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データを開く
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基本情報
| 登録情報 | データベース: PDB / ID: 9oiq | ||||||
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| タイトル | The von Hippel Lindau-ElonginB-ElonginC (VCB) complex with fragment 15 | ||||||
要素 |
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キーワード | PROTEIN TRANSPORT / VHL / E3 ligase / Fragment-based drug discovery | ||||||
| 機能・相同性 | 機能・相同性情報regulation of cellular response to hypoxia / RHOBTB3 ATPase cycle / negative regulation of receptor signaling pathway via JAK-STAT / transcription elongation factor activity / target-directed miRNA degradation / elongin complex / Replication of the SARS-CoV-1 genome / VCB complex / Cul5-RING ubiquitin ligase complex / Cul2-RING ubiquitin ligase complex ...regulation of cellular response to hypoxia / RHOBTB3 ATPase cycle / negative regulation of receptor signaling pathway via JAK-STAT / transcription elongation factor activity / target-directed miRNA degradation / elongin complex / Replication of the SARS-CoV-1 genome / VCB complex / Cul5-RING ubiquitin ligase complex / Cul2-RING ubiquitin ligase complex / intracellular membraneless organelle / SUMOylation of ubiquitinylation proteins / Pausing and recovery of Tat-mediated HIV elongation / Tat-mediated HIV elongation arrest and recovery / negative regulation of transcription elongation by RNA polymerase II / HIV elongation arrest and recovery / Pausing and recovery of HIV elongation / negative regulation of signal transduction / Tat-mediated elongation of the HIV-1 transcript / Formation of HIV-1 elongation complex containing HIV-1 Tat / ubiquitin-like ligase-substrate adaptor activity / Formation of HIV elongation complex in the absence of HIV Tat / RNA Polymerase II Transcription Elongation / Formation of RNA Pol II elongation complex / negative regulation of TORC1 signaling / RNA Polymerase II Pre-transcription Events / negative regulation of autophagy / protein serine/threonine kinase binding / transcription corepressor binding / TP53 Regulates Transcription of DNA Repair Genes / transcription initiation at RNA polymerase II promoter / positive regulation of cell differentiation / transcription elongation by RNA polymerase II / Vif-mediated degradation of APOBEC3G / Inactivation of CSF3 (G-CSF) signaling / Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha / Evasion by RSV of host interferon responses / Regulation of expression of SLITs and ROBOs / cell morphogenesis / ubiquitin-protein transferase activity / transcription corepressor activity / Antigen processing: Ubiquitination & Proteasome degradation / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / Neddylation / microtubule cytoskeleton / regulation of gene expression / protein-containing complex assembly / Replication of the SARS-CoV-2 genome / ubiquitin-dependent protein catabolic process / protein-macromolecule adaptor activity / cellular response to hypoxia / molecular adaptor activity / DNA-binding transcription factor binding / amyloid fibril formation / proteasome-mediated ubiquitin-dependent protein catabolic process / protein stabilization / protein ubiquitination / cilium / negative regulation of cell population proliferation / negative regulation of gene expression / ubiquitin protein ligase binding / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / enzyme binding / endoplasmic reticulum / negative regulation of transcription by RNA polymerase II / mitochondrion / proteolysis / nucleoplasm / nucleus / plasma membrane / cytosol 類似検索 - 分子機能 | ||||||
| 生物種 | Homo sapiens (ヒト) | ||||||
| 手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.66 Å | ||||||
データ登録者 | Amporndanai, K. / Katinas, J.M. / Chopra, A. / Fesik, S.W. | ||||||
| 資金援助 | 米国, 1件
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引用 | ジャーナル: Acs Med.Chem.Lett. / 年: 2025タイトル: NMR-Based Fragment Screen of the von Hippel-Lindau Elongin C&B Complex. 著者: Amporndanai, K. / Katinas, J.M. / Chopra, A. / Kayode, O. / Vadukoot, A.K. / Waterson, A.G. / Fesik, S.W. | ||||||
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構造の表示
| 構造ビューア | 分子: Molmil Jmol/JSmol |
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ダウンロードとリンク
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ダウンロード
| PDBx/mmCIF形式 | 9oiq.cif.gz | 624.8 KB | 表示 | PDBx/mmCIF形式 |
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| PDB形式 | pdb9oiq.ent.gz | 表示 | PDB形式 | |
| PDBx/mmJSON形式 | 9oiq.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
| その他 | その他のダウンロード |
-検証レポート
| 文書・要旨 | 9oiq_validation.pdf.gz | 952.8 KB | 表示 | wwPDB検証レポート |
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| 文書・詳細版 | 9oiq_full_validation.pdf.gz | 967.8 KB | 表示 | |
| XML形式データ | 9oiq_validation.xml.gz | 53.2 KB | 表示 | |
| CIF形式データ | 9oiq_validation.cif.gz | 68.9 KB | 表示 | |
| アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/oi/9oiq ftp://data.pdbj.org/pub/pdb/validation_reports/oi/9oiq | HTTPS FTP |
-関連構造データ
| 関連構造データ | ![]() 9oimC ![]() 9oinC ![]() 9oioC C: 同じ文献を引用 ( |
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| 類似構造データ | 類似検索 - 機能・相同性 F&H 検索 |
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リンク
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集合体
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| 非結晶学的対称性 (NCS) | NCSドメイン:
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ムービー
コントローラー
要素
万見について




Homo sapiens (ヒト)
X線回折
米国, 1件
引用


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