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- PDB-9fmb: Crystal structure of human IgD-Fc -

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Basic information

Entry
Database: PDB / ID: 9fmb
TitleCrystal structure of human IgD-Fc
ComponentsIsoform 1 of Immunoglobulin heavy constant delta
KeywordsIMMUNE SYSTEM / antibody / immunoglobulin / IgD / Fc region
Function / homology
Function and homology information


IgD immunoglobulin complex / positive regulation of interleukin-1 production / CD22 mediated BCR regulation / immunoglobulin mediated immune response / antigen binding / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / B cell receptor signaling pathway / blood microparticle / adaptive immune response / Potential therapeutics for SARS ...IgD immunoglobulin complex / positive regulation of interleukin-1 production / CD22 mediated BCR regulation / immunoglobulin mediated immune response / antigen binding / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / B cell receptor signaling pathway / blood microparticle / adaptive immune response / Potential therapeutics for SARS / immune response / extracellular space / extracellular exosome / plasma membrane
Similarity search - Function
: / Immunoglobulin D, delta linker region / Immunoglobulin / Immunoglobulin domain / : / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain ...: / Immunoglobulin D, delta linker region / Immunoglobulin / Immunoglobulin domain / : / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold
Similarity search - Domain/homology
ACETATE ION / DI(HYDROXYETHYL)ETHER / Immunoglobulin heavy constant delta
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3 Å
AuthorsDavies, A.M. / McDonnell, J.M.
Funding support United Kingdom, 1items
OrganizationGrant numberCountry
Medical Research Council (MRC, United Kingdom)MR/V010557/1 United Kingdom
CitationJournal: Proteins / Year: 2025
Title: The Crystal Structure of Human IgD-Fc Reveals Unexpected Differences With Other Antibody Isotypes.
Authors: Davies, A.M. / Bui, T.T.T. / Pacheco-Gomez, R. / Vester, S.K. / Beavil, A.J. / Gould, H.J. / Sutton, B.J. / McDonnell, J.M.
History
DepositionJun 5, 2024Deposition site: PDBE / Processing site: PDBE
Revision 1.0Dec 4, 2024Provider: repository / Type: Initial release
Revision 1.1Mar 12, 2025Group: Database references / Category: citation / citation_author
Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.year / _citation_author.identifier_ORCID

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Isoform 1 of Immunoglobulin heavy constant delta
B: Isoform 1 of Immunoglobulin heavy constant delta
C: Isoform 1 of Immunoglobulin heavy constant delta
D: Isoform 1 of Immunoglobulin heavy constant delta
hetero molecules


Theoretical massNumber of molelcules
Total (without water)109,64419
Polymers103,0284
Non-polymers6,61615
Water27015
1
A: Isoform 1 of Immunoglobulin heavy constant delta
B: Isoform 1 of Immunoglobulin heavy constant delta
hetero molecules


Theoretical massNumber of molelcules
Total (without water)54,9759
Polymers51,5142
Non-polymers3,4617
Water362
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
2
C: Isoform 1 of Immunoglobulin heavy constant delta
D: Isoform 1 of Immunoglobulin heavy constant delta
hetero molecules


Theoretical massNumber of molelcules
Total (without water)54,66910
Polymers51,5142
Non-polymers3,1558
Water362
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)105.825, 43.667, 121.470
Angle α, β, γ (deg.)90.00, 107.96, 90.00
Int Tables number4
Space group name H-MP1211

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Components

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Protein , 1 types, 4 molecules ABCD

#1: Protein
Isoform 1 of Immunoglobulin heavy constant delta / Ig delta chain C region / Ig delta chain C region NIG-65 / Ig delta chain C region WAH


Mass: 25757.117 Da / Num. of mol.: 4
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: IGHD / Cell line (production host): HEK293 / Production host: Homo sapiens (human) / References: UniProt: P01880

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Sugars , 4 types, 7 molecules

#2: Polysaccharide alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D- ...alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose


Type: oligosaccharide / Mass: 1235.105 Da / Num. of mol.: 1 / Source method: obtained synthetically
DescriptorTypeProgram
DManpa1-2DManpa1-3[DManpa1-3DManpa1-6]DManpb1-4DGlcpNAcb1-4DGlcpNAcb1-ROHGlycam Condensed SequenceGMML 1.0
WURCS=2.0/3,7,6/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1122h-1a_1-5]/1-1-2-3-3-3-3/a4-b1_b4-c1_c3-d1_c6-f1_d2-e1_f3-g1WURCSPDB2Glycan 1.1.0
[][D-1-deoxy-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-Manp]{[(3+1)][a-D-Manp]{[(2+1)][a-D-Manp]{}}[(6+1)][a-D-Manp]{[(3+1)][a-D-Manp]{}}}}}LINUCSPDB-CARE
#3: Polysaccharide alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D- ...alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose


Type: oligosaccharide / Mass: 1559.386 Da / Num. of mol.: 2 / Source method: obtained synthetically
DescriptorTypeProgram
DManpa1-2DManpa1-2DManpa1-3[DManpa1-3[DManpa1-6]DManpa1-6]DManpb1-4DGlcpNAcb1-4DGlcpNAcb1-ROHGlycam Condensed SequenceGMML 1.0
WURCS=2.0/3,9,8/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1122h-1a_1-5]/1-1-2-3-3-3-3-3-3/a4-b1_b4-c1_c3-d1_c6-g1_d2-e1_e2-f1_g3-h1_g6-i1WURCSPDB2Glycan 1.1.0
[][D-1-deoxy-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-Manp]{[(3+1)][a-D-Manp]{[(2+1)][a-D-Manp]{[(2+1)][a-D-Manp]{}}}[(6+1)][a-D-Manp]{[(3+1)][a-D-Manp]{}[(6+1)][a-D-Manp]{}}}}}LINUCSPDB-CARE
#4: Polysaccharide alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D- ...alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose


Type: oligosaccharide / Mass: 1072.964 Da / Num. of mol.: 1 / Source method: obtained synthetically
DescriptorTypeProgram
DManpa1-2DManpa1-3[DManpa1-6]DManpb1-4DGlcpNAcb1-4DGlcpNAcb1-ROHGlycam Condensed SequenceGMML 1.0
WURCS=2.0/3,6,5/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1122h-1a_1-5]/1-1-2-3-3-3/a4-b1_b4-c1_c3-d1_c6-f1_d2-e1WURCSPDB2Glycan 1.1.0
[][D-1-deoxy-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-Manp]{[(3+1)][a-D-Manp]{[(2+1)][a-D-Manp]{}}[(6+1)][a-D-Manp]{}}}}LINUCSPDB-CARE
#5: Sugar ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE


Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 3 / Source method: isolated from a natural source / Formula: C8H15NO6
IdentifierTypeProgram
DGlcpNAcbCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
N-acetyl-b-D-glucopyranosamineCOMMON NAMEGMML 1.0
b-D-GlcpNAcIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
GlcNAcSNFG CARBOHYDRATE SYMBOLGMML 1.0

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Non-polymers , 4 types, 23 molecules

#6: Chemical ChemComp-PEG / DI(HYDROXYETHYL)ETHER


Mass: 106.120 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C4H10O3
#7: Chemical
ChemComp-ACT / ACETATE ION


Mass: 59.044 Da / Num. of mol.: 5 / Source method: obtained synthetically / Formula: C2H3O2
#8: Chemical ChemComp-EDO / 1,2-ETHANEDIOL / ETHYLENE GLYCOL


Mass: 62.068 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C2H6O2
#9: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 15 / Source method: isolated from a natural source / Formula: H2O

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Details

Has ligand of interestN
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.59 Å3/Da / Density % sol: 52.53 %
Crystal growTemperature: 291 K / Method: vapor diffusion, sitting drop / pH: 5.5
Details: 0.1M Bis-Tris pH5.5, 25% PEG 3350, 0.2M ammonium acetate

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: Diamond / Beamline: I24 / Wavelength: 0.6888 Å
DetectorType: DECTRIS EIGER X 9M / Detector: PIXEL / Date: May 8, 2023
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.6888 Å / Relative weight: 1
ReflectionResolution: 3→52.45 Å / Num. obs: 21769 / % possible obs: 99.9 % / Redundancy: 15.5 % / Biso Wilson estimate: 38.73 Å2 / CC1/2: 0.962 / Rpim(I) all: 0.142 / Net I/σ(I): 5.9
Reflection shellResolution: 3→3.18 Å / Redundancy: 15.8 % / Mean I/σ(I) obs: 2 / Num. unique obs: 3452 / CC1/2: 0.349 / Rpim(I) all: 0.504 / % possible all: 99.3

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Processing

Software
NameVersionClassification
PHENIX(1.20.1_4487: ???)refinement
Aimlessdata scaling
DIALSdata reduction
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT / Resolution: 3→52.45 Å / SU ML: 0.51 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 27.92 / Stereochemistry target values: ML
RfactorNum. reflection% reflection
Rfree0.2882 1088 5 %
Rwork0.2283 --
obs0.2313 21745 99.92 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
Refinement stepCycle: LAST / Resolution: 3→52.45 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms5845 0 442 15 6302
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.003
X-RAY DIFFRACTIONf_angle_d0.67
X-RAY DIFFRACTIONf_dihedral_angle_d14.0492390
X-RAY DIFFRACTIONf_chiral_restr0.0471140
X-RAY DIFFRACTIONf_plane_restr0.0051052
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
3-3.140.40791350.33292564X-RAY DIFFRACTION100
3.14-3.30.34571330.26882524X-RAY DIFFRACTION100
3.3-3.510.30451330.25252538X-RAY DIFFRACTION100
3.51-3.780.30251360.22932568X-RAY DIFFRACTION100
3.78-4.160.27921350.20432576X-RAY DIFFRACTION100
4.16-4.760.22961360.18232578X-RAY DIFFRACTION100
4.76-60.23671380.2012603X-RAY DIFFRACTION100
6-52.450.2891420.23162706X-RAY DIFFRACTION100
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
10.1738-0.0978-0.09440.09010.01150.2423-0.10530.0213-0.22790.0031-0.07440.20820.14350.0087-0.18770.1401-0.0028-0.02370.0890.02740.1265-16.924419.0759-16.3583
20.0044-0.0034-0.00290.04140.03910.0119-0.1325-0.0035-0.1054-0.2114-0.00880.0340.0520.0167-0.16230.32390.12230.0518-0.11930.09920.1749-18.626414.9555-11.0782
30.5029-0.0520.01850.166-0.08490.2189-0.18170.2748-0.05480.0935-0.07270.28350.0524-0.113-0.07540.2016-0.04070.00970.1065-0.03240.4583-21.390318.1382-22.0818
40.0662-0.0039-0.00870.01830.01180.00360.1036-0.00450.2296-0.0202-0.02980.0007-0.1256-0.07740.03510.13650.0472-0.02980.110.04710.3314-19.709729.5413-18.2335
50.05780.017-0.02760.15110.02060.02110.0060.0123-0.0686-0.0734-0.016-0.13260.0253-0.0478-0.01580.68520.3533-0.19090.5723-0.01610.3666-3.643719.2285-48.9465
60.6550.003-0.190.03220.09170.3280.33960.10330.182-0.01960.1109-0.00870.00180.0750.37020.27230.11380.05430.3106-0.06540.0706-6.550118.6646-38.8619
70.04790.0319-0.02820.0253-0.03130.05930.04330.12450.04520.03110.0130.0355-0.01710.04760.05760.49040.32980.02010.3269-0.15990.0841-2.407227.1179-39.1164
80.060.0041-0.06680.0820.06590.13450.03160.12420.02760.04410.089-0.02210.0452-0.00470.07810.26230.2031-0.13330.2683-0.20910.2146-11.962417.1213-41.6556
90.38710.2508-0.14160.7256-0.02850.4590.22310.15090.0750.3638-0.0824-0.1670.02110.15020.1510.01220.0185-0.03080.1780.00220.132411.350422.6427-9.6651
100.8726-0.00380.1580.2971-0.070.5138-0.1194-0.06610.12950.0713-0.28-0.0786-0.31120.1483-0.4490.1833-0.1519-0.02820.1637-0.16040.071911.572727.4429-5.6684
110.0842-0.02420.04110.01590.0080.03860.1222-0.00060.00850.1746-0.1305-0.1093-0.07980.1389-0.03250.3489-0.016-0.11820.05620.01350.397718.516123.4632-14.2095
120.225-0.01160.24430.278-0.10170.31560.22540.10260.08010.0709-0.2657-0.16520.05160.3142-0.01920.23120.0193-0.13480.15430.04430.339515.208212.343-10.8279
130.0811-0.03360.08210.0363-0.03780.10360.10030.00960.0624-0.05760.1236-0.07670.02760.10150.23490.31040.21330.17510.29090.05620.228811.723418.6475-38.6245
140.00610.020.01310.05990.0320.0214-0.02750.05990.088-0.0569-0.0617-0.0733-0.0157-0.0537-0.03070.44520.0915-0.12520.490.17360.280710.547827.0405-35.7475
150.0360.00230.00360.00150.00590.0490.04650.0954-0.15740.0919-0.023-0.05070.06020.0305-0.02280.38360.1977-0.20750.2803-0.03550.26917.053113.3555-36.2378
160.00820.01350.02420.00960.00290.0103-0.01580.0125-0.17480.0054-0.1396-0.04050.0277-0.0357-0.03440.17070.08240.05810.3960.11520.346818.121719.7463-33.7247
170.10180.03440.02860.03040.0470.0758-0.01070.1593-0.0413-0.0291-0.0447-0.1507-0.05790.12270.07470.1684-0.04640.1202-0.06730.2686-0.0093-38.19022.4396-22.3794
180.013-0.03960.0090.0741-0.01380.0081-0.0201-0.04860.0802-0.06510.0906-0.15310.1010.01770.0940.13420.0106-0.04880.1344-0.13920.2173-34.24921.6265-11.7229
190.00070.00470.00370.02640.01040.0043-0.00820.00190.08730.02190.02480.0137-0.1149-0.0060.03290.2896-0.1233-0.1480.14280.02390.4572-24.37572.5676-17.0815
200.0422-0.00690.00310.00330.00680.01660.00550.00280.0442-0.04270.0707-0.07120.03140.09130.04420.1751-0.0485-0.0320.27-0.16080.1995-44.10629.93-5.7159
210.1514-0.06160.09410.0243-0.04590.06530.05220.12340.04370.0271-0.114-0.11280.08350.1266-0.01640.20530.00070.04080.13730.01090.3046-31.63362.9354-22.3387
220.3012-0.0228-0.03710.2343-0.05060.01540.245-0.0158-0.03750.1757-0.1673-0.17180.07160.0432-0.0280.2622-0.0284-0.01250.0752-0.03690.1866-33.2674-8.3599-18.0752
230.4142-0.02820.17910.21060.00610.09660.17320.1043-0.0820.14250.1219-0.0277-0.1535-0.13330.21350.34470.14740.00610.4031-0.00530.1885-47.7761-1.5486-40.3144
240.0314-0.0303-0.01550.0146-0.00190.00420.08110.027-0.0510.02870.0139-0.00980.05830.07150.02460.17350.3482-0.00640.56770.11870.4095-47.49464.5021-42.3294
250.1088-0.0398-0.05250.08470.03710.04440.03020.01150.07670.0139-0.10230.0516-0.0046-0.0744-0.06130.2380.1730.16950.4889-0.00340.1093-37.8821-1.2291-39.671
260.1474-0.0416-0.03420.04290.0070.00590.11070.1147-0.04340.089-0.07470.0096-0.0917-0.05490.00330.14770.00740.15290.1896-0.05990.3085-65.431-1.5096-16.2251
270.1069-0.1233-0.0910.21440.02620.1077-0.1642-0.1802-0.08820.22930.00250.02420.3047-0.0589-0.12650.1324-0.0420.05780.25580.02710.1951-64.6953-3.8262-5.4432
280.1866-0.04350.02460.3510.35360.5143-0.06580.0749-0.05250.0057-0.17890.1654-0.024-0.1289-0.19770.16640.0320.08750.0790.04240.1448-71.4826-2.3094-13.8953
290.1666-0.108-0.15130.05450.09410.13230.1567-0.00330.05210.1978-0.07670.1496-0.1442-0.1316-0.00250.1867-0.03260.03020.070.01340.1962-66.18546.0747-3.527
300.06580.01650.03730.188-0.13510.11530.13440.3380.10240.12140.06230.0849-0.03330.10720.21550.14530.091-0.18270.4778-0.0030.1227-66.01814.6833-38.035
310.00580.00120.00620.06430.00680.00450.0108-0.026-0.0337-0.02990.0078-0.06050.03110.0495-0.01790.12280.26140.04720.5859-0.13480.3419-64.4188-1.4657-32.6087
320.0240.012-0.02590.0033-0.00930.01740.02850.03630.0474-0.0083-0.0192-0.00810.0238-0.03440.01120.39840.16560.17910.45320.13810.1791-60.51738.0316-35.9226
330.00850.0525-0.02840.339-0.06710.09150.07940.220.08880.25850.0187-0.0102-0.0380.0209-0.00550.16190.1472-0.06820.4245-0.14820.4238-71.3371.0686-33.277
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection details
1X-RAY DIFFRACTION1chain 'A' and (resid 294 through 335 )
2X-RAY DIFFRACTION2chain 'A' and (resid 336 through 356 )
3X-RAY DIFFRACTION3chain 'A' and (resid 357 through 372 )
4X-RAY DIFFRACTION4chain 'A' and (resid 373 through 402 )
5X-RAY DIFFRACTION5chain 'A' and (resid 403 through 418 )
6X-RAY DIFFRACTION6chain 'A' and (resid 419 through 450 )
7X-RAY DIFFRACTION7chain 'A' and (resid 451 through 471 )
8X-RAY DIFFRACTION8chain 'A' and (resid 472 through 501 )
9X-RAY DIFFRACTION9chain 'B' and (resid 291 through 335 )
10X-RAY DIFFRACTION10chain 'B' and (resid 336 through 356 )
11X-RAY DIFFRACTION11chain 'B' and (resid 357 through 372 )
12X-RAY DIFFRACTION12chain 'B' and (resid 373 through 403 )
13X-RAY DIFFRACTION13chain 'B' and (resid 404 through 439 )
14X-RAY DIFFRACTION14chain 'B' and (resid 440 through 450 )
15X-RAY DIFFRACTION15chain 'B' and (resid 451 through 471 )
16X-RAY DIFFRACTION16chain 'B' and (resid 472 through 500 )
17X-RAY DIFFRACTION17chain 'C' and (resid 294 through 313 )
18X-RAY DIFFRACTION18chain 'C' and (resid 314 through 335 )
19X-RAY DIFFRACTION19chain 'C' and (resid 336 through 346 )
20X-RAY DIFFRACTION20chain 'C' and (resid 347 through 356 )
21X-RAY DIFFRACTION21chain 'C' and (resid 357 through 372 )
22X-RAY DIFFRACTION22chain 'C' and (resid 373 through 402 )
23X-RAY DIFFRACTION23chain 'C' and (resid 403 through 464 )
24X-RAY DIFFRACTION24chain 'C' and (resid 465 through 488 )
25X-RAY DIFFRACTION25chain 'C' and (resid 489 through 501 )
26X-RAY DIFFRACTION26chain 'D' and (resid 294 through 313 )
27X-RAY DIFFRACTION27chain 'D' and (resid 314 through 356 )
28X-RAY DIFFRACTION28chain 'D' and (resid 357 through 372 )
29X-RAY DIFFRACTION29chain 'D' and (resid 373 through 392 )
30X-RAY DIFFRACTION30chain 'D' and (resid 393 through 428 )
31X-RAY DIFFRACTION31chain 'D' and (resid 429 through 450 )
32X-RAY DIFFRACTION32chain 'D' and (resid 451 through 471 )
33X-RAY DIFFRACTION33chain 'D' and (resid 472 through 499 )

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