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- PDB-9h0k: Crystal structure of human CREBBP histone acetyltransferase domai... -

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Basic information

Entry
Database: PDB / ID: 9h0k
TitleCrystal structure of human CREBBP histone acetyltransferase domain in complex with Propionyl- Coenzyme A
ComponentsCREB-binding protein
KeywordsTRANSFERASE / Histone acetyltransferase
Function / homology
Function and homology information


peptide lactyltransferase (CoA-dependent) activity / NFE2L2 regulating ER-stress associated genes / Activation of the TFAP2 (AP-2) family of transcription factors / NFE2L2 regulating inflammation associated genes / histone H3K18 acetyltransferase activity / N-terminal peptidyl-lysine acetylation / histone H3K27 acetyltransferase activity / LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production / NFE2L2 regulates pentose phosphate pathway genes / regulation of smoothened signaling pathway ...peptide lactyltransferase (CoA-dependent) activity / NFE2L2 regulating ER-stress associated genes / Activation of the TFAP2 (AP-2) family of transcription factors / NFE2L2 regulating inflammation associated genes / histone H3K18 acetyltransferase activity / N-terminal peptidyl-lysine acetylation / histone H3K27 acetyltransferase activity / LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production / NFE2L2 regulates pentose phosphate pathway genes / regulation of smoothened signaling pathway / NFE2L2 regulating MDR associated enzymes / MRF binding / RUNX1 regulates transcription of genes involved in differentiation of myeloid cells / Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells / Regulation of FOXO transcriptional activity by acetylation / RUNX3 regulates NOTCH signaling / NOTCH4 Intracellular Domain Regulates Transcription / Nuclear events mediated by NFE2L2 / Regulation of NFE2L2 gene expression / Regulation of gene expression by Hypoxia-inducible Factor / NOTCH3 Intracellular Domain Regulates Transcription / negative regulation of transcription by RNA polymerase I / TRAF6 mediated IRF7 activation / NFE2L2 regulating tumorigenic genes / NFE2L2 regulating anti-oxidant/detoxification enzymes / embryonic digit morphogenesis / protein-lysine-acetyltransferase activity / protein acetylation / homeostatic process / Notch-HLH transcription pathway / Formation of paraxial mesoderm / positive regulation of transforming growth factor beta receptor signaling pathway / acetyltransferase activity / FOXO-mediated transcription of cell death genes / stimulatory C-type lectin receptor signaling pathway / Zygotic genome activation (ZGA) / TP53 Regulates Transcription of Genes Involved in Cytochrome C Release / histone acetyltransferase complex / canonical NF-kappaB signal transduction / Attenuation phase / histone acetyltransferase activity / cellular response to nutrient levels / histone acetyltransferase / positive regulation of double-strand break repair via homologous recombination / regulation of cellular response to heat / : / NPAS4 regulates expression of target genes / Regulation of lipid metabolism by PPARalpha / Transferases; Acyltransferases; Transferring groups other than aminoacyl groups / Transcriptional and post-translational regulation of MITF-M expression and activity / CD209 (DC-SIGN) signaling / BMAL1:CLOCK,NPAS2 activates circadian expression / SUMOylation of transcription cofactors / Activation of gene expression by SREBF (SREBP) / Heme signaling / Transcriptional activation of mitochondrial biogenesis / Formation of the beta-catenin:TCF transactivating complex / PPARA activates gene expression / Cytoprotection by HMOX1 / protein destabilization / chromatin DNA binding / Evasion by RSV of host interferon responses / Transcriptional regulation of white adipocyte differentiation / NOTCH1 Intracellular Domain Regulates Transcription / positive regulation of protein localization to nucleus / Pre-NOTCH Transcription and Translation / Constitutive Signaling by NOTCH1 PEST Domain Mutants / Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants / tau protein binding / transcription coactivator binding / Activation of anterior HOX genes in hindbrain development during early embryogenesis / cellular response to UV / p53 binding / : / rhythmic process / transcription corepressor activity / HATs acetylate histones / MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis / TRAF3-dependent IRF activation pathway / protein-containing complex assembly / transcription regulator complex / DNA-binding transcription factor binding / Estrogen-dependent gene expression / damaged DNA binding / RNA polymerase II-specific DNA-binding transcription factor binding / transcription coactivator activity / response to hypoxia / nuclear body / chromatin binding / regulation of DNA-templated transcription / chromatin / positive regulation of DNA-templated transcription / SARS-CoV-2 activates/modulates innate and adaptive immune responses / negative regulation of transcription by RNA polymerase II / signal transduction / positive regulation of transcription by RNA polymerase II / zinc ion binding / nucleoplasm / nucleus / cytoplasm
Similarity search - Function
Nuclear receptor coactivator, CREB-bp-like, interlocking / Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily / Creb binding / Zinc finger, TAZ-type / TAZ domain superfamily / TAZ zinc finger / Zinc finger TAZ-type profile. / TAZ zinc finger, present in p300 and CBP / : / Histone acetyltransferase p300-like, PHD domain ...Nuclear receptor coactivator, CREB-bp-like, interlocking / Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily / Creb binding / Zinc finger, TAZ-type / TAZ domain superfamily / TAZ zinc finger / Zinc finger TAZ-type profile. / TAZ zinc finger, present in p300 and CBP / : / Histone acetyltransferase p300-like, PHD domain / Coactivator CBP, KIX domain / CREB-binding protein/p300, atypical RING domain / CBP/p300-type histone acetyltransferase domain / CBP/p300, atypical RING domain superfamily / KIX domain / CREB-binding protein/p300, atypical RING domain / KIX domain profile. / CBP/p300-type histone acetyltransferase (HAT) domain profile. / Histone acetyltransferase Rtt109/CBP / Histone acetylation protein / Histone acetylation protein / Coactivator CBP, KIX domain superfamily / Zinc finger ZZ-type signature. / Zinc-binding domain, present in Dystrophin, CREB-binding protein. / Zinc finger, ZZ type / Zinc finger, ZZ-type / Zinc finger, ZZ-type superfamily / Zinc finger ZZ-type profile. / Nuclear receptor coactivator, interlocking / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / bromo domain / Bromodomain / Bromodomain (BrD) profile. / Bromodomain-like superfamily / Zinc finger, RING/FYVE/PHD-type
Similarity search - Domain/homology
propionyl Coenzyme A / CREB-binding protein
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.75 Å
AuthorsMechaly, A.E. / Cui, G. / Green, M.R. / Rodrigues-Lima, F.
Funding support France, United States, China, 3items
OrganizationGrant numberCountry
Centre National de la Recherche Scientifique (CNRS) France
National Institutes of Health/National Cancer Institute (NIH/NCI) United States
Chinese Scholarship Council China
CitationJournal: To Be Published
Title: Crystal structure of human CREBBP histone acetyltransferase domain in complex with Propionyl- Coenzyme A
Authors: Mechaly, A.E. / Cui, G. / Green, M.R. / Rodrigues-Lima, F.
History
DepositionOct 8, 2024Deposition site: PDBE / Processing site: PDBE
Revision 1.0Oct 29, 2025Provider: repository / Type: Initial release

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: CREB-binding protein
B: CREB-binding protein
hetero molecules


Theoretical massNumber of molelcules
Total (without water)82,7155
Polymers80,9722
Non-polymers1,7433
Water7,873437
1
A: CREB-binding protein
hetero molecules


Theoretical massNumber of molelcules
Total (without water)41,3102
Polymers40,4861
Non-polymers8241
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
2
B: CREB-binding protein
hetero molecules


Theoretical massNumber of molelcules
Total (without water)41,4063
Polymers40,4861
Non-polymers9202
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)83.408, 88.513, 112.455
Angle α, β, γ (deg.)90.000, 90.000, 90.000
Int Tables number19
Space group name H-MP212121
Space group name HallP2ac2ab
Symmetry operation#1: x,y,z
#2: x+1/2,-y+1/2,-z
#3: -x,y+1/2,-z+1/2
#4: -x+1/2,-y,z+1/2
Noncrystallographic symmetry (NCS)NCS domain:
IDEns-IDDetails
d_1ens_1(chain "A" and (resid 1323 through 1467 or resid 1469 through 1485 or resid 1487 through 1697))
d_2ens_1(chain "B" and (resid 1323 through 1467 or resid 1469 through 1485 or resid 1487 through 1697))

NCS domain segments:

Ens-ID: ens_1

Dom-IDComponent-IDBeg auth comp-IDBeg label comp-IDEnd auth comp-IDEnd label comp-IDAuth asym-IDLabel asym-IDAuth seq-IDLabel seq-ID
d_11LYSLYSVALVALAA1323 - 146728 - 172
d_12GLYGLYHISHISAA1469 - 1485174 - 190
d_13HISHISGLNGLNAA1487 - 1697192 - 346
d_21LYSLYSVALVALBB1323 - 146728 - 172
d_22GLYGLYHISHISBB1469 - 1485174 - 190
d_23HISHISGLNGLNBB1487 - 1697192 - 346

NCS oper: (Code: givenMatrix: (-0.999040462518, 0.0213292940891, -0.0382519994969), (-0.0210935585196, -0.99975601203, -0.00655577594974), (-0.0383824965424, -0.00574261464711, 0.999246619377)Vector: ...NCS oper: (Code: given
Matrix: (-0.999040462518, 0.0213292940891, -0.0382519994969), (-0.0210935585196, -0.99975601203, -0.00655577594974), (-0.0383824965424, -0.00574261464711, 0.999246619377)
Vector: -1.00907999447, -0.714884600906, 23.6699977929)

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Components

#1: Protein CREB-binding protein / Histone lysine acetyltransferase CREBBP / Protein lactyltransferas CREBBP / Protein-lysine ...Histone lysine acetyltransferase CREBBP / Protein lactyltransferas CREBBP / Protein-lysine acetyltransferase CREBBP


Mass: 40485.988 Da / Num. of mol.: 2 / Mutation: Y1503F
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: CREBBP, CBP / Production host: Escherichia coli (E. coli)
References: UniProt: Q92793, histone acetyltransferase, Transferases; Acyltransferases; Transferring groups other than aminoacyl groups
#2: Chemical ChemComp-1VU / propionyl Coenzyme A


Mass: 823.597 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C24H40N7O17P3S / Feature type: SUBJECT OF INVESTIGATION
#3: Chemical ChemComp-SO4 / SULFATE ION


Mass: 96.063 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: SO4
#4: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 437 / Source method: isolated from a natural source / Formula: H2O
Has ligand of interestY
Has protein modificationN

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.56 Å3/Da / Density % sol: 52.01 %
Crystal growTemperature: 292 K / Method: vapor diffusion / Details: 0.1M Na3 cit , 2.4M (NH4)2SO4

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: SOLEIL / Beamline: PROXIMA 2 / Wavelength: 0.98011 Å
DetectorType: DECTRIS EIGER X 16M / Detector: PIXEL / Date: Sep 9, 2023
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.98011 Å / Relative weight: 1
ReflectionResolution: 1.75→69.553 Å / Num. obs: 58454 / % possible obs: 92 % / Redundancy: 9.1 % / Biso Wilson estimate: 19.3 Å2 / CC1/2: 0.994 / Rmerge(I) obs: 0.21 / Rpim(I) all: 0.074 / Rrim(I) all: 0.223 / Net I/σ(I): 7.2
Reflection shellResolution: 1.75→1.93 Å / Rmerge(I) obs: 2.003 / Mean I/σ(I) obs: 1.6 / Num. unique obs: 2923 / CC1/2: 0.616 / Rpim(I) all: 0.741 / Rrim(I) all: 2.138

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Processing

Software
NameVersionClassification
PHENIX1.21.1_5286refinement
autoPROCdata reduction
Aimlessdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT / Resolution: 1.75→69.55 Å / SU ML: 0.1849 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 28.7404
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
RfactorNum. reflection% reflection
Rfree0.2398 3056 5.23 %
Rwork0.1955 55367 -
obs0.1979 58423 69.28 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso mean: 27.91 Å2
Refinement stepCycle: LAST / Resolution: 1.75→69.55 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms5236 0 109 437 5782
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.0075619
X-RAY DIFFRACTIONf_angle_d1.00317628
X-RAY DIFFRACTIONf_chiral_restr0.0581785
X-RAY DIFFRACTIONf_plane_restr0.0088957
X-RAY DIFFRACTIONf_dihedral_angle_d24.14252150
Refine LS restraints NCSType: Torsion NCS / Rms dev position: 0.588048065006 Å
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
1.75-1.780.570140.468479X-RAY DIFFRACTION2.19
1.78-1.810.50180.3526198X-RAY DIFFRACTION5.5
1.81-1.840.4049220.3451350X-RAY DIFFRACTION9.85
1.84-1.870.3383300.3103583X-RAY DIFFRACTION16.25
1.87-1.910.3116460.3065899X-RAY DIFFRACTION25.02
1.91-1.950.2996950.26881258X-RAY DIFFRACTION35.54
1.95-1.990.30571030.24561780X-RAY DIFFRACTION49.78
1.99-2.040.29361480.23572268X-RAY DIFFRACTION63.73
2.04-2.090.31621390.23412660X-RAY DIFFRACTION73.81
2.09-2.140.26431440.21782939X-RAY DIFFRACTION80.64
2.14-2.210.27681430.20943059X-RAY DIFFRACTION83.89
2.21-2.280.25581670.21563092X-RAY DIFFRACTION86.26
2.28-2.360.26571690.21363266X-RAY DIFFRACTION90.11
2.36-2.450.2821770.22513490X-RAY DIFFRACTION95.42
2.45-2.570.26141890.20753606X-RAY DIFFRACTION99.92
2.57-2.70.20642090.20533653X-RAY DIFFRACTION99.97
2.7-2.870.26261830.20453649X-RAY DIFFRACTION99.95
2.87-3.090.19491890.19783665X-RAY DIFFRACTION99.92
3.09-3.40.24272000.19413652X-RAY DIFFRACTION99.87
3.4-3.890.21061910.1613701X-RAY DIFFRACTION99.92
3.89-4.910.19892490.14483697X-RAY DIFFRACTION99.95
4.91-69.550.24922510.19413823X-RAY DIFFRACTION99.63
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
15.79862264134-2.712116421834.843637858881.89791904979-2.182105987054.73350831651-0.158235232361-0.0563325602640.1434646075470.05260198403990.0723420133482-0.1073523449390.008509842157910.06890725290360.1583870362830.06498876144450.00814068574520.004543381137580.0714655679079-0.01199767455560.03620805392116.2390318802-3.51304473713-3.25418747535
21.90925110263-0.07073230332620.5246617268121.49716671766-0.4375804900112.76029950073-0.112766643310.1111200435560.01222441267560.02006188786540.0402966617334-0.03925992762210.1513784265080.305664077005-0.02793491441080.10901893769-0.0332981475859-0.05880709550920.077805357706-0.0092589343990.088426139677320.1224327315-7.90691148098-3.33831566616
32.421484767351.267443557441.245890940711.956512941641.935146161533.15405797996-0.08188107890590.27613741019-0.06001049191450.01037083493060.179279160547-0.08299810743460.3690328995470.765581504522-0.1811149490960.1105544216270.085882638013-0.05408200556310.176389412873-0.02633182584370.10277407842729.2303036576-7.56898881258-3.87447151595
41.24145341968-0.6763020171150.5396673382052.72214197961-1.046270748591.6644305780.09945545112340.1636199639950.00405451620159-0.0266020999656-0.09242086364210.0004937814895670.2428657667920.08398424999070.01324838030560.100881826206-0.0251001181229-0.004073114642820.0838612152311-0.005663077746940.068343535812714.8738723608-2.93868399398-18.9204498907
52.72859344995-2.07200417128-1.843635378795.299750890032.321710858746.471141242770.1212221474110.1042818822290.414764627361-0.717941638147-0.00317064814839-0.355416094224-0.6020791112480.496148148312-0.008600696201960.1687454148-0.04220844829270.006161241553110.1529271529830.004789614188370.15238747854720.566751320510.6491175137-22.7560522484
62.62546663765-0.546050196483-0.9593685763410.762288382339-0.4961525645832.36953867084-0.05088920033780.0138315725217-0.00473275858808-0.07157668591190.06681412930110.08808151188310.145544785035-0.2320361207220.01066306209770.108229450629-0.039750991768-0.04918695010810.104118579940.02129173103780.1254040630459.98859754627-4.06716667338-6.57239792835
73.88664803437-0.197278456811-0.03280164005874.5073848549-0.8860503763424.696390821390.22591412090.08502290290240.4903011264870.0234741119085-0.008810187177270.168294515066-0.490116711-0.0511032585125-0.1265936153170.1351357509710.0204984321843-0.0174276222450.0800415117408-0.01881003945830.10485506482724.75038183131.9484497593916.5391501245
83.29443488804-0.36723002651-0.7396686316992.629986145160.2017068557611.990361586610.221104221629-0.2836200176030.140426164332-0.0783251670544-0.1176655563170.0936257954943-0.3622457867480.0632780655652-0.07063072199830.126611496661-0.02145875584610.02557786458150.136440439227-0.0409233095350.106933246626-13.840319224514.5360687142-14.183279005
91.932139684240.1043716193890.1739537156841.596907152780.4603455010733.50316545805-0.131788226319-0.3555086302110.2224349579170.3733481385180.2037831102460.171315446992-0.1837884549360.03941769736570.04274899029080.0697248503585-0.05694535808790.04532694865420.07238603367550.03549456679720.116547541013-16.62781603068.53423603377-17.5022701061
101.27432254346-0.472158386625-0.7445812815882.740843034911.271215953963.097528359280.058129549815-0.0483604043749-0.0820117038501-0.0898310686817-0.007380793644430.0657285887268-0.0788941252940.0406855657913-0.07710747697960.05635453598090.0180269654142-0.03519681108470.07060091896980.02197070048190.0971820594168-13.3141300385-2.92639105132-27.3218062156
115.18213790543-2.07817307991-3.046165540582.091094483741.57626308543.09078226448-0.1407655378960.0664131004497-0.04432117372130.1172181521290.09944055629020.171377137110.124838815352-0.325470747090.179552249610.04355448674040.0177874827006-0.006747601183840.116176396310.02565790211370.0898011598637-16.10199419443.33168054936-27.4982973496
122.23910635057-0.598093586637-0.2552118844221.27102684790.1446898806342.436197140480.02897619632820.1290807169570.0966644262620.0598324759119-0.007709459658790.235478070985-0.174986290976-0.39133089263-0.034759616250.07860587735980.04053513691520.0274290176730.1118073421070.01091125538160.131285951919-20.01372739977.82832770819-27.5943970019
130.409809012501-0.496335375750.3882709998221.32081369627-0.53218806463.432220856640.07810491486490.194906794893-0.0493786014319-0.0849687091667-0.2638839172630.346571554706-0.102277113666-1.21892679035-0.655913960590.08470581198950.177436555544-0.02629975267440.2085883112680.1019506142420.174136363901-28.99172262837.64428363239-28.5992448182
141.161231197280.0807272244786-0.03891568006673.492738892550.6360864757961.74446959405-0.001715730232580.2115457387490.003928193712-0.1879917786180.0452420750471-0.00186339065737-0.250547492434-0.241801962348-0.08687878347080.1040125779470.0376994527563-0.02905755777170.1150317831830.0404012811810.0867285196047-13.81578896973.25469762607-43.4029208871
152.26163822617-1.194204561641.70983365024.51161314138-2.322701978085.606149089040.212429042320.237711773119-0.441960754845-0.715276366375-0.04513154342790.334685827550.55686082058-0.291550915746-0.03723923794990.2521651843860.00444502914111-0.09246970648160.214255686954-0.036268017490.236315628686-20.1077407734-10.3762601096-46.7757954362
161.77068758678-0.2272187657170.8805901548781.15700426632-0.003400415670652.209571041280.09319915782960.0559487798327-0.127102626168-0.05736123348-0.05440593372420.1051666872730.122758971303-0.049681010003-0.001586934046660.08642028770370.003670925407940.02293287391530.0693382600014-0.02362630853680.0831299208898-9.771126045283.59883457162-30.5751259122
175.494641740450.3812025682181.719759007185.006905535081.631934483375.957045374820.699768839929-0.122151164924-0.8287534349430.36756012149-0.1728514568660.1490967870870.657180027363-0.365693175525-0.1353563076750.140200259589-0.01589432186370.03270379321110.2132435883290.03300175472970.189880547649-25.5101970084-2.08041400715-8.04715477359
181.94774055704-0.3528614332331.261308869832.779536033131.132621961222.134833847080.224055002694-0.499284925686-0.314079122864-0.2015553548710.07967091178440.2221226998240.674355291316-0.5044308834790.08930437117360.288368854549-0.101913815924-0.06030057525830.0473773547970.05489117486430.18409223241913.5948161093-14.787492034810.0368903736
191.64465692916-0.1548977520280.2606586978361.88281126772-0.4923167442872.72584023752-0.043832486178-0.282597402243-0.1450404628660.1700464805860.16429331709-0.2157341594620.280757676282-0.118330915879-0.01407292626620.126620433196-0.0461965639659-0.04949784802250.0714746622898-0.0150422945220.1082755450916.3981537045-8.851217775486.85421698063
201.4375855454-0.8053034805251.979645842091.22356793831-1.842802091624.075077828750.0338632322676-0.07991485479720.0217443708425-0.01616875366740.00724725697922-0.04814605138680.123319216976-0.0950283572905-0.05394578807750.08462043581250.00480731264788-0.01767110016350.0663576377804-0.01661758085270.067413424041913.24334991472.69813481201-3.04440715798
Refinement TLS group

Refine-ID: X-RAY DIFFRACTION

IDRefine TLS-IDSelection detailsAuth asym-IDLabel asym-IDAuth seq-IDLabel seq-ID
11chain 'B' and (resid 1418 through 1442 )BC1418 - 144299 - 123
22chain 'B' and (resid 1443 through 1482 )BC1443 - 1482124 - 163
33chain 'B' and (resid 1483 through 1512 )BC1483 - 1512164 - 193
44chain 'B' and (resid 1513 through 1544 )BC1513 - 1544194 - 225
55chain 'B' and (resid 1545 through 1626 )BC1545 - 1626226 - 250
66chain 'B' and (resid 1627 through 1663 )BC1627 - 1663251 - 287
77chain 'B' and (resid 1664 through 1697 )BC1664 - 1697288 - 321
88chain 'A' and (resid 1323 through 1348 )AA1323 - 13481 - 26
99chain 'A' and (resid 1349 through 1370 )AA1349 - 137027 - 48
1010chain 'A' and (resid 1371 through 1417 )AA1371 - 141749 - 95
1111chain 'A' and (resid 1418 through 1442 )AA1418 - 144296 - 120
1212chain 'A' and (resid 1443 through 1482 )AA1443 - 1482121 - 160
1313chain 'A' and (resid 1483 through 1512 )AA1483 - 1512161 - 190
1414chain 'A' and (resid 1513 through 1543 )AA1513 - 1543191 - 221
1515chain 'A' and (resid 1544 through 1626 )AA1544 - 1626222 - 247
1616chain 'A' and (resid 1627 through 1663 )AA1627 - 1663248 - 284
1717chain 'A' and (resid 1664 through 1697 )AA1664 - 1697285 - 318
1818chain 'B' and (resid 1323 through 1348 )BC1323 - 13484 - 29
1919chain 'B' and (resid 1349 through 1370 )BC1349 - 137030 - 51
2020chain 'B' and (resid 1371 through 1417 )BC1371 - 141752 - 98

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