PDB-9fik: Structure of the FAB fragment of the Antibody NTF30037 in complex...

ID or keywords:

Entry

Database: PDB / ID: 9fik

Title

Structure of the FAB fragment of the Antibody NTF30037 in complex with NTF3

Components

NTF30037 Heavy Chain
NTF30037 Light Chain
Neurotrophin-3

Keywords

IMMUNE SYSTEM / NTF3 / phage display / X ray crystallography / antibody

Function / homology

Function and homology information

NTF3 activates NTRK3 signaling / NTF3 activates NTRK2 (TRKB) signaling / Activated NTRK3 signals through PLCG1 / Signaling by NTRK3 (TRKC) / nerve growth factor receptor binding / nerve growth factor signaling pathway / nerve development / induction of positive chemotaxis / Activated NTRK3 signals through PI3K / chemoattractant activity ...
Similarity search - Function

Biological species

Homo sapiens (human)

Method

X-RAY DIFFRACTION /

SYNCHROTRON /

MOLECULAR REPLACEMENT / Resolution: 1.86 Å

Authors

Gallego, P. / Aagaard, A. / Sjogren, T. / Chin, S. / Neal, F.

Funding support

1items

Citation

Journal: Slas Discov / Year: 2025
Title: Identification of unique binding mode anti-NTF3 antibodies from a novel long VH CDR3 phage display library.
Authors: Chin, S.E. / Gallego, P. / Aagaard, A. / Carmen, S. / Barrett, N. / Wolny, M. / Cloarec, S. / Paterson, J. / Sivapalan, R. / Hunt, J. / Murray, T.V. / Delaney, T. / Sjogren, T. / Neal, F.

History

Deposition	May 29, 2024	Deposition site: PDBE / Processing site: PDBE
Revision 1.0	Apr 2, 2025	Provider: repository / Type: Initial release
Revision 1.1	Apr 9, 2025	Group: Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title

Structure viewer	Molecule: MolmilJmol/JSmol

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Download

PDBx/mmCIF format	9fik.cif.gz	288.4 KB	Display	PDBx/mmCIF format
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Validation report

Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/fi/9fik ftp://data.pdbj.org/pub/pdb/validation_reports/fi/9fik	HTTPS FTP

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Related structure data

Similar structure data	Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#68 - Aug 2005 Neurotrophins similarity (8) #21 - Sep 2001 Antibodies similarity (1) #256 - Apr 2021 SARS-CoV-2 Spike and Antibodies similarity (1) #267 - Mar 2022 Vascular Endothelial Growth Factor (VegF similarity (1) #43 - Jul 2003 Src Tyrosine Kinase similarity (1) #60 - Dec 2004 Ubiquitin similarity (1) #148 - Apr 2012 Ras Protein similarity (1) #195 - Mar 2016 RAF Protein Kinases similarity (1)

PDB pages

PDBj /

wwPDB /

NCBI

Related items in Molecule of the Month

#68 - Aug 2005
Neurotrophins
similarity (8)
#21 - Sep 2001
Antibodies
similarity (1)
#256 - Apr 2021
SARS-CoV-2 Spike and Antibodies
similarity (1)
#267 - Mar 2022
Vascular Endothelial Growth Factor (VegF
similarity (1)
#43 - Jul 2003
Src Tyrosine Kinase
similarity (1)
#60 - Dec 2004
Ubiquitin
similarity (1)
#148 - Apr 2012
Ras Protein
similarity (1)
#195 - Mar 2016
RAF Protein Kinases
similarity (1)

Deposited unit

A: Neurotrophin-3

B: NTF30037 Heavy Chain

C: NTF30037 Light Chain

hetero molecules

62.4 kDa, 3 polymers
Search similar-shape structures of this assembly by Omokage search (details)

1

Idetical with deposited unit
defined by author&software

Unit cell

Length a, b, c (Å)	69.746, 108.549, 208.217
Angle α, β, γ (deg.)	90.000, 90.000, 90.000
Int Tables number	20
Space group name H-M	C222₁
Space group name Hall	C2c2
Symmetry operation	#1: x,y,z #2: x,-y,-z #3: -x,y,-z+1/2 #4: -x,-y,z+1/2 #5: x+1/2,y+1/2,z #6: x+1/2,-y+1/2,-z #7: -x+1/2,y+1/2,-z+1/2 #8: -x+1/2,-y+1/2,z+1/2

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Protein , 1 types, 1 molecules A

#1: Protein	Neurotrophin-3 / NT-3 / HDNF / Nerve growth factor 2 / NGF-2 / Neurotrophic factor Mass: 13778.517 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: NTF3 / Production host: Escherichia coli (E. coli) / References: UniProt: P20783

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Antibody , 2 types, 2 molecules BC

#2: Antibody	NTF30037 Heavy Chain Mass: 25181.148 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Cell line (production host): HEK293 / Production host: Homo sapiens (human)
#3: Antibody	NTF30037 Light Chain Mass: 22725.016 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Cell line (production host): HEK293 / Production host: Homo sapiens (human)

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Non-polymers , 4 types, 485 molecules

#4: Chemical	ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL Mass: 92.094 Da / Num. of mol.: 5 / Source method: obtained synthetically / Formula: C₃H₈O₃
#5: Chemical	ChemComp-PEG / DI(HYDROXYETHYL)ETHER Mass: 106.120 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C₄H₁₀O₃
#6: Chemical	ChemComp-NA / SODIUM ION Mass: 22.990 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: Na
#7: Water	ChemComp-HOH / water Mass: 18.015 Da / Num. of mol.: 477 / Source method: isolated from a natural source / Formula: H₂O

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Details

Has ligand of interest	N
Has protein modification	Y

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 3.19 Å³/Da / Density % sol: 61.5 %
Crystal grow	Temperature: 293 K / Method: vapor diffusion / pH: 6.5 Details: 15 % w/v Polyethylene glycol 8,000, 0.2 M Sodium Acetate, 0.1 M MES pH 6.5

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Data collection

Diffraction	Mean temperature: 100 K / Serial crystal experiment: N
Diffraction source	Source: SYNCHROTRON / Site: ESRF / Beamline: ID30B / Wavelength: 0.8856 Å
Detector	Type: DECTRIS EIGER2 S 9M / Detector: PIXEL / Date: Jan 19, 2023
Radiation	Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelength	Wavelength: 0.8856 Å / Relative weight: 1
Reflection	Resolution: 1.859→58.68 Å / Num. obs: 51862 / % possible obs: 92.2 % / Redundancy: 13.4 % / B_iso Wilson estimate: 21.18 Å² / CC_1/2: 0.996 / Net I/σ(I): 9.3
Reflection shell	Resolution: 1.859→2.032 Å / Num. unique obs: 2593 / CC_1/2: 0.618

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Processing

Software

Name	Version	Classification
PHENIX	1.20.1_4487	refinement
XDS		data reduction
STARANISO		data scaling
MOLREP		phasing

Refinement

Method to determine structure:

MOLECULAR REPLACEMENT / Resolution: 1.86→58.68 Å / SU ML: 0.1551 / Cross valid method: FREE R-VALUE / σ(F): 1.36 / Phase error: 19.0879
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2

	R_factor	Num. reflection	% reflection
R_free	0.1862	-	-
R_work	0.1862	0	-
obs	0.1862	51851	77.62 %

Solvent computation

Shrinkage radii: 0.9 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL

Displacement parameters

B_iso mean: 36.93 Å²

Refinement step

Cycle: LAST / Resolution: 1.86→58.68 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	4128	0	44	477	4649

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.0078	4333
X-RAY DIFFRACTION	f_angle_d	0.9965	5904
X-RAY DIFFRACTION	f_chiral_restr	0.066	659
X-RAY DIFFRACTION	f_plane_restr	0.0079	754
X-RAY DIFFRACTION	f_dihedral_angle_d	6.9669	618

LS refinement shell

Resolution (Å)	R_factor R_free	Num. reflection R_free	R_factor R_work	Num. reflection R_work	Refine-ID	% reflection obs (%)
1.86-1.88	0.316	15	0.316	15	X-RAY DIFFRACTION
1.88-1.9	0.2989	53	0.2989	53	X-RAY DIFFRACTION
1.9-1.93	0.3072	143	0.3072	143	X-RAY DIFFRACTION
1.93-1.95	0.2952	254	0.2952	254	X-RAY DIFFRACTION
1.95-1.98	0.3127	404	0.3127	404	X-RAY DIFFRACTION
1.98-2	0.275	654	0.275	654	X-RAY DIFFRACTION	29.61
2-2.03	0.2625	1016	0.2625	1016	X-RAY DIFFRACTION	46.14
2.03-2.06	0.2688	1419	0.2688	1419	X-RAY DIFFRACTION	64.74
2.06-2.09	0.258	1701	0.258	1701	X-RAY DIFFRACTION	76.73
2.09-2.13	0.2512	1976	0.2512	1976	X-RAY DIFFRACTION	90.43
2.13-2.16	0.2471		0.2471	2139	X-RAY DIFFRACTION	96.79
2.16-2.2	0.2472		0.2472	2166	X-RAY DIFFRACTION	98.23
2.2-2.25	0.2405		0.2405	2181	X-RAY DIFFRACTION	98.24
2.25-2.29	0.2365		0.2365	2186	X-RAY DIFFRACTION	98.56
2.29-2.34	0.2348		0.2348	2155	X-RAY DIFFRACTION	98.4
2.34-2.4	0.2342	2212	0.2342	2212	X-RAY DIFFRACTION	98.57
2.4-2.46	0.2258	2163	0.2258	2163	X-RAY DIFFRACTION	98.45
2.46-2.52	0.2174	2175	0.2174	2175	X-RAY DIFFRACTION	98.42
2.52-2.6	0.2105	2217	0.2105	2217	X-RAY DIFFRACTION	98.88
2.6-2.68	0.2158	2216	0.2158	2216	X-RAY DIFFRACTION	99.15
2.68-2.78	0.2229	2161	0.2229	2161	X-RAY DIFFRACTION	98.54
2.78-2.89	0.1957	2201	0.1957	2201	X-RAY DIFFRACTION	98.92
2.89-3.02	0.193	2223	0.193	2223	X-RAY DIFFRACTION	98.89
3.02-3.18	0.1814	2217	0.1814	2217	X-RAY DIFFRACTION	99.46
3.18-3.38	0.1698	2232	0.1698	2232	X-RAY DIFFRACTION	99.11
3.38-3.64	0.1511	2214	0.1511	2214	X-RAY DIFFRACTION	99.1
3.64-4	0.1386	2249	0.1386	2249	X-RAY DIFFRACTION	99.51
4-4.58	0.1203	2251	0.1203	2251	X-RAY DIFFRACTION	99.12
4.58-5.77	0.1297	2281	0.1297	2281	X-RAY DIFFRACTION	99.65
5.78-58.68	0.1743	2377	0.1743	2377	X-RAY DIFFRACTION	98.96

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	1.12724386241	0.475737935957	-0.214534049602	4.2672571409	0.61440953365	1.62042185843	-0.0663489870502	0.276551589435	-0.079351041363	-0.389260711632	0.173733266546	0.236532886261	-0.00706274710025	-0.110428838229	-0.0333453342982	0.213167454798	0.0104957295268	-0.0326514011215	0.0827555322406	0.0193501160404	0.228698819591	-41.3791258811	-50.6014164333	-7.86944012161
2	0.164461698444	-0.609481001633	-0.106136179063	2.41653892397	0.0549734089563	0.767461066734	0.192008898962	0.069733628722	-0.534518888588	-0.0455860042083	0.114490811142	-1.27183272988	0.656038280132	0.512859119228	-0.299284855193	0.395696207546	0.0966166714209	0.0437307232496	0.0964039881743	-0.176071062209	0.999875253298	-23.4681413098	-56.1686913375	-7.00308352548
3	5.73134127005	-0.867245458544	-0.441472422895	3.67590769932	-0.163791738043	2.74353775565	0.105576617476	0.496399296088	-0.00351977221781	-0.511111162208	0.0576259816877	0.824949344009	0.11684856246	-0.509637933152	-0.00627742604013	0.267651122992	-0.0252344092447	-0.0795830108871	0.194371538887	0.0295424131708	0.417708169895	-49.2902493598	-55.3009338683	-9.70568740233
4	0.450279411362	-0.532117674799	-0.773778080094	2.92799070977	-0.130127013525	1.9326072869	0.321105849673	0.252700014363	-0.228168568611	-0.0719639808942	0.0491842444367	0.432155136894	-0.150599142058	-0.42055652899	0.240983225896	0.239755171397	0.00492171761164	-0.00655070438898	0.0129864527493	0.00763854149527	0.363682248499	-48.5847574903	-47.8628487905	-4.0128067232
5	2.96528557143	-0.406859078627	2.33695638171	0.496307610252	-0.146617957375	3.75456242815	-0.0575874647013	-0.945988215869	0.46819821486	0.33898153272	-0.0557848431438	-0.185078539545	-0.435486833384	0.178392079982	0.416619852685	0.24674267272	-0.0464795424618	0.0440122613263	0.650884993952	-0.192337510355	0.253387213232	-27.2920125079	-20.1116369314	32.3433879599
6	3.07885937071	-0.156656642944	1.38825718234	0.499810218856	-0.0425035226239	2.36660568209	0.163406814082	-0.859004048581	0.235943986603	0.109559945181	-0.10617232128	0.117494871611	-0.0829092392602	-0.308803295443	0.0333847544108	0.192733027283	-0.0572298431868	0.0350765206665	0.371830527247	-0.0401378178433	0.179746857011	-35.1123071663	-25.1308132101	23.8610048202
7	3.18980354082	-0.306482547422	1.11083894851	1.14123353803	-0.0784219708286	2.61222833125	0.146429836344	-1.3403271176	0.156924993367	0.127242537952	-0.0250437342616	0.108395981524	-0.123877465706	-0.364936264301	0.0648520182949	0.241195664955	-0.0780619818497	0.064708340768	0.693105429368	-0.0639889620165	0.274949882828	-37.1524475778	-25.1484639536	30.6701856936
8	1.666559885	0.186949082868	0.877796057295	0.0978693306783	-0.0926812118294	2.42909106146	0.249358513542	-1.00070460505	-0.159574308692	0.164342088203	0.0079254608662	0.099575431171	0.162536684925	-0.0655292358446	-0.197841858708	0.2470745669	-0.0619326809194	0.0136174866759	0.540411820677	0.0136040678146	0.162039692296	-27.4197263502	-28.3290943993	30.0125658896
9	2.23746618565	0.198004810869	1.28752508253	0.553117904189	0.429399908538	2.15363932452	0.0677591376278	-0.709718988366	0.025348875744	0.0612643199241	-0.061310206209	0.0647292345561	-0.0483156896712	-0.119935531954	-0.125724523611	0.174579398471	-0.0312615695707	0.0322140593419	0.308255180205	-0.0374960593357	0.12876869037	-29.7741544338	-27.2514097674	21.3220847214
10	0.461929204857	-0.489160928016	0.817095222482	2.3010959849	-0.0240198447209	1.84422067261	-0.157519809119	0.149774770025	0.0234235092441	-0.238130755662	0.11632077726	-0.407755239089	-0.181400117243	1.10898173407	0.18433459121	0.32670500775	-0.0838290178884	-0.0481073815266	1.20942580949	0.0265353126723	0.287038154335	9.81089631411	-22.1061245745	40.2300495499
11	2.46021564705	-0.227255050835	-0.071022951628	0.917731580996	-0.64228587055	3.18911697359	-0.147831193131	-0.344984661344	0.300680327864	0.00255343790033	-0.0320137036395	-0.0343326416272	-0.817640267622	0.327165975334	0.30904094859	0.480118050714	-0.0221739736855	-0.111075303515	1.06558124867	-0.0488327195649	0.262170550444	-3.23865357806	-17.3468746942	41.6206473454
12	3.33077550061	-0.600441116231	1.72217795815	1.24948379393	0.319652185363	2.74822768329	0.122343498458	-0.240934994614	0.290159456294	0.0911265685417	-0.318328350249	-0.248693214865	-0.706726208104	0.424466957332	0.125414560898	0.389143251796	-0.0940918997915	-0.0697322423194	0.898574112059	0.00617248821443	0.225309033376	3.02802887565	-20.2585370496	36.2593757961
13	7.41963527215	0.926049003633	2.06983665045	1.30926877488	-0.00814853799068	2.53120927764	-0.282700513883	-0.390615738375	0.795515259893	0.233026938537	0.0667316214567	-0.341159805977	-0.896138180397	0.864282249051	0.388783555941	0.765192969182	-0.263282967136	-0.123947950037	1.06235006271	-0.0101475527003	0.405050515271	8.52889378502	-12.9442208781	44.1962947339
14	5.35585855756	-2.78646408616	1.93797937649	1.76054094938	-1.26424270329	0.909477346335	0.0976811484909	-0.00374560435976	0.395752787468	0.0275064734293	0.0501234506152	-0.274710401961	-0.43526628838	0.49097413148	0.41038073189	0.51582368372	0.0132555954281	-0.0652530231875	1.31726269021	-0.0786429969219	0.388888478515	4.07774378774	-17.2909590673	48.0628205689
15	2.5424724727	0.713653583203	0.287044146624	1.35644417274	0.210597260661	1.30574367809	-0.0869137785407	-0.217478206311	-0.478125591067	0.0391393681166	0.0857047153725	-0.106797996266	0.240070001517	-0.0533790062475	0.0446564024454	0.206535502996	-0.00649117399664	0.00106574041391	0.0880893056367	0.036291999355	0.207903248142	-14.1987462477	-34.0399027254	8.6292463507
16	3.13602528382	0.199673468721	0.336036736496	0.342489392335	0.259653909368	1.8035083267	0.0780305174629	-0.492856998149	0.155827308886	0.0736845173793	-0.148224745747	0.150693207625	0.0210008360687	-0.0462100158758	0.0292762532434	0.161505282986	-0.0320304039261	0.0133192916856	0.0919092627335	-0.00330967501521	0.135567994795	-24.528588889	-29.395095039	11.9220628363
17	2.70664561832	0.654450713209	0.432180749152	0.987452227608	0.459174420288	2.06810198588	-0.0152656169235	0.329359533797	0.16155373166	-0.267587685249	-0.00812547431865	-0.073729568875	-0.19385303119	0.0335336915466	0.169441909289	0.214904546511	-0.0219518631766	0.0198395448384	0.0791421561304	-0.00661216733214	0.236831904105	-24.1601970245	-26.404548002	2.03247871228
18	2.330705006	-0.10242754644	0.52571647785	0.117056580306	0.329718888331	1.9005137148	-0.0183646539511	-0.0730146759988	0.0823823244557	0.0820372498527	-0.0637783172069	0.03138821608	-0.129880402796	0.0329101942098	0.109074757245	0.177787602958	-0.0257402933201	0.0061301768521	0.0720942662938	-0.0148820234898	0.175791375913	-13.7358912648	-26.0526452232	4.56158429146
19	3.36867571279	0.665576077976	0.65998227031	1.04249045998	0.781575055875	1.27170468124	0.00369034366112	-0.564846909786	-0.36813778455	0.0879527506831	-0.144864284288	0.030369582136	0.299605976999	-0.0745496795269	0.0649406464214	0.207273008255	-0.0674774276057	0.0177767629763	0.141784383985	0.00712014236118	0.190600541406	-27.3163387456	-35.1480280489	15.6561259037
20	3.28654442911	0.302313623916	0.82567784835	0.507438357274	0.501878097462	1.7575882665	0.044130568403	-0.541356922582	0.131395818208	0.0274460340527	-0.101848695452	-0.0109584650303	0.125315731263	0.324367509125	0.00712032202264	0.173102479868	-0.00749912222522	0.0111281863379	0.155531091852	0.0279732045116	0.147959799747	-1.21540711311	-25.988834836	12.8919102326
21	0.412139506716	-0.156885238336	1.03117735481	0.0425522058268	-0.352159192376	2.51183780234	-0.0606827698512	-0.770415491725	-0.0722006049669	0.110472966146	0.0108301567617	-0.139769819758	0.52822624524	0.57421236427	-0.192717623419	0.331486061719	0.11628258343	-0.0371002091534	0.840169005036	0.10672112572	0.189636429851	6.62949320675	-30.6855883157	35.0289379887
22	1.58897467278	-0.537025599957	0.473487014612	0.964996090789	-0.145608511868	0.141646158843	-0.00331950759325	-1.05791990991	-0.987859215571	0.259039459611	0.0475123491089	0.0374649070229	0.828489411642	0.429603736638	-0.147105297699	0.793459783766	0.132962402893	-0.0183295430405	0.852776349464	0.219845049208	0.428506734269	4.23064263076	-41.6740022915	33.853273949
23	4.68459931878	0.349347514395	-0.0495742405082	2.98678565636	-0.101389060892	3.99669369356	0.170512171185	-0.541609559778	0.430887835315	0.0844850865165	-0.0533449767321	0.12664869778	-0.354491074448	0.0949373435328	-0.014799691438	0.211980694195	-0.0139308845127	-0.0179660139744	0.358971536497	-0.0360051539895	0.214595669555	-1.17783815871	-21.2972257313	22.5929240214
24	1.03061053983	-0.141077673729	1.0491887253	0.15529119423	-0.134238707524	1.33911792351	-0.0912533100611	-0.805678354126	-0.474158395349	0.326593134748	-0.0883867315413	-0.308496763532	0.840345908419	0.510319759166	-0.197284406192	0.653691627178	0.25770462309	-0.00310997469624	1.05233267166	0.281165000157	0.317687480749	7.22488453078	-37.1881612739	41.3644694441
25	2.59632088439	-0.68963018737	4.10490838467	1.95001940449	-2.53770406022	7.67615770997	0.0406860166294	-0.763799443087	-0.630419902459	0.353778899397	0.123273016254	-0.166977254207	0.746479059739	0.785628549672	-0.199899691851	0.587174445685	0.343803167554	-0.000867587284889	0.902032017156	0.177119899422	0.322231472339	11.2070137086	-37.8678273786	30.9114710215
26	1.62837632086	0.213068979686	3.38765182758	0.191626195636	0.285983629953	7.19775293212	0.107481190728	-0.656397967135	-0.215345779928	0.148292831574	0.0794542471952	-0.246387078479	0.443363529792	0.594296105216	-0.138797837597	0.414403728396	0.244991908303	-0.0227122939448	0.907220484583	0.0828573608674	0.250609286306	12.4494959741	-34.286232324	27.0371372488

Refinement TLS group

Refine-ID: X-RAY DIFFRACTION

ID	Refine TLS-ID	Selection details	Auth asym-ID	Label asym-ID	Auth seq-ID	Label seq-ID
1	1	chain 'A' and (resid 11 through 36 )	A	A	11 - 36	1 - 26
2	2	chain 'A' and (resid 37 through 51 )	A	A	37 - 51	27 - 41
3	3	chain 'A' and (resid 52 through 62 )	A	A	52 - 62	42 - 52
4	4	chain 'A' and (resid 63 through 115 )	A	A	63 - 115	53 - 105
5	5	chain 'B' and (resid -1 through 15 )	B	E	-1 - 15	1 - 17
6	6	chain 'B' and (resid 16 through 60 )	B	E	16 - 60	18 - 62
7	7	chain 'B' and (resid 61 through 83 )	B	E	61 - 83	63 - 85
8	8	chain 'B' and (resid 84 through 100 )	B	E	84 - 100	86 - 102
9	9	chain 'B' and (resid 101 through 136 )	B	E	101 - 136	103 - 138
10	10	chain 'B' and (resid 137 through 160 )	B	E	137 - 160	139 - 158
11	11	chain 'B' and (resid 161 through 174 )	B	E	161 - 174	159 - 172
12	12	chain 'B' and (resid 175 through 205 )	B	E	175 - 205	173 - 203
13	13	chain 'B' and (resid 206 through 217 )	B	E	206 - 217	204 - 215
14	14	chain 'B' and (resid 218 through 232 )	B	E	218 - 232	216 - 230
15	15	chain 'C' and (resid 3 through 25 )	C	G	3 - 25	1 - 23
16	16	chain 'C' and (resid 26 through 49 )	C	G	26 - 49	24 - 47
17	17	chain 'C' and (resid 50 through 70 )	C	G	50 - 70	48 - 68
18	18	chain 'C' and (resid 71 through 84 )	C	G	71 - 84	69 - 82
19	19	chain 'C' and (resid 85 through 104 )	C	G	85 - 104	83 - 102
20	20	chain 'C' and (resid 105 through 117 )	C	G	105 - 117	103 - 115
21	21	chain 'C' and (resid 118 through 154 )	C	G	118 - 154	116 - 152
22	22	chain 'C' and (resid 155 through 165 )	C	G	155 - 165	153 - 163
23	23	chain 'C' and (resid 166 through 177 )	C	G	166 - 177	164 - 175
24	24	chain 'C' and (resid 178 through 191 )	C	G	178 - 191	176 - 189
25	25	chain 'C' and (resid 192 through 201 )	C	G	192 - 201	190 - 199
26	26	chain 'C' and (resid 202 through 212 )	C	G	202 - 212	200 - 210

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