Entry | Database: PDB / ID: 9eou |
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Title | Crystal Structure of the b1b2 domains from Human Neuropilin-1 in complex with a peptide. |
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Components | |
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Keywords | STRUCTURAL PROTEIN / angiogenesis / Neuropilin-1 |
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Function / homology | Function and homology information
negative regulation of collateral sprouting of intact axon in response to injury / positive regulation of estradiol secretion / androgen catabolic process / endothelial tip cell fate specification / basal dendrite development / protein localization to early endosome / otic placode development / basal dendrite arborization / biomineral tissue development / dichotomous subdivision of terminal units involved in salivary gland branching ...negative regulation of collateral sprouting of intact axon in response to injury / positive regulation of estradiol secretion / androgen catabolic process / endothelial tip cell fate specification / basal dendrite development / protein localization to early endosome / otic placode development / basal dendrite arborization / biomineral tissue development / dichotomous subdivision of terminal units involved in salivary gland branching / retina vasculature morphogenesis in camera-type eye / regulation of vascular endothelial growth factor receptor signaling pathway / vestibulocochlear nerve structural organization / dorsal root ganglion morphogenesis / ventral trunk neural crest cell migration / sympathetic neuron projection guidance / facioacoustic ganglion development / trigeminal ganglion development / neurofilament / response to macrophage colony-stimulating factor / postsynapse organization / trigeminal nerve structural organization / sensory neuron axon guidance / facial nerve structural organization / gonadotrophin-releasing hormone neuronal migration to the hypothalamus / branchiomotor neuron axon guidance / renal artery morphogenesis / axon extension involved in axon guidance / VEGF-activated neuropilin signaling pathway / negative regulation of axon extension involved in axon guidance / sympathetic neuron projection extension / vascular endothelial growth factor binding / Neurophilin interactions with VEGF and VEGFR / endothelial cell chemotaxis / motor neuron migration / axonogenesis involved in innervation / sympathetic ganglion development / neural crest cell migration involved in autonomic nervous system development / positive regulation of axon extension involved in axon guidance / CHL1 interactions / vascular endothelial growth factor receptor activity / regulation of vesicle-mediated transport / Signaling by ROBO receptors / angiogenesis involved in coronary vascular morphogenesis / neuropilin signaling pathway / SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion / Signaling by PDGF / coronary artery morphogenesis / hepatocyte growth factor receptor signaling pathway / substrate-dependent cell migration, cell extension / outflow tract septum morphogenesis / semaphorin receptor activity / cellular response to testosterone stimulus / ion binding / CRMPs in Sema3A signaling / response to vitamin D / commissural neuron axon guidance / RUNX3 Regulates Immune Response and Cell Migration / semaphorin receptor complex / extracellular matrix binding / cell migration involved in sprouting angiogenesis / axonal fasciculation / regulation of Cdc42 protein signal transduction / motor neuron axon guidance / response to steroid hormone / sprouting angiogenesis / neural crest cell migration / positive regulation of filopodium assembly / artery morphogenesis / branching involved in blood vessel morphogenesis / positive regulation of cell migration involved in sprouting angiogenesis / cellular response to hepatocyte growth factor stimulus / retinal ganglion cell axon guidance / positive chemotaxis / cytokine binding / positive regulation of smooth muscle cell migration / growth factor binding / sorting endosome / positive regulation of focal adhesion assembly / semaphorin-plexin signaling pathway / platelet-derived growth factor receptor signaling pathway / Sema3A PAK dependent Axon repulsion / decidualization / cellular response to vascular endothelial growth factor stimulus / positive regulation of bone resorption / small molecule binding / vasculogenesis / Integrin cell surface interactions / vascular endothelial growth factor receptor signaling pathway / coreceptor activity / positive regulation of substrate adhesion-dependent cell spreading / positive regulation of stress fiber assembly / positive regulation of endothelial cell proliferation / embryo implantation / Degradation of the extracellular matrix / positive regulation of endothelial cell migration / GTPase activator activity / Signal transduction by L1 / cytokine activity / cell projectionSimilarity search - Function Osteopontin / Osteopontin, conserved site / Osteopontin / Osteopontin signature. / Osteopontin / Neuropilin / Neuropilin, C-terminal / C-terminal domain of neuropilin glycoprotein / MAM domain signature. / Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) ...Osteopontin / Osteopontin, conserved site / Osteopontin / Osteopontin signature. / Osteopontin / Neuropilin / Neuropilin, C-terminal / C-terminal domain of neuropilin glycoprotein / MAM domain signature. / Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) / MAM domain, meprin/A5/mu / MAM domain / MAM domain profile. / Coagulation factors 5/8 type C domain (FA58C) signature 2. / Coagulation factors 5/8 type C domain (FA58C) signature 1. / CUB domain / Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. / CUB domain / CUB domain profile. / Spermadhesin, CUB domain superfamily / Coagulation factor 5/8 C-terminal domain, discoidin domain / Coagulation factors 5/8 type C domain (FA58C) profile. / F5/8 type C domain / Coagulation factor 5/8 C-terminal domain / Galactose-binding-like domain superfamily / Concanavalin A-like lectin/glucanase domain superfamilySimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.55 Å |
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Authors | Caing-Carlsson, R. / Duelli, A. / Walse, B. |
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Funding support | Denmark, Sweden, 3items Organization | Grant number | Country |
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Novo Nordisk Foundation | | Denmark | Swedish Research Council | | Sweden | Vinnova | | Sweden |
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Citation | Journal: Pharmacol Res / Year: 2024 Title: Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular repair responses and angiogenesis. Authors: Chen, Y. / Gialeli, C. / Shen, J. / Duner, P. / Walse, B. / Duelli, A. / Caing-Carlsson, R. / Blom, A.M. / Zibert, J.R. / Nilsson, A.H. / Alenfall, J. / Liang, C. / Nilsson, J. |
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History | Deposition | Mar 15, 2024 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jun 26, 2024 | Provider: repository / Type: Initial release |
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