+Open data
-Basic information
Entry | Database: PDB / ID: 8xwx | |||||||||
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Title | Crystal structure of FIS1-BAP31 complex from human | |||||||||
Components |
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Keywords | APOPTOSIS / MAM complex / mitochondria / ER. | |||||||||
Function / homology | Function and homology information positive regulation of retrograde protein transport, ER to cytosol / negative regulation of fatty acid transport / negative regulation of ATP metabolic process / Class I peroxisomal membrane protein import / positive regulation of mitochondrial calcium ion concentration / protein localization to endoplasmic reticulum exit site / mitochondria-associated endoplasmic reticulum membrane contact site / Apoptotic execution phase / positive regulation of ERAD pathway / peroxisome fission ...positive regulation of retrograde protein transport, ER to cytosol / negative regulation of fatty acid transport / negative regulation of ATP metabolic process / Class I peroxisomal membrane protein import / positive regulation of mitochondrial calcium ion concentration / protein localization to endoplasmic reticulum exit site / mitochondria-associated endoplasmic reticulum membrane contact site / Apoptotic execution phase / positive regulation of ERAD pathway / peroxisome fission / mitochondrial fragmentation involved in apoptotic process / negative regulation of endoplasmic reticulum calcium ion concentration / perinuclear endoplasmic reticulum / autophagy of mitochondrion / protein targeting to mitochondrion / positive regulation of ubiquitin-dependent protein catabolic process / mitochondrial fission / regulation of mitochondrion organization / peroxisomal membrane / mitochondrial fusion / clathrin-coated vesicle / Golgi cisterna membrane / positive regulation of mitochondrial fission / Apoptotic cleavage of cellular proteins / MHC class I protein binding / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / : / RHOA GTPase cycle / positive regulation of protein targeting to membrane / endoplasmic reticulum to Golgi vesicle-mediated transport / positive regulation of intrinsic apoptotic signaling pathway / endoplasmic reticulum-Golgi intermediate compartment membrane / response to endoplasmic reticulum stress / mitochondrion organization / lipid droplet / release of cytochrome c from mitochondria / lumenal side of endoplasmic reticulum membrane / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / intracellular protein transport / peroxisome / positive regulation of cytosolic calcium ion concentration / spermatogenesis / mitochondrial outer membrane / molecular adaptor activity / Golgi membrane / lipid binding / apoptotic process / protein-containing complex binding / endoplasmic reticulum membrane / endoplasmic reticulum / protein-containing complex / mitochondrion / membrane / identical protein binding / plasma membrane / cytosol Similarity search - Function | |||||||||
Biological species | Homo sapiens (human) | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.69 Å | |||||||||
Authors | Nguyen, M.D. / Bong, S.M. / Lee, B.I. | |||||||||
Funding support | Korea, Republic Of, 2items
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Citation | Journal: To Be Published Title: A crystal structure containing FIS1 and BAP31 suggests the clue for FIS1-BAP31 interaction Authors: Nguyen, M.D. / Bong, S.M. / Lee, B.I. #1: Journal: Acta Crystallogr D Struct Biol / Year: 2019 Title: Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix. Authors: Dorothee Liebschner / Pavel V Afonine / Matthew L Baker / Gábor Bunkóczi / Vincent B Chen / Tristan I Croll / Bradley Hintze / Li Wei Hung / Swati Jain / Airlie J McCoy / Nigel W Moriarty ...Authors: Dorothee Liebschner / Pavel V Afonine / Matthew L Baker / Gábor Bunkóczi / Vincent B Chen / Tristan I Croll / Bradley Hintze / Li Wei Hung / Swati Jain / Airlie J McCoy / Nigel W Moriarty / Robert D Oeffner / Billy K Poon / Michael G Prisant / Randy J Read / Jane S Richardson / David C Richardson / Massimo D Sammito / Oleg V Sobolev / Duncan H Stockwell / Thomas C Terwilliger / Alexandre G Urzhumtsev / Lizbeth L Videau / Christopher J Williams / Paul D Adams / Abstract: Diffraction (X-ray, neutron and electron) and electron cryo-microscopy are powerful methods to determine three-dimensional macromolecular structures, which are required to understand biological ...Diffraction (X-ray, neutron and electron) and electron cryo-microscopy are powerful methods to determine three-dimensional macromolecular structures, which are required to understand biological processes and to develop new therapeutics against diseases. The overall structure-solution workflow is similar for these techniques, but nuances exist because the properties of the reduced experimental data are different. Software tools for structure determination should therefore be tailored for each method. Phenix is a comprehensive software package for macromolecular structure determination that handles data from any of these techniques. Tasks performed with Phenix include data-quality assessment, map improvement, model building, the validation/rebuilding/refinement cycle and deposition. Each tool caters to the type of experimental data. The design of Phenix emphasizes the automation of procedures, where possible, to minimize repetitive and time-consuming manual tasks, while default parameters are chosen to encourage best practice. A graphical user interface provides access to many command-line features of Phenix and streamlines the transition between programs, project tracking and re-running of previous tasks. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 8xwx.cif.gz | 299.4 KB | Display | PDBx/mmCIF format |
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PDB format | pdb8xwx.ent.gz | 203.1 KB | Display | PDB format |
PDBx/mmJSON format | 8xwx.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/xw/8xwx ftp://data.pdbj.org/pub/pdb/validation_reports/xw/8xwx | HTTPS FTP |
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-Related structure data
Similar structure data | Similarity search - Function & homologyF&H Search |
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-Links
-Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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