登録情報 | データベース: PDB / ID: 8wtf |
---|
タイトル | The Crystal Structure of IRAK4 from Biortus |
---|
要素 | Interleukin-1 receptor-associated kinase 4 |
---|
キーワード | SIGNALING PROTEIN / Kinase / Serine/threonine-protein kinase / Transferase / Immunity / Innate immunity / ATP-binding / Magnesium / Nucleotide-binding |
---|
機能・相同性 | 機能・相同性情報
IRAK4 deficiency (TLR5) / MyD88 dependent cascade initiated on endosome / TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation / MyD88 cascade initiated on plasma membrane / Toll signaling pathway / neutrophil migration / interleukin-33-mediated signaling pathway / toll-like receptor 9 signaling pathway / neutrophil mediated immunity / interleukin-1 receptor binding ...IRAK4 deficiency (TLR5) / MyD88 dependent cascade initiated on endosome / TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation / MyD88 cascade initiated on plasma membrane / Toll signaling pathway / neutrophil migration / interleukin-33-mediated signaling pathway / toll-like receptor 9 signaling pathway / neutrophil mediated immunity / interleukin-1 receptor binding / MyD88-dependent toll-like receptor signaling pathway / interleukin-1-mediated signaling pathway / IRAK4 deficiency (TLR2/4) / MyD88:MAL(TIRAP) cascade initiated on plasma membrane / toll-like receptor 4 signaling pathway / toll-like receptor signaling pathway / extrinsic component of plasma membrane / JNK cascade / TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling / positive regulation of smooth muscle cell proliferation / cytokine-mediated signaling pathway / Interleukin-1 signaling / PIP3 activates AKT signaling / kinase activity / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / cellular response to lipopolysaccharide / positive regulation of canonical NF-kappaB signal transduction / endosome membrane / non-specific serine/threonine protein kinase / intracellular signal transduction / phosphorylation / innate immune response / protein serine kinase activity / protein serine/threonine kinase activity / protein kinase binding / cell surface / magnesium ion binding / extracellular space / ATP binding / nucleus / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Interleukin-1 receptor-associated kinase 4 / IRAK4, Death domain / Death-like domain superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily類似検索 - ドメイン・相同性 Chem-8CG / Interleukin-1 receptor-associated kinase 4類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2 Å |
---|
データ登録者 | Wang, F. / Cheng, W. / Lv, Z. / Meng, Q. / Xu, Y. |
---|
資金援助 | 1件 |
---|
引用 | ジャーナル: To Be Published タイトル: The Crystal Structure of IRAK4 from Biortus 著者: Wang, F. / Cheng, W. / Lv, Z. / Meng, Q. / Xu, Y. |
---|
履歴 | 登録 | 2023年10月18日 | 登録サイト: PDBJ / 処理サイト: PDBC |
---|
改定 1.0 | 2023年11月15日 | Provider: repository / タイプ: Initial release |
---|
|
---|