登録情報 データベース : PDB / ID : 9c4v 構造の表示 ダウンロードとリンクタイトル Menin mutant G331D in complex with MLL peptide 要素Histone-lysine N-methyltransferase 2A Menin 詳細キーワード PROTEIN BINDING機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
negative regulation of DNA methylation-dependent heterochromatin formation / protein-cysteine methyltransferase activity / negative regulation of cyclin-dependent protein serine/threonine kinase activity / Y-form DNA binding / [histone H3]-lysine4 N-methyltransferase / histone H3K4 monomethyltransferase activity / response to potassium ion / unmethylated CpG binding / histone H3K4 trimethyltransferase activity / MLL1/2 complex ... negative regulation of DNA methylation-dependent heterochromatin formation / protein-cysteine methyltransferase activity / negative regulation of cyclin-dependent protein serine/threonine kinase activity / Y-form DNA binding / [histone H3]-lysine4 N-methyltransferase / histone H3K4 monomethyltransferase activity / response to potassium ion / unmethylated CpG binding / histone H3K4 trimethyltransferase activity / MLL1/2 complex / regulation of short-term neuronal synaptic plasticity / definitive hemopoiesis / histone H3K4 methyltransferase activity / osteoblast development / anterior/posterior pattern specification / negative regulation of JNK cascade / embryonic hemopoiesis / T-helper 2 cell differentiation / Formation of WDR5-containing histone-modifying complexes / positive regulation of transforming growth factor beta receptor signaling pathway / exploration behavior / negative regulation of protein phosphorylation / R-SMAD binding / histone methyltransferase complex / minor groove of adenine-thymine-rich DNA binding / negative regulation of cell cycle / cleavage furrow / MLL1 complex / membrane depolarization / negative regulation of osteoblast differentiation / RHO GTPases activate IQGAPs / cellular response to transforming growth factor beta stimulus / negative regulation of DNA-binding transcription factor activity / negative regulation of fibroblast proliferation / response to UV / four-way junction DNA binding / spleen development / transcription repressor complex / homeostasis of number of cells within a tissue / transcription initiation-coupled chromatin remodeling / Deactivation of the beta-catenin transactivating complex / 転移酵素; 一炭素原子の基を移すもの; メチル基を移すもの / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / post-embryonic development / response to gamma radiation / phosphoprotein binding / Post-translational protein phosphorylation / circadian regulation of gene expression / Formation of the beta-catenin:TCF transactivating complex / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / visual learning / PKMTs methylate histone lysines / protein modification process / nuclear matrix / Transcriptional regulation of granulopoiesis / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / RUNX1 regulates transcription of genes involved in differentiation of HSCs / MAPK cascade / double-stranded DNA binding / protein-containing complex assembly / fibroblast proliferation / protein-macromolecule adaptor activity / methylation / chromosome, telomeric region / transcription cis-regulatory region binding / endoplasmic reticulum lumen / negative regulation of cell population proliferation / DNA repair / negative regulation of DNA-templated transcription / apoptotic process / DNA damage response / chromatin binding / regulation of transcription by RNA polymerase II / chromatin / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / protein-containing complex / zinc ion binding / nucleoplasm / identical protein binding / nucleus / cytosol / cytoplasm 類似検索 - 分子機能 Menin / Menin / KMT2A, ePHD domain / KMT2A, PHD domain 1 / KMT2A, PHD domain 2 / KMT2A, PHD domain 3 / Methyltransferase, trithorax / : / FY-rich, N-terminal / F/Y-rich N-terminus ... Menin / Menin / KMT2A, ePHD domain / KMT2A, PHD domain 1 / KMT2A, PHD domain 2 / KMT2A, PHD domain 3 / Methyltransferase, trithorax / : / FY-rich, N-terminal / F/Y-rich N-terminus / PHD-like zinc-binding domain / FYR domain FYRN motif profile. / "FY-rich" domain, N-terminal region / FY-rich, C-terminal / F/Y rich C-terminus / FYR domain FYRC motif profile. / "FY-rich" domain, C-terminal region / CXXC zinc finger domain / Zinc finger, CXXC-type / Zinc finger CXXC-type profile. / Cysteine-rich motif following a subset of SET domains / Post-SET domain / Post-SET domain profile. / Extended PHD (ePHD) domain / Extended PHD (ePHD) domain profile. / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain / SET domain superfamily / SET domain profile. / SET domain / PHD-finger / Zinc finger PHD-type signature. / Zinc finger PHD-type profile. / Zinc finger, PHD-finger / Zinc finger, PHD-type / PHD zinc finger / Zinc finger, FYVE/PHD-type / bromo domain / Bromodomain / Bromodomain (BrD) profile. / Bromodomain-like superfamily / Zinc finger, RING/FYVE/PHD-type 類似検索 - ドメイン・相同性 Menin / Histone-lysine N-methyltransferase 2A 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.47 Å 詳細データ登録者 Clegg, B.D. / Cierpicki, T. / Grembecka, J. 資金援助 米国, 1件 詳細 詳細を隠す組織 認可番号 国 National Institutes of Health/National Cancer Institute (NIH/NCI) 272561 米国
引用ジャーナル : To Be Published タイトル : Menin mutant G331D in complex with MLL peptide著者 : Clegg, B.D. / Cierpicki, T. / Grembecka, J. 履歴 登録 2024年6月5日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2025年5月14日 Provider : repository / タイプ : Initial release