Entry | Database: PDB / ID: 9kku |
---|
Title | Helix-loop-helix peptide (M49) in complex with VEGF-A |
---|
Components | - M49
- Vascular endothelial growth factor A, long form
|
---|
Keywords | IMMUNE SYSTEM/DE NOVO PROTEIN / Helix-loop-helix / Inhibitor / complex / DE NOVO PROTEIN / IMMUNE SYSTEM-DE NOVO PROTEIN complex |
---|
Function / homology | Function and homology information
basophil chemotaxis / positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway / VEGF-A complex / Signaling by VEGF / cellular stress response to acid chemical / positive regulation of lymphangiogenesis / vascular endothelial growth factor receptor 1 binding / negative regulation of establishment of endothelial barrier / vascular endothelial growth factor receptor binding / VEGF ligand-receptor interactions ...basophil chemotaxis / positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway / VEGF-A complex / Signaling by VEGF / cellular stress response to acid chemical / positive regulation of lymphangiogenesis / vascular endothelial growth factor receptor 1 binding / negative regulation of establishment of endothelial barrier / vascular endothelial growth factor receptor binding / VEGF ligand-receptor interactions / negative regulation of adherens junction organization / post-embryonic camera-type eye development / positive regulation of mast cell chemotaxis / lymph vessel morphogenesis / primitive erythrocyte differentiation / negative regulation of blood-brain barrier permeability / positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway / regulation of nitric oxide mediated signal transduction / VEGF-activated neuropilin signaling pathway / bone trabecula formation / coronary vein morphogenesis / cardiac vascular smooth muscle cell development / lymphangiogenesis / lung vasculature development / vascular endothelial growth factor receptor-2 signaling pathway / positive regulation of epithelial tube formation / VEGF binds to VEGFR leading to receptor dimerization / motor neuron migration / positive regulation of trophoblast cell migration / positive regulation of axon extension involved in axon guidance / endothelial cell chemotaxis / vascular wound healing / positive regulation of protein localization to early endosome / eye photoreceptor cell development / regulation of hematopoietic progenitor cell differentiation / camera-type eye morphogenesis / positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis / positive regulation of protein autophosphorylation / neuropilin binding / positive regulation of branching involved in ureteric bud morphogenesis / induction of positive chemotaxis / coronary artery morphogenesis / negative regulation of cell-cell adhesion mediated by cadherin / transmembrane receptor protein tyrosine kinase activator activity / vascular endothelial growth factor receptor 2 binding / positive regulation of vascular permeability / commissural neuron axon guidance / dopaminergic neuron differentiation / tube formation / positive regulation of vascular endothelial growth factor signaling pathway / positive regulation of blood vessel branching / platelet-derived growth factor receptor binding / surfactant homeostasis / retinal ganglion cell axon guidance / sprouting angiogenesis / cell migration involved in sprouting angiogenesis / extracellular matrix binding / endothelial cell proliferation / epithelial cell maturation / positive regulation of leukocyte migration / positive regulation of positive chemotaxis / cardiac muscle cell development / Regulation of gene expression by Hypoxia-inducible Factor / positive regulation of endothelial cell chemotaxis / positive regulation of cell migration involved in sprouting angiogenesis / vascular endothelial growth factor signaling pathway / artery morphogenesis / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of DNA biosynthetic process / negative regulation of epithelial to mesenchymal transition / branching involved in blood vessel morphogenesis / positive regulation of neuroblast proliferation / negative regulation of fat cell differentiation / positive chemotaxis / positive regulation of sprouting angiogenesis / chemoattractant activity / mesoderm development / outflow tract morphogenesis / monocyte differentiation / fibronectin binding / positive regulation of cell division / positive regulation of receptor internalization / macrophage differentiation / cellular response to vascular endothelial growth factor stimulus / mammary gland alveolus development / positive regulation of focal adhesion assembly / neuroblast proliferation / positive regulation of blood vessel endothelial cell migration / vascular endothelial growth factor receptor signaling pathway / positive regulation of osteoblast differentiation / heart morphogenesis / vasculogenesis / cell maturation / ovarian follicle development / lactation / positive regulation of endothelial cell proliferation / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / epithelial cell differentiation / extracellular matrix / homeostasis of number of cells within a tissueSimilarity search - Function Vascular endothelial growth factor, heparin-binding domain / Vascular endothelial growth factor, heparin-binding domain superfamily / VEGF heparin-binding domain / : / PDGF/VEGF domain / Platelet-derived growth factor, conserved site / PDGF/VEGF domain / Platelet-derived growth factor (PDGF) family signature. / Platelet-derived growth factor (PDGF) family profile. / Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family / Cystine-knot cytokineSimilarity search - Domain/homology |
---|
Biological species | Homo sapiens (human) synthetic construct (others) |
---|
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.46 Å |
---|
Authors | Kamo, M. / Michigami, M. / Inaka, K. / Furubayashi, N. / Kaito, S. / Kobayashi, Y. / Shinohara, Y. / Fujii, I. |
---|
Funding support | Japan, 1items Organization | Grant number | Country |
---|
Japan Agency for Medical Research and Development (AMED) | JP24am121036 | Japan |
|
---|
Citation | Journal: Biochem.Biophys.Res.Commun. / Year: 2024 Title: Structural Insights into Helix-Loop-Helix Peptides for "Ligand-Targeting" Intracellular Drug Delivery via VEGF Receptor-Mediated Endocytosis. Authors: Michigami, M. / Kira, R. / Kamo, M. / Hirokawa, T. / Kinoshita, T. / Inaka, K. / Nakase, I. / Fujii, I. |
---|
History | Deposition | Nov 14, 2024 | Deposition site: PDBJ / Processing site: PDBJ |
---|
Revision 1.0 | Dec 11, 2024 | Provider: repository / Type: Initial release |
---|
|
---|