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- PDB-9fqz: CRYO-EM STRUCTURE OF HCT15 POLYSOMES BOUND TO EEF2, EBP1, AND SERBP1 -

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Open data

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Basic information

Entry

Database: PDB / ID: 9fqz

Title

CRYO-EM STRUCTURE OF HCT15 POLYSOMES BOUND TO EEF2, EBP1, AND SERBP1

Components

(40S ribosomal protein ...) x 30
(60S ribosomal protein ...) x 40
5.8S rRNA
5S rRNA
60S acidic ribosomal protein P0
Elongation factor 2
Isoform 2 of SERPINE1 mRNA-binding protein 1
LSU rRNA
Large ribosomal subunit protein uL30
Proliferation-associated protein 2G4
Receptor of activated protein C kinase 1
SSU rRNA
Ubiquitin
Ubiquitin-60S ribosomal protein L40
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein
tRNA

Keywords

RIBOSOME / CRYO-EM / HCT15 cancer cell / POLYSOMES / dormant ribosome / hybernating ribosome

Function / homology

Function and homology information

Synthesis of diphthamide-EEF2 / translation at postsynapse / PML body organization / glial cell proliferation / skeletal muscle cell differentiation / translation elongation factor binding / ribosome hibernation / response to folic acid / SUMO binding / positive regulation of cytoplasmic translation ...Synthesis of diphthamide-EEF2 / translation at postsynapse / PML body organization / glial cell proliferation / skeletal muscle cell differentiation / translation elongation factor binding / ribosome hibernation / response to folic acid / SUMO binding / positive regulation of cytoplasmic translation / male meiosis I / translation at presynapse / response to insecticide / negative regulation of endoplasmic reticulum unfolded protein response / eukaryotic 80S initiation complex / ribosomal protein import into nucleus / regulation of G1 to G0 transition / oxidized pyrimidine DNA binding / response to TNF agonist / positive regulation of base-excision repair / positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage / positive regulation of respiratory burst involved in inflammatory response / positive regulation of gastrulation / regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway / protein tyrosine kinase inhibitor activity / IRE1-RACK1-PP2A complex / TNFR1-mediated ceramide production / positive regulation of Golgi to plasma membrane protein transport / G1 to G0 transition / negative regulation of formation of translation preinitiation complex / nucleolus organization / positive regulation of ubiquitin-protein transferase activity / positive regulation of DNA-templated transcription initiation / negative regulation of RNA splicing / GAIT complex / negative regulation of DNA repair / TORC2 complex binding / erythrocyte homeostasis / supercoiled DNA binding / regulation of establishment of cell polarity / rRNA modification in the nucleus and cytosol / oxidized purine DNA binding / NF-kappaB complex / negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide / negative regulation of phagocytosis / Uptake and function of diphtheria toxin / ubiquitin-like protein conjugating enzyme binding / cytoplasmic translational initiation / cytoplasmic side of rough endoplasmic reticulum membrane / regulation of translation involved in cellular response to UV / A band / Formation of the ternary complex, and subsequently, the 43S complex / laminin receptor activity / ion channel inhibitor activity / positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / response to aldosterone / negative regulation of myoblast fusion / protein-DNA complex disassembly / lncRNA binding / Ribosomal scanning and start codon recognition / protein kinase A binding / Translation initiation complex formation / negative regulation of Wnt signaling pathway / positive regulation of DNA damage response, signal transduction by p53 class mediator / fibroblast growth factor binding / BH3 domain binding / Protein hydroxylation / TOR signaling / mTORC1-mediated signalling / negative regulation of translational frameshifting / monocyte chemotaxis / PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA / SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) / SARS-CoV-1 modulates host translation machinery / regulation of cell division / positive regulation of GTPase activity / protein localization to nucleus / translational elongation / Peptide chain elongation / Selenocysteine synthesis / negative regulation of protein binding / Formation of a pool of free 40S subunits / translation elongation factor activity / negative regulation of respiratory burst involved in inflammatory response / positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator / protein targeting / protein serine/threonine kinase inhibitor activity / Eukaryotic Translation Termination / Dengue Virus Attachment and Entry / SRP-dependent cotranslational protein targeting to membrane / Response of EIF2AK4 (GCN2) to amino acid deficiency / response to ischemia / ubiquitin ligase inhibitor activity / Viral mRNA Translation / endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / positive regulation of signal transduction by p53 class mediator / GTP hydrolysis and joining of the 60S ribosomal subunit / embryo implantation / L13a-mediated translational silencing of Ceruloplasmin expression
Similarity search - Function

Intracellular hyaluronan-binding protein 4, N-terminal domain / Intracellular hyaluronan-binding protein 4 N-terminal / Hyaluronan / mRNA binding family / PA2G4 family / RNA binding protein HABP4/SERBP1 / : / Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site / Methionine aminopeptidase subfamily 2 signature. / Hyaluronan/mRNA-binding protein / Hyaluronan / mRNA binding family ...Intracellular hyaluronan-binding protein 4, N-terminal domain / Intracellular hyaluronan-binding protein 4 N-terminal / Hyaluronan / mRNA binding family / PA2G4 family / RNA binding protein HABP4/SERBP1 / : / Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site / Methionine aminopeptidase subfamily 2 signature. / Hyaluronan/mRNA-binding protein / Hyaluronan / mRNA binding family / 60s Acidic ribosomal protein / 60S acidic ribosomal protein P0 / Peptidase M24 / Metallopeptidase family M24 / Creatinase/aminopeptidase-like / : / Elongation Factor G, domain II / Elongation Factor G, domain III / Elongation factor G, domain IV / Translation elongation factor EFG/EF2, domain IV / Elongation factor G, domain IV / Elongation factor G C-terminus / 40S ribosomal protein SA / Elongation factor EFG, domain V-like / Elongation factor G C-terminus / 40S ribosomal protein SA, C-terminal domain / 40S ribosomal protein SA C-terminus / Ribosomal protein L6, N-terminal / Ribosomal protein L6, N-terminal domain / 50S ribosomal protein L10, insertion domain superfamily / Ubiquitin-like protein FUBI / EF-G domain III/V-like / 60S ribosomal protein L10P, insertion domain / Insertion domain in 60S ribosomal protein L10P / Tr-type G domain, conserved site / Ribosomal protein L30e / Translational (tr)-type guanine nucleotide-binding (G) domain signature. / Ribosomal protein L28e / Ribosomal L15/L27a, N-terminal / : / Ribosomal L28e/Mak16 / Ribosomal L28e protein family / Ribosomal protein L23 / Ribosomal protein L2, archaeal-type / metallochaperone-like domain / TRASH domain / : / Ribosomal protein S26e signature. / Ribosomal protein L41 / Ribosomal protein L41 / Ribosomal protein L13e, conserved site / Ribosomal protein L13e signature. / Ribosomal protein S21e, conserved site / Ribosomal protein S21e signature. / : / Ribosomal protein S12e signature. / Translation elongation factor EFTu-like, domain 2 / Ribosomal protein S26e / Ribosomal protein S26e superfamily / Ribosomal protein S26e / Ribosomal protein S12e / Ribosomal protein L29e / Ribosomal L29e protein family / Small (40S) ribosomal subunit Asc1/RACK1 / Ribosomal protein L22e / Ribosomal protein L22e superfamily / Ribosomal L22e protein family / Ribosomal protein L27e, conserved site / Ribosomal protein L27e signature. / Ribosomal protein L13e / Ribosomal protein L13e / Ribosomal protein S21e / Ribosomal protein L38e / Ribosomal protein L38e superfamily / Ribosomal protein S21e superfamily / Ribosomal protein S21e / Ribosomal L38e protein family / Elongation factor Tu domain 2 / Ribosomal protein S5, eukaryotic/archaeal / Ribosomal protein S19e, conserved site / Ribosomal protein S19e signature. / : / Ribosomal protein S2, eukaryotic / Ribosomal protein L19, eukaryotic / Ribosomal protein L6e signature. / 60S ribosomal protein L18a/ L20, eukaryotes / 40S Ribosomal protein S10 / Ribosomal protein L10e, conserved site / Ribosomal protein L10e signature. / S27a-like superfamily / Plectin/S10, N-terminal / Ribosomal protein L18/L18-A/B/e, conserved site / Ribosomal protein L19/L19e conserved site / Plectin/S10 domain / Ribosomal protein L19e signature. / Ribosomal protein L18e signature. / Ribosomal protein L44e signature. / Ribosomal protein L24e, conserved site / Ribosomal protein L24e signature. / Ribosomal protein L10e
Similarity search - Domain/homology

Chem-3HE / ANISOMYCIN / GUANOSINE-5'-DIPHOSPHATE / HYGROMYCIN B / : / 1,4-DIAMINOBUTANE / SPERMIDINE / : / RNA / RNA (> 10) ...Chem-3HE / ANISOMYCIN / GUANOSINE-5'-DIPHOSPHATE / HYGROMYCIN B / : / 1,4-DIAMINOBUTANE / SPERMIDINE / : / RNA / RNA (> 10) / RNA (> 100) / RNA (> 1000) / Large ribosomal subunit protein uL10 / Small ribosomal subunit protein eS17 / Small ribosomal subunit protein uS2 / Elongation factor 2 / Small ribosomal subunit protein uS5 / Large ribosomal subunit protein eL33 / Large ribosomal subunit protein uL30 / Large ribosomal subunit protein uL22 / Small ribosomal subunit protein uS3 / Small ribosomal subunit protein eS12 / Large ribosomal subunit protein eL13 / Large ribosomal subunit protein uL6 / Large ribosomal subunit protein eL22 / Large ribosomal subunit protein uL4 / Small ribosomal subunit protein eS19 / Large ribosomal subunit protein uL3 / Large ribosomal subunit protein uL13 / Small ribosomal subunit protein eS27 / Large ribosomal subunit protein uL29 / Large ribosomal subunit protein uL15 / Large ribosomal subunit protein uL18 / Large ribosomal subunit protein eL21 / Large ribosomal subunit protein eL28 / Small ribosomal subunit protein uS4 / Small ribosomal subunit protein uS7 / Small ribosomal subunit protein eS10 / Large ribosomal subunit protein eL29 / Large ribosomal subunit protein eL34 / Large ribosomal subunit protein eL14 / Small ribosomal subunit protein uS10 / Small ribosomal subunit protein eS1 / Large ribosomal subunit protein uL24 / Large ribosomal subunit protein eL15 / Large ribosomal subunit protein eL27 / Large ribosomal subunit protein eL43 / Large ribosomal subunit protein eL37 / Small ribosomal subunit protein eS7 / Small ribosomal subunit protein eS8 / Small ribosomal subunit protein uS8 / Small ribosomal subunit protein uS9 / Small ribosomal subunit protein uS11 / Small ribosomal subunit protein uS12 / Small ribosomal subunit protein uS13 / Small ribosomal subunit protein uS14 / Small ribosomal subunit protein uS15 / Small ribosomal subunit protein uS17 / Large ribosomal subunit protein eL8 / Small ribosomal subunit protein eS4, X isoform / Large ribosomal subunit protein uL23 / Small ribosomal subunit protein eS6 / Large ribosomal subunit protein uL14 / Small ribosomal subunit protein uS19 / Small ribosomal subunit protein eS24 / Small ribosomal subunit protein eS25 / Small ribosomal subunit protein eS26 / Small ribosomal subunit protein eS28 / Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein / Large ribosomal subunit protein eL30 / Large ribosomal subunit protein eL39 / Large ribosomal subunit protein eL31 / Large ribosomal subunit protein eL32 / Large ribosomal subunit protein uL5 / Large ribosomal subunit protein uL2 / Small ribosomal subunit protein eS32 / Ubiquitin-ribosomal protein eS31 fusion protein / Ubiquitin-ribosomal protein eL40 fusion protein / Large ribosomal subunit protein eL38 / Small ribosomal subunit protein eS21 / Small ribosomal subunit protein RACK1 / Large ribosomal subunit protein eL24 / Large ribosomal subunit protein eL42 / Large ribosomal subunit protein eL19 / Large ribosomal subunit protein eL20 / Large ribosomal subunit protein eL6 / Large ribosomal subunit protein eL18 / SERPINE1 mRNA-binding protein 1 / Ribosomal protein uL16-like / Proliferation-associated protein 2G4 / Large ribosomal subunit protein eL36
Similarity search - Component

Biological species

Homo sapiens (human)

Method

ELECTRON MICROSCOPY / single particle reconstruction / cryo EM / Resolution: 2.85 Å

Authors

Rajan, K.S. / Yonath, A.

Funding support

1items

Citation

Journal: To Be Published
Title: CRYO-EM STRUCTURE OF HCT15 POLYSOMES BOUND TO EEF2, EBP1, AND SERBP1
Authors: Rajan, K.S. / Yonath, A.

History

Deposition	Jun 17, 2024	Deposition site: PDBE / Processing site: PDBE
Revision 1.0	Jan 14, 2026	Provider: repository / Type: Initial release
Revision 1.0	Jan 14, 2026	Data content type: EM metadata / Data content type: EM metadata / Provider: repository / Type: Initial release
Revision 1.0	Jan 14, 2026	Data content type: FSC / Data content type: FSC / Provider: repository / Type: Initial release
Revision 1.0	Jan 14, 2026	Data content type: Image / Data content type: Image / Provider: repository / Type: Initial release
Revision 1.0	Jan 14, 2026	Data content type: Primary map / Data content type: Primary map / Provider: repository / Type: Initial release
Revision 2.0	Jun 24, 2026	Group: Atomic model / Data collection ...Atomic model / Data collection / Database references / Derived calculations Category: atom_site / chem_comp_atom ...atom_site / chem_comp_atom / chem_comp_bond / em_admin / pdbx_struct_conn_angle / struct_conn / struct_ref Item: _atom_site.auth_atom_id / _atom_site.label_atom_id ..._atom_site.auth_atom_id / _atom_site.label_atom_id / _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_1 / _chem_comp_bond.atom_id_2 / _em_admin.last_update / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _struct_conn.ptnr1_label_atom_id / _struct_ref.pdbx_seq_one_letter_code
Revision 1.1	Jun 24, 2026	Data content type: EM metadata / Data content type: EM metadata / EM metadata / Group: Database references / Experimental summary / Data content type: EM metadata / EM metadata / Category: em_admin / struct_ref / Data content type: EM metadata / EM metadata Item: _em_admin.last_update / _struct_ref.pdbx_seq_one_letter_code

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Structure visualization

Structure viewer	Molecule: MolmilJmol/JSmol

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Downloads & links

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PDBx/mmCIF format	9fqz.cif.gz	5.4 MB	Display	PDBx/mmCIF format
PDB format	pdb9fqz.ent.gz		Display	PDB format
PDBx/mmJSON format	9fqz.json.gz		Tree view	PDBx/mmJSON format
Others	Other downloads

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Validation report

Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/fq/9fqz ftp://data.pdbj.org/pub/pdb/validation_reports/fq/9fqz	HTTPS FTP

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Related structure data

Related structure data	50673MC 50726C 50735 M: map data used to model this data C: citing same article (ref.)
Similar structure data	Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#121 - Jan 2010 70S Ribosomes similarity (105) #130 - Oct 2010 Riboswitches similarity (2) #16 - Apr 2001 Aminoacyl-tRNA Synthetases similarity (1) #10 - Oct 2000 Ribosome similarity (84) #157 - Jan 2013 Transfer-Messenger RNA similarity (10) #253 - Jan 2021 Expressome similarity (6) #260 - Aug 2021 Ribonuclease P similarity (8) #161 - May 2013 Ricin similarity (245) #181 - Jan 2015 Cascade and CRISPR similarity (1) #229 - Jan 2019 Fluorescent RNA Aptamers similarity (1) #146 - Feb 2012 Aminoglycoside Antibiotics similarity (4) #15 - Mar 2001 Transfer RNA similarity (1) #249 - Sep 2020 SARS-CoV-2 RNA-dependent RNA Polymerase similarity (1) #266 - Feb 2022 Oligosaccharyltransferase similarity (119) #60 - Dec 2004 Ubiquitin similarity (83) #210 - Jun 2017 Adenine Riboswitch in Action similarity (1) #87 - Mar 2007 Zinc Fingers similarity (1) #245 - May 2020 Spliceosomes similarity (15) #81 - Sep 2006 Elongation Factors similarity (17) #226 - Oct 2018 Aminoglycoside Antibiotics and Resistance similarity (3) #262 - Oct 2021 Fifty Years of Open Access to PDB Structures similarity (3) #65 - May 2005 Self-splicing RNA similarity (2) #105 - Sep 2008 Ribonuclease A similarity (1) #98 - Feb 2008 Small Interfering RNA similarity (1) #234 - Jun 2019 MDM2 and Cancer similarity (79) #230 - Feb 2019 Initiation Factor eIF4E similarity (8) #104 - Aug 2008 Selenocysteine Synthase similarity (7) #227 - Nov 2018 Telomerase similarity (2) #106 - Oct 2008 Poly(A) Polymerase similarity (5) #143 - Nov 2011 Toll-like Receptors similarity (5) #89 - May 2007 Aconitase and Iron Regulatory Protein 1 similarity (1) #122 - Feb 2010 Enhanceosome similarity (7) #88 - Apr 2007 Clathrin similarity (1) #205 - Jan 2017 Nuclear Pore Complex similarity (6) #150 - Jun 2012 Sliding Clamps similarity (5) #241 - Jan 2020 Twenty Years of Molecules similarity (1) #172 - Apr 2014 RecA and Rad51 similarity (8) #68 - Aug 2005 Neurotrophins similarity (3) #43 - Jul 2003 Src Tyrosine Kinase similarity (3) #56 - Aug 2004 Caspases similarity (3) #69 - Sep 2005 Cholera Toxin similarity (1) #165 - Sep 2013 Designed Protein Cages similarity (1) #62 - Feb 2005 Major Histocompatibility Complex similarity (1) #86 - Feb 2007 Exosomes similarity (1) #44 - Aug 2003 Calmodulin similarity (1) #128 - Aug 2010 Interferons similarity (1) #163 - Jul 2013 HIV Capsid similarity (2) #94 - Oct 2007 Superoxide Dismutase similarity (1) #126 - Jun 2010 Epidermal Growth Factor similarity (1) #91 - Jul 2007 Thymine Dimers similarity (1) #255 - Mar 2021 Cisplatin and DNA similarity (2) #196 - Apr 2016 Lead Poisoning similarity (1) #28 - Apr 2002 Anthrax Toxin similarity (1) #195 - Mar 2016 RAF Protein Kinases similarity (1) #112 - Apr 2009 Oct and Sox Transcription Factors similarity (1)

PDB pages

PDBj /

wwPDB /

NCBI

Related items in Molecule of the Month

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Assembly

Deposited unit

CB: Elongation factor 2

CC: tRNA

CD: Isoform 2 of SERPINE1 mRNA-binding protein 1

L8: 5.8S rRNA

LA: 60S ribosomal protein L8

LB: 60S ribosomal protein L3

LC: 60S ribosomal protein L4

LD: 60S ribosomal protein L5

LE: 60S ribosomal protein L6

LF: Large ribosomal subunit protein uL30

LG: 60S ribosomal protein L7a

LH: 60S ribosomal protein L9

LI: 60S ribosomal protein L10-like

LJ: 60S ribosomal protein L11

LL: 60S ribosomal protein L13

LM: 60S ribosomal protein L14

LN: 60S ribosomal protein L15

LO: 60S ribosomal protein L13a

LP: 60S ribosomal protein L17

LQ: 60S ribosomal protein L18

LR: 60S ribosomal protein L19

LS: 60S ribosomal protein L18a

LT: 60S ribosomal protein L21

LU: 60S ribosomal protein L22

LV: 60S ribosomal protein L23

LW: 60S ribosomal protein L24

LX: 60S ribosomal protein L23a

LY: 60S ribosomal protein L26

LZ: 60S ribosomal protein L27

La: 60S ribosomal protein L27a

Lb: 60S ribosomal protein L29

Lc: 60S ribosomal protein L30

Ld: 60S ribosomal protein L31

Le: 60S ribosomal protein L32

Lf: 60S ribosomal protein L35a

Lg: 60S ribosomal protein L34

Lh: 60S ribosomal protein L35

Li: 60S ribosomal protein L36

Lj: 60S ribosomal protein L37

Lk: 60S ribosomal protein L38

Ll: 60S ribosomal protein L39

Lm: Ubiquitin-60S ribosomal protein L40

Ln: 60S ribosomal protein L41

Lo: 60S ribosomal protein L36a

Lp: 60S ribosomal protein L37a

Lr: 60S ribosomal protein L28

S2: SSU rRNA

SA: 40S ribosomal protein SA

SB: 40S ribosomal protein S3a

SC: 40S ribosomal protein S2

SD: 40S ribosomal protein S3

SE: 40S ribosomal protein S4, X isoform

SF: 40S ribosomal protein S5

SG: 40S ribosomal protein S6

SH: 40S ribosomal protein S7

SI: 40S ribosomal protein S8

SJ: 40S ribosomal protein S9

SK: 40S ribosomal protein S10

SL: 40S ribosomal protein S11

SM: 40S ribosomal protein S12

SN: 40S ribosomal protein S13

SO: 40S ribosomal protein S14

SP: 40S ribosomal protein S15

SQ: 40S ribosomal protein S16

SR: 40S ribosomal protein S17

SS: 40S ribosomal protein S18

ST: 40S ribosomal protein S19

SU: 40S ribosomal protein S20

SV: 40S ribosomal protein S21

SW: 40S ribosomal protein S15a

SX: 40S ribosomal protein S23

SY: 40S ribosomal protein S24

SZ: 40S ribosomal protein S25

Sa: 40S ribosomal protein S26

Sb: 40S ribosomal protein S27

Sc: 40S ribosomal protein S28

Sd: 40S ribosomal protein S29

Se: Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

Sf: Ubiquitin

Sg: Receptor of activated protein C kinase 1

L5: LSU rRNA

L7: 5S rRNA

Lq: 60S acidic ribosomal protein P0

CA: Proliferation-associated protein 2G4

hetero molecules

4.05 MDa, 84 polymers
Search similar-shape structures of this assembly by Omokage search (details)

Idetical with deposited unit
defined by author&software
Evidence: electron microscopy, not applicable

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Components

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Protein , 9 types, 9 molecules CBCDLFLmSeSfSgLqCA

#1: Protein	Elongation factor 2 / EF-2 Mass: 95463.211 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P13639
#3: Protein	Isoform 2 of SERPINE1 mRNA-binding protein 1 / PAI1 RNA-binding protein 1 / PAI-RBP1 / Plasminogen activator inhibitor 1 RNA-binding protein Mass: 44341.781 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q8NC51
#10: Protein	Large ribosomal subunit protein uL30 / 60S ribosomal protein L7 Mass: 29290.973 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P18124
#42: Protein	Ubiquitin-60S ribosomal protein L40 / CEP52 / Ubiquitin A-52 residue ribosomal protein fusion product 1 Mass: 14758.394 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62987
#78: Protein	Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein / FAU ubiquitin like and ribosomal protein S30 fusion Mass: 14415.724 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62861
#79: Protein	Ubiquitin Mass: 18004.041 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62979
#80: Protein	Receptor of activated protein C kinase 1 / Cell proliferation-inducing gene 21 protein / Guanine nucleotide-binding protein subunit beta-2- ...Cell proliferation-inducing gene 21 protein / Guanine nucleotide-binding protein subunit beta-2-like 1 / Guanine nucleotide-binding protein subunit beta-like protein 12.3 / Human lung cancer oncogene 7 protein / HLC-7 / Receptor for activated C kinase / Small ribosomal subunit protein RACK1 Mass: 35115.652 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P63244
#83: Protein	60S acidic ribosomal protein P0 / 60S ribosomal protein L10E / Large ribosomal subunit protein uL10 Mass: 34309.418 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P05388
#84: Protein	Proliferation-associated protein 2G4 / Cell cycle protein p38-2G4 homolog / hG4-1 / ErbB3-binding protein 1 Mass: 43851.879 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q9UQ80

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RNA chain , 5 types, 5 molecules CCL8S2L5L7

#2: RNA chain	tRNA Mass: 27379.225 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human)
#4: RNA chain	5.8S rRNA Mass: 50171.703 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human)
#47: RNA chain	SSU rRNA Mass: 604155.375 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human)
#81: RNA chain	LSU rRNA Mass: 1640786.500 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human)
#82: RNA chain	5S rRNA Mass: 38691.914 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: GenBank: 23898

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60S ribosomal protein ... , 40 types, 40 molecules LALBLCLDLELGLHLILJLLLMLNLOLPLQLRLSLTLULVLWLXLYLZLaLbLcLdLeLf...

#5: Protein	60S ribosomal protein L8 / Large ribosomal subunit protein uL2 Mass: 28088.863 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62917
#6: Protein	60S ribosomal protein L3 / HIV-1 TAR RNA-binding protein B / TARBP-B / Large ribosomal subunit protein uL3 Mass: 46211.113 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P39023
#7: Protein	60S ribosomal protein L4 / 60S ribosomal protein L1 / Large ribosomal subunit protein uL4 Mass: 47804.621 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P36578
#8: Protein	60S ribosomal protein L5 / Large ribosomal subunit protein uL18 Mass: 34426.789 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P46777
#9: Protein	60S ribosomal protein L6 / Large ribosomal subunit protein eL6 / Neoplasm-related protein C140 / Tax-responsive enhancer ...Large ribosomal subunit protein eL6 / Neoplasm-related protein C140 / Tax-responsive enhancer element-binding protein 107 / TaxREB107 Mass: 32810.176 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q02878
#11: Protein	60S ribosomal protein L7a / Large ribosomal subunit protein eL8 / PLA-X polypeptide / Surfeit locus protein 3 Mass: 30061.785 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62424
#12: Protein	60S ribosomal protein L9 / Large ribosomal subunit protein uL6 Mass: 21899.471 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P32969
#13: Protein	60S ribosomal protein L10-like / Large ribosomal subunit protein uL16-like Mass: 24617.039 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q96L21
#14: Protein	60S ribosomal protein L11 / CLL-associated antigen KW-12 / Large ribosomal subunit protein uL5 Mass: 20288.465 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62913
#15: Protein	60S ribosomal protein L13 / Breast basic conserved protein 1 / Large ribosomal subunit protein eL13 Mass: 24321.682 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P26373
#16: Protein	60S ribosomal protein L14 / CAG-ISL 7 / Large ribosomal subunit protein eL14 Mass: 23485.016 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P50914
#17: Protein	60S ribosomal protein L15 / Large ribosomal subunit protein eL15 Mass: 24207.285 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P61313
#18: Protein	60S ribosomal protein L13a / 23 kDa highly basic protein / Large ribosomal subunit protein uL13 Mass: 23633.412 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P40429
#19: Protein	60S ribosomal protein L17 / 60S ribosomal protein L23 / Large ribosomal subunit protein uL22 / PD-1 Mass: 21443.170 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P18621
#20: Protein	60S ribosomal protein L18 / Large ribosomal subunit protein eL18 Mass: 21687.676 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q07020
#21: Protein	60S ribosomal protein L19 / Large ribosomal subunit protein eL19 Mass: 23535.281 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P84098
#22: Protein	60S ribosomal protein L18a / Large ribosomal subunit protein eL20 Mass: 20808.514 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q02543
#23: Protein	60S ribosomal protein L21 / Large ribosomal subunit protein eL21 Mass: 18609.988 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P46778
#24: Protein	60S ribosomal protein L22 / EBER-associated protein / EAP / Epstein-Barr virus small RNA-associated protein / Heparin-binding ...EBER-associated protein / EAP / Epstein-Barr virus small RNA-associated protein / Heparin-binding protein HBp15 / Large ribosomal subunit protein eL22 Mass: 14813.015 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P35268
#25: Protein	60S ribosomal protein L23 / 60S ribosomal protein L17 / Large ribosomal subunit protein uL14 Mass: 14892.505 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62829
#26: Protein	60S ribosomal protein L24 / 60S ribosomal protein L30 / Large ribosomal subunit protein eL24 Mass: 17825.111 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P83731
#27: Protein	60S ribosomal protein L23a / Large ribosomal subunit protein uL23 Mass: 17740.193 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62750
#28: Protein	60S ribosomal protein L26 / Large ribosomal subunit protein uL24 Mass: 17303.363 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P61254
#29: Protein	60S ribosomal protein L27 / Large ribosomal subunit protein eL27 Mass: 15835.831 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P61353
#30: Protein	60S ribosomal protein L27a / Large ribosomal subunit protein uL15 Mass: 16604.535 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P46776
#31: Protein	60S ribosomal protein L29 / Cell surface heparin-binding protein HIP / Large ribosomal subunit protein eL29 Mass: 17804.275 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P47914
#32: Protein	60S ribosomal protein L30 / Large ribosomal subunit protein eL30 Mass: 12805.092 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62888
#33: Protein	60S ribosomal protein L31 / Large ribosomal subunit protein eL31 Mass: 14494.938 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62899
#34: Protein	60S ribosomal protein L32 / Large ribosomal subunit protein eL32 Mass: 15898.932 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62910
#35: Protein	60S ribosomal protein L35a / Cell growth-inhibiting gene 33 protein / Large ribosomal subunit protein eL33 Mass: 12564.743 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P18077
#36: Protein	60S ribosomal protein L34 / Large ribosomal subunit protein eL34 Mass: 13326.074 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P49207
#37: Protein	60S ribosomal protein L35 / Large ribosomal subunit protein uL29 Mass: 14593.624 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P42766
#38: Protein	60S ribosomal protein L36 / Large ribosomal subunit protein eL36 Mass: 12290.859 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: Q9Y3U8
#39: Protein	60S ribosomal protein L37 / G1.16 / Large ribosomal subunit protein eL37 Mass: 11111.032 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P61927
#40: Protein	60S ribosomal protein L38 / Large ribosomal subunit protein eL38 Mass: 8238.948 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P63173
#41: Protein	60S ribosomal protein L39 / Large ribosomal subunit protein eL39 Mass: 6426.759 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62891
#43: Protein/peptide	60S ribosomal protein L41 / HG12 / Large ribosomal subunit protein eL41 Mass: 3473.451 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62945
#44: Protein	60S ribosomal protein L36a / 60S ribosomal protein L44 / Cell growth-inhibiting gene 15 protein / Cell migration-inducing gene 6 ...60S ribosomal protein L44 / Cell growth-inhibiting gene 15 protein / Cell migration-inducing gene 6 protein / Large ribosomal subunit protein eL42 Mass: 12476.973 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P83881
#45: Protein	60S ribosomal protein L37a / Large ribosomal subunit protein eL43 Mass: 10299.350 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P61513
#46: Protein	60S ribosomal protein L28 / Large ribosomal subunit protein eL28 Mass: 15784.622 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P46779

+
40S ribosomal protein ... , 30 types, 30 molecules SASBSCSDSESFSGSHSISJSKSLSMSNSOSPSQSRSSSTSUSVSWSXSYSZSaSbScSd

#48: Protein	40S ribosomal protein SA / 37 kDa laminin receptor precursor / 37LRP / 37/67 kDa laminin receptor / LRP/LR / 67 kDa laminin ...37 kDa laminin receptor precursor / 37LRP / 37/67 kDa laminin receptor / LRP/LR / 67 kDa laminin receptor / 67LR / Colon carcinoma laminin-binding protein / Laminin receptor 1 / LamR / Laminin-binding protein precursor p40 / LBP/p40 / Multidrug resistance-associated protein MGr1-Ag / NEM/1CHD4 / Small ribosomal subunit protein uS2 Mass: 32883.938 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P08865
#49: Protein	40S ribosomal protein S3a / Small ribosomal subunit protein eS1 / v-fos transformation effector protein / Fte-1 Mass: 30002.061 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P61247
#50: Protein	40S ribosomal protein S2 / 40S ribosomal protein S4 / Protein LLRep3 / Small ribosomal subunit protein uS5 Mass: 31376.516 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P15880
#51: Protein	40S ribosomal protein S3 / Small ribosomal subunit protein uS3 Mass: 26729.369 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) References: UniProt: P23396, DNA-(apurinic or apyrimidinic site) lyase
#52: Protein	40S ribosomal protein S4, X isoform / SCR10 / Single copy abundant mRNA protein / Small ribosomal subunit protein eS4 Mass: 29654.869 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62701
#53: Protein	40S ribosomal protein S5 / Small ribosomal subunit protein uS7 Mass: 22913.453 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P46782
#54: Protein	40S ribosomal protein S6 / Phosphoprotein NP33 / Small ribosomal subunit protein eS6 Mass: 28751.906 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62753
#55: Protein	40S ribosomal protein S7 / Small ribosomal subunit protein eS7 Mass: 22168.914 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62081
#56: Protein	40S ribosomal protein S8 / Small ribosomal subunit protein eS8 Mass: 24263.387 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62241
#57: Protein	40S ribosomal protein S9 / Small ribosomal subunit protein uS4 Mass: 22641.564 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P46781
#58: Protein	40S ribosomal protein S10 / Small ribosomal subunit protein eS10 Mass: 18933.846 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P46783
#59: Protein	40S ribosomal protein S11 / Small ribosomal subunit protein uS17 Mass: 18468.826 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62280
#60: Protein	40S ribosomal protein S12 / Small ribosomal subunit protein eS12 Mass: 14538.987 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P25398
#61: Protein	40S ribosomal protein S13 / Small ribosomal subunit protein uS15 Mass: 17259.389 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62277
#62: Protein	40S ribosomal protein S14 / Small ribosomal subunit protein uS11 Mass: 16302.772 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62263
#63: Protein	40S ribosomal protein S15 / RIG protein / Small ribosomal subunit protein uS19 Mass: 17076.207 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62841
#64: Protein	40S ribosomal protein S16 / Small ribosomal subunit protein uS9 Mass: 16477.377 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62249
#65: Protein	40S ribosomal protein S17 / Small ribosomal subunit protein eS17 Mass: 15578.156 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P08708
#66: Protein	40S ribosomal protein S18 / Ke-3 / Ke3 / Small ribosomal subunit protein uS13 Mass: 17759.777 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62269
#67: Protein	40S ribosomal protein S19 / Small ribosomal subunit protein eS19 Mass: 16091.562 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P39019
#68: Protein	40S ribosomal protein S20 / Small ribosomal subunit protein uS10 Mass: 13398.763 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P60866
#69: Protein	40S ribosomal protein S21 / Small ribosomal subunit protein eS21 Mass: 9124.389 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P63220
#70: Protein	40S ribosomal protein S15a / Small ribosomal subunit protein uS8 Mass: 14865.555 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62244
#71: Protein	40S ribosomal protein S23 / Small ribosomal subunit protein uS12 Mass: 15844.666 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62266
#72: Protein	40S ribosomal protein S24 / Small ribosomal subunit protein eS24 Mass: 15463.333 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62847
#73: Protein	40S ribosomal protein S25 / Small ribosomal subunit protein eS25 Mass: 13776.224 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62851
#74: Protein	40S ribosomal protein S26 / Small ribosomal subunit protein eS26 Mass: 13047.532 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62854
#75: Protein	40S ribosomal protein S27 / Metallopan-stimulin 1 / MPS-1 / Small ribosomal subunit protein eS27 Mass: 9480.186 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P42677
#76: Protein	40S ribosomal protein S28 / Small ribosomal subunit protein eS28 Mass: 7855.052 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62857
#77: Protein	40S ribosomal protein S29 / Small ribosomal subunit protein uS14 Mass: 6690.821 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P62273

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Non-polymers , 11 types, 801 molecules

#85: Chemical	ChemComp-GDP / GUANOSINE-5'-DIPHOSPHATE Type: RNA linking / Mass: 443.201 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C₁₀H₁₅N₅O₁₁P₂ / Comment: GDP, energy-carrying molecule*YM
#86: Chemical	... ChemComp-MG / MAGNESIUM ION Mass: 24.305 Da / Num. of mol.: 271 / Source method: obtained synthetically / Formula: Mg
#87: Chemical	... ChemComp-K / POTASSIUM ION Mass: 39.098 Da / Num. of mol.: 104 / Source method: obtained synthetically / Formula: K
#88: Chemical	ChemComp-ZN / ZINC ION Mass: 65.409 Da / Num. of mol.: 8 / Source method: obtained synthetically / Formula: Zn
#89: Chemical	ChemComp-PUT / 1,4-DIAMINOBUTANE / PUTRESCINE Mass: 88.151 Da / Num. of mol.: 7 / Source method: obtained synthetically / Formula: C₄H₁₂N₂
#90: Chemical	ChemComp-HYG / HYGROMYCIN B / HYGROMIX / ANTIHELMYCIN / HYDROMYCIN B / DESTOMYSIN / ANTIBIOTIC A-396-II Mass: 527.520 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C₂₀H₃₇N₃O₁₃ / Comment: antibiotic*YM
#91: Chemical	ChemComp-SPD / SPERMIDINE / N-(2-AMINO-PROPYL)-1,4-DIAMINOBUTANE / PA(34) Mass: 145.246 Da / Num. of mol.: 8 / Source method: obtained synthetically / Formula: C₇H₁₉N₃
#92: Chemical	ChemComp-3HE / 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione Mass: 281.347 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C₁₅H₂₃NO₄
#93: Chemical	ChemComp-ANM / ANISOMYCIN Mass: 265.305 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C₁₄H₁₉NO₄ / Comment: antibiotic*YM
#94: Chemical	ChemComp-NA / SODIUM ION Mass: 22.990 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: Na
#95: Water	ChemComp-HOH / water Mass: 18.015 Da / Num. of mol.: 398 / Source method: isolated from a natural source / Formula: H₂O

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Details

Has ligand of interest	Y
Has protein modification	Y

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Experimental details

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Experiment

Experiment	Method: ELECTRON MICROSCOPY
EM experiment	Aggregation state: PARTICLE / 3D reconstruction method: single particle reconstruction

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Sample preparation

Component	Name: CRYO-EM STRUCTURE OF HCT15 POLYSOMES BOUND TO EEF2, EBP1, AND SERBP1 Type: RIBOSOME / Entity ID: #1-#84 / Source: NATURAL
Source (natural)	Organism: Homo sapiens (human)
Buffer solution	pH: 7.6
Specimen	Embedding applied: NO / Shadowing applied: NO / Staining applied: NO / Vitrification applied: YES
Specimen support	Grid material: COPPER / Grid type: Quantifoil R2/2
Vitrification	Cryogen name: ETHANE

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Electron microscopy imaging

Experimental equipment	Model: Titan Krios / Image courtesy: FEI Company
Microscopy	Model: FEI TITAN KRIOS
Electron gun	Electron source: FIELD EMISSION GUN / Accelerating voltage: 300 kV / Illumination mode: FLOOD BEAM
Electron lens	Mode: BRIGHT FIELD / Nominal defocus max: 1700 nm / Nominal defocus min: 600 nm
Image recording	Electron dose: 1 e/Å² / Film or detector model: GATAN K3 BIOQUANTUM (6k x 4k)

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Processing

EM software

Name: PHENIX / Version: 1.20.1_4487: / Category: model refinement

CTF correction

Type: PHASE FLIPPING AND AMPLITUDE CORRECTION

3D reconstruction

Resolution: 2.85 Å / Resolution method: FSC 0.143 CUT-OFF / Num. of particles: 546553 / Symmetry type: POINT

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
ELECTRON MICROSCOPY	f_bond_d	0.005	230602
ELECTRON MICROSCOPY	f_angle_d	0.658	337057
ELECTRON MICROSCOPY	f_dihedral_angle_d	15.81	77358
ELECTRON MICROSCOPY	f_chiral_restr	0.042	41560
ELECTRON MICROSCOPY	f_plane_restr	0.006	22703

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Protein , 9 types, 9 molecules CBCDLFLmSeSfSgLqCA

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RNA chain , 5 types, 5 molecules CCL8S2L5L7

+
60S ribosomal protein ... , 40 types, 40 molecules LALBLCLDLELGLHLILJLLLMLNLOLPLQLRLSLTLULVLWLXLYLZLaLbLcLdLeLf...

+
40S ribosomal protein ... , 30 types, 30 molecules SASBSCSDSESFSGSHSISJSKSLSMSNSOSPSQSRSSSTSUSVSWSXSYSZSaSbScSd

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Non-polymers , 11 types, 801 molecules

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Details

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Experimental details

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Experiment

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-Protein , 9 types, 9 molecules CBCDLFLmSeSfSgLqCA

-RNA chain , 5 types, 5 molecules CCL8S2L5L7

+60S ribosomal protein ... , 40 types, 40 molecules LALBLCLDLELGLHLILJLLLMLNLOLPLQLRLSLTLULVLWLXLYLZLaLbLcLdLeLf...

+40S ribosomal protein ... , 30 types, 30 molecules SASBSCSDSESFSGSHSISJSKSLSMSNSOSPSQSRSSSTSUSVSWSXSYSZSaSbScSd

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Protein , 9 types, 9 molecules CBCDLFLmSeSfSgLqCA

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RNA chain , 5 types, 5 molecules CCL8S2L5L7

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60S ribosomal protein ... , 40 types, 40 molecules LALBLCLDLELGLHLILJLLLMLNLOLPLQLRLSLTLULVLWLXLYLZLaLbLcLdLeLf...

+
40S ribosomal protein ... , 30 types, 30 molecules SASBSCSDSESFSGSHSISJSKSLSMSNSOSPSQSRSSSTSUSVSWSXSYSZSaSbScSd

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Non-polymers , 11 types, 801 molecules

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Details

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Experimental details

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Experiment

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Sample preparation

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Electron microscopy imaging

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