登録情報 | データベース: PDB / ID: 9gao |
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タイトル | Crystal structure of CRBNmidi in complex with 2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)-N-methylacetamide |
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要素 | Protein cereblon |
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キーワード | LIGASE / E3 ligase / PROTAC / TPD / molecular glue / targeted protein degradation |
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機能・相同性 | 機能・相同性情報
negative regulation of monoatomic ion transmembrane transport / Cul4A-RING E3 ubiquitin ligase complex / locomotory exploration behavior / positive regulation of Wnt signaling pathway / negative regulation of protein-containing complex assembly / positive regulation of protein-containing complex assembly / proteasome-mediated ubiquitin-dependent protein catabolic process / transmembrane transporter binding / Potential therapeutics for SARS / protein ubiquitination ...negative regulation of monoatomic ion transmembrane transport / Cul4A-RING E3 ubiquitin ligase complex / locomotory exploration behavior / positive regulation of Wnt signaling pathway / negative regulation of protein-containing complex assembly / positive regulation of protein-containing complex assembly / proteasome-mediated ubiquitin-dependent protein catabolic process / transmembrane transporter binding / Potential therapeutics for SARS / protein ubiquitination / perinuclear region of cytoplasm / membrane / nucleus / metal ion binding / cytosol / cytoplasm類似検索 - 分子機能 Yippee/Mis18/Cereblon / Yippee zinc-binding/DNA-binding /Mis18, centromere assembly / CULT domain / CULT domain profile. / Lon protease, N-terminal domain superfamily / Lon N-terminal domain profile. / Lon protease, N-terminal domain / ATP-dependent protease La (LON) substrate-binding domain / Found in ATP-dependent protease La (LON) / PUA-like superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.95 Å |
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データ登録者 | Rutter, Z.J. / Kroupova, A. / Zollman, D. / Ciulli, A. |
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資金援助 | 1件 |
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引用 | ジャーナル: To Be Published タイトル: Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders 著者: Rutter, Z.J. / Kroupova, A. / Zollman, D. / Ciulli, A. |
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履歴 | 登録 | 2024年7月29日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2024年10月2日 | Provider: repository / タイプ: Initial release |
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