登録情報 | データベース: PDB / ID: 8x71 |
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タイトル | Crystal structure of Peroxiredoxin I in complex with compound 19-064 |
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要素 | Peroxiredoxin-1 |
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キーワード | OXIDOREDUCTASE/INHIBITOR / OXIDOREDUCTASE-INHIBITOR COMPLEX |
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機能・相同性 | 機能・相同性情報
leukocyte activation / regulation of non-canonical NF-kappaB signal transduction / thioredoxin-dependent peroxiredoxin / natural killer cell mediated cytotoxicity / thioredoxin peroxidase activity / natural killer cell activation / erythrocyte homeostasis / NFE2L2 regulating anti-oxidant/detoxification enzymes / regulation of stress-activated MAPK cascade / Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models ...leukocyte activation / regulation of non-canonical NF-kappaB signal transduction / thioredoxin-dependent peroxiredoxin / natural killer cell mediated cytotoxicity / thioredoxin peroxidase activity / natural killer cell activation / erythrocyte homeostasis / NFE2L2 regulating anti-oxidant/detoxification enzymes / regulation of stress-activated MAPK cascade / Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models / Detoxification of Reactive Oxygen Species / canonical NF-kappaB signal transduction / removal of superoxide radicals / cell redox homeostasis / skeletal system development / hydrogen peroxide catabolic process / TP53 Regulates Metabolic Genes / peroxidase activity / melanosome / fibroblast proliferation / response to oxidative stress / cell population proliferation / cadherin binding / RNA binding / extracellular space / extracellular exosome / identical protein binding / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Peroxiredoxin, AhpC-type / Peroxiredoxin, C-terminal / C-terminal domain of 1-Cys peroxiredoxin / Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant / AhpC/TSA family / Thioredoxin domain profile. / Thioredoxin domain / Thioredoxin-like superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.58 Å |
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データ登録者 | Zhang, H. / Luo, C. |
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資金援助 | 中国, 1件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China (NSFC) | 81903538 | 中国 |
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引用 | ジャーナル: J.Med.Chem. / 年: 2024 タイトル: Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors. 著者: Wang, J. / Rong, Q. / Ye, L. / Fang, B. / Zhao, Y. / Sun, Y. / Zhou, H. / Wang, D. / He, J. / Cui, Z. / Zhang, Q. / Kang, D. / Hu, L. |
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履歴 | 登録 | 2023年11月22日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2024年6月19日 | Provider: repository / タイプ: Initial release |
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