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- PDB-9eiq: Crystal structure of HLA-B*07:02 with the 9-mer TP53 peptide RPILTIITL -

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Basic information

Entry
Database: PDB / ID: 9eiq
TitleCrystal structure of HLA-B*07:02 with the 9-mer TP53 peptide RPILTIITL
Components
  • Beta-2-microglobulin
  • HLA class I histocompatibility antigen, B alpha chain
  • Peptide from Cellular tumor antigen p53
KeywordsIMMUNE SYSTEM / HLA-B*07:02 / TP53
Function / homology
Function and homology information


regulation of interleukin-12 production / regulation of dendritic cell differentiation / regulation of T cell anergy / negative regulation of helicase activity / Loss of function of TP53 in cancer due to loss of tetramerization ability / Regulation of TP53 Expression / signal transduction by p53 class mediator / negative regulation of G1 to G0 transition / negative regulation of glucose catabolic process to lactate via pyruvate / Transcriptional activation of cell cycle inhibitor p21 ...regulation of interleukin-12 production / regulation of dendritic cell differentiation / regulation of T cell anergy / negative regulation of helicase activity / Loss of function of TP53 in cancer due to loss of tetramerization ability / Regulation of TP53 Expression / signal transduction by p53 class mediator / negative regulation of G1 to G0 transition / negative regulation of glucose catabolic process to lactate via pyruvate / Transcriptional activation of cell cycle inhibitor p21 / regulation of intrinsic apoptotic signaling pathway by p53 class mediator / negative regulation of pentose-phosphate shunt / Activation of NOXA and translocation to mitochondria / ATP-dependent DNA/DNA annealing activity / regulation of cell cycle G2/M phase transition / regulation of interleukin-6 production / oligodendrocyte apoptotic process / negative regulation of miRNA processing / intrinsic apoptotic signaling pathway in response to hypoxia / oxidative stress-induced premature senescence / regulation of tissue remodeling / positive regulation of thymocyte apoptotic process / positive regulation of mitochondrial membrane permeability / germ cell nucleus / regulation of fibroblast apoptotic process / bone marrow development / cellular response to actinomycin D / circadian behavior / histone deacetylase regulator activity / positive regulation of programmed necrotic cell death / : / regulation of mitochondrial membrane permeability involved in apoptotic process / RUNX3 regulates CDKN1A transcription / T cell proliferation involved in immune response / TP53 Regulates Transcription of Death Receptors and Ligands / Activation of PUMA and translocation to mitochondria / TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain / mRNA transcription / negative regulation of glial cell proliferation / negative regulation of neuroblast proliferation / regulation of DNA damage response, signal transduction by p53 class mediator / Regulation of TP53 Activity through Association with Co-factors / Formation of Senescence-Associated Heterochromatin Foci (SAHF) / mitochondrial DNA repair / T cell lineage commitment / thymocyte apoptotic process / ER overload response / TP53 Regulates Transcription of Caspase Activators and Caspases / cardiac septum morphogenesis / B cell lineage commitment / entrainment of circadian clock by photoperiod / negative regulation of DNA replication / Zygotic genome activation (ZGA) / negative regulation of mitophagy / TP53 Regulates Transcription of Genes Involved in Cytochrome C Release / necroptotic process / PI5P Regulates TP53 Acetylation / Association of TriC/CCT with target proteins during biosynthesis / positive regulation of release of cytochrome c from mitochondria / negative regulation of telomere maintenance via telomerase / SUMOylation of transcription factors / TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain / protection from natural killer cell mediated cytotoxicity / rRNA transcription / negative regulation of reactive oxygen species metabolic process / intrinsic apoptotic signaling pathway by p53 class mediator / TFIID-class transcription factor complex binding / Transcriptional Regulation by VENTX / cellular response to UV-C / viral process / neuroblast proliferation / intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress / TAP binding / replicative senescence / intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / Pyroptosis / positive regulation of RNA polymerase II transcription preinitiation complex assembly / chromosome organization / general transcription initiation factor binding / positive regulation of execution phase of apoptosis / hematopoietic stem cell differentiation / detection of bacterium / embryonic organ development / type II interferon-mediated signaling pathway / antigen processing and presentation of endogenous peptide antigen via MHC class Ib / antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent / TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest / response to X-ray / hematopoietic progenitor cell differentiation / somitogenesis / negative regulation of stem cell proliferation / core promoter sequence-specific DNA binding / glial cell proliferation / negative regulation of fibroblast proliferation / cis-regulatory region sequence-specific DNA binding / cellular response to glucose starvation / mitophagy / Regulation of TP53 Activity through Acetylation / negative regulation of proteolysis / mitotic G1 DNA damage checkpoint signaling
Similarity search - Function
Cellular tumor antigen p53, transactivation domain 2 / Transactivation domain 2 / p53 transactivation domain / P53 transactivation motif / : / p53 family signature. / p53, tetramerisation domain / P53 tetramerisation motif / p53, DNA-binding domain / P53 DNA-binding domain ...Cellular tumor antigen p53, transactivation domain 2 / Transactivation domain 2 / p53 transactivation domain / P53 transactivation motif / : / p53 family signature. / p53, tetramerisation domain / P53 tetramerisation motif / p53, DNA-binding domain / P53 DNA-binding domain / p53 tumour suppressor family / p53-like tetramerisation domain superfamily / p53/RUNT-type transcription factor, DNA-binding domain superfamily / p53-like transcription factor, DNA-binding / MHC class I, alpha chain, C-terminal / MHC_I C-terminus / MHC class I alpha chain, alpha1 alpha2 domains / Class I Histocompatibility antigen, domains alpha 1 and 2 / Beta-2-Microglobulin / : / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / MHC classes I/II-like antigen recognition protein / : / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold
Similarity search - Domain/homology
NICKEL (II) ION / HLA class I histocompatibility antigen, B alpha chain / Cellular tumor antigen p53 / Beta-2-microglobulin
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.21 Å
AuthorsTan, K. / Mallis, R.J. / Reinherz, E.L.
Funding support United States, 3items
OrganizationGrant numberCountry
National Institutes of Health/National Cancer Institute (NIH/NCI)R01CA265928 United States
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)P01AI143565 United States
Department of Energy (DOE, United States)KP1605010 United States
CitationJournal: To Be Published
Title: Crystal structure of HLA-B*07:02 with the 9-mer TP53 peptide RPILTIITL
Authors: Tan, K. / Mallis, R.J. / Reinherz, E.L.
History
DepositionNov 26, 2024Deposition site: RCSB / Processing site: RCSB
Revision 1.0Jun 24, 2026Provider: repository / Type: Initial release

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: HLA class I histocompatibility antigen, B alpha chain
B: Beta-2-microglobulin
C: Peptide from Cellular tumor antigen p53
D: HLA class I histocompatibility antigen, B alpha chain
E: Beta-2-microglobulin
F: Peptide from Cellular tumor antigen p53
hetero molecules


Theoretical massNumber of molelcules
Total (without water)92,33136
Polymers90,2206
Non-polymers2,11130
Water4,666259
1
A: HLA class I histocompatibility antigen, B alpha chain
B: Beta-2-microglobulin
C: Peptide from Cellular tumor antigen p53
hetero molecules


Theoretical massNumber of molelcules
Total (without water)46,19019
Polymers45,1103
Non-polymers1,08016
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area6700 Å2
ΔGint-103 kcal/mol
Surface area19320 Å2
MethodPISA
2
D: HLA class I histocompatibility antigen, B alpha chain
E: Beta-2-microglobulin
F: Peptide from Cellular tumor antigen p53
hetero molecules


Theoretical massNumber of molelcules
Total (without water)46,14117
Polymers45,1103
Non-polymers1,03114
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area6590 Å2
ΔGint-160 kcal/mol
Surface area19610 Å2
MethodPISA
Unit cell
Length a, b, c (Å)174.901, 64.510, 83.763
Angle α, β, γ (deg.)90.000, 90.000, 90.000
Int Tables number18
Space group name H-MP21212
Space group name HallP22ab
Symmetry operation#1: x,y,z
#2: x+1/2,-y+1/2,-z
#3: -x+1/2,y+1/2,-z
#4: -x,-y,z

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Components

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Protein , 2 types, 4 molecules ADBE

#1: Protein HLA class I histocompatibility antigen, B alpha chain / Human leukocyte antigen B / HLA-B


Mass: 32190.324 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: HLA-B, HLAB / Production host: Escherichia coli BL21(DE3) (bacteria) / References: UniProt: P01889
#2: Protein Beta-2-microglobulin


Mass: 11879.356 Da / Num. of mol.: 2 / Fragment: UNP residues 21-119
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: B2M, CDABP0092, HDCMA22P / Production host: Escherichia coli BL21(DE3) (bacteria) / References: UniProt: P61769

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Protein/peptide , 1 types, 2 molecules CF

#3: Protein/peptide Peptide from Cellular tumor antigen p53 / Antigen NY-CO-13 / Phosphoprotein p53 / Tumor suppressor p53


Mass: 1040.320 Da / Num. of mol.: 2 / Fragment: residues 249-257 (Uniprot numbering) / Source method: obtained synthetically / Source: (synth.) Homo sapiens (human) / References: UniProt: P04637

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Non-polymers , 5 types, 289 molecules

#4: Chemical
ChemComp-EDO / 1,2-ETHANEDIOL / ETHYLENE GLYCOL


Mass: 62.068 Da / Num. of mol.: 8 / Source method: obtained synthetically / Formula: C2H6O2
#5: Chemical
ChemComp-SO4 / SULFATE ION


Mass: 96.063 Da / Num. of mol.: 13 / Source method: obtained synthetically / Formula: SO4
#6: Chemical
ChemComp-CL / CHLORIDE ION


Mass: 35.453 Da / Num. of mol.: 7 / Source method: obtained synthetically / Formula: Cl
#7: Chemical ChemComp-NI / NICKEL (II) ION


Mass: 58.693 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: Ni
#8: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 259 / Source method: isolated from a natural source / Formula: H2O

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Details

Has ligand of interestN
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.62 Å3/Da / Density % sol: 53.03 %
Crystal growTemperature: 290 K / Method: vapor diffusion, sitting drop / pH: 8.5
Details: 0.2M Ammonium Sulfate, 0.1M Tris:HCl, 25% (w/v) PEG 3350

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: NSLS-II / Beamline: 17-ID-2 / Wavelength: 0.9793 Å
DetectorType: DECTRIS EIGER2 S 16M / Detector: PIXEL / Date: Sep 18, 2024
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.9793 Å / Relative weight: 1
ReflectionResolution: 2.2→48 Å / Num. obs: 48361 / % possible obs: 100 % / Redundancy: 7.2 % / Biso Wilson estimate: 27.73 Å2 / CC1/2: 0.992 / CC star: 0.998 / Rmerge(I) obs: 0.155 / Rpim(I) all: 0.062 / Rrim(I) all: 0.167 / Χ2: 0.606 / Net I/σ(I): 10.7
Reflection shellResolution: 2.2→2.24 Å / Redundancy: 7 % / Rmerge(I) obs: 0.719 / Mean I/σ(I) obs: 1.76 / Num. unique obs: 2410 / CC1/2: 0.704 / CC star: 0.909 / Rpim(I) all: 0.293 / Rrim(I) all: 0.777 / Χ2: 0.417 / % possible all: 100

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Processing

Software
NameVersionClassification
PHENIX1.21.2_5419refinement
HKL-3000data reduction
HKL-3000data scaling
HKL-3000phasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT / Resolution: 2.21→47.85 Å / SU ML: 0.3565 / Cross valid method: FREE R-VALUE / σ(F): 1.39 / Phase error: 32.0549
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
RfactorNum. reflection% reflection
Rfree0.2927 2347 4.86 %
Rwork0.2506 45950 -
obs0.2527 48297 99.5 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso mean: 35.73 Å2
Refinement stepCycle: LAST / Resolution: 2.21→47.85 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms6344 0 106 259 6709
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.00226592
X-RAY DIFFRACTIONf_angle_d0.48088940
X-RAY DIFFRACTIONf_chiral_restr0.0389900
X-RAY DIFFRACTIONf_plane_restr0.00431172
X-RAY DIFFRACTIONf_dihedral_angle_d17.02882444
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
2.21-2.250.41541230.34582456X-RAY DIFFRACTION92.14
2.25-2.30.3871510.33422683X-RAY DIFFRACTION100
2.3-2.350.41121300.32632652X-RAY DIFFRACTION100
2.35-2.410.35861220.32522696X-RAY DIFFRACTION99.96
2.41-2.480.36221400.3142690X-RAY DIFFRACTION99.96
2.48-2.550.36411290.30712667X-RAY DIFFRACTION100
2.55-2.630.36371500.30422681X-RAY DIFFRACTION100
2.63-2.730.34761340.30192697X-RAY DIFFRACTION100
2.73-2.840.29671120.29982714X-RAY DIFFRACTION100
2.84-2.970.3451450.29172693X-RAY DIFFRACTION99.96
2.97-3.120.3671470.27252703X-RAY DIFFRACTION100
3.12-3.320.31241330.25992708X-RAY DIFFRACTION100
3.32-3.570.3121550.23922736X-RAY DIFFRACTION100
3.57-3.930.21731510.20832706X-RAY DIFFRACTION99.97
3.93-4.50.23381320.19592758X-RAY DIFFRACTION99.93
4.5-5.670.22841510.18472784X-RAY DIFFRACTION99.93
5.67-47.850.21351420.19462926X-RAY DIFFRACTION99.64
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
11.38307141091-0.753147772003-1.148282273140.5212708678320.03410201421044.117636688290.07363620039520.0579005664125-0.01905822484560.06451005520060.124538555004-0.450352251239-0.5585863808750.470034921281-0.1707493186890.242206274003-0.0801300668648-0.06437162590160.220795819174-0.0146207197090.41214050450336.93211525514.6099110398145.041461688
20.278901641931-0.0234339036725-0.02933905917310.2316796534810.407837555031.04553202103-0.05831468659640.0610231115023-0.08325618149910.0005437982369940.00791277588118-0.01666330063990.124916501232-0.05102653834520.06302144648570.244529589638-0.02292381393320.1621667615340.2993384795070.0604841516760.23988544110117.5371038802-24.822129206720.1275868205
30.779538526463-0.3705292067040.1124316558430.9963792148960.02150354199561.74417984993-0.0765968267356-0.1861604514150.0147841703681-0.07915096380320.096731645541-0.138070337-0.153318635374-0.16452975983-0.02496793445820.2620901125990.03185125032350.1941556716670.2438927879960.01340772585450.3059209708519.638479977420.378806071815.60051263
41.22913316521-0.8954399453190.008032674942443.416983123821.109178663530.8916595346790.07895758744190.207661193912-0.24820158585-0.799675299585-0.008963681726650.1246894117930.185195265116-0.0483381823296-0.05778785366020.74808856435-0.09281076024860.1731101148450.268028731962-0.01807773516610.30621194512517.640368218-1.49627588802-8.80379317444
51.99632215464-0.3509843155190.5376817298530.604578953409-1.00318169531.824325433280.04519023096710.02671713406070.0202748414619-0.3197611909640.0707256716928-0.106320943152-0.221058549732-0.00402699117506-0.128304809730.479944149984-0.002540476877530.2824056412430.213315282498-0.05135144417750.42236241374332.20444348233.62714847029-2.01356621871
60.347546166553-0.0876480156071-0.5263981118220.0740916633389-0.02843999815241.85115699997-0.003523500482840.05572459431010.00449341167069-0.2877881034780.0356335796233-0.243853781161-0.05101820820220.2346364198130.005238209033260.344045440846-0.02617613187140.5699616716790.216969747985-0.02193123380280.40981756924335.00870195799.509068717642.34725370653
71.95655415494-0.693001759241-1.159424218990.2803572376730.2596151825471.743322645060.02658999212660.410413777066-0.159038969948-0.32799617515-0.0437964168767-0.2328741751870.06869007081890.1222536820180.07887220447920.5432434986190.0179613081620.4083704999090.387648181899-0.00940339377350.45288726368837.59508303697.33221203993-6.86469561536
80.751181988854-0.3838134619-1.703593173290.5062379285111.219080712424.250254361210.0683004757750.168261874644-0.042828214191-0.0578585839650.0384291300146-0.1110643705660.2069773127180.560011394839-0.1216244868060.4105087662270.06862461005960.2607600244320.277190843271-0.0471845943920.27995221750439.49905897530.1173329281191.06003492262
90.1264819927220.3084897472640.2499785710560.7734345343130.581274864220.555627538756-0.296167217574-0.259679440265-0.3656514792480.1566768183140.0941182810467-0.040219374209-0.1560033947-0.4654110090760.1709246494250.4456008689870.1230654207630.1976399373430.315551712930.08699419973850.30467311653217.295273491826.56520214319.1064953139
100.6332277465980.206263585325-0.4747399713711.64330575059-0.08779425629722.811271787150.070570606154-0.06310856288330.0178191596999-0.0622097164937-0.0766497062696-0.04988253841610.0706618488904-0.1710424049260.005823054725940.1391827092470.01223518537590.07675970655130.211202537632-0.009173062806610.24317503056619.7400756788-18.651704093623.3924880248
113.60673128585-0.340983148321-3.073991792571.66344243022-0.2804906933143.798456150650.109929354278-0.5307266430610.137933728870.302608010678-0.070547277980.110810375768-0.03915489402940.152514023429-0.02709625087540.288591580627-0.1646014902320.1895135406390.530185839137-0.02695963711590.353476154539.48569151661-22.120106269540.0578941242
122.49045537698-1.13812248132-0.272077771294.461608408020.8694345161413.082031730540.0885158475698-0.2390571837840.3480715980860.4556797358810.00366374431922-0.0575714887414-0.554982145349-0.203322700275-0.08098370513140.3364115338870.02209817886770.03319262179670.276010824603-0.008004734490790.16873384936819.20822513918.4189389800649.2419234052
130.4230569563420.4506210363970.7811366637110.6541128951791.479482605816.93370920738-0.137636961790.105319089866-0.218858668272-0.35493457721-0.172709260701-0.307076186885-0.016783194629-0.1451849054460.2889775186090.267899006235-0.01328666267150.11549668890.167973893774-0.08828863026530.34224700933930.9678670666-0.99777135886121.7721775794
141.110883720060.663169866822-0.6891461052341.050447545930.3280874331964.674119331670.0131011540675-0.262074164216-0.2908235542890.0980351883463-0.265283026466-0.2884708462620.06159861139130.01159729345030.2503182010640.117895761973-0.07154701523060.01131232104290.2687590393810.03658811953220.39854095457931.76270921570.16697530797540.8077764327
152.39591354523-1.16686334521-0.1111778281391.89982723047-1.778106849252.526643310730.0704316091104-0.851786580306-0.007037795758891.087174225450.134233482259-0.509968868237-0.323554655433-0.206815430104-0.1824815435080.529933568079-0.0198083529601-0.1372605319750.4309226221790.07447420074520.24309374625833.4248904799-3.6212135379856.0897619135
163.06228919003-0.1945245241061.542353343013.092065754120.2484138351014.956756093010.169994508316-0.0719623193924-0.03991174244850.1944708558360.0937298395768-0.428833220691-0.10792555606-0.0287840150269-0.2358435524110.143255387055-0.00774304872069-0.001947055663470.2225847542650.04135979172360.21427282956632.6227289412-5.2224673163841.5104107046
172.18934095509-0.1588278665120.1271446952252.58494917231-0.4540909862762.186151103290.1066867095080.4265960105080.00505563816001-0.17382900691-0.0121500289461-0.713074542098-0.05555100626190.748824902853-0.09640615952710.116546180103-0.01177707135260.127571294460.349088254540.007511608595190.3639612176239.1349254758-6.2807643352533.070934915
180.5702770177460.2222485329310.02042937291331.932684581120.732235846711.77816310431-0.0368743916329-0.0511403833382-0.1626497837210.3542236162230.0814082677402-0.930896981908-0.04015959902920.881955321964-0.04197045924590.197943547892-0.0215642190817-0.05792360623330.5956205270840.009678247815070.51210818558143.948970741-9.7487428355942.3920094318
190.1086776112470.266002637557-0.3662554490221.993347394580.3822893072092.44972736580.02851946078650.0198755896644-0.07409699290960.147865979252-0.051030562498-0.2930859021850.004671676328620.1650597873380.005079656008340.08266604299930.0252151142290.08743795558880.178853540758-0.01974394276740.28819945010729.3571368802-8.9569274412435.7097276842
209.159521911824.330728112591.888087286024.077906696871.783778564136.269326248050.393389848771-0.618913293929-0.1542546674620.4228850505780.0968365063428-0.810799145377-0.1981932568890.456135709533-0.475584604350.3750694657430.0463959564249-0.1369879625820.519347105391-0.1019024145410.61739076324544.26915138091.8646743850154.2362296644
211.725863743-0.784272785610.04351610450420.382316178413-0.3723219857614.466941099630.1776141517340.225059969436-0.01779808932490.0117249994405-0.122464753231-0.387347072072-0.2227884389580.548733412144-0.06469641800830.123858392002-0.09810526837460.04956080581010.379161919084-0.04495568307010.54401611767641.2989614466-0.21246060120332.2023683294
Refinement TLS group

Refine-ID: X-RAY DIFFRACTION

IDRefine TLS-IDSelection detailsAuth asym-IDLabel asym-IDAuth seq-IDLabel seq-ID
11chain 'B' and (resid 91 through 99 )BD91 - 9992 - 100
22chain 'C' and (resid 1 through 9 )CG1 - 91 - 9
33chain 'D' and (resid 1 through 162 )DH1 - 1621 - 162
44chain 'D' and (resid 163 through 276 )DH163 - 276163 - 276
55chain 'E' and (resid 0 through 19 )EJ0 - 191 - 20
66chain 'E' and (resid 20 through 61 )EJ20 - 6121 - 62
77chain 'E' and (resid 62 through 77 )EJ62 - 7763 - 78
88chain 'E' and (resid 78 through 99 )EJ78 - 9979 - 100
99chain 'F' and (resid 1 through 9 )FK1 - 91 - 9
1010chain 'A' and (resid 1 through 162 )AA1 - 1621 - 162
1111chain 'A' and (resid 163 through 180 )AA163 - 180163 - 180
1212chain 'A' and (resid 181 through 276 )AA181 - 276181 - 276
1313chain 'B' and (resid 0 through 5 )BD0 - 51 - 6
1414chain 'B' and (resid 6 through 11 )BD6 - 117 - 12
1515chain 'B' and (resid 12 through 19 )BD12 - 1913 - 20
1616chain 'B' and (resid 20 through 30 )BD20 - 3021 - 31
1717chain 'B' and (resid 31 through 41 )BD31 - 4132 - 42
1818chain 'B' and (resid 42 through 51 )BD42 - 5143 - 52
1919chain 'B' and (resid 52 through 71 )BD52 - 7153 - 72
2020chain 'B' and (resid 72 through 77 )BD72 - 7773 - 78
2121chain 'B' and (resid 78 through 90 )BD78 - 9079 - 91

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