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- PDB-9bai: Crystal structure of GDP-bound human K-RAS in a covalent complex ... -

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Basic information

Entry
Database: PDB / ID: 9bai
TitleCrystal structure of GDP-bound human K-RAS in a covalent complex with aryl sulfonyl fluoride compounds.
Components(Isoform 2B of GTPase ...) x 2
KeywordsHYDROLASE / KRAS / cancer / GTPase / covalent inhibitor / sulfonyl fluoride
Function / homology
Function and homology information


response to mineralocorticoid / GMP binding / forebrain astrocyte development / LRR domain binding / regulation of synaptic transmission, GABAergic / negative regulation of epithelial cell differentiation / response to isolation stress / response to gravity / epithelial tube branching involved in lung morphogenesis / type I pneumocyte differentiation ...response to mineralocorticoid / GMP binding / forebrain astrocyte development / LRR domain binding / regulation of synaptic transmission, GABAergic / negative regulation of epithelial cell differentiation / response to isolation stress / response to gravity / epithelial tube branching involved in lung morphogenesis / type I pneumocyte differentiation / Rac protein signal transduction / positive regulation of Rac protein signal transduction / Signaling by RAS GAP mutants / Signaling by RAS GTPase mutants / Activation of RAS in B cells / myoblast proliferation / skeletal muscle cell differentiation / RAS signaling downstream of NF1 loss-of-function variants / RUNX3 regulates p14-ARF / positive regulation of glial cell proliferation / SOS-mediated signalling / Activated NTRK3 signals through RAS / Activated NTRK2 signals through RAS / SHC1 events in ERBB4 signaling / cardiac muscle cell proliferation / Signalling to RAS / Activated NTRK2 signals through FRS2 and FRS3 / SHC-related events triggered by IGF1R / Estrogen-stimulated signaling through PRKCZ / glial cell proliferation / SHC-mediated cascade:FGFR3 / MET activates RAS signaling / SHC-mediated cascade:FGFR2 / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases / Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants / Signaling by PDGFRA extracellular domain mutants / SHC-mediated cascade:FGFR4 / Erythropoietin activates RAS / SHC-mediated cascade:FGFR1 / Signaling by FGFR4 in disease / FRS-mediated FGFR3 signaling / Signaling by CSF3 (G-CSF) / Signaling by FLT3 ITD and TKD mutants / FRS-mediated FGFR2 signaling / FRS-mediated FGFR4 signaling / FRS-mediated FGFR1 signaling / p38MAPK events / Signaling by FGFR3 in disease / protein-membrane adaptor activity / Tie2 Signaling / striated muscle cell differentiation / Signaling by FGFR2 in disease / GRB2 events in EGFR signaling / Signaling by FLT3 fusion proteins / SHC1 events in EGFR signaling / FLT3 Signaling / Signaling by FGFR1 in disease / EGFR Transactivation by Gastrin / NCAM signaling for neurite out-growth / CD209 (DC-SIGN) signaling / homeostasis of number of cells within a tissue / Downstream signal transduction / GRB2 events in ERBB2 signaling / Insulin receptor signalling cascade / Ras activation upon Ca2+ influx through NMDA receptor / SHC1 events in ERBB2 signaling / response to glucocorticoid / Constitutive Signaling by Overexpressed ERBB2 / Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants / VEGFR2 mediated cell proliferation / small monomeric GTPase / FCERI mediated MAPK activation / liver development / female pregnancy / RAF activation / Signaling by ERBB2 TMD/JMD mutants / Signaling by SCF-KIT / Constitutive Signaling by EGFRvIII / Signaling by high-kinase activity BRAF mutants / regulation of long-term neuronal synaptic plasticity / MAP2K and MAPK activation / Signaling by ERBB2 ECD mutants / visual learning / Signaling by ERBB2 KD Mutants / cytoplasmic side of plasma membrane / cytokine-mediated signaling pathway / Regulation of RAS by GAPs / Signaling by CSF1 (M-CSF) in myeloid cells / RAS processing / Negative regulation of MAPK pathway / Signaling by RAF1 mutants / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / GDP binding / Signaling by BRAF and RAF1 fusions / positive regulation of cellular senescence / DAP12 signaling / MAPK cascade / Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Similarity search - Function
Small GTPase, Ras-type / Small GTPase Ras domain profile. / Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases / Rho (Ras homology) subfamily of Ras-like small GTPases / Ras subfamily of RAS small GTPases / Small GTPase / Ras family / Rab subfamily of small GTPases / Small GTP-binding protein domain / P-loop containing nucleoside triphosphate hydrolase
Similarity search - Domain/homology
GUANOSINE-5'-DIPHOSPHATE / : / GTPase KRas
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.49 Å
AuthorsLandgraf, A.D. / Brenner, R.J. / Ghozayel, M.K. / Bum-Erdene, K. / Gonzalez-Gutierrez, G. / Meroueh, S.
Funding support United States, 2items
OrganizationGrant numberCountry
National Institutes of Health/National Cancer Institute (NIH/NCI)R01CA264471 United States
National Institutes of Health/National Cancer Institute (NIH/NCI)R01CA197928 United States
CitationJournal: Chemmedchem / Year: 2025
Title: Small-Molecule KRAS Inhibitors by Tyrosine Covalent Bond Formation.
Authors: Landgraf, A.D. / Brenner, R. / Ghozayel, M.K. / Bum-Erdene, K. / Gonzalez-Gutierrez, G. / Meroueh, S.O.
History
DepositionApr 4, 2024Deposition site: RCSB / Processing site: RCSB
Revision 1.0Apr 9, 2025Provider: repository / Type: Initial release
Revision 1.1Jun 11, 2025Group: Database references / Category: citation / citation_author
Item: _citation.page_first / _citation.page_last ..._citation.page_first / _citation.page_last / _citation_author.identifier_ORCID / _citation_author.name
Revision 1.2Jul 2, 2025Group: Database references / Category: citation
Item: _citation.journal_volume / _citation.page_first / _citation.page_last

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Isoform 2B of GTPase KRas
B: Isoform 2B of GTPase KRas
C: Isoform 2B of GTPase KRas
D: Isoform 2B of GTPase KRas
hetero molecules


Theoretical massNumber of molelcules
Total (without water)80,11816
Polymers77,0554
Non-polymers3,06312
Water16,538918
1
A: Isoform 2B of GTPase KRas
hetero molecules


Theoretical massNumber of molelcules
Total (without water)20,0224
Polymers19,2561
Non-polymers7663
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
2
B: Isoform 2B of GTPase KRas
hetero molecules


Theoretical massNumber of molelcules
Total (without water)20,0384
Polymers19,2721
Non-polymers7663
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
3
C: Isoform 2B of GTPase KRas
hetero molecules


Theoretical massNumber of molelcules
Total (without water)20,0224
Polymers19,2561
Non-polymers7663
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
4
D: Isoform 2B of GTPase KRas
hetero molecules


Theoretical massNumber of molelcules
Total (without water)20,0384
Polymers19,2721
Non-polymers7663
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)36.022, 83.944, 104.553
Angle α, β, γ (deg.)90.000, 90.000, 90.000
Int Tables number4
Space group name H-MP1211
Space group name HallP2yb
Symmetry operation#1: x,y,z
#2: -x,y+1/2,-z

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Components

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Isoform 2B of GTPase ... , 2 types, 4 molecules ACBD

#1: Protein Isoform 2B of GTPase KRas / K-Ras 2 / Ki-Ras / c-K-ras / c-Ki-ras


Mass: 19255.693 Da / Num. of mol.: 2 / Mutation: C118S
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: KRAS, KRAS2, RASK2 / Production host: Escherichia coli BL21(DE3) (bacteria) / References: UniProt: P01116, small monomeric GTPase
#2: Protein Isoform 2B of GTPase KRas / K-Ras 2 / Ki-Ras / c-K-ras / c-Ki-ras


Mass: 19271.693 Da / Num. of mol.: 2 / Mutation: C118S
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: KRAS, KRAS2, RASK2 / Production host: Escherichia coli BL21(DE3) (bacteria) / References: UniProt: P01116, small monomeric GTPase

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Non-polymers , 4 types, 930 molecules

#3: Chemical
ChemComp-MG / MAGNESIUM ION


Mass: 24.305 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: Mg
#4: Chemical
ChemComp-WMU / 3-[bis(oxidanylidene)-$l^{5}-sulfanyl]-~{N}-pyridin-4-yl-benzenesulfonamide


Mass: 298.338 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: C11H10N2O4S2 / Feature type: SUBJECT OF INVESTIGATION
#5: Chemical
ChemComp-GDP / GUANOSINE-5'-DIPHOSPHATE


Type: RNA linking / Mass: 443.201 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: C10H15N5O11P2 / Comment: GDP, energy-carrying molecule*YM
#6: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 918 / Source method: isolated from a natural source / Formula: H2O

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Details

Has ligand of interestY
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.07 Å3/Da / Density % sol: 40.65 %
Crystal growTemperature: 293 K / Method: vapor diffusion, sitting drop / Details: Ammonium chloride 0.2 M and PEG 3350 20%.

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: ALS / Beamline: 4.2.2 / Wavelength: 1.0722 Å
DetectorType: RDI CMOS_8M / Detector: CMOS / Date: Oct 21, 2021
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 1.0722 Å / Relative weight: 1
ReflectionResolution: 1.49→104.55 Å / Num. obs: 98547 / % possible obs: 97.9 % / Redundancy: 3.7 % / Biso Wilson estimate: 13.16 Å2 / CC1/2: 0.996 / Rpim(I) all: 0.053 / Rrim(I) all: 0.1 / Rsym value: 0.085 / Net I/σ(I): 9.9
Reflection shellResolution: 1.49→1.52 Å / Mean I/σ(I) obs: 1.3 / Num. unique obs: 4602 / CC1/2: 0.539 / Rpim(I) all: 0.497 / Rrim(I) all: 0.915 / Rsym value: 0.763 / % possible all: 92.5

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Processing

Software
NameVersionClassification
PHENIX1.20.1_4487refinement
XDSdata reduction
Aimlessdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT / Resolution: 1.49→65.46 Å / SU ML: 0.1754 / Cross valid method: FREE R-VALUE / σ(F): 1.33 / Phase error: 22.0745
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
RfactorNum. reflection% reflection
Rfree0.2249 4742 5 %
Rwork0.1857 90100 -
obs0.1877 94842 94.19 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso mean: 19.35 Å2
Refinement stepCycle: LAST / Resolution: 1.49→65.46 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms5433 0 80 918 6431
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.01365626
X-RAY DIFFRACTIONf_angle_d1.33447621
X-RAY DIFFRACTIONf_chiral_restr0.0887838
X-RAY DIFFRACTIONf_plane_restr0.0147970
X-RAY DIFFRACTIONf_dihedral_angle_d00
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
1.49-1.510.31421500.26712839X-RAY DIFFRACTION90
1.51-1.530.26561520.24882993X-RAY DIFFRACTION95.85
1.53-1.550.22931560.2243072X-RAY DIFFRACTION96.1
1.55-1.570.24791440.2113117X-RAY DIFFRACTION96.14
1.57-1.590.25621550.2113045X-RAY DIFFRACTION96.88
1.59-1.610.24821730.20213071X-RAY DIFFRACTION96.63
1.61-1.630.24121380.20183148X-RAY DIFFRACTION96.59
1.63-1.660.27911480.19893067X-RAY DIFFRACTION97.31
1.66-1.680.25131290.19483083X-RAY DIFFRACTION97.24
1.68-1.710.24071840.19363135X-RAY DIFFRACTION97.56
1.71-1.740.24591460.19843090X-RAY DIFFRACTION97.79
1.74-1.770.24871680.18793113X-RAY DIFFRACTION97.71
1.77-1.80.20371810.19233127X-RAY DIFFRACTION97.99
1.8-1.840.231640.19793091X-RAY DIFFRACTION98.19
1.84-1.880.26161640.23933114X-RAY DIFFRACTION96.78
1.88-1.930.4963720.44431587X-RAY DIFFRACTION49.95
1.93-1.970.27971500.21692887X-RAY DIFFRACTION90.55
1.97-2.030.22681840.17623117X-RAY DIFFRACTION98.74
2.03-2.090.22031730.17913162X-RAY DIFFRACTION98.61
2.09-2.150.19371560.16843136X-RAY DIFFRACTION99.1
2.15-2.230.26691720.23682816X-RAY DIFFRACTION89.57
2.23-2.320.32261240.27031929X-RAY DIFFRACTION64.58
2.32-2.430.17731820.15863182X-RAY DIFFRACTION99.32
2.43-2.550.23231540.16943178X-RAY DIFFRACTION99.43
2.55-2.710.21561830.17063156X-RAY DIFFRACTION99.55
2.71-2.920.21911890.16963176X-RAY DIFFRACTION99.62
2.92-3.220.21751620.15473203X-RAY DIFFRACTION99.79
3.22-3.680.20921600.15563030X-RAY DIFFRACTION93.85
3.68-4.640.16631680.14293191X-RAY DIFFRACTION99.23
4.64-65.460.18091610.173245X-RAY DIFFRACTION98.61
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
11.7253749670.3881050213680.1846336586323.582020888340.6708844918620.9426821436090.01921109079850.05806474069040.179674435554-0.266293218171-0.03429819260.055402173806-0.144871572762-0.008728670629310.00622663991920.07275839998860.01710482577010.02292097326020.1221711918610.00339952230660.03913660771-8.568-6.4849.674
23.07663480578-1.38443072972-3.11525683191.094426899961.220779768053.61585968765-0.206038536360.23157066173-0.0191995817615-0.1605107740030.0008075674896540.2094003480510.0401485411809-0.09616404099940.2240917138290.1042634579670.001112343736980.002896183518020.1180993028180.0001215778120740.12052320567-11.148-16.1363.441
33.20807217278-3.48661383734-1.316720569774.1888984681.811324218171.32281247840.04135496675410.0709512128150.0360648182316-0.104810580862-0.09923938598790.0564909211648-0.04556572360490.01366523557260.05360616582070.1076484553350.001534848653840.02310617968830.1236308238320.02166455164390.064788268152-3.122-3.357.612
41.785624019051.21653164591-0.04141933315513.96398718941-0.0590762214161.083008445970.0356980591018-0.0907994571767-0.02128693610110.0630426100988-0.038289638067-0.330603338649-0.01092583587450.1494590426560.005505076333140.06386683503370.0053299864898-0.002061682569090.12549257891-0.0009954132078980.0580300920072-0.153-11.19119.914
52.767623577151.233820595980.9607296413462.14441704238-0.1797683665381.838474871110.0267343708874-0.136343468202-0.01561867889390.099744637586-0.04603407414230.05326227953190.0169205712709-0.2740826372360.01630055501590.06470383256610.005447911519140.02496294739450.12614933754-0.02038699656440.0625253928208-11.975-14.74523.924
61.711329722380.352533717311-0.1373588546445.170496100921.733605199951.869396111220.0116115617516-0.01968684440020.256728957628-0.04325716775820.0109049424334-0.162975035096-0.168240753540.00959528469813-0.04505882865240.08029013051680.0148677325947-0.01055021784940.1484532148880.01414225778380.082385123388-8.592-1.77915.422
72.05644849745-0.003750939788980.1303138196633.395076371920.5442171257271.5463974869-0.0106675843754-0.128858019562-0.2497728622370.3254859605730.03490912440580.1034574393240.088170859834-0.259548398352-0.02728323085580.096016466342-0.0162781730089-0.005663234953890.1515604926080.02239504727890.0457340889263.8678.05743.472
83.95608222068-1.468416143953.340495300660.745851827431-1.392008512732.98798336565-0.14950924134-0.7505990740650.1287972481990.345382300380.07498715392930.0729418519494-0.214408365586-0.5010028604240.1839906555570.1567790456040.0196270762474-0.003509429667140.227175218657-0.03209879714090.1150628058514.34218.46349.033
92.466099047380.6680237511242.386905763343.871542398941.14723655252.516972266590.195801914555-0.0358067902293-0.1633153880010.1040908133050.06336689932740.222011793570.282043535906-0.0542558800093-0.1903030883940.132035880590.00318351307678-0.03390914204030.1299588751030.03045144498620.09369750896398.5723.72245.713
102.10327232752-0.832845039841-0.4281160499054.03124109827-0.7615898698852.070878272730.01629133040830.065110989191-0.0659077065513-0.311094911882-0.0630311289814-0.4987168918710.1155452176580.252617907267-0.001334370058430.06790528925210.005725526681650.006628490148610.166691374419-0.006853266827520.10410963200313.6199.28833.197
110.95837479472-0.2232469401230.1916819796933.79155683680.1508229810341.204445584570.01894396195530.0798316864317-0.058845506264-0.140957118287-0.01674016656340.109763149829-0.0383971121847-0.0574520819795-0.0029858087390.0491398268256-0.00228384789304-0.03087119036030.136625260992-0.01180412103170.06657235218162.40311.09830.755
121.99851878021-0.421022918768-0.3641023922183.605045164080.8283128698350.915483672461-0.0614397628022-0.0330088819945-0.2019271137750.3296603617960.01686529524540.06970961040860.177865680627-0.01423403896370.03885450163980.0777379747419-0.00950266761532-0.02075530670580.1205297701660.001323029054820.0479477148013-26.58847.28842.605
137.038238869851.549363812613.513101468960.5021511008610.5048407984283.10115205276-0.219435963875-0.4678087446030.1208916066880.207080439863-0.01522386200620.187924293007-0.144191685188-0.1888620886830.2522925175630.1138849467520.003356552634460.008027103119110.116939335397-0.02072893810920.111616310697-29.23856.90448.904
146.241037696.709828924964.558405830087.167625153574.792186226783.793823515160.148363740514-0.06421997522130.1004912669160.320124886229-0.2118485123510.2559581057380.205832990828-0.001415557159140.03877359111880.112237421856-0.01031047308420.008903793736660.118200372661-0.01428773633140.0884196129904-28.74839.38244.429
157.53770176076-1.898442484010.4573073734593.627851789783.419889935834.03633916768-0.01219223530930.166746167568-0.1644544917110.03329421563950.04697075237770.08429532586380.1060658578820.28944258476-0.03649871844510.117992026097-0.014823170451-0.01684360964060.1541136517220.01505297634210.0581746859843-12.25749.76344.972
162.57191478164-2.010194210560.3780830017595.40055357695-1.318982960181.90608253270.09832057527730.1514314194890.0974630831743-0.153618660639-0.137058832535-0.3675793049590.03504302248830.1916289663930.03958362361480.0739434733089-0.002903280569570.002306404011140.12631858543-0.006750783109130.0518562668386-17.8654.06932.934
173.11996500144-3.047399943170.678574616393.91481476758-0.3474654726041.285852075690.02948144175090.3668609929050.224688428690.0350379997971-0.122610139962-0.4302412546890.144003443910.1752082337230.01593184592980.0783583227177-0.006341442170770.01846465276480.125499484396-0.006548966909520.0993889946212-18.99346.06930.793
182.90595989105-1.01654328138-1.418794393451.77802628918-0.1804616761152.577942093450.0241555220190.184588110206-0.00782717963446-0.0791609769011-0.0284846667120.0127577571607-0.0151504221543-0.2545789612580.00414100866910.0577589836497-0.00750887462553-0.01766741770190.12712298885-0.02740309134320.0709770406309-29.9955.52128.351
191.62453863515-0.909559487296-0.372001657848.391340413823.052363986792.32922136331-0.02432720585290.0834689569274-0.188147588264-0.1827948006250.0270917575143-0.0917236759560.06069191468950.008159593261170.03091127093910.0652789636342-0.004420797304260.01231391090450.1145398913920.008094237466080.052347949533-27.78343.45135.575
202.116076387290.0571963271546-0.1087749424873.026938267970.2726986215521.669412550460.01018319428820.0874872300150.221051106932-0.2788802882160.02629601096110.117013998062-0.153463681713-0.22423538705-0.03468867613620.09528522310030.01765099677210.007947365812540.1279163939970.01755423591660.043876678449-14.15832.748.798
213.802996861661.62141657348-3.641851083621.16672968164-1.721315100753.57812173686-0.2262938713230.62414587169-0.146325101828-0.4624181003040.06054276426810.1346626648620.32741189056-0.4493398020210.2294083088210.165747639669-0.01983157489550.01759963332730.214629732043-0.03181524399830.12221201011-13.67522.3073.221
222.49669425703-0.761440427852-2.341245168393.957482181621.193687629452.55699040740.2048012184680.07407391922770.113209683596-0.1699858570180.03335270167670.235741593875-0.267412149796-0.0532198517647-0.1636544888910.125320370653-0.004451557825290.03008061246230.130155504280.03247702169070.0852157949313-9.49437.0356.536
232.119632343780.6846257491390.2705854698593.56197721585-0.8680676316982.233793921710.019900068134-0.1771211729910.09088128297430.234045204191-0.0990407853134-0.508032763524-0.0922446590360.2175753381730.03533160524430.0664619286351-0.00963705448645-0.006213127650370.160173386025-0.006750700211670.116294338967-4.4231.47419.119
240.8812658816260.334750109443-0.1823833541514.186640962310.5029087682561.0306657964-0.00228686131955-0.09558892727220.0412482446010.145425120370.005825881522840.1220998442410.0730077739459-0.06206548872720.00408417325060.05693181256060.003026934141130.0292017090540.136298545296-0.01039609963280.0723702873109-15.69529.5421.501
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1( CHAIN A AND RESID 1:25 )A1 - 25
2X-RAY DIFFRACTION2( CHAIN A AND RESID 26:37 )A26 - 37
3X-RAY DIFFRACTION3( CHAIN A AND RESID 38:74 )A38 - 74
4X-RAY DIFFRACTION4( CHAIN A AND RESID 75:116 )A75 - 116
5X-RAY DIFFRACTION5( CHAIN A AND RESID 117:151 )A117 - 151
6X-RAY DIFFRACTION6( CHAIN A AND RESID 152:168 )A152 - 168
7X-RAY DIFFRACTION7( CHAIN B AND RESID 1:25 )B1 - 25
8X-RAY DIFFRACTION8( CHAIN B AND RESID 26:37 )B26 - 37
9X-RAY DIFFRACTION9( CHAIN B AND RESID 38:74 )B38 - 74
10X-RAY DIFFRACTION10( CHAIN B AND RESID 75:116 )B75 - 116
11X-RAY DIFFRACTION11( CHAIN B AND RESID 117:166 )B117 - 166
12X-RAY DIFFRACTION12( CHAIN C AND RESID 1:25 )C1 - 25
13X-RAY DIFFRACTION13( CHAIN C AND RESID 26:37 )C26 - 37
14X-RAY DIFFRACTION14( CHAIN C AND RESID 38:57 )C38 - 57
15X-RAY DIFFRACTION15( CHAIN C AND RESID 58:74 )C58 - 74
16X-RAY DIFFRACTION16( CHAIN C AND RESID 75:104 )C75 - 104
17X-RAY DIFFRACTION17( CHAIN C AND RESID 105:116 )C105 - 116
18X-RAY DIFFRACTION18( CHAIN C AND RESID 117:151 )C117 - 151
19X-RAY DIFFRACTION19( CHAIN C AND RESID 152:167 )C152 - 167
20X-RAY DIFFRACTION20( CHAIN D AND RESID 1:25 )D1 - 25
21X-RAY DIFFRACTION21( CHAIN D AND RESID 26:37 )D26 - 37
22X-RAY DIFFRACTION22( CHAIN D AND RESID 38:74 )D38 - 74
23X-RAY DIFFRACTION23( CHAIN D AND RESID 75:116 )D75 - 116
24X-RAY DIFFRACTION24( CHAIN D AND RESID 117:166 )D117 - 166

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