登録情報 | データベース: PDB / ID: 9ibr |
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タイトル | Crystal structure of HNF4 alpha LBD complexed with GRIP-1 peptide and ESY13 |
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要素 | - Hepatocyte nuclear factor 4-alpha
- Nuclear receptor coactivator 2
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キーワード | TRANSCRIPTION / Hepatocyte nuclear factor 4-alpha / Nuclear receptor |
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機能・相同性 | 機能・相同性情報
regulation of growth hormone receptor signaling pathway / regulation of ornithine metabolic process / regulation of gastrulation / Nephron development / sex differentiation / phospholipid homeostasis / signal transduction involved in regulation of gene expression / triglyceride homeostasis / lipid homeostasis / Regulation of gene expression in beta cells ...regulation of growth hormone receptor signaling pathway / regulation of ornithine metabolic process / regulation of gastrulation / Nephron development / sex differentiation / phospholipid homeostasis / signal transduction involved in regulation of gene expression / triglyceride homeostasis / lipid homeostasis / Regulation of gene expression in beta cells / regulation of lipid metabolic process / response to glucose / regulation of insulin secretion / xenobiotic metabolic process / cholesterol homeostasis / fatty acid binding / regulation of circadian rhythm / negative regulation of cell growth / Nuclear Receptor transcription pathway / lipid metabolic process / nuclear receptor activity / blood coagulation / sequence-specific double-stranded DNA binding / rhythmic process / glucose homeostasis / DNA-binding transcription activator activity, RNA polymerase II-specific / RNA polymerase II-specific DNA-binding transcription factor binding / transcription by RNA polymerase II / cell differentiation / DNA-binding transcription factor activity, RNA polymerase II-specific / transcription cis-regulatory region binding / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / signaling receptor binding / negative regulation of cell population proliferation / negative regulation of DNA-templated transcription / chromatin binding / regulation of transcription by RNA polymerase II / chromatin / positive regulation of DNA-templated transcription / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / DNA binding / zinc ion binding / nucleoplasm / nucleus / cytoplasm類似検索 - 分子機能 : / : / : / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Double treble clef zinc finger, C4 type / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain ...: / : / : / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Double treble clef zinc finger, C4 type / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.78 Å |
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データ登録者 | Morozov, V. / Merk, D. / Schallmayer, A. |
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資金援助 | 1件 |
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引用 | ジャーナル: J.Med.Chem. / 年: 2025 タイトル: A First-in-Class Hepatocyte Nuclear Factor 4 Agonist. 著者: Schallmayer, E. / Morozov, V. / Duensing-Kropp, S. / Schallmayer, L. / Schuffner, L. / Schubert-Zsilavecz, M. / Pabel, J. / Hofner, G. / Heering, J. / Marschner, J.A. / Merk, D. |
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履歴 | 登録 | 2025年2月13日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2025年8月13日 | Provider: repository / タイプ: Initial release |
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