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- PDB-9ebl: Crystal structure of the hERbeta LBD complexed with androstenedio... -

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Basic information

Entry
Database: PDB / ID: 9ebl
TitleCrystal structure of the hERbeta LBD complexed with androstenediol and SRC 2-2 peptide (crystal form 1)
Components
  • Estrogen receptor beta
  • Nuclear receptor coactivator 2
KeywordsNUCLEAR PROTEIN / nuclear receptor / transcription factor
Function / homology
Function and homology information


receptor antagonist activity / RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding / nuclear estrogen receptor activity / nuclear steroid receptor activity / locomotor rhythm / aryl hydrocarbon receptor binding / regulation of glucose metabolic process / Synthesis of bile acids and bile salts / estrogen response element binding / Synthesis of bile acids and bile salts via 27-hydroxycholesterol ...receptor antagonist activity / RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding / nuclear estrogen receptor activity / nuclear steroid receptor activity / locomotor rhythm / aryl hydrocarbon receptor binding / regulation of glucose metabolic process / Synthesis of bile acids and bile salts / estrogen response element binding / Synthesis of bile acids and bile salts via 27-hydroxycholesterol / regulation of lipid metabolic process / Endogenous sterols / Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol / Recycling of bile acids and salts / estrogen receptor signaling pathway / transcription regulator inhibitor activity / cellular response to hormone stimulus / steroid binding / peroxisome proliferator activated receptor signaling pathway / Regulation of lipid metabolism by PPARalpha / positive regulation of adipose tissue development / bile acid and bile salt transport / BMAL1:CLOCK,NPAS2 activates circadian expression / regulation of cellular response to insulin stimulus / RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression / SUMOylation of transcription cofactors / Expression of BMAL (ARNTL), CLOCK, and NPAS2 / Activation of gene expression by SREBF (SREBP) / ESR-mediated signaling / negative regulation of smoothened signaling pathway / nuclear receptor binding / cellular response to estradiol stimulus / circadian regulation of gene expression / Heme signaling / PPARA activates gene expression / Cytoprotection by HMOX1 / Transcriptional activation of mitochondrial biogenesis / Transcriptional regulation of white adipocyte differentiation / negative regulation of cell growth / Nuclear Receptor transcription pathway / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / mRNA transcription by RNA polymerase II / nuclear receptor activity / transcription coregulator activity / Constitutive Signaling by Aberrant PI3K in Cancer / PIP3 activates AKT signaling / cell-cell signaling / HATs acetylate histones / MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / Estrogen-dependent gene expression / nuclear body / DNA-binding transcription factor activity, RNA polymerase II-specific / transcription coactivator activity / Extra-nuclear estrogen signaling / protein dimerization activity / RNA polymerase II cis-regulatory region sequence-specific DNA binding / protein domain specific binding / chromatin binding / regulation of transcription by RNA polymerase II / regulation of DNA-templated transcription / positive regulation of DNA-templated transcription / chromatin / negative regulation of transcription by RNA polymerase II / enzyme binding / signal transduction / positive regulation of transcription by RNA polymerase II / protein-containing complex / mitochondrion / DNA binding / zinc ion binding / nucleoplasm / nucleus / cytoplasm
Similarity search - Function
Estrogen receptor beta-like, N-terminal / Estrogen receptor beta/gamma / Estrogen receptor beta / Nuclear receptor coactivator 2 / Nuclear receptor coactivator 2/3, DUF4927 / Domain of unknown function (DUF4927) / Estrogen receptor/oestrogen-related receptor / Nuclear receptor coactivator, DUF1518 / Nuclear receptor coactivator, Ncoa-type, interlocking / Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily ...Estrogen receptor beta-like, N-terminal / Estrogen receptor beta/gamma / Estrogen receptor beta / Nuclear receptor coactivator 2 / Nuclear receptor coactivator 2/3, DUF4927 / Domain of unknown function (DUF4927) / Estrogen receptor/oestrogen-related receptor / Nuclear receptor coactivator, DUF1518 / Nuclear receptor coactivator, Ncoa-type, interlocking / Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily / Nuclear receptor coactivator, DUF1518 / Nuclear receptor coactivator / DUF1518 / Nuclear receptor coactivator, receptor-binding domain / Nuclear receptor coactivator / : / Steroid receptor coactivator / Unstructured region on nuclear receptor coactivator protein / Nuclear receptor coactivators bHLH domain / PAS domain / : / Nuclear receptor coactivator, interlocking / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. / Helix-loop-helix DNA-binding domain superfamily / PAS fold / PAS fold / PAS domain / PAS repeat profile. / PAS domain / PAS domain superfamily / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Double treble clef zinc finger, C4 type / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type
Similarity search - Domain/homology
(3alpha,8alpha,17beta)-androst-5-ene-3,17-diol / Nuclear receptor coactivator 2 / Estrogen receptor beta
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.2 Å
AuthorsPederick, J.L. / Bruning, J.B.
Funding support Australia, 1items
OrganizationGrant numberCountry
Australian Research Council (ARC)DP230100609 Australia
CitationJournal: To Be Published
Title: Crystal structure of the hERalpha LBD complexed with androstenediol and SRC 2-2 peptide
Authors: Pederick, J.L. / Bruning, J.B.
History
DepositionNov 12, 2024Deposition site: RCSB / Processing site: RCSB
Revision 1.0Nov 19, 2025Provider: repository / Type: Initial release

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Estrogen receptor beta
B: Estrogen receptor beta
C: Nuclear receptor coactivator 2
D: Nuclear receptor coactivator 2
E: Estrogen receptor beta
F: Estrogen receptor beta
G: Nuclear receptor coactivator 2
H: Nuclear receptor coactivator 2
hetero molecules


Theoretical massNumber of molelcules
Total (without water)115,45712
Polymers114,2968
Non-polymers1,1624
Water2,270126
1
A: Estrogen receptor beta
B: Estrogen receptor beta
C: Nuclear receptor coactivator 2
D: Nuclear receptor coactivator 2
E: Estrogen receptor beta
F: Estrogen receptor beta
G: Nuclear receptor coactivator 2
H: Nuclear receptor coactivator 2
hetero molecules

A: Estrogen receptor beta
B: Estrogen receptor beta
C: Nuclear receptor coactivator 2
D: Nuclear receptor coactivator 2
E: Estrogen receptor beta
F: Estrogen receptor beta
G: Nuclear receptor coactivator 2
H: Nuclear receptor coactivator 2
hetero molecules


  • defined by author
  • 231 kDa, 16 polymers
Theoretical massNumber of molelcules
Total (without water)230,91524
Polymers228,59116
Non-polymers2,3248
Water18010
TypeNameSymmetry operationNumber
identity operation1_555x,y,z2
Unit cell
Length a, b, c (Å)47.940, 213.735, 52.507
Angle α, β, γ (deg.)90.00, 98.66, 90.00
Int Tables number4
Space group name H-MP1211

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Components

#1: Protein
Estrogen receptor beta / ER-beta / Nuclear receptor subfamily 3 group A member 2


Mass: 26994.053 Da / Num. of mol.: 4
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: ESR2, ESTRB, NR3A2 / Production host: Escherichia coli BL21(DE3) (bacteria) / References: UniProt: Q92731
#2: Protein/peptide
Nuclear receptor coactivator 2 / NCoA-2 / Class E basic helix-loop-helix protein 75 / bHLHe75 / Transcriptional intermediary factor 2 / hTIF2


Mass: 1579.866 Da / Num. of mol.: 4 / Source method: obtained synthetically / Source: (synth.) Homo sapiens (human) / References: UniProt: Q15596
#3: Chemical
ChemComp-B81 / (3alpha,8alpha,17beta)-androst-5-ene-3,17-diol / 5-Androstenediol


Mass: 290.440 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: C19H30O2 / Feature type: SUBJECT OF INVESTIGATION
#4: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 126 / Source method: isolated from a natural source / Formula: H2O
Has ligand of interestY
Has protein modificationN

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.33 Å3/Da / Density % sol: 47.11 %
Crystal growTemperature: 289.15 K / Method: vapor diffusion, sitting drop / Details: 0.1 M sodium HEPES pH 7.5, 22% w/v PEG 5000 MME

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: Australian Synchrotron / Beamline: MX2 / Wavelength: 0.9537 Å
DetectorType: DECTRIS EIGER X 16M / Detector: PIXEL / Date: Oct 4, 2024
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.9537 Å / Relative weight: 1
ReflectionResolution: 2.2→39.46 Å / Num. obs: 52733 / % possible obs: 100 % / Redundancy: 7 % / CC1/2: 0.998 / Rmerge(I) obs: 0.19 / Rpim(I) all: 0.077 / Rrim(I) all: 0.205 / Χ2: 0.99 / Net I/σ(I): 8.2 / Num. measured all: 371225
Reflection shellResolution: 2.2→2.27 Å / % possible obs: 100 % / Redundancy: 7.3 % / Rmerge(I) obs: 1.506 / Num. measured all: 33365 / Num. unique obs: 4599 / CC1/2: 0.371 / Rpim(I) all: 0.597 / Rrim(I) all: 1.622 / Χ2: 0.98 / Net I/σ(I) obs: 1.6

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Processing

Software
NameVersionClassification
PHENIX(1.20.1_4487: ???)refinement
Aimlessdata scaling
XDSdata reduction
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT / Resolution: 2.2→39.46 Å / SU ML: 0.37 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 34.17 / Stereochemistry target values: ML
RfactorNum. reflection% reflection
Rfree0.2765 2659 5.05 %
Rwork0.2344 --
obs0.2366 52632 99.87 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL
Refinement stepCycle: LAST / Resolution: 2.2→39.46 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms6997 0 84 126 7207
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.0027209
X-RAY DIFFRACTIONf_angle_d0.5449796
X-RAY DIFFRACTIONf_dihedral_angle_d4.053970
X-RAY DIFFRACTIONf_chiral_restr0.0341213
X-RAY DIFFRACTIONf_plane_restr0.0041193
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
2.2-2.240.40431480.37352594X-RAY DIFFRACTION100
2.24-2.280.39341340.34562698X-RAY DIFFRACTION100
2.28-2.330.36451350.32342561X-RAY DIFFRACTION100
2.33-2.380.35341400.31942663X-RAY DIFFRACTION100
2.38-2.440.36971450.31192608X-RAY DIFFRACTION100
2.44-2.50.33481270.30312630X-RAY DIFFRACTION100
2.5-2.560.34011430.29672598X-RAY DIFFRACTION100
2.56-2.640.32391420.28852688X-RAY DIFFRACTION100
2.64-2.720.32761380.29092590X-RAY DIFFRACTION100
2.72-2.820.32631320.27722668X-RAY DIFFRACTION100
2.82-2.930.32151490.27542593X-RAY DIFFRACTION100
2.94-3.070.30071360.25512616X-RAY DIFFRACTION100
3.07-3.230.33461400.25812645X-RAY DIFFRACTION100
3.23-3.430.27671370.2322635X-RAY DIFFRACTION100
3.43-3.70.26721450.21342610X-RAY DIFFRACTION100
3.7-4.070.23291430.19432634X-RAY DIFFRACTION100
4.07-4.660.23221550.17592630X-RAY DIFFRACTION100
4.66-5.860.22081380.19332651X-RAY DIFFRACTION100
5.86-39.460.21611320.1842661X-RAY DIFFRACTION100
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
11.3692-0.0415-0.12212.9568-0.48990.15990.5378-0.00720.7986-0.061-0.09450.1788-0.4160.0571-0.38940.959-0.0120.49530.34160.06921.160213.218520.24366.6073
20.03160.1423-0.02521.3028-0.23530.04480.2615-0.2051-0.23090.9261-0.2585-0.66560.00250.0151-0.03871.6965-0.43610.00460.9589-0.31611.43131.924118.435930.5227
31.8283-1.7348-0.79942.33380.44041.05120.0429-0.35240.2870.15940.21770.4446-0.4080.04950.01850.9084-0.02180.58840.2407-0.2160.946814.237314.24716.1455
40.0769-0.0089-0.25730.09870.12040.94610.6122-0.56790.03350.5936-0.2007-0.7125-0.67491.0182-0.40280.842-0.38450.08831.1248-0.41721.219332.624811.015622.9204
53.38440.47120.92383.489-0.94188.94650.2722-0.14640.29-0.09920.3346-0.4198-0.14010.7233-0.53560.4183-0.01570.22460.3769-0.07040.665627.50515.044712.7115
62.7485-1.22170.48072.38441.21841.19770.09950.1750.2796-0.28710.18250.2525-0.11510.0689-0.3120.8055-0.01960.29070.21750.06370.660813.32529.16214.5022
72.6929-0.11110.0552.6104-0.77111.26540.17710.0320.385-0.4053-0.00890.2104-0.0273-0.0637-0.03650.7786-0.0130.22120.18920.02330.567814.45623.6056.0752
82.0099-0.6543-0.87983.58840.03620.40350.1493-1.23350.86120.82410.3845-0.0109-0.23730.0122-0.45180.99130.00930.32810.766-0.19330.677612.830413.045230.8402
93.5470.0879-0.81120.3239-0.29840.4252-0.04250.496-0.2389-0.25660.04860.37250.3202-0.6514-0.06110.4379-0.01730.05130.3723-0.06840.241719.137-21.2447-4.8593
100.8393-0.37330.07891.95280.14110.76240.0284-0.0618-0.26890.3229-0.05650.20160.0334-0.0138-0.1404-0.0452-0.0445-0.19180.28580.06360.104312.5646-24.500220.7681
115.93040.9611-0.06541.99550.10262.11490.1111-0.0250.48280.033-0.02890.1818-0.0881-0.0132-0.05320.23170.01060.09320.12420.06750.23616.1627-16.859212.5243
121.7094-1.4257-1.77944.31910.54682.7308-0.1262-0.51620.34220.66090.14490.6794-0.0174-0.38380.03970.40490.05850.19430.3928-0.03150.58140.2617-16.31926.76
132.2463-0.31250.26852.27640.81955.1471-0.0389-0.1520.55220.27610.05620.3095-0.417-0.4055-0.08480.33380.05460.20920.2626-0.0660.56062.4848-9.732815.5098
140.967-0.9839-0.35191.2594-0.22961.4752-0.2544-0.06910.2854-0.00890.0545-0.0439-0.18880.24940.11940.03480.008-0.22710.39080.08630.034716.0088-12.07114.657
153.25880.19994.43841.86420.23176.0497-0.02620.89330.1669-0.3249-0.1218-0.15580.10420.67850.14450.51640.06780.1680.29590.06540.302518.4541-10.221-4.3684
162.7690.27061.19383.4648-1.30737.00910.0679-0.13890.49050.186-0.1750.1954-1.0422-0.21920.10150.3707-0.01830.14980.1745-0.04830.321811.4605-6.172712.6753
172.54050.3912-1.9150.69971.28015.4295-0.1067-0.2275-0.36110.61740.1027-0.12230.56090.16670.02060.8150.06720.13770.6240.2440.393317.2519-19.143834.2311
182.42140.7713-0.80934.07712.8544.29630.3033-0.2329-0.47420.27520.0683-0.19850.86510.2766-0.4370.22190.0416-0.10020.39070.0580.142624.4315-18.612224.8945
190.0433-0.1808-0.14880.85070.91331.4095-0.0845-0.15260.17750.1540.11320.015-0.2644-0.139-0.00320.7720.06980.43430.4523-0.12461.29441.205619.883223.7776
202.84930.97950.58911.78432.79764.774-0.377-0.4350.60920.25490.1614-0.5017-0.1640.49670.33770.24440.0313-0.14220.47580.24730.545231.4515-24.328316.5558
214.84491.4962-1.57461.0826-2.51527.14550.2332-0.08190.09910.3290.10040.6717-0.1349-0.4403-0.28590.9189-0.09720.6020.4211-0.05831.2969-8.6162-75.505321.029
221.6595-0.4028-0.86880.85460.67690.9136-0.0404-0.053-0.00820.16030.11250.14350.28320.066-0.01690.86530.05020.42440.2473-0.10710.884512.9187-84.15994.838
234.649-0.2967-1.58840.41040.2391.269-0.00730.1962-0.143-0.6868-0.01880.05680.3274-0.03150.03131.0156-0.04640.22280.2729-0.04640.83136.6021-77.73041.412
241.5317-1.3558-0.05663.5582-0.60280.52070.07190.09030.7584-0.3135-0.14560.8462-0.609-0.45060.06180.93540.1467-0.09460.3997-0.1481.4794-12.0355-69.42688.1059
251.08860.56470.67963.12451.37162.575-0.2373-0.0719-0.05470.2069-0.0207-0.0197-0.2338-0.19220.13590.85920.07780.32550.15080.03950.75336.9721-72.91349.2177
260.13140.524-0.26112.4227-1.45221.0277-0.13660.01560.10130.31150.0355-0.6523-0.00010.13510.08080.73510.10340.34440.4530.11251.646624.0756-75.45225.9565
272.9182-1.0508-3.13281.69721.44654.20330.1212-0.1441-0.07490.51040.3583-0.6332-0.42480.195-0.41590.8556-0.01390.1430.31560.11040.959917.7348-68.544114.2405
280.9983-0.0280.291.9440.19512.2009-0.1001-0.27810.06220.7912-0.30160.81830.1002-0.18340.3380.9379-0.08240.38520.3102-0.04570.9401-1.9467-66.70320.6707
290.8184-0.0845-0.54262.5364-0.12452.54190.05980.0071-0.0283-0.09480.02710.0539-0.16820.044-0.06250.91610.03740.30040.16330.02890.64169.4952-62.803512.6252
305.65020.9703-3.61630.4216-1.00842.90210.04550.9697-0.4024-0.80490.2334-0.23540.4249-0.1633-0.30581.4515-0.04670.01330.5061-0.08840.6017.5152-72.5062-7.7657
312.472-1.06762.51562.8308-3.35925.26290.0973-0.40630.29480.06150.1950.0964-0.8249-0.8923-0.26690.66040.00150.15280.3176-0.05450.159111.2082-40.642530.3775
321.80960.2230.49232.40230.15981.9814-0.06080.19720.1902-0.50710.0266-0.2678-0.02360.10880.0240.72450.0230.1860.22080.04560.425813.4975-36.40714.1479
332.53770.24570.39832.73830.56922.26410.03960.0584-0.1778-0.0329-0.1166-0.07080.3610.18820.05090.54110.01990.10740.15390.04820.365212.0122-44.022612.6112
342.76862.16341.52865.86541.74033.8226-0.00260.42960.2598-1.0024-0.01580.3223-0.0858-0.11830.04010.85520.03320.01360.24510.06540.42572.0089-41.1742-5.3394
352.25520.33970.36053.9648-1.08882.6154-0.0911-0.0656-0.04950.11840.11530.59290.207-0.2212-0.02110.54420.03510.10910.21970.03470.36763.1518-47.262813.4457
364.5250.1677-1.81363.76740.16543.4584-0.403-0.8588-0.42940.8819-0.06990.28190.10710.20960.39761.03050.0570.24480.33810.05320.39825.8096-50.540529.6497
372.6709-0.4947-1.112.33470.34454.2428-0.0737-0.0581-0.0778-0.18710.02860.64050.6574-0.12240.02480.83160.04930.24080.21490.02840.49565.7489-53.486110.8494
382.034-1.21920.24990.73550.03196.68850.12230.50460.6176-0.73390.069-0.1184-0.19910.2952-0.19050.98550.02040.25180.62460.13190.604820.5011-42.8019-7.5608
391.9878-1.0971-1.18821.64640.9272.9170.20520.03820.3164-0.34930.1192-0.4583-0.00290.5136-0.30660.87210.16170.36810.27410.02040.443824.0966-43.91363.6022
405.62094.5111-5.98025.1806-6.78029.7919-0.03350.70081.2226-0.53610.2493-0.2465-0.90840.0067-0.19440.94060.18-0.37980.5783-0.22181.0204-8.5643-75.3393-3.9326
411.4163-2.4989-2.53084.72524.9295.6469-0.1590.2094-1.3844-0.3083-0.0543-0.4580.70820.35340.15810.4762-0.0491-0.00010.3274-0.02890.768329.2003-40.785113.385
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection details
1X-RAY DIFFRACTION1chain 'A' and (resid 264 through 284 )
2X-RAY DIFFRACTION2chain 'A' and (resid 285 through 292 )
3X-RAY DIFFRACTION3chain 'A' and (resid 293 through 359 )
4X-RAY DIFFRACTION4chain 'A' and (resid 360 through 372 )
5X-RAY DIFFRACTION5chain 'A' and (resid 373 through 389 )
6X-RAY DIFFRACTION6chain 'A' and (resid 390 through 424 )
7X-RAY DIFFRACTION7chain 'A' and (resid 425 through 481 )
8X-RAY DIFFRACTION8chain 'A' and (resid 482 through 496 )
9X-RAY DIFFRACTION9chain 'B' and (resid 262 through 275 )
10X-RAY DIFFRACTION10chain 'B' and (resid 276 through 315 )
11X-RAY DIFFRACTION11chain 'B' and (resid 316 through 359 )
12X-RAY DIFFRACTION12chain 'B' and (resid 360 through 372 )
13X-RAY DIFFRACTION13chain 'B' and (resid 373 through 389 )
14X-RAY DIFFRACTION14chain 'B' and (resid 390 through 421 )
15X-RAY DIFFRACTION15chain 'B' and (resid 422 through 447 )
16X-RAY DIFFRACTION16chain 'B' and (resid 448 through 481 )
17X-RAY DIFFRACTION17chain 'B' and (resid 482 through 488 )
18X-RAY DIFFRACTION18chain 'B' and (resid 489 through 497 )
19X-RAY DIFFRACTION19chain 'C' and (resid 3 through 9 )
20X-RAY DIFFRACTION20chain 'D' and (resid 2 through 12 )
21X-RAY DIFFRACTION21chain 'E' and (resid 264 through 274 )
22X-RAY DIFFRACTION22chain 'E' and (resid 275 through 290 )
23X-RAY DIFFRACTION23chain 'E' and (resid 291 through 314 )
24X-RAY DIFFRACTION24chain 'E' and (resid 315 through 323 )
25X-RAY DIFFRACTION25chain 'E' and (resid 324 through 360 )
26X-RAY DIFFRACTION26chain 'E' and (resid 361 through 372 )
27X-RAY DIFFRACTION27chain 'E' and (resid 373 through 389 )
28X-RAY DIFFRACTION28chain 'E' and (resid 390 through 447 )
29X-RAY DIFFRACTION29chain 'E' and (resid 448 through 481 )
30X-RAY DIFFRACTION30chain 'E' and (resid 482 through 496 )
31X-RAY DIFFRACTION31chain 'F' and (resid 262 through 275 )
32X-RAY DIFFRACTION32chain 'F' and (resid 276 through 315 )
33X-RAY DIFFRACTION33chain 'F' and (resid 316 through 359 )
34X-RAY DIFFRACTION34chain 'F' and (resid 360 through 372 )
35X-RAY DIFFRACTION35chain 'F' and (resid 373 through 425 )
36X-RAY DIFFRACTION36chain 'F' and (resid 426 through 447 )
37X-RAY DIFFRACTION37chain 'F' and (resid 448 through 481 )
38X-RAY DIFFRACTION38chain 'F' and (resid 482 through 488 )
39X-RAY DIFFRACTION39chain 'F' and (resid 489 through 495 )
40X-RAY DIFFRACTION40chain 'G' and (resid 3 through 11 )
41X-RAY DIFFRACTION41chain 'H' and (resid 2 through 12 )

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