- PDB-9aqz: Crystal structure of Bcl-xL in complex with a small molecule inhibitor -
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基本情報
登録情報
データベース: PDB / ID: 9aqz
タイトル
Crystal structure of Bcl-xL in complex with a small molecule inhibitor
要素
Bcl-2-like protein 1
キーワード
APOPTOSIS / Bcl-xL / inhibitor
機能・相同性
機能・相同性情報
apoptotic process in bone marrow cell / The NLRP1 inflammasome / dendritic cell apoptotic process / SARS-CoV-1-mediated effects on programmed cell death / dendritic cell proliferation / positive regulation of mononuclear cell proliferation / BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members / negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage / negative regulation of dendritic cell apoptotic process ...apoptotic process in bone marrow cell / The NLRP1 inflammasome / dendritic cell apoptotic process / SARS-CoV-1-mediated effects on programmed cell death / dendritic cell proliferation / positive regulation of mononuclear cell proliferation / BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members / negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage / negative regulation of dendritic cell apoptotic process / negative regulation of execution phase of apoptosis / regulation of mitochondrial membrane permeability / fertilization / regulation of growth / Bcl-2 family protein complex / BH domain binding / NFE2L2 regulating tumorigenic genes / response to cycloheximide / cellular response to alkaloid / negative regulation of release of cytochrome c from mitochondria / negative regulation of reproductive process / STAT5 activation downstream of FLT3 ITD mutants / negative regulation of developmental process / hepatocyte apoptotic process / BH3 domain binding / germ cell development / apoptotic mitochondrial changes / ectopic germ cell programmed cell death / negative regulation of anoikis / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of protein localization to plasma membrane / negative regulation of extrinsic apoptotic signaling pathway via death domain receptors / negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway / ovarian follicle development / extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of intrinsic apoptotic signaling pathway / negative regulation of autophagy / release of cytochrome c from mitochondria / response to cytokine / epithelial cell proliferation / regulation of mitochondrial membrane potential / regulation of cytokinesis / cellular response to amino acid stimulus / cellular response to gamma radiation / synaptic vesicle membrane / intrinsic apoptotic signaling pathway in response to DNA damage / endocytosis / male gonad development / RAS processing / spermatogenesis / Interleukin-4 and Interleukin-13 signaling / nuclear membrane / defense response to virus / in utero embryonic development / neuron apoptotic process / negative regulation of neuron apoptotic process / mitochondrial outer membrane / mitochondrial inner membrane / mitochondrial matrix / centrosome / negative regulation of apoptotic process / protein kinase binding / endoplasmic reticulum / mitochondrion / identical protein binding / cytosol / cytoplasm 類似検索 - 分子機能
Apoptosis regulator, Bcl-X / Apoptosis regulator, Bcl-2/ BclX / Apoptosis regulator, Bcl-2, BH4 motif, conserved site / Apoptosis regulator, Bcl-2 family BH4 motif signature. / Apoptosis regulator, Bcl-2 protein, BH4 / Bcl-2 homology region 4 / Apoptosis regulator, Bcl-2 family BH4 motif profile. / BH4 Bcl-2 homology region 4 / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. ...Apoptosis regulator, Bcl-X / Apoptosis regulator, Bcl-2/ BclX / Apoptosis regulator, Bcl-2, BH4 motif, conserved site / Apoptosis regulator, Bcl-2 family BH4 motif signature. / Apoptosis regulator, Bcl-2 protein, BH4 / Bcl-2 homology region 4 / Apoptosis regulator, Bcl-2 family BH4 motif profile. / BH4 Bcl-2 homology region 4 / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site / Apoptosis regulator, Bcl-2 family BH2 motif signature. / Bcl-2 family / BCL (B-Cell lymphoma); contains BH1, BH2 regions / Bcl-2, Bcl-2 homology region 1-3 / Bcl2-like / BCL2-like apoptosis inhibitors family profile. / Apoptosis regulator proteins, Bcl-2 family / Bcl-2-like superfamily 類似検索 - ドメイン・相同性
分子量: 18689.816 Da / 分子数: 1 / 変異: W24A,E158K,D189A / 由来タイプ: 組換発現 詳細: The following clone was used for structure studies [Bcl-xL (1-25)-GGGGGGG-(83-209) W24A, E158K, D189A]-LE-6His. In this form of the protein, an extended loop, residues 26-82 has been deleted ...詳細: The following clone was used for structure studies [Bcl-xL (1-25)-GGGGGGG-(83-209) W24A, E158K, D189A]-LE-6His. In this form of the protein, an extended loop, residues 26-82 has been deleted and replaced with seven glycine residues. Point mutations are listed above.,The following clone was used for structure studies [Bcl-xL (1-25)-GGGGGGG-(83-209) W24A, E158K, D189A]-LE-6His. In this form of the protein, an extended loop, residues 26-82 has been deleted and replaced with seven glycine residues. Point mutations are listed above. 由来: (組換発現) Homo sapiens (ヒト) / 遺伝子: BCL2L1, BCL2L, BCLX / 発現宿主: Escherichia phage EcSzw-2 (ファージ) / 参照: UniProt: Q07817