登録情報 | データベース: PDB / ID: 8zm2 |
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タイトル | Structure of human pyruvate dehydrogenase kinase 2 complexed with compound 16 |
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要素 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
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キーワード | TRANSFERASE / pdhk / kinase inhibitors / fragment screening / pdk1 / pdk2 / pdk3 / pdk4 / transferase-inhibitor complex / transferase/inhibitor |
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機能・相同性 | 機能・相同性情報
[pyruvate dehydrogenase (acetyl-transferring)] kinase / regulation of acetyl-CoA biosynthetic process from pyruvate / : / pyruvate dehydrogenase (acetyl-transferring) kinase activity / Regulation of pyruvate dehydrogenase (PDH) complex / pyruvate dehydrogenase complex / regulation of cellular ketone metabolic process / regulation of pH / cellular response to nutrient / Signaling by Retinoic Acid ...[pyruvate dehydrogenase (acetyl-transferring)] kinase / regulation of acetyl-CoA biosynthetic process from pyruvate / : / pyruvate dehydrogenase (acetyl-transferring) kinase activity / Regulation of pyruvate dehydrogenase (PDH) complex / pyruvate dehydrogenase complex / regulation of cellular ketone metabolic process / regulation of pH / cellular response to nutrient / Signaling by Retinoic Acid / regulation of gluconeogenesis / intrinsic apoptotic signaling pathway by p53 class mediator / regulation of glucose metabolic process / regulation of calcium-mediated signaling / cellular response to reactive oxygen species / glucose metabolic process / phosphorylation / insulin receptor signaling pathway / glucose homeostasis / protein kinase activity / mitochondrial matrix / protein homodimerization activity / mitochondrion / nucleoplasm / ATP binding / cytosol類似検索 - 分子機能 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal / Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily / PDK/BCKDK protein kinase / Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase / Histidine kinase domain / Histidine kinase domain profile. / Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase / Histidine kinase-like ATPases / Histidine kinase/HSP90-like ATPase / Histidine kinase/HSP90-like ATPase superfamily類似検索 - ドメイン・相同性 : / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.34 Å |
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データ登録者 | Akai, S. / Orita, T. / Nomura, A. / Adachi, T. |
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資金援助 | 1件 |
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引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2024 タイトル: Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase. 著者: Inoue, M. / Nagamori, H. / Morita, T. / Kobayashi, S. / Suzawa, K. / Kitao, Y. / Saito, T. / Kawahara, I. / Orita, T. / Akai, S. / Adachi, T. / Motomura, T. |
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履歴 | 登録 | 2024年5月22日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2024年6月19日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年7月3日 | Group: Database references / カテゴリ: citation / Item: _citation.journal_volume |
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