Entry | Database: PDB / ID: 9bkr |
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Title | Crystal structure of the Human TRIP12 WWE domain (isoform 2) in complex with ATP |
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Components | Isoform 2 of E3 ubiquitin-protein ligase TRIP12 |
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Keywords | LIGASE / TRIP12 / Isoform 2 / WWE / SGC / TRANSPORT PROTEIN / Structural Genomics Consortium / PSI-Biology / Protein Structure Initiative |
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Function / homology | Function and homology information
: / negative regulation of double-strand break repair / regulation of double-strand break repair / HECT-type E3 ubiquitin transferase / nuclear thyroid hormone receptor binding / regulation of embryonic development / protein polyubiquitination / ubiquitin protein ligase activity / Antigen processing: Ubiquitination & Proteasome degradation / ubiquitin-dependent protein catabolic process ...: / negative regulation of double-strand break repair / regulation of double-strand break repair / HECT-type E3 ubiquitin transferase / nuclear thyroid hormone receptor binding / regulation of embryonic development / protein polyubiquitination / ubiquitin protein ligase activity / Antigen processing: Ubiquitination & Proteasome degradation / ubiquitin-dependent protein catabolic process / nuclear speck / DNA repair / DNA damage response / nucleoplasm / nucleus / cytosolSimilarity search - Function E3 ubiquitin-protein ligase HECTD1/TRIP12-like / WWE domain superfamily / WWE domain / WWE domain profile. / HECT domain / HECT, E3 ligase catalytic domain / HECT-domain (ubiquitin-transferase) / HECT domain profile. / Domain Homologous to E6-AP Carboxyl Terminus with / Armadillo-like helical / Armadillo-type foldSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.4 Å |
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Authors | Kimani, S. / Dong, A. / Li, Y. / Arrowsmith, C.H. / Edwards, A.M. / Halabelian, L. / Structural Genomics Consortium (SGC) |
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Funding support | 1items Organization | Grant number | Country |
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Other private | | |
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Citation | Journal: To be published Title: Crystal structure of the Human TRIP12 WWE domain (isoform 2) in complex with ATP Authors: Kimani, S. / Dong, A. / Li, Y. / Arrowsmith, C.H. / Edwards, A.M. / Halabelian, L. / Structural Genomics Consortium (SGC) |
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History | Deposition | Apr 29, 2024 | Deposition site: RCSB / Processing site: RCSB |
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Supersession | Jul 31, 2024 | ID: 8TRE |
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Revision 1.0 | Jul 31, 2024 | Provider: repository / Type: Initial release |
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