UniProt: Q96BP2

+
39S ribosomal protein ... , 46 types, 52 molecules DEFIJLMNOPQRSTVWXYZ0123456789a...

#39: Protein 39S ribosomal protein L2, mitochondrial / L2mt / MRP-L2 / Mitochondrial large ribosomal subunit protein uL2m


Mass: 33355.941 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL2, CGI-22 / Production host: Homo sapiens (human) / References: UniProt: Q5T653
#40: Protein 39S ribosomal protein L3, mitochondrial / L3mt / MRP-L3 / Mitochondrial large ribosomal subunit protein uL3m


Mass: 38689.562 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL3, MRL3, RPML3 / Production host: Homo sapiens (human) / References: UniProt: P09001
#41: Protein 39S ribosomal protein L4, mitochondrial / L4mt / MRP-L4 / Mitochondrial large ribosomal subunit protein uL4m


Mass: 34970.195 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL4, CDABP0091, CGI-28 / Production host: Homo sapiens (human) / References: UniProt: Q9BYD3
#42: Protein 39S ribosomal protein L10, mitochondrial / L10mt / MRP-L10 / 39S ribosomal protein L8 / mitochondrial / L8mt / MRP-L8 / Mitochondrial large ...L10mt / MRP-L10 / 39S ribosomal protein L8 / mitochondrial / L8mt / MRP-L8 / Mitochondrial large ribosomal subunit protein uL10m


Mass: 29322.529 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL10, MRPL8, RPML8 / Production host: Homo sapiens (human) / References: UniProt: Q7Z7H8
#43: Protein 39S ribosomal protein L11, mitochondrial / L11mt / MRP-L11 / Mitochondrial large ribosomal subunit protein uL11m


Mass: 20716.227 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL11, CGI-113 / Production host: Homo sapiens (human) / References: UniProt: Q9Y3B7
#45: Protein 39S ribosomal protein L14, mitochondrial / L14mt / MRP-L14 / 39S ribosomal protein L32 / mitochondrial / L32mt / MRP-L32 / Mitochondrial large ...L14mt / MRP-L14 / 39S ribosomal protein L32 / mitochondrial / L32mt / MRP-L32 / Mitochondrial large ribosomal subunit protein uL14m


Mass: 15973.702 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL14, MRPL32, RPML32 / Production host: Homo sapiens (human) / References: UniProt: Q6P1L8
#46: Protein 39S ribosomal protein L15, mitochondrial / L15mt / MRP-L15 / Mitochondrial large ribosomal subunit protein uL15m


Mass: 33473.820 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL15, HSPC145 / Production host: Homo sapiens (human) / References: UniProt: Q9P015
#47: Protein 39S ribosomal protein L16, mitochondrial / L16mt / MRP-L16 / Mitochondrial large ribosomal subunit protein uL16m


Mass: 28496.285 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL16, PNAS-111 / Production host: Homo sapiens (human) / References: UniProt: Q9NX20
#48: Protein 39S ribosomal protein L17, mitochondrial / L17mt / MRP-L17 / LYST-interacting protein 2 / Mitochondrial large ribosomal subunit protein bL17m


Mass: 20083.266 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL17, LIP2 / Production host: Homo sapiens (human) / References: UniProt: Q9NRX2
#49: Protein 39S ribosomal protein L18, mitochondrial / L18mt / MRP-L18 / Mitochondrial large ribosomal subunit protein uL18m


Mass: 20607.570 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL18, HSPC071 / Production host: Homo sapiens (human) / References: UniProt: Q9H0U6
#50: Protein 39S ribosomal protein L19, mitochondrial / L19mt / MRP-L19 / 39S ribosomal protein L15 / mitochondrial / L15mt / MRP-L15 / Mitochondrial large ...L19mt / MRP-L19 / 39S ribosomal protein L15 / mitochondrial / L15mt / MRP-L15 / Mitochondrial large ribosomal subunit protein bL19m


Mass: 33584.996 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL19, KIAA0104, MRPL15 / Production host: Homo sapiens (human) / References: UniProt: P49406
#51: Protein 39S ribosomal protein L20, mitochondrial / L20mt / MRP-L20 / Mitochondrial large ribosomal subunit protein bL20m


Mass: 17479.654 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL20 / Production host: Homo sapiens (human) / References: UniProt: Q9BYC9
#52: Protein 39S ribosomal protein L21, mitochondrial / L21mt / MRP-L21 / Mitochondrial large ribosomal subunit protein bL21m


Mass: 22847.682 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL21 / Production host: Homo sapiens (human) / References: UniProt: Q7Z2W9
#53: Protein 39S ribosomal protein L22, mitochondrial / L22mt / MRP-L22 / 39S ribosomal protein L25 / mitochondrial / L25mt / MRP-L25 / Mitochondrial large ...L22mt / MRP-L22 / 39S ribosomal protein L25 / mitochondrial / L25mt / MRP-L25 / Mitochondrial large ribosomal subunit protein uL22m


Mass: 23683.732 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL22, MRPL25, RPML25, HSPC158 / Production host: Homo sapiens (human) / References: UniProt: Q9NWU5
#55: Protein 39S ribosomal protein L24, mitochondrial / L24mt / MRP-L24 / Mitochondrial large ribosomal subunit protein uL24m


Mass: 24953.875 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL24 / Production host: Homo sapiens (human) / References: UniProt: Q96A35
#56: Protein 39S ribosomal protein L27, mitochondrial / L27mt / MRP-L27 / Mitochondrial large ribosomal subunit protein bL27m


Mass: 16102.859 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL27, HSPC250 / Production host: Homo sapiens (human) / References: UniProt: Q9P0M9
#57: Protein 39S ribosomal protein L28, mitochondrial / L28mt / MRP-L28 / Melanoma antigen p15 / Melanoma-associated antigen recognized by T-lymphocytes / ...L28mt / MRP-L28 / Melanoma antigen p15 / Melanoma-associated antigen recognized by T-lymphocytes / Mitochondrial large ribosomal subunit protein bL28m


Mass: 30202.867 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL28, MAAT1 / Production host: Homo sapiens (human) / References: UniProt: Q13084
#58: Protein 39S ribosomal protein L47, mitochondrial / L47mt / MRP-L47 / Mitochondrial large ribosomal subunit protein uL29m / Nasopharyngeal carcinoma ...L47mt / MRP-L47 / Mitochondrial large ribosomal subunit protein uL29m / Nasopharyngeal carcinoma metastasis-related protein 1


Mass: 29508.535 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL47, NCM1, CGI-204 / Production host: Homo sapiens (human) / References: UniProt: Q9HD33
#59: Protein 39S ribosomal protein L30, mitochondrial / L30mt / MRP-L30 / 39S ribosomal protein L28 / mitochondrial / L28mt / MRP-L28 / Mitochondrial large ...L30mt / MRP-L30 / 39S ribosomal protein L28 / mitochondrial / L28mt / MRP-L28 / Mitochondrial large ribosomal subunit protein uL30m


Mass: 18582.812 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL30, MRPL28, RPML28, HSPC249 / Production host: Homo sapiens (human) / References: UniProt: Q8TCC3
#60: Protein 39S ribosomal protein L32, mitochondrial / L32mt / MRP-L32 / Mitochondrial large ribosomal subunit protein bL32m


Mass: 21437.799 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL32, HSPC283 / Production host: Homo sapiens (human) / References: UniProt: Q9BYC8
#61: Protein 39S ribosomal protein L33, mitochondrial / L33mt / MRP-L33 / Mitochondrial large ribosomal subunit protein bL33m


Mass: 7635.204 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL33, C2orf1 / Production host: Homo sapiens (human) / References: UniProt: O75394
#62: Protein 39S ribosomal protein L34, mitochondrial / L34mt / MRP-L34 / Mitochondrial large ribosomal subunit protein bL34m


Mass: 10183.913 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL34 / Production host: Homo sapiens (human) / References: UniProt: Q9BQ48
#63: Protein 39S ribosomal protein L35, mitochondrial / L35mt / MRP-L35 / Mitochondrial large ribosomal subunit protein bL35m


Mass: 21558.488 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL35, BM-007 / Production host: Homo sapiens (human) / References: UniProt: Q9NZE8
#64: Protein 39S ribosomal protein L36, mitochondrial / L36mt / MRP-L36 / BRCA1-interacting protein 1 / Mitochondrial large ribosomal subunit protein bL36m


Mass: 11809.301 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL36, BRIP1 / Production host: Homo sapiens (human) / References: UniProt: Q9P0J6
#65: Protein 39S ribosomal protein L37, mitochondrial / L37mt / MRP-L37 / 39S ribosomal protein L2 / mitochondrial / L2mt / MRP-L2 / Mitochondrial large ...L37mt / MRP-L37 / 39S ribosomal protein L2 / mitochondrial / L2mt / MRP-L2 / Mitochondrial large ribosomal subunit protein mL37


Mass: 48183.344 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL37, MRPL2, RPML2, HSPC235 / Production host: Homo sapiens (human) / References: UniProt: Q9BZE1
#66: Protein 39S ribosomal protein L38, mitochondrial / L38mt / MRP-L38 / Mitochondrial large ribosomal subunit protein mL38


Mass: 44659.430 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL38, HSPC262 / Production host: Homo sapiens (human) / References: UniProt: Q96DV4
#67: Protein 39S ribosomal protein L39, mitochondrial / L39mt / MRP-L39 / 39S ribosomal protein L5 / mitochondrial / L5mt / MRP-L5 / Mitochondrial large ...L39mt / MRP-L39 / 39S ribosomal protein L5 / mitochondrial / L5mt / MRP-L5 / Mitochondrial large ribosomal subunit protein mL39


Mass: 38764.785 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL39, C21orf92, MRPL5, RPML5, MSTP003, PRED22 / Production host: Homo sapiens (human) / References: UniProt: Q9NYK5
#68: Protein 39S ribosomal protein L40, mitochondrial / L40mt / MRP-L40 / Mitochondrial large ribosomal subunit protein mL40 / Nuclear localization signal- ...L40mt / MRP-L40 / Mitochondrial large ribosomal subunit protein mL40 / Nuclear localization signal-containing protein deleted in velocardiofacial syndrome / Up-regulated in metastasis


Mass: 24534.422 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL40, NLVCF, URIM / Production host: Homo sapiens (human) / References: UniProt: Q9NQ50
#69: Protein 39S ribosomal protein L41, mitochondrial / L41mt / MRP-L41 / 39S ribosomal protein L27 homolog / Bcl-2-interacting mitochondrial ribosomal ...L41mt / MRP-L41 / 39S ribosomal protein L27 homolog / Bcl-2-interacting mitochondrial ribosomal protein L41 / Cell proliferation-inducing gene 3 protein / MRP-L27 homolog / Mitochondrial large ribosomal subunit protein mL41


Mass: 15404.708 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL41, BMRP, MRPL27, RPML27, PIG3 / Production host: Homo sapiens (human) / References: UniProt: Q8IXM3
#70: Protein 39S ribosomal protein L42, mitochondrial / L42mt / MRP-L42 / 39S ribosomal protein L31 / mitochondrial / L31mt / MRP-L31 / Mitochondrial large ...L42mt / MRP-L42 / 39S ribosomal protein L31 / mitochondrial / L31mt / MRP-L31 / Mitochondrial large ribosomal subunit protein mL42


Mass: 16691.176 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL42, MRPL31, MRPS32, RPML31, HSPC204, PTD007 / Production host: Homo sapiens (human) / References: UniProt: Q9Y6G3
#71: Protein 39S ribosomal protein L43, mitochondrial / L43mt / MRP-L43 / Mitochondrial large ribosomal subunit protein mL43 / Mitochondrial ribosomal protein bMRP36a


Mass: 23499.828 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL43 / Production host: Homo sapiens (human) / References: UniProt: Q8N983
#72: Protein 39S ribosomal protein L44, mitochondrial / L44mt / MRP-L44 / Mitochondrial large ribosomal subunit protein mL44


Mass: 37583.312 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL44 / Production host: Homo sapiens (human)
References: UniProt: Q9H9J2, Hydrolases; Acting on ester bonds; Endoribonucleases producing 5'-phosphomonoesters
#73: Protein 39S ribosomal protein L45, mitochondrial / L45mt / MRP-L45 / Mitochondrial large ribosomal subunit protein mL45


Mass: 35402.918 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL45 / Production host: Homo sapiens (human) / References: UniProt: Q9BRJ2
#74: Protein 39S ribosomal protein L46, mitochondrial / L46mt / MRP-L46 / Mitochondrial large ribosomal subunit protein mL46 / P2ECSL


Mass: 31748.107 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL46, C15orf4, LIECG2 / Production host: Homo sapiens (human) / References: UniProt: Q9H2W6
#75: Protein 39S ribosomal protein L48, mitochondrial / L48mt / MRP-L48 / Mitochondrial large ribosomal subunit protein mL48


Mass: 23970.814 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL48, CGI-118, HSPC290 / Production host: Homo sapiens (human) / References: UniProt: Q96GC5
#76: Protein 39S ribosomal protein L49, mitochondrial / L49mt / MRP-L49 / Mitochondrial large ribosomal subunit protein mL49 / Neighbor of FAU / NOF / Protein NOF1


Mass: 19225.043 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL49, C11orf4, NOF1, OK/SW-cl.67 / Production host: Homo sapiens (human) / References: UniProt: Q13405
#77: Protein 39S ribosomal protein L50, mitochondrial / L50mt / MRP-L50 / Mitochondrial large ribosomal subunit protein mL50


Mass: 18349.943 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL50 / Production host: Homo sapiens (human) / References: UniProt: Q8N5N7
#78: Protein 39S ribosomal protein L51, mitochondrial / L51mt / MRP-L51 / Mitochondrial large ribosomal subunit protein mL51 / bMRP-64 / bMRP64


Mass: 15125.917 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL51, MRP64, CDA09, HSPC241 / Production host: Homo sapiens (human) / References: UniProt: Q4U2R6
#79: Protein 39S ribosomal protein L52, mitochondrial / L52mt / MRP-L52 / Mitochondrial large ribosomal subunit protein mL52


Mass: 13682.658 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL52 / Production host: Homo sapiens (human) / References: UniProt: Q86TS9
#81: Protein 39S ribosomal protein L54, mitochondrial / L54mt / MRP-L54 / Mitochondrial large ribosomal subunit protein mL54


Mass: 15844.178 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL54 / Production host: Homo sapiens (human) / References: UniProt: Q6P161
#82: Protein 39S ribosomal protein L55, mitochondrial / L55mt / MRP-L55 / Mitochondrial large ribosomal subunit protein bL31m / Mitochondrial large ...L55mt / MRP-L55 / Mitochondrial large ribosomal subunit protein bL31m / Mitochondrial large ribosomal subunit protein mL55


Mass: 15160.433 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL55, UNQ5835/PRO19675 / Production host: Homo sapiens (human) / References: UniProt: Q7Z7F7
#86: Protein 39S ribosomal protein S18a, mitochondrial / MRP-S18-a / Mrps18a / S18mt-a / 39S ribosomal protein S18-3 / mitochondrial / MRP-S18-3 / ...MRP-S18-a / Mrps18a / S18mt-a / 39S ribosomal protein S18-3 / mitochondrial / MRP-S18-3 / Mitochondrial large ribosomal subunit protein bS18a / Mitochondrial large ribosomal subunit protein mL66


Mass: 22224.078 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS18A / Production host: Homo sapiens (human) / References: UniProt: Q9NVS2
#87: Protein 39S ribosomal protein S30, mitochondrial / MRP-S30 / S30mt / Mitochondrial large ribosomal subunit protein mL65 / Mitochondrial large ...MRP-S30 / S30mt / Mitochondrial large ribosomal subunit protein mL65 / Mitochondrial large ribosomal subunit protein mS30 / Programmed cell death protein 9


Mass: 50429.578 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPS30, PDCD9, BM-047 / Production host: Homo sapiens (human) / References: UniProt: Q9NP92
#88: Protein
39S ribosomal protein L12, mitochondrial / L12mt / MRP-L12 / 5c5-2 / Mitochondrial large ribosomal subunit protein bL12m


Mass: 21378.164 Da / Num. of mol.: 7
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL12, MRPL7, RPML12 / Production host: Homo sapiens (human) / References: UniProt: P52815
#89: Protein 39S ribosomal protein L9, mitochondrial / L9mt / MRP-L9 / Mitochondrial large ribosomal subunit protein bL9m


Mass: 30296.355 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL9 / Production host: Homo sapiens (human) / References: UniProt: Q9BYD2
#90: Protein 39S ribosomal protein L1, mitochondrial / L1mt / MRP-L1 / Mitochondrial large ribosomal subunit protein uL1m


Mass: 36967.746 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL1, BM-022 / Production host: Homo sapiens (human) / References: UniProt: Q9BYD6

-
Large ribosomal subunit protein ... , 3 types, 3 molecules KUk

#44: Protein Large ribosomal subunit protein uL13m / 39S ribosomal protein L13 / mitochondrial / L13mt / MRP-L13


Mass: 20617.828 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL13 / Production host: Homo sapiens (human) / References: UniProt: Q9BYD1
#54: Protein Large ribosomal subunit protein uL23m / 39S ribosomal protein L23 / mitochondrial / L23mt / MRP-L23 / L23 mitochondrial-related protein / ...39S ribosomal protein L23 / mitochondrial / L23mt / MRP-L23 / L23 mitochondrial-related protein / Ribosomal protein L23-like


Mass: 17702.029 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL23, L23MRP, RPL23L / Production host: Homo sapiens (human) / References: UniProt: Q16540
#80: Protein Large ribosomal subunit protein mL53 / 39S ribosomal protein L53 / mitochondrial / L53mt / MRP-L53


Mass: 12020.701 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MRPL53 / Production host: Homo sapiens (human) / References: UniProt: Q96EL3

-
Non-polymers , 10 types, 246 molecules

#91: Chemical ChemComp-NAD / NICOTINAMIDE-ADENINE-DINUCLEOTIDE


Mass: 663.425 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C21H27N7O14P2 / Comment: NAD*YM
#92: Chemical...
ChemComp-MG / MAGNESIUM ION


Mass: 24.305 Da / Num. of mol.: 195 / Source method: obtained synthetically / Formula: Mg
#93: Chemical...
ChemComp-K / POTASSIUM ION


Mass: 39.098 Da / Num. of mol.: 39 / Source method: obtained synthetically / Formula: K
#94: Chemical ChemComp-5F0 / (3~{S})-3-azanyl-4-methoxy-4-oxidanylidene-butanoic acid / 1-methyl isoaspartic acid


Type: L-peptide linking / Mass: 147.129 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C5H9NO4
#95: Chemical ChemComp-ZN / ZINC ION


Mass: 65.409 Da / Num. of mol.: 3 / Source method: obtained synthetically / Formula: Zn
#96: Chemical ChemComp-FES / FE2/S2 (INORGANIC) CLUSTER


Mass: 175.820 Da / Num. of mol.: 3 / Source method: obtained synthetically / Formula: Fe2S2
#97: Chemical ChemComp-ATP / ADENOSINE-5'-TRIPHOSPHATE


Mass: 507.181 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C10H16N5O13P3 / Comment: ATP, energy-carrying molecule*YM
#98: Chemical ChemComp-GDP / GUANOSINE-5'-DIPHOSPHATE


Type: RNA linking / Mass: 443.201 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C10H15N5O11P2 / Comment: GDP, energy-carrying molecule*YM
#99: Chemical ChemComp-SPD / SPERMIDINE / N-(2-AMINO-PROPYL)-1,4-DIAMINOBUTANE / PA(34)


Mass: 145.246 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C7H19N3
#100: Chemical ChemComp-VOL / L-VALINOL


Type: L-peptide linking / Mass: 103.163 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C5H13NO

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Details

Has ligand of interestN
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: ELECTRON MICROSCOPY
EM experimentAggregation state: PARTICLE / 3D reconstruction method: single particle reconstruction

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Sample preparation

ComponentName: mitoribosomal small subunit assembly intermediate / Type: RIBOSOME / Entity ID: #1-#30 / Source: NATURAL
Source (natural)Organism: Homo sapiens (human)
Buffer solutionpH: 7.5
SpecimenEmbedding applied: NO / Shadowing applied: NO / Staining applied: NO / Vitrification applied: YES
VitrificationCryogen name: ETHANE

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Electron microscopy imaging

Experimental equipment
Model: Titan Krios / Image courtesy: FEI Company
MicroscopyModel: TFS KRIOS
Electron gunElectron source: FIELD EMISSION GUN / Accelerating voltage: 300 kV / Illumination mode: FLOOD BEAM
Electron lensMode: BRIGHT FIELD / Nominal defocus max: 1800 nm / Nominal defocus min: 400 nm
Image recordingElectron dose: 45 e/Å2 / Film or detector model: GATAN K3 (6k x 4k)

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Processing

EM software
IDNameVersionCategory
1RELION5particle selection
2PHENIX1.20.1_4487model refinement
13RELION53D reconstruction
CTF correctionType: PHASE FLIPPING AND AMPLITUDE CORRECTION
3D reconstructionResolution: 2.64 Å / Resolution method: FSC 0.143 CUT-OFF / Num. of particles: 61682 / Symmetry type: POINT
RefinementHighest resolution: 2.64 Å
Stereochemistry target values: REAL-SPACE (WEIGHTED MAP SUM AT ATOM CENTERS)
Refine LS restraints
Refine-IDTypeDev idealNumber
ELECTRON MICROSCOPYf_bond_d0.002192850
ELECTRON MICROSCOPYf_angle_d0.438274102
ELECTRON MICROSCOPYf_dihedral_angle_d11.7750478
ELECTRON MICROSCOPYf_chiral_restr0.03332355
ELECTRON MICROSCOPYf_plane_restr0.00324813

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