登録情報 データベース : PDB / ID : 9ccv 構造の表示 ダウンロードとリンクタイトル Crystal structure of human respiratory syncytial virus NS1 bound to human MED25 ACID 要素Mediator of RNA polymerase II transcription subunit 25 Non-structural protein 1 詳細キーワード VIRAL PROTEIN / complex / host nuclear protein機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
symbiont-mediated suppression of host adaptive immune response / positive regulation of mediator complex assembly / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity / symbiont-mediated perturbation of host apoptosis / core mediator complex / nuclear retinoic acid receptor binding / mediator complex / Generic Transcription Pathway / positive regulation of chromatin binding / : ... symbiont-mediated suppression of host adaptive immune response / positive regulation of mediator complex assembly / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity / symbiont-mediated perturbation of host apoptosis / core mediator complex / nuclear retinoic acid receptor binding / mediator complex / Generic Transcription Pathway / positive regulation of chromatin binding / : / RSV-host interactions / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity / positive regulation of transcription initiation by RNA polymerase II / host cell mitochondrion / nuclear retinoid X receptor binding / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity / RNA polymerase II preinitiation complex assembly / negative regulation of fibroblast proliferation / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity / positive regulation of transcription elongation by RNA polymerase II / transcription coactivator binding / PPARA activates gene expression / Transcriptional regulation of white adipocyte differentiation / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity / symbiont-mediated suppression of host toll-like receptor signaling pathway / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity / transcription regulator complex / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / host cell nucleus / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus 類似検索 - 分子機能 Pneumovirus NS1 protein / Pneumovirus NS1 protein / Mediator complex, subunit Med25, PTOV domain / Mediator complex, subunit Med25, synapsin 1 / Mediator complex subunit 25, PTOV domain superfamily / Mediator complex subunit 25 PTOV activation and synapsin 2 / Mediator complex subunit 25 synapsin 1 / Mediator of RNA polymerase II transcription subunit 25, von Willebrand factor type A domain / Mediator complex subunit 25 von Willebrand factor type A / von Willebrand factor A-like domain superfamily 類似検索 - ドメイン・相同性 Non-structural protein 1 / Mediator of RNA polymerase II transcription subunit 25 類似検索 - 構成要素生物種 Human respiratory syncytial virus A (ウイルス)Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.53 Å 詳細データ登録者 Kalita, P. / Borek, D.M. / Amarasinghe, G.K. / Leung, D.W. 資金援助 米国, 2件 詳細 詳細を隠す組織 認可番号 国 National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) AI159678 米国 National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) AI140758 米国
引用ジャーナル : Nat Commun / 年 : 2025タイトル : Molecular basis for human respiratory syncytial virus transcriptional regulator NS1 interactions with MED25.著者 : Kalita, P. / Khatavkar, O. / Uwase, G. / Korshunova, Y. / Hu, Y. / Wagner, N.D. / Xu, J. / Pan, J. / Nix, J.C. / Gross, M.L. / Brody, S.L. / Borek, D. / Amarasinghe, G.K. / Payton, J.E. / Leung, D.W. 履歴 登録 2024年6月23日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2025年4月9日 Provider : repository / タイプ : Initial release