登録情報 | データベース: PDB / ID: 9biu |
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タイトル | Cryo-EM structure of the mammalian peptide transporter PepT2 bound to cloxacillin, pose 2 |
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要素 | - Solute carrier family 15 member 2
- nanobody
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キーワード | MEMBRANE PROTEIN / protein-coupled peptide transporter / peptide transport / antibiotics |
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機能・相同性 | 機能・相同性情報
high-affinity oligopeptide transmembrane transporter activity / Proton/oligopeptide cotransporters / tripeptide import across plasma membrane / peptidoglycan transport / tripeptide transmembrane transporter activity / dipeptide transport / metanephric proximal tubule development / dipeptide import across plasma membrane / oligopeptide transport / peptide:proton symporter activity ...high-affinity oligopeptide transmembrane transporter activity / Proton/oligopeptide cotransporters / tripeptide import across plasma membrane / peptidoglycan transport / tripeptide transmembrane transporter activity / dipeptide transport / metanephric proximal tubule development / dipeptide import across plasma membrane / oligopeptide transport / peptide:proton symporter activity / dipeptide transmembrane transporter activity / antibacterial innate immune response / regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway / xenobiotic transport / peptide transport / renal absorption / phagocytic vesicle membrane / protein transport / apical plasma membrane / membrane / plasma membrane類似検索 - 分子機能 Oligopeptide transporter / PTR2 family proton/oligopeptide symporters signature 1. / PTR2 family proton/oligopeptide symporters signature 2. / PTR2 family proton/oligopeptide symporter, conserved site / Proton-dependent oligopeptide transporter family / POT family / Alpha/beta knot methyltransferases / MFS transporter superfamily類似検索 - ドメイン・相同性 CLOXACILLIN / Solute carrier family 15 member 2類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Rattus norvegicus (ドブネズミ)
![](img/tx_mammal.gif) Lama glama (ラマ) |
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手法 | 電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 2.9 Å |
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データ登録者 | Parker, J.L. / Deme, J.C. / Lea, S.M. / Newstead, S. |
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資金援助 | 英国, 米国, 4件 組織 | 認可番号 | 国 |
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Wellcome Trust | 215519 | 英国 | Wellcome Trust | 219531 | 英国 | Wellcome Trust | 218514 | 英国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | Intramural Research Program | 米国 |
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引用 | ジャーナル: To Be Published タイトル: Structural basis for antibiotic transport and inhibition in the mammalian proton-coupled peptide transporter, PepT2 著者: Parker, J.L. / Deme, J.C. / Lichtinger, S.M. / Kuteyi, G. / Biggin, P.C. / Lea, S.M. / Newstead, S. |
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履歴 | 登録 | 2024年4月24日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2024年7月24日 | Provider: repository / タイプ: Initial release |
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