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- PDB-8zdx: Crystal structure of MjHKU4r-CoV-1 RBD bound to hDPP4 -

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Basic information

Entry
Database: PDB / ID: 8zdx
TitleCrystal structure of MjHKU4r-CoV-1 RBD bound to hDPP4
Components
  • Dipeptidyl peptidase 4 membrane form
  • Spike glycoprotein
KeywordsVIRAL PROTEIN / Complex of a pangolin coronavirus spike protein bound to receptor
Function / homology
Function and homology information


glucagon processing / negative regulation of neutrophil chemotaxis / regulation of cell-cell adhesion mediated by integrin / Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) / negative regulation of extracellular matrix disassembly / dipeptidyl-peptidase IV / chemorepellent activity / psychomotor behavior / intercellular canaliculus / dipeptidyl-peptidase activity ...glucagon processing / negative regulation of neutrophil chemotaxis / regulation of cell-cell adhesion mediated by integrin / Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) / negative regulation of extracellular matrix disassembly / dipeptidyl-peptidase IV / chemorepellent activity / psychomotor behavior / intercellular canaliculus / dipeptidyl-peptidase activity / peptide hormone processing / locomotory exploration behavior / lamellipodium membrane / endocytic vesicle / behavioral fear response / endothelial cell migration / aminopeptidase activity / receptor-mediated endocytosis of virus by host cell / T cell costimulation / serine-type peptidase activity / T cell activation / Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) / lamellipodium / virus receptor activity / protease binding / membrane fusion / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / response to hypoxia / receptor-mediated virion attachment to host cell / cell adhesion / apical plasma membrane / membrane raft / endocytosis involved in viral entry into host cell / symbiont entry into host cell / signaling receptor binding / lysosomal membrane / fusion of virus membrane with host plasma membrane / serine-type endopeptidase activity / focal adhesion / fusion of virus membrane with host endosome membrane / positive regulation of cell population proliferation / viral envelope / host cell plasma membrane / virion membrane / cell surface / protein homodimerization activity / proteolysis / extracellular exosome / extracellular region / identical protein binding / membrane / plasma membrane
Similarity search - Function
Spike (S) protein S1 subunit, N-terminal domain, MERS-CoV-like / Prolyl endopeptidase family serine active site. / Peptidase S9, serine active site / : / Dipeptidylpeptidase IV, N-terminal domain / Dipeptidyl peptidase IV (DPP IV) N-terminal region / Peptidase S9, prolyl oligopeptidase, catalytic domain / Prolyl oligopeptidase family / Spike glycoprotein S2, coronavirus, C-terminal / Coronavirus spike glycoprotein S2, intravirion ...Spike (S) protein S1 subunit, N-terminal domain, MERS-CoV-like / Prolyl endopeptidase family serine active site. / Peptidase S9, serine active site / : / Dipeptidylpeptidase IV, N-terminal domain / Dipeptidyl peptidase IV (DPP IV) N-terminal region / Peptidase S9, prolyl oligopeptidase, catalytic domain / Prolyl oligopeptidase family / Spike glycoprotein S2, coronavirus, C-terminal / Coronavirus spike glycoprotein S2, intravirion / Alpha/Beta hydrolase fold / Coronavirus spike glycoprotein S1, C-terminal / Coronavirus spike glycoprotein S1, C-terminal / Spike glycoprotein, betacoronavirus / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Betacoronavirus spike glycoprotein S1, receptor binding / Spike glycoprotein S1, N-terminal domain, betacoronavirus-like / Betacoronavirus-like spike glycoprotein S1, N-terminal / Spike glycoprotein S2, coronavirus, heptad repeat 1 / Spike glycoprotein S2, coronavirus, heptad repeat 2 / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region profile. / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region profile. / Spike glycoprotein S2 superfamily, coronavirus / Spike glycoprotein S2, coronavirus / Coronavirus spike glycoprotein S2
Similarity search - Domain/homology
Spike glycoprotein / Dipeptidyl peptidase 4
Similarity search - Component
Biological speciesHomo sapiens (human)
Pangolin coronavirus HKU4
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.6 Å
AuthorsYang, M. / Li, Z. / Xu, Y. / Zhang, S.
Funding support China, 2items
OrganizationGrant numberCountry
National Natural Science Foundation of China (NSFC)32170158 China
National Natural Science Foundation of China (NSFC)32000659 China
CitationJournal: Plos Pathog. / Year: 2024
Title: Structural basis for human DPP4 receptor recognition by a pangolin MERS-like coronavirus.
Authors: Yang, M. / Li, Z. / Chen, J. / Li, Y. / Xu, R. / Wang, M. / Xu, Y. / Chen, R. / Ji, W. / Li, X. / Wei, J. / Zhou, Z. / Ren, M. / Ma, K. / Guan, J. / Mo, G. / Zhou, P. / Shu, B. / Guo, J. / ...Authors: Yang, M. / Li, Z. / Chen, J. / Li, Y. / Xu, R. / Wang, M. / Xu, Y. / Chen, R. / Ji, W. / Li, X. / Wei, J. / Zhou, Z. / Ren, M. / Ma, K. / Guan, J. / Mo, G. / Zhou, P. / Shu, B. / Guo, J. / Yuan, Y. / Shi, Z.L. / Zhang, S.
History
DepositionMay 3, 2024Deposition site: PDBJ / Processing site: PDBC
Revision 1.0Oct 30, 2024Provider: repository / Type: Initial release
Revision 1.1May 14, 2025Group: Database references / Category: citation / citation_author
Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Dipeptidyl peptidase 4 membrane form
C: Dipeptidyl peptidase 4 membrane form
D: Spike glycoprotein
B: Spike glycoprotein
hetero molecules


Theoretical massNumber of molelcules
Total (without water)219,20816
Polymers215,1964
Non-polymers4,01212
Water41423
1


  • Idetical with deposited unit
  • defined by author
  • Evidence: surface plasmon resonance
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)74.980, 121.901, 144.664
Angle α, β, γ (deg.)90.00, 93.82, 90.00
Int Tables number4
Space group name H-MP1211

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Components

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Protein , 2 types, 4 molecules ACDB

#1: Protein Dipeptidyl peptidase 4 membrane form / Dipeptidyl peptidase IV membrane form


Mass: 84577.703 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: DPP4, ADCP2, CD26 / Production host: Baculovirus expression vector pFastBac1-HM / References: UniProt: P27487
#2: Protein Spike glycoprotein / S glycoprotein / E2 / Peplomer protein


Mass: 23020.182 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Details: Sequence reference for source organism Pangolin coronavirus HKU4 is not available in UniProt at the time of biocuration. Current sequence reference is from UniProt id A0AAE8ZFM2.
Source: (gene. exp.) Pangolin coronavirus HKU4 / Production host: Baculovirus expression vector pFastBac1-HM / References: UniProt: A0AAE8ZFM2

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Sugars , 3 types, 11 molecules

#3: Polysaccharide beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta- ...beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose


Type: oligosaccharide / Mass: 586.542 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
DescriptorTypeProgram
DManpb1-4DGlcpNAcb1-4DGlcpNAcb1-ROHGlycam Condensed SequenceGMML 1.0
WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5]/1-1-2/a4-b1_b4-c1WURCSPDB2Glycan 1.1.0
[][D-1-deoxy-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-Manp]{}}}LINUCSPDB-CARE
#4: Polysaccharide 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose


Type: oligosaccharide / Mass: 424.401 Da / Num. of mol.: 3
Source method: isolated from a genetically manipulated source
DescriptorTypeProgram
DGlcpNAcb1-4DGlcpNAcb1-ROHGlycam Condensed SequenceGMML 1.0
WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1WURCSPDB2Glycan 1.1.0
[][D-1-deoxy-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{}}LINUCSPDB-CARE
#5: Sugar
ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE


Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 6 / Source method: obtained synthetically / Formula: C8H15NO6
IdentifierTypeProgram
DGlcpNAcbCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
N-acetyl-b-D-glucopyranosamineCOMMON NAMEGMML 1.0
b-D-GlcpNAcIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
GlcNAcSNFG CARBOHYDRATE SYMBOLGMML 1.0

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Non-polymers , 2 types, 24 molecules

#6: Chemical ChemComp-EPE / 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / HEPES


Mass: 238.305 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C8H18N2O4S / Feature type: SUBJECT OF INVESTIGATION / Comment: pH buffer*YM
#7: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 23 / Source method: isolated from a natural source / Formula: H2O

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Details

Has ligand of interestY
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 3.07 Å3/Da / Density % sol: 59.9 %
Crystal growTemperature: 291 K / Method: vapor diffusion, hanging drop / Details: 0.1 M HEPES (pH 7.0) and 10% (wt/vol) PEG 6000

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: SSRF / Beamline: BL02U1 / Wavelength: 0.979183 Å
DetectorType: DECTRIS EIGER2 S 9M / Detector: PIXEL / Date: Oct 12, 2023
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.979183 Å / Relative weight: 1
ReflectionResolution: 2.6→20 Å / Num. obs: 79444 / % possible obs: 99 % / Redundancy: 6.95 % / CC1/2: 0.997 / Net I/σ(I): 8.85
Reflection shellResolution: 2.6→2.75 Å / Num. unique obs: 12098 / CC1/2: 0.372

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Processing

Software
NameVersionClassification
PHENIX(1.20.1_4487: ???)refinement
XDSdata reduction
XDSdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT / Resolution: 2.6→19.69 Å / SU ML: 0.44 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 32.14 / Stereochemistry target values: ML
RfactorNum. reflection% reflection
Rfree0.2519 3934 4.98 %
Rwork0.2077 --
obs0.2099 78995 98.84 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL
Refinement stepCycle: LAST / Resolution: 2.6→19.69 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms15152 0 261 23 15436
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.00215837
X-RAY DIFFRACTIONf_angle_d0.48521531
X-RAY DIFFRACTIONf_dihedral_angle_d14.9735727
X-RAY DIFFRACTIONf_chiral_restr0.0452337
X-RAY DIFFRACTIONf_plane_restr0.0032724
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
2.6-2.630.47571100.42621837X-RAY DIFFRACTION70
2.63-2.660.45911520.40612678X-RAY DIFFRACTION99
2.66-2.70.39191720.39142689X-RAY DIFFRACTION100
2.7-2.730.38211320.38072673X-RAY DIFFRACTION100
2.73-2.770.39991320.37072736X-RAY DIFFRACTION100
2.77-2.810.38061490.35832672X-RAY DIFFRACTION100
2.81-2.860.41151270.34092708X-RAY DIFFRACTION100
2.86-2.90.36751730.32982703X-RAY DIFFRACTION100
2.9-2.950.31571470.31412671X-RAY DIFFRACTION100
2.95-3.010.34341360.30862723X-RAY DIFFRACTION100
3.01-3.070.33351430.29392702X-RAY DIFFRACTION100
3.07-3.130.33471460.2622729X-RAY DIFFRACTION100
3.13-3.20.32521300.25352672X-RAY DIFFRACTION100
3.2-3.270.31421410.25682751X-RAY DIFFRACTION100
3.27-3.350.28821200.23932670X-RAY DIFFRACTION100
3.35-3.440.29281470.23432731X-RAY DIFFRACTION100
3.44-3.540.28661460.22462683X-RAY DIFFRACTION100
3.54-3.660.27111290.21372724X-RAY DIFFRACTION100
3.66-3.780.23971350.22747X-RAY DIFFRACTION100
3.78-3.940.26411490.19562710X-RAY DIFFRACTION100
3.94-4.110.22991260.18122714X-RAY DIFFRACTION100
4.11-4.330.2021400.16892708X-RAY DIFFRACTION100
4.33-4.60.16891310.15182718X-RAY DIFFRACTION100
4.6-4.940.17321520.15222741X-RAY DIFFRACTION100
4.95-5.430.20961520.16112703X-RAY DIFFRACTION100
5.43-6.20.23951370.18572741X-RAY DIFFRACTION100
6.2-7.730.25331320.1962756X-RAY DIFFRACTION100
7.73-19.690.20641480.16332771X-RAY DIFFRACTION100
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
11.47140.5518-0.27970.4140.43432.5751-0.3257-0.58380.35380.0548-0.19010.43210.0391-1.16660.37610.84670.10140.06991.71370.02571.02410.625175.5172129.5702
21.2405-0.24560.43532.43320.37232.3395-0.0962-0.35810.09840.0735-0.00380.2961-0.3711-0.16670.19140.81640.03690.04211.16970.05520.824232.958781.2449134.505
30.9804-0.15740.15261.0693-0.24731.92180.0048-0.5806-0.13090.38560.02550.02140.3675-0.3105-0.0310.8561-0.00140.01451.16750.22520.785241.342365.3174136.3304
42.32040.67870.99811.5959-0.45442.91540.1673-0.9377-0.58890.34440.19570.28780.4234-0.2422-0.34861.3207-0.29550.08521.58490.47941.01827.700247.627144.3336
51.45890.1368-0.01290.7684-0.22622.40380.0242-0.4068-0.44920.1338-0.00670.18810.9054-0.7133-0.00990.9315-0.28470.02270.98670.25580.850121.579850.2637118.6783
62.4487-0.3909-0.30113.4573-0.29734.59150.2132-0.0059-0.0712-0.092-0.09990.32190.5269-0.733-0.09160.7152-0.07380.0070.82860.13240.757128.805562.2736101.1393
72.66510.87430.15551.03960.69191.3778-0.06480.2916-0.250.08730.2276-0.36490.44240.7324-0.18070.73480.188-0.0070.968-0.00630.775666.473165.021676.0695
81.47050.46-0.14991.3186-0.39311.76240.00230.0057-0.11340.07840.0126-0.25590.04970.6405-0.01710.48070.00680.00590.82660.06460.675366.362983.374894.1906
91.03740.1755-0.30130.87320.25371.87020.010.3160.1314-0.17290.01070.0985-0.2111-0.1615-0.02270.49690.0863-0.0290.6690.14180.609744.626882.730975.1564
101.444-1.2171-0.23661.8742-1.16132.2140.1416-1.16160.32510.9366-0.1474-0.2415-0.49670.95220.03891.15250.03660.04381.71760.07590.660384.9665122.7556114.3075
111.8781.46580.66214.0306-0.58843.52810.018-0.4472-0.12460.1241-0.1093-0.48960.01150.77380.00950.68550.0579-0.04891.1268-0.03210.731388.1163121.2784101.5751
123.4617-0.5757-1.18974.8377-1.09692.9024-0.1187-0.7229-0.00670.76350.233-0.1411-0.16811.1841-0.17250.8081-0.05270.0850.80010.00720.534176.6209110.5119104.6592
135.95813.07091.0313.39341.92111.2789-0.01840.1710.1669-0.09530.234-0.1249-0.11080.3359-0.16080.80770.0311-0.07511.08240.07420.767865.2591117.199590.5914
143.2156-1.18920.43580.82920.69951.94250.3755-1.203-0.31041.1047-0.15390.04280.4995-0.0205-0.02421.0691-0.04460.12271.42780.1320.860969.0128109.5343105.5635
157.2413-0.35051.84627.31030.15764.8595-0.2068-0.80840.53670.4475-0.03310.66480.0617-0.66820.29040.76530.0085-0.0031.14170.04420.831259.1649116.882997.8855
164.9373-1.6860.92014.6232-0.28613.05640.0789-0.6181-0.10780.21230.2245-0.4030.58880.458-0.39670.8797-0.0530.05850.71110.14140.878475.0728106.067102.8462
174.58782.7188-0.92422.3745-2.40745.28460.1735-0.22030.50111.20970.1038-0.2436-1.09180.6679-0.32180.8989-0.0430.00331.2727-0.13530.803390.508130.8129104.7449
180.2025-0.1387-0.1430.9401-0.22560.2283-0.21320.47610.39-0.22980.3833-0.4179-0.68991.2655-0.29981.0959-0.39270.08342.04180.03041.032573.655870.1361164.5601
190.28660.05460.1241.70341.76233.2871-0.30920.16570.44420.24050.6282-0.9054-0.25551.7278-0.40071.0036-0.0388-0.05462.0363-0.24181.252877.418464.7723173.3283
204.31270.06221.81134.3218-3.00614.496-1.0063-0.06040.1630.56791.1466-0.9818-1.288-0.2901-0.05351.38050.0502-0.03551.3819-0.14861.189865.012973.5847175.2416
213.9739-1.29960.83814.8952-1.84545.6116-0.1454-0.91780.55230.67330.6116-0.8035-0.60040.4693-0.32511.0873-0.1144-0.01981.7141-0.22561.012869.313964.5397176.8782
222.0208-0.95180.89063.6056-1.13953.8742-0.0138-0.54270.0785-0.25920.42220.2328-0.0597-0.4047-0.58750.91010.01680.09661.28310.15490.87157.866464.1475166.1362
235.0921.2105-1.72112.1183-1.45451.1926-0.1546-0.8159-0.00970.11530.724-0.31631.1731-0.6965-0.52691.7302-0.2804-0.00681.50230.10451.05168.596480.951160.2954
244.0066-0.8091.58842.19192.70515.14710.37230.48760.1285-0.27680.18080.03280.18990.7362-0.4951.2115-0.00710.04161.43830.2970.883759.324357.7308150.0669
253.7955-2.5687-1.91066.02413.58752.7773-0.0250.4688-0.4982-0.34650.3229-0.06990.4510.359-0.05581.28770.1457-0.00581.60770.18270.925562.085754.8817145.2679
262.14050.80071.25430.97882.1494.8882-0.25360.39061.143-0.4606-0.3347-0.4362-1.01910.73990.54381.237-0.25040.01871.37690.13461.079963.304673.6947165.1845
275.30995.70671.11586.5311-0.07314.25870.1005-0.7922-0.67641.7982-0.3706-2.86550.60072.04740.18591.32910.2133-0.37251.9702-0.17381.254377.116857.2191182.3013
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection details
1X-RAY DIFFRACTION1chain 'A' and (resid 38 through 118 )
2X-RAY DIFFRACTION2chain 'A' and (resid 119 through 206 )
3X-RAY DIFFRACTION3chain 'A' and (resid 207 through 363 )
4X-RAY DIFFRACTION4chain 'A' and (resid 364 through 413 )
5X-RAY DIFFRACTION5chain 'A' and (resid 414 through 712 )
6X-RAY DIFFRACTION6chain 'A' and (resid 713 through 766 )
7X-RAY DIFFRACTION7chain 'C' and (resid 38 through 143 )
8X-RAY DIFFRACTION8chain 'C' and (resid 144 through 297 )
9X-RAY DIFFRACTION9chain 'C' and (resid 298 through 766 )
10X-RAY DIFFRACTION10chain 'D' and (resid 389 through 403 )
11X-RAY DIFFRACTION11chain 'D' and (resid 404 through 492 )
12X-RAY DIFFRACTION12chain 'D' and (resid 493 through 514 )
13X-RAY DIFFRACTION13chain 'D' and (resid 515 through 534 )
14X-RAY DIFFRACTION14chain 'D' and (resid 535 through 546 )
15X-RAY DIFFRACTION15chain 'D' and (resid 547 through 560 )
16X-RAY DIFFRACTION16chain 'D' and (resid 561 through 574 )
17X-RAY DIFFRACTION17chain 'D' and (resid 575 through 596 )
18X-RAY DIFFRACTION18chain 'B' and (resid 389 through 407 )
19X-RAY DIFFRACTION19chain 'B' and (resid 408 through 418 )
20X-RAY DIFFRACTION20chain 'B' and (resid 419 through 434 )
21X-RAY DIFFRACTION21chain 'B' and (resid 435 through 455 )
22X-RAY DIFFRACTION22chain 'B' and (resid 456 through 492 )
23X-RAY DIFFRACTION23chain 'B' and (resid 493 through 503 )
24X-RAY DIFFRACTION24chain 'B' and (resid 504 through 547 )
25X-RAY DIFFRACTION25chain 'B' and (resid 548 through 569 )
26X-RAY DIFFRACTION26chain 'B' and (resid 570 through 583 )
27X-RAY DIFFRACTION27chain 'B' and (resid 584 through 594 )

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