登録情報 データベース : PDB / ID : 8ydd 構造の表示 ダウンロードとリンクタイトル Crystal structure of Nanog(R100A) in complex with Wdr5 要素Homeobox protein NANOG WD repeat-containing protein 5 詳細キーワード NUCLEAR PROTEIN / transcription factor / protein-protein interaction機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
negative regulation of endodermal cell fate specification / negative regulation of cell fate commitment / Epigenetic regulation of gene expression by MLL3 and MLL4 complexes / Formation of WDR5-containing histone-modifying complexes / RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity / mesodermal cell fate commitment / cellular response to erythropoietin / multidimensional cell growth / cell dedifferentiation / endodermal cell fate specification ... negative regulation of endodermal cell fate specification / negative regulation of cell fate commitment / Epigenetic regulation of gene expression by MLL3 and MLL4 complexes / Formation of WDR5-containing histone-modifying complexes / RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity / mesodermal cell fate commitment / cellular response to erythropoietin / multidimensional cell growth / cell dedifferentiation / endodermal cell fate specification / regulation of stem cell division / cellular response to rapamycin / HATs acetylate histones / gonad development / PKMTs methylate histone lysines / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / RMTs methylate histone arginines / tissue regeneration / Neddylation / embryonic pattern specification / MLL3/4 complex / stem cell division / negative regulation of stem cell differentiation / Set1C/COMPASS complex / ATAC complex / NSL complex / histone H3K4 methyltransferase activity / histone methyltransferase complex / stem cell population maintenance / transcription factor binding / regulation of cell division / regulation of embryonic development / MLL1 complex / histone acetyltransferase complex / negative regulation of BMP signaling pathway / somatic stem cell population maintenance / BMP signaling pathway / response to retinoic acid / : / positive regulation of gluconeogenesis / positive regulation of mitotic cell cycle / transcription initiation-coupled chromatin remodeling / gluconeogenesis / skeletal system development / : / stem cell differentiation / DNA-binding transcription repressor activity, RNA polymerase II-specific / mitotic spindle / DNA-binding transcription activator activity, RNA polymerase II-specific / gene expression / sequence-specific DNA binding / transcription cis-regulatory region binding / regulation of cell cycle / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / positive regulation of cell population proliferation / chromatin binding / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / chromatin / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / DNA binding / nucleoplasm / identical protein binding / nucleus 類似検索 - 分子機能 : / Homeobox, conserved site / 'Homeobox' domain signature. / Homeodomain / 'Homeobox' domain profile. / Homeodomain / Homeobox domain / Homeobox-like domain superfamily / G-protein beta WD-40 repeat / WD40 repeat, conserved site ... : / Homeobox, conserved site / 'Homeobox' domain signature. / Homeodomain / 'Homeobox' domain profile. / Homeodomain / Homeobox domain / Homeobox-like domain superfamily / G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / WD domain, G-beta repeat / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily 類似検索 - ドメイン・相同性 WD repeat-containing protein 5 / Homeobox protein NANOG 類似検索 - 構成要素生物種 Mus musculus (ハツカネズミ)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.5 Å 詳細データ登録者 Wang, D. / Shi, X. / Zhao, L. / Wu, B. / Chen, Y. 資金援助 中国, 4件 詳細 詳細を隠す組織 認可番号 国 National Natural Science Foundation of China (NSFC) 31670748 中国 National Natural Science Foundation of China (NSFC) 31970576 中国 National Natural Science Foundation of China (NSFC) 32071195 中国 National Natural Science Foundation of China (NSFC) 31900934 中国
引用ジャーナル : To Be Published タイトル : Crystal structure of Nanog(R100A) in complex with Wdr5著者 : Wang, D. / Shi, X. / Zhao, L. / Wu, B. / Chen, Y. / Li, Y. 履歴 登録 2024年2月20日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2025年3月26日 Provider : repository / タイプ : Initial release